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Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 04/2016, Volume 84, Issue 4, pp. 427 - 434
Journal Article
Journal of alzheimers disease, ISSN 1387-2877, 2018, Volume 65, Issue 1, pp. 265 - 281
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2005, Volume 171, Issue 1, pp. 87 - 98
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2019, Volume 38, Issue 12, p. n/a
γ‐Secretase complexes (GSECs) are multimeric membrane proteases involved in a variety of physiological processes and linked to Alzheimer's disease (AD).... 
γ‐secretase | γ‐secretase modulators | Nicastrin | Alzheimer's disease | amyloid‐beta | amyloid-beta | γ-secretase modulators | γ-secretase | APH-1 | SPECIFICITY | PRESENILIN GENERATE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | gamma-secretase | NOTCH | TRANSMEMBRANE DOMAIN | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | CELL BIOLOGY | gamma-secretase modulators | MUTATIONS | MOLECULAR-DYNAMICS SIMULATIONS | Membrane Glycoproteins - metabolism | Protein Interaction Domains and Motifs - physiology | Amyloid beta-Protein Precursor - chemistry | Humans | Membrane Glycoproteins - chemistry | Cells, Cultured | Models, Molecular | Structure-Activity Relationship | Extracellular Space | Amyloid Precursor Protein Secretases - chemistry | Amyloid Precursor Protein Secretases - metabolism | Animals | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Protein Structure, Quaternary | Protein Binding | Mice | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Enzyme Activation | Amyloidogenesis | PEN-2 protein | Peptides | Neurodegenerative diseases | Pathogenesis | Nucleotides | Pharynx | Neuromodulation | Modulators | Amyloid precursor protein | Substrates | Anchors | Neurotoxicity | Interface stability | Presenilin 2 | Mutation | Catalysis | Drug discovery | Alzheimers disease | Secretase | Index Medicus | Neuroscience | Post-translational Modifications, Proteolysis & Proteomics | Molecular Biology of Disease
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2017, Volume 13, Issue 7, pp. P963 - P963
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 04/2016, Volume 84, Issue 4, pp. 427 - 434
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31084
BACE1 is a key enzyme for amyloid-beta (A beta) production, and an attractive therapeutic target in Alzheimer's disease (AD). Here we report that BACE1... 
ALZHEIMERS-DISEASE | SECRETASE ACTIVITY | PURIFICATION | BIOLOGY | PROTEIN-CLEAVING ENZYME | GENERATION | PRECURSOR PROTEIN | CLEAVAGE | EXPRESSION | PEPTIDE | BRAIN | Cell Line | Immunoassay | Central Nervous System - metabolism | Immunoprecipitation | Aspartic Acid Endopeptidases - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Dimethyl Sulfoxide - pharmacology | Male | Tandem Mass Spectrometry | Animals | Cerebrospinal Fluid - metabolism | Mass Spectrometry | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Dogs | Central Nervous System - drug effects | Chromatography, Liquid | Female | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Cell culture | Neurosciences | Biomedical research | Peptides | Laboratories | Central nervous system | Cognitive ability | Clinical trials | Nervous system | Cerebrospinal fluid | Neuroblastoma | Proteins | Physiology | Inhibition | Alzheimer's disease | Neurochemistry | Medical research | b-Site APP cleaving enzyme 1 | Neurodegenerative diseases | Research & development--R&D | Cloning | Mass spectroscopy | Pharmacology | Metabolism | Mammals | Amyloid precursor protein | Brain research | Inhibitors | Isoforms | β-Amyloid | Alzheimers disease | Mass spectrometry | Psychiatry | Enzyme Inhibitors | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides | pharmacology | Dimethyl Sulfoxide | Neurovetenskaper | Neurologi | Cerebrospinal Fluid | drug effects | antagonists & inhibitors | Chromatography | Neurology | Liquid | Central Nervous System | metabolism | Amyloid beta-Protein Precursor | Research & development | R&D
Journal Article