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1. Full Text Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
by Fang, Mark Y and Markmiller, Sebastian and Vu, Anthony Q and Javaherian, Ashkan and Dowdle, William E and Jolivet, Philippe and Bushway, Paul J and Castello, Nicholas A and Baral, Ashmita and Chan, Michelle Y and Linsley, Jeremy W and Linsley, Drew and Mercola, Mark and Finkbeiner, Steven and Lecuyer, Eric and Lewcock, Joseph W and Yeo, Gene W
Neuron (Cambridge, Mass.), ISSN 0896-6273, 09/2019, Volume 103, Issue 5, pp. 802 - 819.e11
motor neurons | ALS-FTD | planar molecule | stress granule | TDP-43 | high-content screening | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Small Molecule Libraries - pharmacology | Humans | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | Cytoplasmic Granules - metabolism | HEK293 Cells | RNA Helicases - genetics | Stress, Physiological - drug effects | DNA Helicases - genetics | Motor Neurons - drug effects | Cell Line | Cytoplasmic Granules - drug effects | DNA-Binding Proteins - drug effects | Intrinsically Disordered Proteins | Neural Stem Cells - drug effects | Poly-ADP-Ribose Binding Proteins - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | RNA-Binding Protein FUS - metabolism | Motor Neurons - metabolism | High-Throughput Screening Assays | Amyotrophic Lateral Sclerosis - metabolism | RNA Recognition Motif Proteins - genetics | Induced Pluripotent Stem Cells | Neural Stem Cells - metabolism | Protein Aggregation, Pathological - metabolism | Proteins | Motor neurons | RNA-binding protein | Disease | Neurodegenerative diseases | Stem cells | Dementia disorders | Amyotrophic lateral sclerosis | Mutation | Ribonucleic acid--RNA | Frontotemporal dementia | Index Medicus
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2. Full Text Stars in the Night Sky: iPSC-Cardiomyocytes Return the Patient Context to Drug Screening
by Hnatiuk, Anna and Mercola, Mark
Cell stem cell, ISSN 1934-5909, 04/2019, Volume 24, Issue 4, pp. 506 - 507
Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Myocytes, Cardiac | Humans | Protein-Serine-Threonine Kinases | Intracellular Signaling Peptides and Proteins | Cell Differentiation | Infarction | Drug Evaluation, Preclinical | Induced Pluripotent Stem Cells | Index Medicus
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3. Full Text A boost for heart regeneration
by Mercola, Mark
Nature (London), ISSN 0028-0836, 12/2012, Volume 492, Issue 7429, pp. 360 - 361
Regeneration | Medical research | MicroRNA | Heart cells | Physiological aspects | Muscles | Medicine, Experimental | Genetic aspects | Research | Injuries | Heart muscle | Studies | Heart | Proteins | Heart attacks
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4. Full Text Cardiovascular biology: A boost for heart regeneration
by Mercola, Mark
Nature (London), ISSN 0028-0836, 12/2012, Volume 492, Issue 7429, pp. 360 - 362
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | MicroRNAs - genetics | Animals | MicroRNAs - analysis | Regeneration - genetics | Humans | Myocardium - cytology
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5. Full Text Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery
by Mercola, Mark and Colas, Alexandre and Willems, Erik
Circulation research, ISSN 0009-7330, 02/2013, Volume 112, Issue 3, pp. 534 - 548
functional genomics | induced pluripotent stem cells | chemical biology | high throughput screening | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Genetic Predisposition to Disease | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Risk Assessment | Cardiovascular Diseases - drug therapy | Genomics | Humans | Gene Expression Regulation | Drug Discovery - methods | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | Cardiovascular Agents - pharmacology | Myocytes, Cardiac - pathology | Phenotype | Animals | High-Throughput Screening Assays | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - metabolism | Cardiovascular Diseases - chemically induced | Toxicity Tests | Induced Pluripotent Stem Cells - metabolism | Index Medicus
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6. Full Text Inhibition of miR-25 improves cardiac contractility in the failing heart
by Wahlquist, Christine and Jeong, Dongtak and Rojas-Muñoz, Agustin and Kho, Changwon and Lee, Ahyoung and Mitsuyama, Shinichi and Van Mil, Alain and Jin Park, Woo and Sluijter, Joost P. G and Doevendans, Pieter A. F and Hajjar, Roger J and Mercola, Mark
Nature (London), ISSN 0028-0836, 2014, Volume 508, Issue 7497, pp. 531 - 535
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Dependovirus - genetics | MicroRNAs - antagonists & inhibitors | Calcium - metabolism | Heart - physiology | Humans | Oligonucleotides, Antisense - metabolism | Myocardial Contraction - drug effects | Male | MicroRNAs - metabolism | RNA, Messenger - metabolism | Heart Failure - therapy | MicroRNAs - analysis | Myocardium - metabolism | HEK293 Cells | Sarcoplasmic Reticulum - metabolism | Disease Models, Animal | Heart - physiopathology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Oligonucleotides, Antisense - pharmacology | RNA, Messenger - genetics | Heart Failure - genetics | Up-Regulation - genetics | Animals | Oligonucleotides, Antisense - genetics | Survival Analysis | Heart - drug effects | Myocytes, Cardiac - metabolism | Mice | MicroRNAs - genetics | Kinetics | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Proteins | Heart failure | Rodents | Cardiomyocytes | Kinases | Variance analysis | Index Medicus | microRNAs | heart failure | calcium | SERCA2a | miRNAs | sarcoplasmic reticulum
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7. Full Text Technical Variations in Low-Input RNA-seq Methodologies
by Bhargava, Vipul and Head, Steven R and Ordoukhanian, Phillip and Mercola, Mark and Subramaniam, Shankar
Scientific reports, ISSN 2045-2322, 04/2015, Volume 4, Issue 1, pp. 3678 - 3678
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Sequence Analysis, RNA - methods | Reproducibility of Results | Animals | Gene Expression Regulation | Transcriptome | Gene Expression Profiling - methods | Mice | Sequence Analysis, RNA - standards | Cluster Analysis | Hybridization | Index Medicus
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8. Full Text Reprogramming the Cardiac Field
by Willems, Erik and Mercola, Mark
Circulation research, ISSN 0009-7330, 01/2014, Volume 114, Issue 3, pp. 409 - 411
Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Cellular Reprogramming - drug effects | Small Molecule Libraries - pharmacology | Animals | Cell Engineering - methods | Fibroblasts - drug effects | Female | Male | Induced Pluripotent Stem Cells - cytology | Totipotent Stem Cells - cytology | Teratoma - metabolism | Index Medicus
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9. Full Text Jumonji and Cardiac Fate
by Willems, Erik and Mercola, Mark
Circulation research, ISSN 0009-7330, 09/2013, Volume 113, Issue 7, pp. 837 - 839
Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Endothelium, Vascular - cytology | Embryonic Stem Cells - metabolism | Animals | Myocytes, Cardiac - cytology | Cell Differentiation | Mesoderm - cytology | Jumonji Domain-Containing Histone Demethylases - metabolism | Index Medicus
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10. Full Text Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
by Wei, Ke and Serpooshan, Vahid and Hurtado, Cecilia and Diez-Cuñado, Marta and Zhao, Mingming and Maruyama, Sonomi and Zhu, Wenhong and Fajardo, Giovanni and Noseda, Michela and Nakamura, Kazuto and Tian, Xueying and Liu, Qiaozhen and Wang, Anew and Matsuura, Yuka and Bushway, Paul and Cai, Wenqing and Savchenko, Alex and Mahmoudi, Morteza and Schneider, Michael D and van den Hoff, Maurice J. B and Butte, Manish J and Yang, Phillip C and Walsh, Kenneth and Zhou, Bin and Bernstein, Daniel and Mercola, Mark and Ruiz-Lozano, Pilar
Nature (London), ISSN 0028-0836, 2015, Volume 525, Issue 7570, pp. 479 - 485
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Myocardial Infarction - genetics | Humans | Culture Media, Conditioned - pharmacology | Male | Pericardium - metabolism | Swine | Myocardial Infarction - pathology | Myocardium - metabolism | Female | Myocardial Infarction - physiopathology | Myoblasts, Cardiac - drug effects | Follistatin-Related Proteins - genetics | Follistatin-Related Proteins - metabolism | Myoblasts, Cardiac - cytology | Myocytes, Cardiac - cytology | Signal Transduction | Transgenes - genetics | Pericardium - drug effects | Rats | Myocardial Infarction - metabolism | Pericardium - cytology | Regeneration - drug effects | Animals | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - metabolism | Cell Proliferation - drug effects | Mice | Cell Cycle - drug effects | Pericardium - growth & development | Physiological aspects | Physiological research | Regeneration (Biology) | Research | Heart cells | Proteins | Heart | Heart attacks | Collagen | Stem cells | Cardiomyocytes | Mammals | Index Medicus
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11. Full Text Cardiac muscle regeneration: Lessons from development
by Mercola, Mark and Ruiz-Lozano, Pilar and Schneider, Michael D
Genes & development, ISSN 0890-9369, 02/2011, Volume 25, Issue 4, pp. 299 - 309
Embryonic development | Myocyte regeneration | Differentiation | Stem cells | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Animals | Models, Biological | Myocytes, Cardiac - physiology | Heart - embryology | Heart - physiology | Humans | Adult | Regeneration - physiology | Regenerative Medicine - methods | Embryonic Stem Cells - physiology | Myocardium - cytology | Index Medicus | myocyte regeneration | stem cells | differentiation | Review | embryonic development
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