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Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6838 - 6851
alpha-Synuclein is central in Parkinson's disease pathogenesis. Although initially alpha-synuclein was considered a purely intracellular protein, recent data... 
FIBRIL FORMATION | PROTEIN | MULTIVESICULAR BODIES | HUMAN PLASMA | ACTIVATES MICROGLIA | CONGO RED | ENDOPLASMIC-RETICULUM | FAMILIAL PARKINSONS-DISEASE | RELEASE | BODY FORMATION | NEUROSCIENCES | Molecular Weight | Serum - metabolism | Calcium - metabolism | Microscopy, Electron, Transmission - methods | Humans | Culture Media, Conditioned - chemistry | Cell Survival - genetics | Brefeldin A - pharmacology | Neurons - ultrastructure | Piperidines - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Protein Synthesis Inhibitors - pharmacology | Exosomes - ultrastructure | Cell Survival - drug effects | Calcium - pharmacology | Immunoprecipitation - methods | Multivesicular Bodies - pathology | Endocytosis - drug effects | Rats | Microscopy, Confocal - methods | Analysis of Variance | Cell Line, Tumor | beta-Galactosidase - genetics | Multivesicular Bodies - drug effects | Temperature | Chromatography, High Pressure Liquid - methods | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Subcellular Fractions - ultrastructure | Transfection | Exosomes - physiology | beta-Galactosidase - metabolism | Presenilin-1 - pharmacology | Cell Death - drug effects | Cytotoxicity Tests, Immunologic - methods | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Neuroblastoma - pathology | Pyrazoles - pharmacology | Subcellular Fractions - drug effects | Multivesicular Bodies - ultrastructure | Cells, Cultured | Hydrogen Peroxide - pharmacology | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Peptides - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Neuroblastoma - ultrastructure | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mass Spectrometry - methods | alpha-Synuclein - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, pp. e0166053 - e0166053
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 17
In experimental models, both in vivo and cellular, over-expression of Parkinson’s linked mutant leucine-rich repeat kinase 2 (LRRK2) is sufficient to induce... 
FADD protein | Neuroprotection | Mitochondria | Overexpression | Bax protein | Clonal deletion | Cell death | Homology | Leucine | LRRK2 protein
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2019, Volume 476, Issue 3, pp. 559 - 579
The Parkinson's disease (PD) protein leucine-rich repeat kinase 2 (LRRK2) exists as a mixture of monomeric and dimeric species, with its kinase activity highly... 
DISEASE-ASSOCIATED MUTATIONS | LOCALIZATION | ACTIVATION | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 14-3-3 BINDING | PHENOTYPES | GTP-BINDING | DEATH-DOMAIN | REVEALS
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3455 - 3455
In experimental models, both in vivo and cellular, over-expression of Parkinson's linked mutant leucine-rich repeat kinase 2 (LRRK2) is sufficient to induce... 
KINASE-ACTIVITY | APOPTOSIS | PROTEIN | CORTICAL-NEURONS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | DISEASE | FAS | BAX | MUTATIONS | CELL-DEATH
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 12/2013, Volume 34, Issue 12, pp. 2853 - 2865
I--Synuclein (AS) plays a crucial role in Parkinson's disease pathogenesis. AS is normally secreted from neuronal cells and can thus exert paracrine effects.... 
Aging
Journal Article
Journal of Clinical Research in Pediatric Endocrinology, ISSN 1308-5727, 09/2016, Volume 8, Issue 3
  Familial hypocalciuric hypercalcemia (FHH) is an autosomal dominant disorder, associated with inactivating mutations of the calcium-sensing receptor (CaSR).... 
Journal Article
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