Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10016, pp. 349 - 356
Summary Background REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a...
Internal Medicine | MEDICINE, GENERAL & INTERNAL | REVASCULARIZATION | METAANALYSIS | EFFICACY | SAFETY | THROMBOSIS | RNA APTAMERS | ANTIBODY | COAGULATION | PHARMACODYNAMICS | INHIBITORS | Recombinant Proteins - therapeutic use | Hemorrhage - epidemiology | Hirudins | Humans | Middle Aged | Europe - epidemiology | Anticoagulants - therapeutic use | Aptamers, Nucleotide - therapeutic use | Male | Early Termination of Clinical Trials | Drug Hypersensitivity - epidemiology | Factor IXa - antagonists & inhibitors | Coagulants - administration & dosage | Female | Aged | Peptide Fragments - therapeutic use | North America - epidemiology | Oligonucleotides - administration & dosage | Percutaneous Coronary Intervention | Transluminal angioplasty | Clinical trials | Medical colleges | Anticoagulants (Medicine) | Hospitals | RNA | Anticoagulants | Stroke | Heart attacks | Heart surgery | Angioplasty | Mortality | Cardiovascular disease | Thrombosis | Clinical outcomes | Coronary vessels | Biomarkers | Patient safety | Cardiology | Acute coronary syndromes
Internal Medicine | MEDICINE, GENERAL & INTERNAL | REVASCULARIZATION | METAANALYSIS | EFFICACY | SAFETY | THROMBOSIS | RNA APTAMERS | ANTIBODY | COAGULATION | PHARMACODYNAMICS | INHIBITORS | Recombinant Proteins - therapeutic use | Hemorrhage - epidemiology | Hirudins | Humans | Middle Aged | Europe - epidemiology | Anticoagulants - therapeutic use | Aptamers, Nucleotide - therapeutic use | Male | Early Termination of Clinical Trials | Drug Hypersensitivity - epidemiology | Factor IXa - antagonists & inhibitors | Coagulants - administration & dosage | Female | Aged | Peptide Fragments - therapeutic use | North America - epidemiology | Oligonucleotides - administration & dosage | Percutaneous Coronary Intervention | Transluminal angioplasty | Clinical trials | Medical colleges | Anticoagulants (Medicine) | Hospitals | RNA | Anticoagulants | Stroke | Heart attacks | Heart surgery | Angioplasty | Mortality | Cardiovascular disease | Thrombosis | Clinical outcomes | Coronary vessels | Biomarkers | Patient safety | Cardiology | Acute coronary syndromes
Journal Article
Lancet, The, ISSN 0140-6736, 2016, Volume 388, Issue 10055, pp. 1995 - 2003
Summary Background Edoxaban, an oral factor Xa inhibitor, is non-inferior for prevention of stroke and systemic embolism in patients with atrial fibrillation...
Internal Medicine | MEDICINE, GENERAL & INTERNAL | EFFICACY | SAFETY | ORAL ANTICOAGULANTS | Stroke - prevention & control | Prospective Studies | Atrial Fibrillation - therapy | Humans | Middle Aged | Electric Countershock | Warfarin - adverse effects | Anticoagulants - therapeutic use | Enoxaparin - therapeutic use | Thiazoles - therapeutic use | Anticoagulants - adverse effects | Enoxaparin - adverse effects | Thiazoles - adverse effects | Warfarin - therapeutic use | Factor Xa Inhibitors - therapeutic use | Pyridines - adverse effects | Thromboembolism - prevention & control | Factor Xa Inhibitors - adverse effects | Aged | Hemorrhage - chemically induced | Pyridines - therapeutic use | Stroke (Disease) | Medical colleges | Warfarin | Atrial fibrillation | Clinical trials | Product development | Electric countershock | Cardiology | Public finance | Cardiac arrhythmia | Anticoagulants | Stroke | Drug therapy | Coagulation
Internal Medicine | MEDICINE, GENERAL & INTERNAL | EFFICACY | SAFETY | ORAL ANTICOAGULANTS | Stroke - prevention & control | Prospective Studies | Atrial Fibrillation - therapy | Humans | Middle Aged | Electric Countershock | Warfarin - adverse effects | Anticoagulants - therapeutic use | Enoxaparin - therapeutic use | Thiazoles - therapeutic use | Anticoagulants - adverse effects | Enoxaparin - adverse effects | Thiazoles - adverse effects | Warfarin - therapeutic use | Factor Xa Inhibitors - therapeutic use | Pyridines - adverse effects | Thromboembolism - prevention & control | Factor Xa Inhibitors - adverse effects | Aged | Hemorrhage - chemically induced | Pyridines - therapeutic use | Stroke (Disease) | Medical colleges | Warfarin | Atrial fibrillation | Clinical trials | Product development | Electric countershock | Cardiology | Public finance | Cardiac arrhythmia | Anticoagulants | Stroke | Drug therapy | Coagulation
Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 385, Issue 9970, pp. 785 - 791
Summary Background Defibrillation testing by induction and termination of ventricular fibrillation is widely done at the time of implantation of implantable...
Internal Medicine | MEDICINE, GENERAL & INTERNAL | THRESHOLD | AMIODARONE | INSERTION | THERAPY | EFFICACY | HEART-FAILURE | PREVENTION | TIME | DYSFUNCTION | REGISTRY | Single-Blind Method | Postoperative Complications - etiology | Prognosis | Arrhythmias, Cardiac - mortality | Arrhythmias, Cardiac - therapy | Risk Assessment | Humans | Middle Aged | Electric Countershock - mortality | Male | Postoperative Complications - mortality | Ventricular Fibrillation - etiology | Defibrillators, Implantable | Patient Safety | Female | Prosthesis Implantation - methods | Prosthesis Implantation - mortality | Heart Failure - etiology | Electric Countershock - methods | Defibrillators | Implants, Artificial | Prosthesis | Muscle contraction | Abnormalities | Heart failure | Cardiac arrhythmia | Transplants & implants | Mortality | Clinical medicine | Cardiology | Life Sciences
Internal Medicine | MEDICINE, GENERAL & INTERNAL | THRESHOLD | AMIODARONE | INSERTION | THERAPY | EFFICACY | HEART-FAILURE | PREVENTION | TIME | DYSFUNCTION | REGISTRY | Single-Blind Method | Postoperative Complications - etiology | Prognosis | Arrhythmias, Cardiac - mortality | Arrhythmias, Cardiac - therapy | Risk Assessment | Humans | Middle Aged | Electric Countershock - mortality | Male | Postoperative Complications - mortality | Ventricular Fibrillation - etiology | Defibrillators, Implantable | Patient Safety | Female | Prosthesis Implantation - methods | Prosthesis Implantation - mortality | Heart Failure - etiology | Electric Countershock - methods | Defibrillators | Implants, Artificial | Prosthesis | Muscle contraction | Abnormalities | Heart failure | Cardiac arrhythmia | Transplants & implants | Mortality | Clinical medicine | Cardiology | Life Sciences
Journal Article
The Lancet, ISSN 0140-6736, 10/2017, Volume 390, Issue 10104, pp. 1747 - 1757
Current guidelines recommend potent platelet inhibition with prasugrel or ticagrelor for 12 months after an acute coronary syndrome managed with percutaneous...
ELUTING STENTS | MEDICINE, GENERAL & INTERNAL | CLOPIDOGREL | THERAPY | TICAGRELOR | TREATMENT PATTERNS | PRASUGREL | DIPHOSPHATE RECEPTOR INHIBITOR | OUTCOMES | MYOCARDIAL-INFARCTION PATIENTS | PLATELET REACTIVITY | Myocardial Infarction - epidemiology | Acute Coronary Syndrome - epidemiology | Drug Administration Schedule | Hemorrhage - epidemiology | Humans | Middle Aged | Europe - epidemiology | Male | Prasugrel Hydrochloride - adverse effects | Ticlopidine - analogs & derivatives | Platelet Aggregation Inhibitors - administration & dosage | Platelet Function Tests | Ticlopidine - adverse effects | Ticlopidine - administration & dosage | Acute Coronary Syndrome - therapy | Clopidogrel | Female | Stroke - epidemiology | Hemorrhage - chemically induced | Prasugrel Hydrochloride - administration & dosage | Drug Monitoring | Percutaneous Coronary Intervention | Platelet Aggregation Inhibitors - adverse effects | Transluminal angioplasty | Care and treatment | Coronary heart disease | Cardiac patients | Analysis | Anticoagulants | Heart attacks | Blood platelets | Angioplasty | Clinical trials | Acute coronary syndromes | Drug therapy | Patients | Clinical outcomes | Myocardial infarction | Intervention | Medical services | Bleeding | Consortia | Randomization | Motivation | Inhibition | Cerebral infarction | Stroke | Test procedures | Health risks | Thrombosis | Coronary vessels | Biomarkers | Infarction | Cardiovascular diseases | Platelets
ELUTING STENTS | MEDICINE, GENERAL & INTERNAL | CLOPIDOGREL | THERAPY | TICAGRELOR | TREATMENT PATTERNS | PRASUGREL | DIPHOSPHATE RECEPTOR INHIBITOR | OUTCOMES | MYOCARDIAL-INFARCTION PATIENTS | PLATELET REACTIVITY | Myocardial Infarction - epidemiology | Acute Coronary Syndrome - epidemiology | Drug Administration Schedule | Hemorrhage - epidemiology | Humans | Middle Aged | Europe - epidemiology | Male | Prasugrel Hydrochloride - adverse effects | Ticlopidine - analogs & derivatives | Platelet Aggregation Inhibitors - administration & dosage | Platelet Function Tests | Ticlopidine - adverse effects | Ticlopidine - administration & dosage | Acute Coronary Syndrome - therapy | Clopidogrel | Female | Stroke - epidemiology | Hemorrhage - chemically induced | Prasugrel Hydrochloride - administration & dosage | Drug Monitoring | Percutaneous Coronary Intervention | Platelet Aggregation Inhibitors - adverse effects | Transluminal angioplasty | Care and treatment | Coronary heart disease | Cardiac patients | Analysis | Anticoagulants | Heart attacks | Blood platelets | Angioplasty | Clinical trials | Acute coronary syndromes | Drug therapy | Patients | Clinical outcomes | Myocardial infarction | Intervention | Medical services | Bleeding | Consortia | Randomization | Motivation | Inhibition | Cerebral infarction | Stroke | Test procedures | Health risks | Thrombosis | Coronary vessels | Biomarkers | Infarction | Cardiovascular diseases | Platelets
Journal Article
The Lancet, ISSN 0140-6736, 03/2019, Volume 393, Issue 10175, pp. 987 - 997
Supraflex is a sirolimus-eluting stent with a biodegradable polymer coating and ultra-thin struts. We aimed to compare Supraflex with the standard of care,...
NON-INFERIORITY | DEFINITION | LEADERS | MEDICINE, GENERAL & INTERNAL | BIODEGRADABLE POLYMER | REVASCULARIZATION | XIENCE | DURABLE POLYMER | Clinical trials | Analysis | Myocardial infarction | Surgical implants | Heart attacks | Sirolimus | Biodegradability | Stenosis | Drug delivery | Chromium alloys | Coatings | Clinical outcomes | Randomization | Motivation | Atherosclerosis | Implants | Electrocardiography | Safety | Polymers | Lesions | Thromboembolism | Cardiology | Stents | Biodegradation | Coronary artery | Alloys | Implantation | Patients | Thrombosis | Composite materials | Arteriosclerosis | Coronary vessels | Infarction | Polymer coatings | Coating | Veins & arteries
NON-INFERIORITY | DEFINITION | LEADERS | MEDICINE, GENERAL & INTERNAL | BIODEGRADABLE POLYMER | REVASCULARIZATION | XIENCE | DURABLE POLYMER | Clinical trials | Analysis | Myocardial infarction | Surgical implants | Heart attacks | Sirolimus | Biodegradability | Stenosis | Drug delivery | Chromium alloys | Coatings | Clinical outcomes | Randomization | Motivation | Atherosclerosis | Implants | Electrocardiography | Safety | Polymers | Lesions | Thromboembolism | Cardiology | Stents | Biodegradation | Coronary artery | Alloys | Implantation | Patients | Thrombosis | Composite materials | Arteriosclerosis | Coronary vessels | Infarction | Polymer coatings | Coating | Veins & arteries
Journal Article
The Lancet, ISSN 0140-6736, 10/2019, Volume 394, Issue 10206, pp. 1344 - 1351
A small proportion of patients undergoing primary prophylactic implantation of implantable cardioverter defibrillators (ICDs) experiences malignant...
PREVENTION | MEDICINE, GENERAL & INTERNAL | RISK | DEATH | CARDIOVERTER-DEFIBRILLATOR | SUDDEN | Austria | Mortality | Analysis | Germany | Heart | Heart failure | Cardiac arrhythmia | Adjustment | Cardiomyopathy | Implantation | Patients | Studies | Consortia | Reduction | Defibrillators | Dynamics | Dynamic stability | Predictions | Clinical medicine | Ventricle | Ejection
PREVENTION | MEDICINE, GENERAL & INTERNAL | RISK | DEATH | CARDIOVERTER-DEFIBRILLATOR | SUDDEN | Austria | Mortality | Analysis | Germany | Heart | Heart failure | Cardiac arrhythmia | Adjustment | Cardiomyopathy | Implantation | Patients | Studies | Consortia | Reduction | Defibrillators | Dynamics | Dynamic stability | Predictions | Clinical medicine | Ventricle | Ejection
Journal Article
The Lancet, ISSN 0140-6736, 09/2018, Volume 392, Issue 10151, pp. 940 - 949
We hypothesised that ticagrelor, in combination with aspirin for 1 month, followed by ticagrelor alone, improves outcomes after percutaneous coronary...
DEFINITIONS | MEDICINE, GENERAL & INTERNAL | BIODEGRADABLE POLYMER | METAANALYSIS | DUAL-ANTIPLATELET THERAPY | MYOCARDIAL-INFARCTION | ACADEMIC RESEARCH CONSORTIUM | CLINICAL-TRIALS | ACUTE CORONARY SYNDROMES | DURABLE POLYMER | INTERVENTION | Myocardial Infarction - mortality | Purinergic P2Y Receptor Antagonists - administration & dosage | Humans | Middle Aged | Male | Coronary Artery Disease - drug therapy | Coronary Artery Disease - mortality | Adenosine - administration & dosage | Ticlopidine - analogs & derivatives | Aspirin - administration & dosage | Drug-Eluting Stents - adverse effects | Coronary Angiography | Adenosine - analogs & derivatives | Platelet Aggregation Inhibitors - administration & dosage | Intention to Treat Analysis | Ticlopidine - administration & dosage | Clopidogrel | Female | Aged | Myocardial Infarction - prevention & control | Drug Therapy, Combination | Ticagrelor | Percutaneous Coronary Intervention | Aggregation | Blood platelets | Analysis | Myocardial infarction | Intervention | Therapy | Surgical implants | Heart attacks | Disorders | Cardiovascular disease | Drug delivery | Bleeding | Subgroups | Consortia | Randomization | Motivation | Implants | Heart diseases | Stents | Drug dosages | Aspirin | Stroke | Mortality | Coronary artery | Implantation | Coronary artery disease | Patients | Coronary vessels | Fatalities | Infarction | Acute coronary syndromes | Biosensors
DEFINITIONS | MEDICINE, GENERAL & INTERNAL | BIODEGRADABLE POLYMER | METAANALYSIS | DUAL-ANTIPLATELET THERAPY | MYOCARDIAL-INFARCTION | ACADEMIC RESEARCH CONSORTIUM | CLINICAL-TRIALS | ACUTE CORONARY SYNDROMES | DURABLE POLYMER | INTERVENTION | Myocardial Infarction - mortality | Purinergic P2Y Receptor Antagonists - administration & dosage | Humans | Middle Aged | Male | Coronary Artery Disease - drug therapy | Coronary Artery Disease - mortality | Adenosine - administration & dosage | Ticlopidine - analogs & derivatives | Aspirin - administration & dosage | Drug-Eluting Stents - adverse effects | Coronary Angiography | Adenosine - analogs & derivatives | Platelet Aggregation Inhibitors - administration & dosage | Intention to Treat Analysis | Ticlopidine - administration & dosage | Clopidogrel | Female | Aged | Myocardial Infarction - prevention & control | Drug Therapy, Combination | Ticagrelor | Percutaneous Coronary Intervention | Aggregation | Blood platelets | Analysis | Myocardial infarction | Intervention | Therapy | Surgical implants | Heart attacks | Disorders | Cardiovascular disease | Drug delivery | Bleeding | Subgroups | Consortia | Randomization | Motivation | Implants | Heart diseases | Stents | Drug dosages | Aspirin | Stroke | Mortality | Coronary artery | Implantation | Coronary artery disease | Patients | Coronary vessels | Fatalities | Infarction | Acute coronary syndromes | Biosensors
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2015, Volume 65, Issue 24, pp. 2581 - 2588
Abstract Background Magnetic resonance imaging (MRI) of patients with conventional implantable cardioverter-defibrillators (ICD) is contraindicated. Objectives...
magnetic resonance imaging | implantable cardioverter-defibrillator | CARDIAC & CARDIOVASCULAR SYSTEMS | TASK-FORCE | HEART-FAILURE | GUIDELINES | DEVICES | ICD | Defibrillators, Implantable - adverse effects | Follow-Up Studies | Humans | Magnetic Resonance Imaging - adverse effects | Middle Aged | Cardiovascular Diseases - therapy | Magnetic Resonance Imaging - methods | Male | Electric Countershock - adverse effects | Electric Countershock - instrumentation | Internationality | Cardiovascular Diseases - epidemiology | Female | Aged | Cardiovascular Diseases - diagnosis | Electric Countershock - methods | Heart beat | Defibrillators | Implants, Artificial | Prosthesis
magnetic resonance imaging | implantable cardioverter-defibrillator | CARDIAC & CARDIOVASCULAR SYSTEMS | TASK-FORCE | HEART-FAILURE | GUIDELINES | DEVICES | ICD | Defibrillators, Implantable - adverse effects | Follow-Up Studies | Humans | Magnetic Resonance Imaging - adverse effects | Middle Aged | Cardiovascular Diseases - therapy | Magnetic Resonance Imaging - methods | Male | Electric Countershock - adverse effects | Electric Countershock - instrumentation | Internationality | Cardiovascular Diseases - epidemiology | Female | Aged | Cardiovascular Diseases - diagnosis | Electric Countershock - methods | Heart beat | Defibrillators | Implants, Artificial | Prosthesis
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2017, Volume 70, Issue 7, pp. 845 - 853
Background Clinical outcomes in large patient populations from real-world clinical practice with a next-generation self-expanding transcatheter aortic valve...
transcatheter aortic valve replacement | degenerative valve | aortic stenosis | REPLACEMENT | SURGERY | INTERMEDIATE-RISK PATIENTS | CARDIAC & CARDIOVASCULAR SYSTEMS | STENOSIS | THERAPY | IMPLANTATION | BIOPROSTHESIS | DEEMED EXTREME RISK | END-POINT DEFINITIONS | REGISTRY | Severity of Illness Index | Multidetector Computed Tomography | Echocardiography | Prospective Studies | Survival Rate - trends | Follow-Up Studies | Global Health | Heart Valve Prosthesis | Humans | Risk Factors | Male | Treatment Outcome | Aortic Valve Stenosis - diagnosis | Prosthesis Design | Aortic Valve Stenosis - mortality | Time Factors | Aged, 80 and over | Cause of Death - trends | Female | Aortic Valve Stenosis - surgery | Transcatheter Aortic Valve Replacement - methods | Heart valve diseases | Implants, Artificial | Prosthesis | Patient outcomes | Prostheses | Stroke | Mortality | Stenosis | Risk | Thorax | Patients | Collaboration | Surgery | Regurgitation | Electrocardiography | Aorta | Mercury | Aortic valve
transcatheter aortic valve replacement | degenerative valve | aortic stenosis | REPLACEMENT | SURGERY | INTERMEDIATE-RISK PATIENTS | CARDIAC & CARDIOVASCULAR SYSTEMS | STENOSIS | THERAPY | IMPLANTATION | BIOPROSTHESIS | DEEMED EXTREME RISK | END-POINT DEFINITIONS | REGISTRY | Severity of Illness Index | Multidetector Computed Tomography | Echocardiography | Prospective Studies | Survival Rate - trends | Follow-Up Studies | Global Health | Heart Valve Prosthesis | Humans | Risk Factors | Male | Treatment Outcome | Aortic Valve Stenosis - diagnosis | Prosthesis Design | Aortic Valve Stenosis - mortality | Time Factors | Aged, 80 and over | Cause of Death - trends | Female | Aortic Valve Stenosis - surgery | Transcatheter Aortic Valve Replacement - methods | Heart valve diseases | Implants, Artificial | Prosthesis | Patient outcomes | Prostheses | Stroke | Mortality | Stenosis | Risk | Thorax | Patients | Collaboration | Surgery | Regurgitation | Electrocardiography | Aorta | Mercury | Aortic valve
Journal Article