Journal of the American College of Cardiology, ISSN 0735-1097, 10/2017, Volume 70, Issue 18, pp. B169 - B170
Methods We evaluated 453 intermediate coronary lesions with intracoronary pressure and flow sensors (298 lesions by Doppler flow velocity and 155 lesions by...
Journal Article
Circulation. Cardiovascular interventions, ISSN 1941-7640, 2014, Volume 7, Issue 3, pp. 301 - 311
Discordance between fractional flow reserve (FFR) and coronary flow velocity reserve (CFVR) may reflect important coronary pathophysiology but usually remains...
Fractional fow reserve | Stable coronary artery disease | Coronary fow velocity reserve | Coronary microcirculation | CARDIAC & CARDIOVASCULAR SYSTEMS | coronary flow velocity reserve | CARDIAC MORTALITY | MYOCARDIAL-PERFUSION | BLOOD-FLOW | PROGNOSTIC VALUE | stable coronary artery disease | PRESSURE | ANGIOGRAPHY | coronary microcirculation | MICROVASCULAR RESISTANCE | INTERVENTION | ASSOCIATION | fractional flow reserve | ARTERY-DISEASE | Severity of Illness Index | Myocardial Infarction - epidemiology | Follow-Up Studies | Coronary Vessels - physiopathology | Death, Sudden, Cardiac - epidemiology | Humans | Middle Aged | Risk Factors | Male | Hemodynamics - physiology | Fractional Flow Reserve, Myocardial - physiology | Incidence | Coronary Stenosis - physiopathology | Female | Myocardial Revascularization - statistics & numerical data | Aged | Coronary Stenosis - epidemiology | Retrospective Studies | Blood Flow Velocity - physiology | Longitudinal Studies
Fractional fow reserve | Stable coronary artery disease | Coronary fow velocity reserve | Coronary microcirculation | CARDIAC & CARDIOVASCULAR SYSTEMS | coronary flow velocity reserve | CARDIAC MORTALITY | MYOCARDIAL-PERFUSION | BLOOD-FLOW | PROGNOSTIC VALUE | stable coronary artery disease | PRESSURE | ANGIOGRAPHY | coronary microcirculation | MICROVASCULAR RESISTANCE | INTERVENTION | ASSOCIATION | fractional flow reserve | ARTERY-DISEASE | Severity of Illness Index | Myocardial Infarction - epidemiology | Follow-Up Studies | Coronary Vessels - physiopathology | Death, Sudden, Cardiac - epidemiology | Humans | Middle Aged | Risk Factors | Male | Hemodynamics - physiology | Fractional Flow Reserve, Myocardial - physiology | Incidence | Coronary Stenosis - physiopathology | Female | Myocardial Revascularization - statistics & numerical data | Aged | Coronary Stenosis - epidemiology | Retrospective Studies | Blood Flow Velocity - physiology | Longitudinal Studies
Journal Article
JACC: Cardiovascular Interventions, ISSN 1936-8798, 2015, Volume 8, Issue 13, pp. 1681 - 1691
Abstract Objectives This study sought to understand the physiological basis of baseline distal-to-aortic pressure ratio (Pd/Pa) and fractional flow reserve...
Cardiovascular | coronary stenosis | hyperemia | coronary flow reserve | vasodilation | fractional flow reserve | VELOCITY RESERVE | CARDIAC & CARDIOVASCULAR SYSTEMS | HEMODYNAMICS | PHYSIOLOGICAL-BASIS | THERMODILUTION | REST | ANGINA | PERFUSION | WAVE-FREE RATIO | ARTERY-DISEASE | Coronary Vessels - diagnostic imaging | Transducers, Pressure | Predictive Value of Tests | Prognosis | Coronary Vessels - physiopathology | Humans | Middle Aged | Male | Microcirculation | Arterial Pressure | Echocardiography, Doppler | Female | Aorta - physiopathology | Severity of Illness Index | Vascular Resistance | Aorta - diagnostic imaging | Cardiac Catheters | Cardiac Catheterization - instrumentation | Coronary Angiography | Fractional Flow Reserve, Myocardial | Thermodilution | Coronary Stenosis - physiopathology | Hyperemia - physiopathology | Blood Flow Velocity | Aged | Coronary Stenosis - diagnosis
Cardiovascular | coronary stenosis | hyperemia | coronary flow reserve | vasodilation | fractional flow reserve | VELOCITY RESERVE | CARDIAC & CARDIOVASCULAR SYSTEMS | HEMODYNAMICS | PHYSIOLOGICAL-BASIS | THERMODILUTION | REST | ANGINA | PERFUSION | WAVE-FREE RATIO | ARTERY-DISEASE | Coronary Vessels - diagnostic imaging | Transducers, Pressure | Predictive Value of Tests | Prognosis | Coronary Vessels - physiopathology | Humans | Middle Aged | Male | Microcirculation | Arterial Pressure | Echocardiography, Doppler | Female | Aorta - physiopathology | Severity of Illness Index | Vascular Resistance | Aorta - diagnostic imaging | Cardiac Catheters | Cardiac Catheterization - instrumentation | Coronary Angiography | Fractional Flow Reserve, Myocardial | Thermodilution | Coronary Stenosis - physiopathology | Hyperemia - physiopathology | Blood Flow Velocity | Aged | Coronary Stenosis - diagnosis
Journal Article
Heart, ISSN 1355-6037, 06/2014, Volume 100, Issue 12, pp. 951 - 959
Background Fractional flow reserve (FFR) aims to identify the extent of epicardial disease, but may be obscured by involvement of the coronary...
MULTIVESSEL DISEASE | PRESSURE | VELOCITY | ANGIOGRAPHY | CARDIAC & CARDIOVASCULAR SYSTEMS | INTERMEDIATE | INCREMENTAL PROGNOSTIC VALUE | MYOCARDIAL-PERFUSION | BLOOD-FLOW | INTERVENTION | EMISSION COMPUTED-TOMOGRAPHY | Blood Pressure | Coronary Vessels - diagnostic imaging | Predictive Value of Tests | Coronary Vessels - physiopathology | Humans | Middle Aged | Male | Myocardial Perfusion Imaging | Microcirculation | Cardiac Catheterization | Coronary Artery Disease - physiopathology | Female | Retrospective Studies | Severity of Illness Index | Adenosine | Vascular Resistance | Chi-Square Distribution | Vasodilator Agents | Fractional Flow Reserve, Myocardial | Coronary Artery Disease - diagnosis | Coronary Stenosis - physiopathology | Hyperemia - physiopathology | Blood Flow Velocity | Aged | Coronary Stenosis - diagnosis | Complications and side effects | Care and treatment | Ischemia | Analysis | Coronary stenosis | Stenosis | Coronary heart disease | Risk factors | Heart attacks | Medical imaging | Coronary vessels | Flow velocity | Cardiovascular disease | Physiology | Software | Wire | Stents | Variance analysis | Defects
MULTIVESSEL DISEASE | PRESSURE | VELOCITY | ANGIOGRAPHY | CARDIAC & CARDIOVASCULAR SYSTEMS | INTERMEDIATE | INCREMENTAL PROGNOSTIC VALUE | MYOCARDIAL-PERFUSION | BLOOD-FLOW | INTERVENTION | EMISSION COMPUTED-TOMOGRAPHY | Blood Pressure | Coronary Vessels - diagnostic imaging | Predictive Value of Tests | Coronary Vessels - physiopathology | Humans | Middle Aged | Male | Myocardial Perfusion Imaging | Microcirculation | Cardiac Catheterization | Coronary Artery Disease - physiopathology | Female | Retrospective Studies | Severity of Illness Index | Adenosine | Vascular Resistance | Chi-Square Distribution | Vasodilator Agents | Fractional Flow Reserve, Myocardial | Coronary Artery Disease - diagnosis | Coronary Stenosis - physiopathology | Hyperemia - physiopathology | Blood Flow Velocity | Aged | Coronary Stenosis - diagnosis | Complications and side effects | Care and treatment | Ischemia | Analysis | Coronary stenosis | Stenosis | Coronary heart disease | Risk factors | Heart attacks | Medical imaging | Coronary vessels | Flow velocity | Cardiovascular disease | Physiology | Software | Wire | Stents | Variance analysis | Defects
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 68, Issue 18, pp. B207 - B208
Since CFR is a critical determinant of myocardial ischemia and clinical outcome, we hypothesized that this agreement with CFR results in dominant prognostic...
Cardiovascular | Internal Medicine | Electrocardiography | Clinical outcomes | Agreements
Cardiovascular | Internal Medicine | Electrocardiography | Clinical outcomes | Agreements
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 10, pp. A1739 - A1739
Background: Discordance between Fractional Flow Reserve (FFR) and Coronary Flow Reserve (CFVR) is suggested to originate from diverging distributions of...
Cardiovascular | Internal Medicine | Aging | Medical research
Cardiovascular | Internal Medicine | Aging | Medical research
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 10, pp. A1759 - A1759
Despite normal flow characteristics in the normal and mildly reduced CFC group, FFR<=0.80 occurred in over 40% of cases. [...]FFR decreased to 0.49...
Cardiovascular | Internal Medicine | Ischemia | Cardiology
Cardiovascular | Internal Medicine | Ischemia | Cardiology
Journal Article
JACC: Cardiovascular Interventions, ISSN 1936-8798, 2015, Volume 8, Issue 13, pp. 1670 - 1680
Abstract Objectives The purpose of this study is to evaluate whether coronary flow capacity (CFC) improves discrimination of patients at risk for major adverse...
Cardiovascular | microvascular ischemia | nonobstructive flow impairment | coronary flow reserve | fractional flow reserve | coronary microcirculation
Cardiovascular | microvascular ischemia | nonobstructive flow impairment | coronary flow reserve | fractional flow reserve | coronary microcirculation
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 68, Issue 18, pp. B211 - B211
Using a customized, automated algorithm (written in R project software) the diastolic period was recognized using the peak flow velocity and the sharp...
Cardiovascular | Internal Medicine | Physiological aspects | Medical colleges | Analysis | Flow velocity | Cardiovascular disease
Cardiovascular | Internal Medicine | Physiological aspects | Medical colleges | Analysis | Flow velocity | Cardiovascular disease
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 68, Issue 18, pp. B206 - B207
The mechanism underlying fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) discordance is not fully defined but may be related to...
Cardiovascular | Internal Medicine | Legislators | Analysis
Cardiovascular | Internal Medicine | Legislators | Analysis
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2014, Volume 64, Issue 11, pp. B93 - B93
Analogous to PET-derived CFC, we derived an invasive CFC concept, and studied the relationship of fractional flow reserve (FFR) and hyperemic stenosis...
Cardiovascular | Internal Medicine | Flow velocity | Physiology | Ischemia | Cardiology
Cardiovascular | Internal Medicine | Flow velocity | Physiology | Ischemia | Cardiology
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2014, Volume 64, Issue 11, pp. B91 - B91
After stratification in normal, mildly reduced, moderately reduced, and severely reduced CFC, using literature-derived CFR cut-offs and the corresponding...
Cardiovascular | Internal Medicine | Medical research | Flow velocity | Physiology | Cardiology
Cardiovascular | Internal Medicine | Medical research | Flow velocity | Physiology | Cardiology
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 66, Issue 15, pp. B16 - B17
[...]interest emerged in physiological indices obtained in the resting state that overcome the need for hyperemia.
Cardiovascular | Internal Medicine | Medical colleges | Flow velocity | Physiology | Clinical outcomes
Cardiovascular | Internal Medicine | Medical colleges | Flow velocity | Physiology | Clinical outcomes
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 66, Issue 15, pp. B119 - B119
Conclusions Combining baseline Pd/Pa with FFR seems to provide a more comprehensive physiological examination of stenosed coronary arteries, and a closer...
Cardiovascular | Internal Medicine | Cardiology | Physiology
Cardiovascular | Internal Medicine | Cardiology | Physiology
Journal Article
European heart journal, ISSN 0195-668X, 2016, Volume 37, Issue 26, pp. 2069 - 2080
Background Our understanding of human coronary physiological behaviour is derived from animal models. We sought to describe physiological behaviour across a...
Autoregulation | Stenosis | Physiological lesion assessment | Microvascular resistance | VELOCITY RESERVE | CARDIAC & CARDIOVASCULAR SYSTEMS | ADENOSINE | Physiological Lesion assessment | BLOOD-FLOW | RESERVE MEASUREMENTS | PHYSIOLOGICAL-BASIS | INTERMEDIATE | WAVE-FREE RATIO | LESION SEVERITY | ARTERY-DISEASE | Coronary Circulation | Coronary Angiography | Fractional Flow Reserve, Myocardial | Constriction, Pathologic | Humans | Blood Flow Velocity | Coronary Stenosis | Coronary Vessels
Autoregulation | Stenosis | Physiological lesion assessment | Microvascular resistance | VELOCITY RESERVE | CARDIAC & CARDIOVASCULAR SYSTEMS | ADENOSINE | Physiological Lesion assessment | BLOOD-FLOW | RESERVE MEASUREMENTS | PHYSIOLOGICAL-BASIS | INTERMEDIATE | WAVE-FREE RATIO | LESION SEVERITY | ARTERY-DISEASE | Coronary Circulation | Coronary Angiography | Fractional Flow Reserve, Myocardial | Constriction, Pathologic | Humans | Blood Flow Velocity | Coronary Stenosis | Coronary Vessels
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2016, Volume 68, Issue 15, pp. 1622 - 1632
In 10% to 15% of patients with ST-segment elevation myocardial infarction (STEMI), concurrent coronary chronic total occlusion (CTO) in a non-infarct-related...
chronic total occlusion percutaneous coronary intervention | ST-segment elevation myocardial infarction | MULTIVESSEL DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | RANDOMIZED-TRIAL | TARGET VESSEL | IMPACT | HEART-ASSOCIATION | ST-SEGMENT ELEVATION | ELEVATION MYOCARDIAL-INFARCTION | LEFT-VENTRICULAR FUNCTION | CORONARY INTERVENTION | ST Elevation Myocardial Infarction - complications | Prospective Studies | Humans | Middle Aged | ST Elevation Myocardial Infarction - surgery | Female | Male | Chronic Disease | Coronary Occlusion - surgery | Coronary Occlusion - complications | Percutaneous Coronary Intervention | Hypotheses | Heart attacks | Nuclear magnetic resonance--NMR | Heart surgery | Mortality | Coronary vessels | Electrocardiography | Cardiovascular disease | Stents | Thrombosis
chronic total occlusion percutaneous coronary intervention | ST-segment elevation myocardial infarction | MULTIVESSEL DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | RANDOMIZED-TRIAL | TARGET VESSEL | IMPACT | HEART-ASSOCIATION | ST-SEGMENT ELEVATION | ELEVATION MYOCARDIAL-INFARCTION | LEFT-VENTRICULAR FUNCTION | CORONARY INTERVENTION | ST Elevation Myocardial Infarction - complications | Prospective Studies | Humans | Middle Aged | ST Elevation Myocardial Infarction - surgery | Female | Male | Chronic Disease | Coronary Occlusion - surgery | Coronary Occlusion - complications | Percutaneous Coronary Intervention | Hypotheses | Heart attacks | Nuclear magnetic resonance--NMR | Heart surgery | Mortality | Coronary vessels | Electrocardiography | Cardiovascular disease | Stents | Thrombosis
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2011, Volume 57, Issue 1, pp. 29 - 36
Objectives We investigated whether multiple biomarkers improve prognostication in ST-segment elevation myocardial infarction (STEMI) patients undergoing...
Cardiovascular | Internal Medicine | biomarker | prognostication | ST-segment elevation myocardial infarction | C-REACTIVE PROTEIN | RENAL DYSFUNCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | HYPERGLYCEMIA | TROPONIN-T | DEATH | NATRIURETIC PEPTIDE | PROGNOSTIC VALUE | TIMI RISK SCORE | Myocardial Infarction - blood | Myocardial Infarction - mortality | Prognosis | Survival Rate - trends | Follow-Up Studies | Angioplasty, Balloon, Coronary - methods | Humans | Middle Aged | Netherlands - epidemiology | Patient Admission | Risk Factors | Proportional Hazards Models | Male | Biomarkers - blood | Myocardial Infarction - therapy | C-Reactive Protein - metabolism | Troponin T - blood | Peptide Fragments - blood | Protein Precursors | Electrocardiography | Female | Receptor, Epidermal Growth Factor - blood | Retrospective Studies | Natriuretic Peptide, Brain - blood | Transluminal angioplasty | C-reactive protein | Patient outcomes | Cardiac patients | Mortality | Biological markers | Cardiology | Heart attack | Natriuretic peptides | Heart attacks | Drug therapy | Older people
Cardiovascular | Internal Medicine | biomarker | prognostication | ST-segment elevation myocardial infarction | C-REACTIVE PROTEIN | RENAL DYSFUNCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | HYPERGLYCEMIA | TROPONIN-T | DEATH | NATRIURETIC PEPTIDE | PROGNOSTIC VALUE | TIMI RISK SCORE | Myocardial Infarction - blood | Myocardial Infarction - mortality | Prognosis | Survival Rate - trends | Follow-Up Studies | Angioplasty, Balloon, Coronary - methods | Humans | Middle Aged | Netherlands - epidemiology | Patient Admission | Risk Factors | Proportional Hazards Models | Male | Biomarkers - blood | Myocardial Infarction - therapy | C-Reactive Protein - metabolism | Troponin T - blood | Peptide Fragments - blood | Protein Precursors | Electrocardiography | Female | Receptor, Epidermal Growth Factor - blood | Retrospective Studies | Natriuretic Peptide, Brain - blood | Transluminal angioplasty | C-reactive protein | Patient outcomes | Cardiac patients | Mortality | Biological markers | Cardiology | Heart attack | Natriuretic peptides | Heart attacks | Drug therapy | Older people
Journal Article
Nature Reviews Cardiology, ISSN 1759-5002, 2013, Volume 10, Issue 8, pp. 439 - 452
Documentation of inducible myocardial ischaemia, related to the coronary stenosis of interest, is of increasing importance in lesion selection for percutaneous...
CONTINUOUS ADENOSINE INFUSION | PERCUTANEOUS CORONARY INTERVENTION | CARDIAC & CARDIOVASCULAR SYSTEMS | INTRAVENOUS ADENOSINE | FUNCTIONAL SEVERITY | PULSE TRANSMISSION COEFFICIENT | MICROVASCULAR RESISTANCE | OPTIMAL MEDICAL THERAPY | WAVE-FREE RATIO | BLOOD-FLOW | INTRACORONARY ADENOSINE | Severity of Illness Index | Predictive Value of Tests | Coronary Stenosis - complications | Coronary Stenosis - therapy | Models, Cardiovascular | Coronary Vessels - physiopathology | Humans | Patient Selection | Vasodilator Agents | Cardiac Catheterization | Fractional Flow Reserve, Myocardial | Coronary Stenosis - physiopathology | Hyperemia - physiopathology | Hemodynamics | Percutaneous Coronary Intervention | Coronary Stenosis - diagnosis | Usage | Care and treatment | Control | Angiography | Physiological aspects | Myocardial ischemia | Health aspects | Blood flow
CONTINUOUS ADENOSINE INFUSION | PERCUTANEOUS CORONARY INTERVENTION | CARDIAC & CARDIOVASCULAR SYSTEMS | INTRAVENOUS ADENOSINE | FUNCTIONAL SEVERITY | PULSE TRANSMISSION COEFFICIENT | MICROVASCULAR RESISTANCE | OPTIMAL MEDICAL THERAPY | WAVE-FREE RATIO | BLOOD-FLOW | INTRACORONARY ADENOSINE | Severity of Illness Index | Predictive Value of Tests | Coronary Stenosis - complications | Coronary Stenosis - therapy | Models, Cardiovascular | Coronary Vessels - physiopathology | Humans | Patient Selection | Vasodilator Agents | Cardiac Catheterization | Fractional Flow Reserve, Myocardial | Coronary Stenosis - physiopathology | Hyperemia - physiopathology | Hemodynamics | Percutaneous Coronary Intervention | Coronary Stenosis - diagnosis | Usage | Care and treatment | Control | Angiography | Physiological aspects | Myocardial ischemia | Health aspects | Blood flow
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 04/2014, Volume 63, Issue 12, p. A1787
Journal Article
American Heart Journal, ISSN 0002-8703, 2016, Volume 180, pp. 39 - 45
Background Ischemic heart disease is a major cause of out of hospital cardiac arrest. The role of immediate coronary angiography (CAG) and percutaneous...
Cardiovascular | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | THERAPEUTIC HYPOTHERMIA | STENT THROMBOSIS | POSTRESUSCITATION CARE | COMATOSE SURVIVORS | ST-SEGMENT ELEVATION | INTERVENTION | IMMEDIATE | ELEVATION MYOCARDIAL-INFARCTION | RESUSCITATION | Coronary Angiography | Out-of-Hospital Cardiac Arrest - therapy | Prospective Studies | Time-to-Treatment | Humans | Intention to Treat Analysis | Out-of-Hospital Cardiac Arrest - diagnostic imaging | Adult | Research Design | Percutaneous Coronary Intervention | Transluminal angioplasty | Angiography | Cardiac arrest | Electrocardiography | Cardiac arrhythmia | Defibrillators | Mortality
Cardiovascular | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | THERAPEUTIC HYPOTHERMIA | STENT THROMBOSIS | POSTRESUSCITATION CARE | COMATOSE SURVIVORS | ST-SEGMENT ELEVATION | INTERVENTION | IMMEDIATE | ELEVATION MYOCARDIAL-INFARCTION | RESUSCITATION | Coronary Angiography | Out-of-Hospital Cardiac Arrest - therapy | Prospective Studies | Time-to-Treatment | Humans | Intention to Treat Analysis | Out-of-Hospital Cardiac Arrest - diagnostic imaging | Adult | Research Design | Percutaneous Coronary Intervention | Transluminal angioplasty | Angiography | Cardiac arrest | Electrocardiography | Cardiac arrhythmia | Defibrillators | Mortality
Journal Article