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1. Full Text CDK8-Novel Therapeutic Opportunities
by Menzl, Ingeborg and Witalisz-Siepracka, Agnieszka and Sexl, Veronika
Pharmaceuticals (Basel, Switzerland), ISSN 1424-8247, 06/2019, Volume 12, Issue 2, p. 92
Improvements in cancer therapy frequently stem from the development of new small-molecule inhibitors, paralleled by the identification of biomarkers that can... 
mediator complex | CDK8 | cancer
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2. Full Text Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32
by Gonzalez-Cano, Laura and Gonzalez-Cano, Laura and Menzl, Ingeborg and Menzl, Ingeborg and Tisserand, Johan and Tisserand, Johan and Nicklas, Sarah and Nicklas, Sarah and Schwamborn, Jens C and Schwamborn, Jens C
Molecular Neurobiology, ISSN 0893-7648, 4/2018, Volume 55, Issue 4, pp. 3490 - 3498
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Accumulating evidences suggest that PD might have a strong neurodevelopmental... 
Neurology | Neurosciences | Biomedicine | LRRK2 | Neurobiology | miRNA activity | Neuronal differentiation | TRIM32 | Parkinson’s disease | Cell Biology | Parkinson's disease | Cell fate | Neurodegenerative diseases | Therapeutic applications | MiRNA | Leucine | Inhibition | Mutation | LRRK2 protein | Kinases | Movement disorders
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3. Full Text Phenotyping and Target Expression Profiling of CD34+/CD38− and CD34+/CD38+ Stem- and Progenitor cells in Acute Lymphoblastic Leukemia
by Blatt, Katharina and Menzl, Ingeborg and Eisenwort, Gregor and Cerny-Reiterer, Sabine and Herrmann, Harald and Herndlhofer, Susanne and Stefanzl, Gabriele and Sadovnik, Irina and Berger, Daniela and Keller, Alexandra and Hauswirth, Alexander and Hoermann, Gregor and Willmann, Michael and Rülicke, Thomas and Sill, Heinz and Sperr, Wolfgang R and Mannhalter, Christine and Melo, Junia V and Jäger, Ulrich and Sexl, Veronika and Valent, Peter
Neoplasia, ISSN 1476-5586, 06/2018, Volume 20, Issue 6, pp. 632 - 642
Leukemic stem cells (LSCs) are an emerging target of curative anti-leukemia therapy. In acute lymphoblastic leukemia (ALL), LSCs frequently express CD34 and... 
INITIATING CELLS | STEM-CELLS | THERAPY | COMPLETE REMISSION | ONCOLOGY | PHILADELPHIA-CHROMOSOME | TYROSINE KINASE | IMATINIB | CHRONIC MYELOID-LEUKEMIA | PRIMITIVE HEMATOPOIETIC-CELL | TRANSPLANTATION | Cell Line | Antigens, CD34 - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Stem Cells - metabolism | Gene Expression Regulation, Leukemic - physiology | Animals | Neoplastic Stem Cells - metabolism | Biomarkers, Tumor - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | ADP-ribosyl Cyclase 1 - metabolism | Female | Mice, Inbred NOD | Mice | Flow cytometry | CD26 antigen | Leukemia | Antibodies | Stem cell transplantation | Interleukin 1 receptors | CD44 antigen | CD38 antigen | Xenografts | CD25 antigen | CD123 antigen | CD34 antigen | Interleukin 2 receptors | Phenotypes | CD19 antigen | Acute lymphatic leukemia | Myeloid leukemia | Chronic myeloid leukemia | Lymphatic leukemia | Progenitor cells | CXCR4 protein | CD22 antigen | Stem cells | Phenotyping | CD20 antigen | CD18 antigen
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4. Full Text A kinase-independent role for CDK8 in BCR-ABL1(+) leukemia
by Menzl, I and Zhang, TH and Berger-Becvar, A and Grausenburger, R and Heller, G and Prchal-Murphy, M and Edlinger, L and Knab, VM and Uras, IZ and Grundschober, E and Bauer, K and Roth, M and Skucha, A and Liu, Y and Hatcher, JM and Liang, YK and Kwiatkowski, NP and Fuxl, D and Hoelbl-Kovacic, A and Kubicek, S and Melo, JV and Valent, P and Weichhart, T and Grebien, F and Zuber, J and Gray, NS and Sexl, V
NATURE COMMUNICATIONS, ISSN 2041-1723, 10/2019, Volume 10, Issue 1, pp. 1 - 15
Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in... 
TARGET | AML CELLS | PALBOCICLIB | POTENT | INHIBITION | SET ENRICHMENT ANALYSIS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | B-CELL COMMITMENT | SERINE PHOSPHORYLATION | CANCER | TOR protein | BCR protein | Deregulation | Animal models | Transcription | Leukemia | Cyclin-dependent kinases | Cyclin-dependent kinase 8 | Maintenance | Kinases | Latency | Degradation | Signal transduction | Cell death | Inhibition | Chemical synthesis | Acute myeloid leukemia | Index Medicus
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5. Full Text Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1
by Edlinger, Leo and Berger‐Becvar, Angelika and Menzl, Ingeborg and Hoermann, Gregor and Greiner, Georg and Grundschober, Eva and Bago‐Horvath, Zsuzsanna and Al‐Zoughbi, Wael and Hoefler, Gerald and Brostjan, Christine and Gille, Lars and Moriggl, Richard and Spittler, Andreas and Sexl, Veronika and Hoelbl‐Kovacic, Andrea
British Journal of Haematology, ISSN 0007-1048, 10/2017, Volume 179, Issue 2, pp. 229 - 241
Summary The p21‐activated kinases (PAKs) are key nodes in oncogenic signalling pathways controlling growth, survival, and motility of cancer cells. Their... 
CML | p21‐activated kinases | BCR/ABL1 | PAK2 | exosomes | lymphoma | p21-activated kinases | TRANSFORMATION | PROTEIN | CANCER CELLS | PHOSPHORYLATION | TUMOR SURVEILLANCE | IN-VIVO | STAT5 | LEUKEMIA | HEMATOLOGY | EXPRESSION | Exosomes - metabolism | Cell Proliferation | Leukemia - pathology | Humans | Extracellular Matrix - metabolism | Exosomes - genetics | Exosomes - pathology | Hematologic Neoplasms - pathology | Leukemia - metabolism | Neovascularization, Pathologic - pathology | Lymphoma - metabolism | Extracellular Matrix - genetics | Lymphoma - pathology | Hematologic Neoplasms - metabolism | Leukemia - genetics | p21-Activated Kinases - genetics | Endothelial Cells - metabolism | Lymphoma - genetics | p21-Activated Kinases - metabolism | Fusion Proteins, bcr-abl - genetics | Animals | Cell Line, Tumor | Mice, Inbred NOD | Neovascularization, Pathologic - genetics | Hematologic Neoplasms - genetics | Mice | Neovascularization, Pathologic - metabolism | Endothelial Cells - pathology | Extracellular Matrix - pathology | Fusion Proteins, bcr-abl - metabolism | Methylcellulose | Lymphomas | Analysis | Leukemia | Endothelium | Cell proliferation | Deregulation | Cell survival | Hematology | Colonies | Medical treatment | Malignancy | Exosomes | Kinases | Endothelial cells | Vascularization | Signal transduction | Signaling | Cell growth | Medical prognosis | Isoforms | Extracellular matrix | Conditioning | Tumors | Cancer | Apoptosis | Index Medicus | BCR | Haematological Malignancy | ABL1 | Research Paper
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6. Full Text Parkinson's Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32
by Gonzalez-Cano, L and Menzl, I and Tisserand, J and Nicklas, S and Schwamborn, JC
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 04/2018, Volume 55, Issue 4, pp. 3490 - 3498
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Accumulating evidences suggest that PD might have a strong neurodevelopmental... 
NEURAL STEM-CELLS | Parkinson'sdisease | LRRK2 | miRNA activity | Neuronal differentiation | DIFFERENTIATION | TRIM32 | NEUROSCIENCES | Neurons - pathology | Argonaute Proteins - metabolism | Humans | Mice, Inbred C57BL | Ubiquitin-Protein Ligases - metabolism | MicroRNAs - metabolism | Parkinson Disease - genetics | Mutation - genetics | Animals | HEK293 Cells | RNA-Induced Silencing Complex - metabolism | Protein Binding | Cell Differentiation | MicroRNAs - genetics | Neurons - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics | Neurons | MicroRNA
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7. Full Text Expansion ofBCR/ABL1+cells requires PAK2 but not PAK1
by Edlinger, Leo and Berger-Becvar, Angelika and Menzl, Ingeborg and Hoermann, Gregor and Greiner, Georg and Grundschober, Eva and Bago-Horvath, Zsuzsanna and Al-Zoughbi, Wael and Hoefler, Gerald and Brostjan, Christine and Gille, Lars and Moriggl, Richard and Spittler, Andreas and Sexl, Veronika and Hoelbl-Kovacic, Andrea
British Journal of Haematology, ISSN 0007-1048, 10/2017, Volume 179, Issue 2, pp. 229 - 241
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8. Full Text The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells
by Bahnassawy, Lamia'a and Nicklas, Sarah and Palm, Thomas and Menzl, Ingeborg and Birzele, Fabian and Gillardon, Frank and Schwamborn, Jens C
Stem Cells and Development, ISSN 1547-3287, 09/2013, Volume 22, Issue 18, pp. 2487 - 2496
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause familial as well as sporadic Parkinson's disease (PD) that is characterized by an... 
Original Research Reports | MOUSE-BRAIN | MEDICINE, RESEARCH & EXPERIMENTAL | LOCALIZATION | PROGENITORS | LEUCINE-RICH-REPEAT-KINASE-2 | NUCLEAR RECEPTOR TLX | SELF-RENEWAL | CELL & TISSUE ENGINEERING | TRANSPLANTATION | PATHOGENESIS | MICRORNA-9 | PATHWAY | MICE | HEMATOLOGY | Parkinson Disease - therapy | Protein-Serine-Threonine Kinases - deficiency | Up-Regulation | Humans | Cell Survival - genetics | MicroRNAs - metabolism | Gene Expression Profiling | Neural Stem Cells - cytology | Cell Differentiation - genetics | Mitochondria - genetics | Base Sequence | Parkinson Disease - metabolism | Oxidation-Reduction | Down-Regulation | Mice, Inbred C57BL | Cells, Cultured | Oxidative Stress - genetics | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Cell- and Tissue-Based Therapy | Parkinson Disease - genetics | Sequence Analysis, DNA | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Mice, Knockout | Animals | Mice | MicroRNAs - genetics | Mutation | Neural Stem Cells - metabolism | Parkinson's disease | Research | Gene mutations | Analysis | Stem cells
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9. Full Text NK cell–specific CDK8 deletion enhances antitumor responses
by Witalisz-Siepracka, Agnieszka and Gotthardt, Dagmar and Prchal-Murphy, Michaela and Didara, Zrinka and Menzl, Ingeborg and Prinz, Daniela and Edlinger, Leo and Putz, Eva Maria and Sexl, Veronika
Cancer Immunology Research, ISSN 2326-6066, 04/2018, Volume 6, Issue 4, pp. 458 - 466
Cyclin-dependent kinase 8 (CDK8) is a member of the transcription-regulating CDK family. CDK8 activates or represses transcription by associating with the... 
REGULATOR | ONCOLOGY | REJECTION | KINASE | CATENIN | STAT1 TRANSACTIVATION DOMAIN | IMMUNOLOGY | SERINE PHOSPHORYLATION | MATURATION | INHIBITOR | TUMOR SURVEILLANCE | CANCER | Mice, Transgenic | Immunity, Innate | Cell Differentiation - genetics | Killer Cells, Natural - cytology | Animals | Melanoma, Experimental | Neoplasms - genetics | Neoplasms - immunology | Gene Deletion | Cell Line, Tumor | Cyclin-Dependent Kinase 8 - genetics | Killer Cells, Natural - immunology | Mice | Killer Cells, Natural - metabolism | Neoplasms - pathology | Cytotoxicity, Immunologic | Disease Models, Animal
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