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1. Full Text Update on Typical and Atypical Antipsychotic Drugs
by Meltzer, Herbert Y
Annual Review of Medicine, ISSN 0066-4219, 1/2013, Volume 64, Issue 1, pp. 393 - 406
Antipsychotic drugs (APDs) are best classified as typical or atypical. The distinction is based solely on their ability to cause extrapyramidal side effects... 
cognition | clozapine | extrapyramidal | antipsychotic | schizophrenia | psychosis | metabolic | MEDICINE, RESEARCH & EXPERIMENTAL | COST-EFFECTIVENESS | NEUROLEPTIC DRUGS | ACETYLCHOLINE-RELEASE | COGNITIVE DYSFUNCTION | SEROTONIN 5-HT1A | TREATMENT-RESISTANT SCHIZOPHRENIA | 2ND-GENERATION ANTIPSYCHOTICS | CLOZAPINE TREATMENT | DOUBLE-BLIND | TARDIVE-DYSKINESIA | Antipsychotic Agents - classification | Psychotic Disorders - physiopathology | Antipsychotic Agents - therapeutic use | Humans | Treatment Outcome | Psychotic Disorders - drug therapy | Cognition - drug effects | Physiological aspects | Antipsychotic drugs | Neural circuitry | Health aspects
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2. Clozapine: Balancing safety with superior antipsychotic efficacy
by Meltzer, Herbert Y
Clinical Schizophrenia and Related Psychoses, ISSN 1935-1232, 10/2012, Volume 6, Issue 3, pp. 134 - 144
Clozapine is often referred to as the gold standard for the treatment of schizophrenia and yet has also been described as the most underutilized treatment for... 
Myocarditis | Metabolic side effects | Agranulocytosis | Schizophrenia | Treatment resistant | Clozapine | Suicide | Myocarditis - chemically induced | Agranulocytosis - chemically induced | Antipsychotic Agents - adverse effects | Clozapine - administration & dosage | Humans | Risk Factors | Metabolic Diseases - epidemiology | Metabolic Diseases - chemically induced | Schizophrenia - epidemiology | Agranulocytosis - epidemiology | Antipsychotic Agents - administration & dosage | Myocarditis - epidemiology | Schizophrenia - drug therapy | Clozapine - adverse effects
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3. Full Text 5-HT1A parital agonism and 5-HT7 antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA
by Huang, Mei and Kwon, Sunoh and Rajagopal, Lakshmi and He, Wenqi and Meltzer, Herbert Y
Psychopharmacology, ISSN 0033-3158, 10/2018, Volume 235, Issue 10, pp. 2795 - 2808
The effect of atypical antipsychotic drugs (AAPDs), e.g., lurasidone, to improve cognitive impairment associated with schizophrenia (CIAS), has been suggested... 
Neurosciences | Biomedicine | SB-269970 | Schizophrenia | Lurasidone | Cognition | WAY-100635 | Pharmacology/Toxicology | Psychiatry | IN-VIVO MICRODIALYSIS | GABAERGIC TRANSMISSION | PSYCHIATRY | OBJECT RECOGNITION NOR | RAT PREFRONTAL CORTEX | NEUROSCIENCES | SEROTONERGIC REGULATION | PYRAMIDAL NEURONS | INDUCED CORTICAL DOPAMINE | ATYPICAL ANTIPSYCHOTIC-DRUG | STRIATAL CHOLINERGIC INTERNEURONS | RECEPTOR ACTIVATION | PHARMACOLOGY & PHARMACY | Efflux | Brain | Cortex (prefrontal) | Neuroleptics | Dopamine | Mental disorders | Serotonin | Cognitive ability | Stimulation | Pattern recognition | Object recognition | Serotonin S1 receptors | Antagonism | γ-Aminobutyric acid | Neurotransmitters | Phencyclidine | Rodents | Serotonin receptors | Neostriatum | Mice | Acetylcholine | Inhibition | Pretreatment
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4. TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABAA receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia
by Lakshmi Rajagopal and Mei Huang and Eric Michael and Sunoh Kwon and Herbert Y Meltzer
Neuropsychopharmacology, ISSN 0893-133X, 11/2018, Volume 43, Issue 12, pp. 2468 - 2477
GABAergic drugs are of interest for the treatment of anxiety, depression, bipolar disorder, pain, cognitive impairment associated with schizophrenia (CIAS),... 
Neuroleptics | γ-Aminobutyric acid A receptors | Mental disorders | Hyperactivity | Cognitive ability | Clinical trials | Schizophrenia | Reversing | Bipolar disorder | Glutamic acid receptors | Mental depression | Drug development | γ-Aminobutyric acid | Pain | Phencyclidine | Reversal learning | Rodents | Neostriatum | Anxiety | Locomotor activity | Medical research | Efflux | Dopamine | Serotonin | Cortex | N-Methyl-D-aspartic acid receptors | Pattern recognition | Object recognition | Neurotransmitters | Norepinephrine | Acetylcholine
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5. Full Text Interaction of mGlu 2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats
by Horiguchi, Masakuni and Huang, Mei and Meltzer, Herbert Y
Psychopharmacology, ISSN 0033-3158, 09/2011, Volume 217, Issue 1, pp. 13 - 24
LY379268 | Dopamine | Memory | Schizophrenia | Clozapine | Pimavanserin | Glutamate | Object recognition | mGlu | Microdialysis | Phencyclidine | Antipsychotic | Lurasidone | Metabotropic glutamate receptor
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6. Full Text Serotonergic mechanisms as targets for existing and novel antipsychotics
by Meltzer, Herbert Y
Handbook of Experimental Pharmacology, ISSN 0171-2004, 2012, Volume 212, Issue 212, pp. 87 - 124
A variety of serotonin (5-HT) receptors, especially 5-HT(2A), 5-HT(1A), 5-HT(6), 5-HT(7), and 5-HT(2C), have been postulated to contribute to the mechanism of... 
Dopamine | Phencyclidine | Serotonin | Memory | Hallucinations | GABA | Schizophrenia | Antipsychotic | Glutamate | Receptor, Serotonin, 5-HT2C - physiology | Receptors, Serotonin - physiology | Receptor, Serotonin, 5-HT2A - physiology | Animals | Humans | Receptors, Serotonin - drug effects | Receptor, Serotonin, 5-HT1A - physiology | Serotonin Antagonists - therapeutic use | Antipsychotic Agents - pharmacology | Cognition - drug effects
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7. Therapy-resistant schizophrenia
by Elkis, Hélio and Meltzer, Herbert Y
2010, Advances in biological psychiatry, ISBN 9783805595124, Volume 26
Antipsychotic Agents | Chemotherapy | Antipsychotic drugs | drug therapy | Schizophrenia | Clozapine | Drug resistance | therapeutic use
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8. Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: An update and meta-analysis
by Sicard, Michelle N and Zai, Clement C and Tiwari, Arun K and Souza, Renan P and Meltzer, Herbert Y and Lieberman, Jeffrey A and Kennedy, James L and Müller, Daniel J
Pharmacogenomics, ISSN 1462-2416, 11/2010, Volume 11, Issue 11, pp. 1561 - 1571
Aims: This study aims to test for possible associations between the gene coding for the 5-HT2C receptor and antipsychotic-induced weight gain. Materials &... 
antipsychotics | meta-analysis | HTR2C | 5-HT2C receptor | genetics | weight gain | CLOZAPINE | THE-759C/T POLYMORPHISM | SCHIZOPHRENIA | MONOZYGOTIC TWINS | 5-HT2C RECEPTOR GENE | C/T POLYMORPHISM | PROMOTER REGION | PHARMACOLOGY & PHARMACY | OLANZAPINE | ASSOCIATION | 5HT2C RECEPTOR | Antipsychotic Agents - adverse effects | Humans | Male | Antipsychotic Agents - pharmacokinetics | Antipsychotic Agents - administration & dosage | Schizophrenia - genetics | Antipsychotic Agents - therapeutic use | Alleles | Weight Gain - genetics | Adult | Female | Weight Gain - drug effects | Polymorphism, Single Nucleotide | Receptor, Serotonin, 5-HT2C - genetics | Schizophrenia - drug therapy
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9. Full Text 5-HT 1A parital agonism and 5-HT 7 antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA
by Huang, Mei and Kwon, Sunoh and Rajagopal, Lakshmi and He, Wenqi and Meltzer, Herbert Y
Psychopharmacology, ISSN 0033-3158, 10/2018, Volume 235, Issue 10, pp. 2795 - 2808
The effect of atypical antipsychotic drugs (AAPDs), e.g., lurasidone, to improve cognitive impairment associated with schizophrenia (CIAS), has been suggested... 
Schizophrenia | Cognition | Lurasidone | WAY-100635 | SB-269970 | Receptors, Serotonin - physiology | Drug Partial Agonism | Mice, Inbred C57BL | Glutamic Acid - physiology | Memory, Episodic | Serotonin 5-HT1 Receptor Agonists - pharmacology | Male | Serotonin Antagonists - pharmacology | Mice, Knockout | gamma-Aminobutyric Acid - physiology | Animals | Dopamine - physiology | Lurasidone Hydrochloride - pharmacology | Mice | Antipsychotic Agents - pharmacology | Acetylcholine - physiology | Phencyclidine - toxicity
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10. Full Text Association of Serotonin2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia
by Li, Jiang and Hashimoto, Hitoshi and Meltzer, Herbert Y
Frontiers in Psychiatry, ISSN 1664-0640, 02/2019, Volume 10
There is conflicting evidence for the association between genetic polymorphisms in the serotonin (5-HT)2C receptor (HTR2C) and response to antipsychotic drugs... 
Care and treatment | Usage | Antipsychotic drugs | Serotonin | Schizophrenia | Genetic aspects | Research | Genetic polymorphisms | genetic | clozapine | schizophrenia | serotonin2C | antipsychotic agents | treatment response
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11. Full Text 5-HT.sub.1A parital agonism and 5-HT.sub.7 antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA
by Huang, Mei and Kwon, Sunoh and Rajagopal, Lakshmi and He, Wenqi and Meltzer, Herbert Y
Psychopharmacology, ISSN 0033-3158, 10/2018, Volume 235, Issue 10, p. 2795
The effect of atypical antipsychotic drugs (AAPDs), e.g., lurasidone, to improve cognitive impairment associated with schizophrenia (CIAS), has been suggested... 
Cerebral cortex | Dopamine | Schizophrenia | Physiological aspects | Acetylcholine | Hippocampus (Brain) | Drug therapy | Glutamate | Episodic memory | Health aspects
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12. Update on Typical and Atypical Antipsychotic Drugs
by Herbert Y Meltzer
Annual Review of Medicine, ISSN 0066-4219, 01/2013, Volume 64, p. 393
  Antipsychotic drugs (APDs) are best classified as typical or atypical. The distinction is based solely on their ability to cause extrapyramidal side effects... 
Psychotropic drugs | Mental health care | Side effects | Schizophrenia | Psychopathology
Journal Article
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13. Full Text The novel alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens
by Huang, M and Felix, AR and Flood, DG and Bhuvaneswaran, C and Hilt, D and Koenig, G and Meltzer, HY
PSYCHOPHARMACOLOGY, ISSN 0033-3158, 12/2014, Volume 231, Issue 23, pp. 4541 - 4551
Background Alpha7 and alpha 4 beta 2 nicotinic acetylcholine receptor (nAChR) agonists have been shown to improve cognition in various animal models of... 
FREELY MOVING RATS | IN-VIVO MICRODIALYSIS | EXTRACELLULAR DOPAMINE | Dopamine | PSYCHIATRY | PHARMACOLOGICAL CHARACTERIZATION | EVP-6124 | Glutamate | NEUROSCIENCES | VENTRAL TEGMENTAL AREA | alpha 7 nicotinic acetylcholine receptor | 5-HT3 RECEPTOR | SELECTIVE STIMULATION | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | Acetylcholine | NEUROTRANSMITTER LEVELS | METHYL-D-ASPARTATE
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14. Full Text Muscarinic receptor signaling contributes to atypical antipsychotic drug reversal of the phencyclidine-induced deficit in novel object recognition in rats
by Miyauchi, Masanori and Neugebauer, Nichole M and Sato, Tatsuya and Ardehali, Hossein and Meltzer, Herbert Y
Journal of Psychopharmacology, ISSN 0269-8811, 12/2017, Volume 31, Issue 12, pp. 1588 - 1604
Enhancement of cholinergic function via muscarinic acetylcholine receptor M1 agonism improves cognition in some schizophrenia patients. Most atypical... 
antipsychotics | Muscarinic | acetylcholine | cognition | novel object | SCHIZOPHRENIC-PATIENTS | DOPAMINE RELEASE | PSYCHIATRY | COGNITIVE IMPAIRMENT | NICOTINIC ACETYLCHOLINE-RECEPTORS | PSYCHIATRIC-SYMPTOMS | NEUROSCIENCES | CLINICAL NEUROLOGY | N-DESMETHYLCLOZAPINE | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | TARDIVE-DYSKINESIA | WORKING-MEMORY | Benzoxazines - agonists | Cognitive Dysfunction - drug therapy | Phencyclidine - antagonists & inhibitors | Thiadiazoles - antagonists & inhibitors | Phencyclidine - pharmacology | Scopolamine - antagonists & inhibitors | Sulfonamides - antagonists & inhibitors | Rats | Receptor, Muscarinic M1 - antagonists & inhibitors | Clozapine - analogs & derivatives | Sulfonamides - pharmacology | Receptor, Muscarinic M1 - agonists | Clozapine - pharmacology | Animals | Drug Interactions | Recognition (Psychology) - drug effects | Scopolamine - pharmacology | Signal Transduction - drug effects | Lurasidone Hydrochloride - pharmacology | Female | Antipsychotic Agents - pharmacology | Cognitive Dysfunction - chemically induced | Receptor, Muscarinic M1 - metabolism | Thiadiazoles - pharmacology | Schizophrenia | Care and treatment | Dosage and administration | Antipsychotic drugs | Muscarinic receptors | Drugs | Brain | Neuroleptics | Scopolamine | Acetylcholine receptors (muscarinic) | Mental disorders | Cognitive ability | Impairment | Cognition | Pattern recognition | Clozapine | Gene expression | Object recognition | Psychotropic drugs | Signaling | Phencyclidine | Cognition & reasoning | Rodents | Hippocampus
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15. Full Text Association of Serotonin 2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia
by Li, Jiang and Hashimoto, Hitoshi and Meltzer, Herbert Y
Frontiers in psychiatry, ISSN 1664-0640, 2019, Volume 10, p. 58
There is conflicting evidence for the association between genetic polymorphisms in the serotonin (5-HT) receptor (HTR2C) and response to antipsychotic drugs... 
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16. Full Text Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression
by Rajkowska, Grazyna and Miguel-Hidalgo, José J and Wei, Jinrong and Dilley, Ginny and Pittman, Stephen D and Meltzer, Herbert Y and Overholser, James C and Roth, Bryan L and Stockmeier, Craig A
Biological Psychiatry, ISSN 0006-3223, 1999, Volume 45, Issue 9, pp. 1085 - 1098
Background: This report provides histopathological evidence to support prior neuroimaging findings of decreased volume and altered metabolism in the frontal... 
neuroanatomy | prefrontal cortex | neuropathology | Postmortem | frontal lobe | neuroimaging | Neuroimaging | Frontal lobe | Prefrontal cortex | Neuropathology | Neuroanatomy | DOPAMINE SYSTEM | PSYCHIATRY | RHESUS-MONKEY | SUICIDE VICTIMS | SEROTONIN 5-HT2 | NEUROSCIENCES | PYRAMIDAL NEURONS | postmortem | MOOD DISORDERS | POSITRON EMISSION TOMOGRAPHY | LOCUS-COERULEUS | UNIPOLAR DEPRESSION | BINDING-SITES | Neurons - pathology | Depression - pathology | Neuroglia - pathology | Humans | Middle Aged | Adult | Cell Size | Female | Male | Aged | Prefrontal Cortex - pathology
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17. Full Text Dopamine D4receptor stimulation contributes to novel object recognition: Relevance to cognitive impairment in schizophrenia
by Miyauchi, Masanori and Neugebauer, Nichole M and Meltzer, Herbert Y
Journal of Psychopharmacology, ISSN 0269-8811, 04/2017, Volume 31, Issue 4, pp. 442 - 452
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18. Full Text Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia
by Huang, Mei and Kwon, Sunoh and He, Wenqi and Meltzer, Herbert Y
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 06/2017, Volume 157, pp. 16 - 23
Dopamine (DA) D receptors have been implicated in schizophrenia and the ability of some atypical antipsychotic drugs (APDs) to improve the cognitive impairment... 
Antipsychotic | Cognition | Lurasidone | D4 agonism | Dopamine | agonism
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