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by Peloso, Gina M and Auer, Paul L and Bis, Joshua C and Voorman, Arend and Morrison, Alanna C and Stitziel, Nathan O and Brody, Jennifer A and Khetarpal, Sumeet A and Crosby, Jacy R and Fornage, Myriam and Isaacs, Aaron and Jakobsdottir, Johanna and Feitosa, Mary F and Davies, Gail and Huffman, Jennifer E and Manichaikul, Ani and Davis, Brian and Lohman, Kurt and Joon, Aron Y and Smith, Albert V and Grove, Megan L and Zanoni, Paolo and Redon, Valeska and Demissie, Serkalem and Lawson, Kim and Peters, Ulrike and Carlson, Christopher and Jackson, Rebecca D and Ryckman, Kelli K and Mackey, Rachel H and Robinson, Jennifer G and Siscovick, David S and Schreiner, Pamela J and Mychaleckyj, Josyf C and Pankow, James S and Hofman, Albert and Uitterlinden, Andre G and Harris, Tamara B and Taylor, Herman A and Taylor, Kent D and Stafford, Jeanette M and Reynolds, Lindsay M and Marioni, Riccardo E and Dehghan, Abbas and Franco, Oscar H and Patel, Aniruddh P and Lu, Yingchang and Hindy, George and Gottesman, Omri and Bottinger, Erwin P and Melander, Olle and Orho-Melander, Marju and Loos, Ruth J.F and Duga, Stefano and Merlini, Piera Angelica and Farrall, Martin and Goel, Anuj and Asselta, Rosanna and Girelli, Domenico and Martinelli, Nicola and Shah, Svati H and Kraus, William E and Li, Mingyao and Rader, Daniel J and Reilly, Muredach P and McPherson, Ruth and Watkins, Hugh and Ardissino, Diego and Zhang, Qunyuan and Wang, Judy and Tsai, Michael Y and Correa, Adolfo and Griswold, Michael E and Lange, Leslie A and Starr, John M and Rudan, Igor and Eiriksdottir, Gudny and Launer, Lenore J and Ordovas, Jose M and Levy, Daniel and Chen, Y.-D. Ida and Reiner, Alexander P and Hayward, Caroline and Polasek, Ozren and Deary, Ian J and Borecki, Ingrid B and Liu, Yongmei and Gudnason, Vilmundur and Wilson, James G and van Duijn, Cornelia M and Kooperberg, Charles and Rich, Stephen S and Psaty, Bruce M and Rotter, Jerome I and O’Donnell, Christopher J and Rice, Kenneth and Boerwinkle, Eric and Kathiresan, Sekar and Cupples, L. Adrienne and NHLBI GO Exome Sequencing Project and Diabetes - Cardiovascular Disease and Diabetes - kardiovaskulär sjukdom and Kardiovaskulär forskning - hypertoni and Cardiovascular Research - Hypertension and Lund University and EpiHealth: Epidemiology for Health and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
The American Journal of Human Genetics, ISSN 0002-9297, 02/2014, Volume 94, Issue 2, pp. 223 - 232
Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene ( ) lower plasma low-density lipoprotein cholesterol... 
DENSITY-LIPOPROTEIN CHOLESTEROL | FACTOR ACETYLHYDROLASES | PROTEIN | LDL | GENETICS & HEREDITY | PCSK9 | PLATELET-ACTIVATING-FACTOR | TRAITS | Genetic Code | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Male | Genetic Variation | 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics | Adult | Cholesterol, LDL - blood | Female | Subtilisins - metabolism | African Continental Ancestry Group - genetics | Coronary Disease - blood | European Continental Ancestry Group - genetics | Genetic Association Studies | Gene Frequency | Mice, Inbred C57BL | Linear Models | Cholesterol, HDL - genetics | Sequence Analysis, DNA | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | Cholesterol, LDL - genetics | Phenotype | Animals | Coronary Disease - genetics | Alleles | Triglycerides - blood | Cholesterol, HDL - blood | Subtilisins - genetics | Aged | Mice | Cohort Studies | Genetic code | Genetic variation | Physiological aspects | Genetic research | Genetic aspects | Research | Coronary heart disease | Population genetics | Lipids | Cardiovascular disease | Low density lipoprotein | Risk assessment | Deoxyribonucleic acid--DNA | Index Medicus | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 67, Issue 22, pp. 2578 - 2589
Abstract Background Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl),... 
Cardiovascular | Internal Medicine | coronary artery disease | gene sequencing | genetics | low-density lipoprotein cholesterol | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | MYOCARDIAL-INFARCTION | RANDOMIZED-TRIALS | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | RISK | MUTATION DETECTION RATE | CORONARY-HEART-DISEASE | ASSOCIATION | PARTICIPANTS | Receptors, LDL - genetics | Humans | Middle Aged | Hyperlipoproteinemia Type II - diagnosis | Male | Proprotein Convertase 9 - genetics | Apolipoprotein B-100 - genetics | Case-Control Studies | Genetic Variation | Cholesterol, LDL - blood | Female | Heterozygote | Coronary Artery Disease - epidemiology | Sequence Analysis | Cohort Studies | Hypercholesterolemia - epidemiology | Hyperlipoproteinemia Type II - genetics | Medical colleges | Care and treatment | Low density lipoproteins | Genes | Coronary heart disease | Population genetics | Epidemiology | Blood | Hypercholesterolemia | Analysis and chemistry | Atherosclerosis | Genetic research | Genetic aspects | Diagnosis | Research institutes | Cardiology | Trans fatty acids | Heart attacks | Cardiovascular disease | Lipids | Apolipoproteins | Low density lipoprotein | Cholesterol | Proteins | Studies | Confidence intervals | Consortia | Algorithms | Coronary vessels | Population | Mutation | Deoxyribonucleic acid--DNA | Index Medicus | Abridged Index Medicus
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 12/2016, Volume 68, Issue 25, pp. 2761 - 2772
Journal Article
Journal Article
Journal Article
by Furberg, Helena and Kim, Yunjung and Dackor, Jennifer and Boerwinkle, Eric and Franceschini, Nora and Ardissino, Diego and Bernardinelli, Luisa and Mannucci, Pier and Mauri, Francesco and Merlini, Piera and Absher, Devin and Assimes, Themistocles and Fortmann, Stephen and Iribarren, Carlos and Knowles, Joshua and Quertermous, Thomas and Ferrucci, Luigi and Tanaka, Toshiko and Bis, Joshua and Haritunians, Talin and McKnight, Barbara and Psaty, Bruce and Taylor, Kent and Thacker, Evan and Almgren, Peter and Groop, Leif and Ladenvall, Claes and Boehnke, Michael and Jackson, Anne and Mohlke, Karen and Stringham, Heather and Tuomilehto, Jaakko and Benjamin, Emelia and Hwang, S.J and Levy, Daniel and Preis, S.R and Vasan, Ramachanan Srini and Duan, Jubao and Gejman, Pablo and Levinson, Douglas and Sanders, Alan and Shi, Jianxin and Lips, Esther and McKay, James and Agudo, Antonio and Barzan, Luigi and Bencko, Vladimir and Benhamou, Simone and Castellsagué, Xavier and Canova, Cristina and Conway, David and Fabianova, Eleonora and Foretova, Lenka and Janout, Vladimir and Healy, Claire and Holcátová, Ivana and Kjaerheim, Kristina and Lagiou, P and Lissowska, Jolanta and Lowry, Ray and MacFarlane, Tatiana and Mates, Dana and Richiardi, Lorenzo and Rudnai, Peter and Szeszenia-Dabrowska, Neonilia and Zaridze, D and Znaor, Ariana and Lathrop, Mark and Brennan, Paul and Bandinelli, Stefania and Frayling, Timothy and Guralnik, Jack and Milaneschi, Yuri and Perry, John and Altshuler, David and Elosua, Roberto and Kathiresan, Sekar and Lucas, Gavin and Melander, Olle and Salomaa, Veikko and Schwartz, Stephen and Voight, Benjamin and Penninx, Brenda and Smit, Johannes and Vogelzangs, Nicole and Boomsma, Dorret and Geus, Eco and Vink, Jacqueline and Willemsen, Gonneke and Chanock, Stephen and Gu, Fangyi and Hankinson, Susan and Hunter, David and Hofman, Albert and Tiemeier, Henning and Uitterlinden, Ané and Tikka-Kleemola, Päivi and Walter, Stefan and Chasman, Daniel and Everett, Brendan and ... and Tobacco and Genetics Consortium and The Tobacco and Genetics Consortium
Nature Genetics, ISSN 1061-4036, 05/2010, Volume 42, Issue 5, pp. 441 - 447
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 05/2018, Volume 71, Issue 17, pp. 1869 - 1877
Journal Article
by Perret, Claire and Blankenberg, Stefan and Stark, Klaus and Braund, Peter S and Rubin, Diana and Deloukas, Panos and Ball, Stephen G and Schäfer, Arne and Thompson, John R and Voight, Benjamin F and Zeller, Tanja and Schunkert, Heribert and Ouwehand, Willem H and Merlini, Piera Angelica and Schrezenmeir, Jürgen and Linsel-Nitschke, Patrick and Bernardinelli, Luisa and Elosua, Roberto and Wright, Ben and Peyvandi, Flora and Schillert, Arne and Meisinger, Christa and Hengstenberg, Christian and Samani, Nilesh J and Salomaa, Veikko and Peltonen, Leena and Melander, Olle and Schreiber, Stefan and Trégouët, David-Alexandre and Mokhtari, Nour Eddine El and Schwarz, Daniel F and Balmforth, Anthony J and Kathiresan, Sekar and Wagner, Arnika K and Siscovick, David S and Schwartz, Stephen M and Bugert, Peter and Ardissino, Diego and König, Inke R and Aherrahrou, Zouhair and Wild, Philipp and Erdmann, Jeanette and Baumert, Jens and Renner, Wilfried and Bruse, Petra and Klüter, Harald and Altshuler, David and März, Winfried and Wichmann, H-Erich and Ziegler, Andreas and Fischer, Marcus and Hall, Alistair S and Cambien, Francois and Meitinger, Thomas and Großhennig, Anika and Tiret, Laurence and O'Donnell, Christopher J and Peters, Annette and Italian Atherosclerosis Thrombosis and Cardiogenics Consortium and Myocardial Infarction Genetics Con and Wellcome Trust Case Control Consor and Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group and Wellcome Trust Case Control Consortium and Myocardial Infarction Genetics Consortium and Kardiovaskulär forskning - hypertoni and Cardiovascular Research - Hypertension and Lund University and Lunds universitet
Nature Genetics, ISSN 1061-4036, 03/2009, Volume 41, Issue 3, pp. 280 - 282
Journal Article