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Advances in experimental medicine and biology, ISSN 0065-2598, 2019, Volume 1165, p. 381
Renal inflammation is the initial, healthy response to renal injury. However, prolonged inflammation promotes the fibrosis process, which leads to chronic... 
Kidney Diseases - physiopathology | Myofibroblasts - cytology | Kidney - pathology | Humans | Fibrosis | Cell Transdifferentiation | Macrophages - cytology | Inflammation Mediators - physiology | Leukocytes - cytology
Journal Article
Advances in experimental medicine and biology, ISSN 0065-2598, 2019, Volume 1165, p. 347
Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that disrupts and replaces functional parenchyma, which leads to organ... 
Kidney - pathology | Signal Transduction | Humans | Fibrosis | Transforming Growth Factor beta - physiology | Smad Proteins - physiology | Renal Insufficiency, Chronic - physiopathology
Journal Article
Journal Article
Advances in experimental medicine and biology, ISSN 0065-2598, 2019, Volume 1165, p. 285
Monocytes/macrophages are highly involved in the process of renal injury, repair and fibrosis in many aspects of experimental and human renal diseases.... 
Kidney Diseases - physiopathology | Myofibroblasts - cytology | Monocytes | Kidney - pathology | Humans | Fibrosis | Cell Differentiation | Macrophages - cytology
Journal Article
by Meng, XM and Tang, PMK and Li, J and Lan, HY
FRONTIERS IN PHYSIOLOGY, ISSN 1664-042X, 03/2015, Volume 6, p. 82
TGF-beta (transforming growth factor-beta) is well identified as a central mediator in renal fibrosis. TGF-beta initiates canonical and non-canonical pathways... 
CRESCENTIC GLOMERULONEPHRITIS | therapeutics | PHYSIOLOGY | DIABETIC-NEPHROPATHY | renal fibrosis | MESENCHYMAL TRANSITION | TGF-beta | GROWTH-FACTOR-BETA | TRANSFORMING GROWTH-FACTOR-BETA-1 | MOUSE MODEL | THERAPEUTIC TARGET | LATENT TGF-BETA-1 | GENE-TRANSFER | Smads mediators | CHRONIC KIDNEY-DISEASE | mechanisms | TGF-β | Smads Mediators | Therapeutics
Journal Article
Sheng li xue bao : [Acta physiologica Sinica], ISSN 0371-0874, 12/2018, Volume 70, Issue 6, pp. 612 - 622
Journal Article
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 08/2019, Volume 33, Issue 8, pp. 9279 - 9290
Diabetes nephropathy (DN) is characterized by abnormal interactions between kidney-infiltrating macrophages and glomerular mesangial cells. Recently, a novel... 
Journal Article