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PLoS Computational Biology, ISSN 1553-734X, 04/2015, Volume 11, Issue 4, p. e1004120
The observation that disease associated proteins often interact with each other has fueled the development of network-based approaches to elucidate the... 
INTERACTION NETWORK | PROFILES | RANDOM-WALKS | PROTEOME-SCALE MAP | COVER TIME | GENES | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | COMPREHENSIVE RESOURCE | MEDICINE | GENOME | GRAPHS | Usage | Algorithms | Health aspects | Protein-protein interactions | Proteins | Neighborhoods | Disease | Genes | Connectivity | Methods
Journal Article
Nature Communications, ISSN 2041-1723, 06/2014, Volume 5, Issue 1, p. 4212
In the post-genomic era, the elucidation of the relationship between the molecular origins of diseases and their resulting phenotypes is a crucial task for... 
COMMUNITY | PHENOTYPE ONTOLOGY | GENETICS | ELECTRONIC HEALTH RECORDS | ALZHEIMERS-DISEASE | INFORMATION | MULTIDISCIPLINARY SCIENCES | GENES | MODEL | MEDICINE | INTERACTOME | Models, Theoretical | Proteins - genetics | Systems Theory | Genetic Predisposition to Disease | Phenotype | Disease - genetics | Humans
Journal Article
Science, ISSN 0036-8075, 02/2015, Volume 347, Issue 6224, pp. 841 - 1257601
According to the diseasemodule hypothesis, the cellular components associated with a disease segregate in the same neighborhood of the human interactome,... 
PROTEIN-INTERACTION NETWORKS | GWAS DATA | MULTIDISCIPLINARY SCIENCES | CANDIDATE GENES | BIOLOGY | MOLECULAR NETWORKS | INTERACTION DATASETS | DISORDERS | MEDICINE | GENOME-WIDE ASSOCIATION | CELIAC-DISEASE | Disease | Molecular biology | Genes | Proteins | Networks | Maps | Similarity | Mathematical analysis | Modules | Disease control
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, p. 10331
The increasing cost of drug development together with a significant drop in the number of new drug approvals raises the need for innovative approaches for... 
ALZHEIMER-DISEASE | PROFILES | HUMAN-DISEASE | PROTEIN | INTEGRATION | MULTIDISCIPLINARY SCIENCES | COMPREHENSIVE RESOURCE | PATHOLOGY | IDENTIFICATION | GENOME-WIDE ASSOCIATION | INTERACTOME
Journal Article
Scientific Reports, ISSN 2045-2322, 10/2016, Volume 6, Issue 1, p. 35241
Genes carrying mutations associated with genetic diseases are present in all human cells; yet, clinical manifestations of genetic diseases are usually highly... 
PROTEIN INTERACTION NETWORK | GENOTYPE | ALZHEIMERS-DISEASE | SCALE MAP | MULTIDISCIPLINARY SCIENCES | GENES | COMPLEXES | PHENOTYPE | MEDICINE | EXPRESSION | GENOME-WIDE ASSOCIATION | Disease | Genetic disorders
Journal Article
Nature Immunology, ISSN 1529-2908, 04/2017, Volume 18, Issue 5, pp. 481 - 482
The immune system employs a multitude of molecules, cells and organs that act together throughout the entire body to guard human health. Much like in a social... 
IMMUNOLOGY | Cell Communication | Immune System - immunology | Humans | Proteomics | Social Support | Cellular proteins | Genetic aspects | Properties | Immune system | Immunological research
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2280 - 14
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia ( FA) is a rare disease characterized by bone... 
UBIQUITINATION | DAMAGE RESPONSE | CHROMATIN | CROSS-LINK REPAIR | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HOMOLOGOUS RECOMBINATION | BRCA1 | ENRICHMENT ANALYSIS | ASSOCIATION | Genetic Therapy | Ubiquitin-Specific Proteases - genetics | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | DNA Repair - physiology | DNA Repair - genetics | Fanconi Anemia Complementation Group C Protein - genetics | Fanconi Anemia Complementation Group A Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - deficiency | Fanconi Anemia Complementation Group A Protein - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Fanconi Anemia Complementation Group G Protein - genetics | Ubiquitin-Specific Proteases - deficiency | Fanconi Anemia Complementation Group G Protein - deficiency | BRCA1 Protein - metabolism | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Chromosomal Instability | Rad51 Recombinase - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - deficiency | Fanconi Anemia Complementation Group Proteins - genetics | Fanconi Anemia Complementation Group G Protein - metabolism | Gene Knockout Techniques | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Fanconi Anemia Complementation Group A Protein - deficiency | CRISPR-Cas Systems | Fanconi Anemia Complementation Group C Protein - deficiency | Fanconi Anemia - therapy | DNA Damage | Histones - metabolism | Mutation
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 10/2018, Volume 77, Issue 10, pp. 1490 - 1497
Journal Article
Journal Article