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2012, 1. Aufl., Current topics in microbiology and immunology, ISBN 3642282954, Volume 355., x, 234
Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function,... 
Chemotherapy | Antineoplastic Protocols | Cancer | Clinical & internal medicine | Protein kinases | Inhibitors
Book
Journal of Nuclear Medicine, ISSN 0161-5505, 10/2019, p. jnumed.119.229740
Journal Article
2012, Current topics in microbiology and immunology, ISBN 3642282954, Volume 355
Web Resource
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 2621 - 2621
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2018, Volume 36, Issue 15_suppl, pp. 2577 - 2577
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2672 - 2672
Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types. These... 
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 1498 - 1498
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 626 - 630
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One... 
Enzymes | Cell growth | Glioma | RNA | Neurons | REPORTS | Methylation | Cellular differentiation | Genetic mutation | Heterologous transplantation | Tumors | TRANSFORMATION | GLIOBLASTOMA | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | MUTATIONS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | BRAIN | Benzeneacetamides - toxicity | Protein Multimerization | Imidazoles - administration & dosage | Gene Expression Profiling | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - genetics | RNA Interference | Enzyme Inhibitors - toxicity | Glioma - pathology | Imidazoles - toxicity | Gene Expression Regulation, Neoplastic - drug effects | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Glioma - enzymology | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Imidazoles - pharmacology | Mice, SCID | Benzeneacetamides - administration & dosage | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Cell Transformation, Neoplastic | Isocitrate Dehydrogenase - chemistry | Mutant Proteins - chemistry | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Histones - metabolism | Glioma - drug therapy | Cell proliferation | Gene mutations | Gliomas | Growth | Cancer cells | Physiological aspects | Genetic aspects | Research | Cancer | Genes | Cells | Mutation | Drugs | Binding | Mutations | Inhibitors | Online | Delay
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7390, pp. 474 - 478
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2014, Volume 32, Issue 15_suppl, pp. 2045 - 2045
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2013, Volume 18, Issue 5, pp. 726 - 739
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2009, Volume 119, Issue 10, pp. 3000 - 3010
EGFR is a major anticancer drug target in human epithelial. tumors. One effective class of agents is the tyrosine kinase inhibitors (TKIs), such as gefitinib... 
MEDICINE, RESEARCH & EXPERIMENTAL | CETUXIMAB | GEFITINIB | FACTOR RECEPTOR MUTATIONS | COMBINATION THERAPY | EPIDERMAL-GROWTH-FACTOR | T790M MUTATIONS | ACQUIRED-RESISTANCE | TYROSINE KINASE INHIBITOR | GENE MUTATION | ERLOTINIB | Erlotinib Hydrochloride | Lung Neoplasms - drug therapy | Neoplasm Transplantation | Receptor, Epidermal Growth Factor - genetics | Humans | Glycoproteins - metabolism | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Epiregulin | Amphiregulin | Antibodies, Monoclonal, Humanized | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Quinazolines - metabolism | Tumor Cells, Cultured | Cetuximab | Disease Models, Animal | Glycoproteins - genetics | Lung Neoplasms - genetics | Epidermal Growth Factor - genetics | Intercellular Signaling Peptides and Proteins - genetics | Epidermal Growth Factor - metabolism | Mice, Transgenic | Paclitaxel - therapeutic use | Drug Resistance, Neoplasm - genetics | Animals | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Mice | Mutation | Genetic aspects | Gene mutations | Drug therapy | Drug resistance | Identification and classification | Lung cancer
Journal Article