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Science, ISSN 0036-8075, 08/2016, Volume 353, Issue 6299, pp. 603 - 608
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 364 - 370
The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL) led to clinical testing of g-secretase inhibitors (GSIs) that... 
NOTCH1 | INHIBITION | CHROMATIN | PATHWAY | GENES | GENETICS & HEREDITY | C-MYC | ACUTE MYELOID-LEUKEMIA | CANCER | LENTIVIRAL RNAI LIBRARY | GENOME | Chromatin - metabolism | Humans | Flow Cytometry | Chromatin Immunoprecipitation | Gene Expression Regulation, Neoplastic - drug effects | Indoles | Nuclear Proteins - genetics | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Neoplastic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Enzyme-Linked Immunosorbent Assay | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | Enzyme Inhibitors - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Epigenesis, Genetic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Histones - metabolism | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Chromatin - genetics | Care and treatment | Pharmacology, Experimental | Acute lymphocytic leukemia | Research | Drug resistance | Proteins | Genotype & phenotype | Leukemia | Epigenetics | Genomes | Kinases | Gene expression | Cancer therapies
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2014, Volume 111, Issue 20, pp. 7391 - 7396
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 65 - 70
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2009, Volume 5, Issue 7, pp. e1000500 - e1000500
While the recognition of microbial infection often occurs at the cell surface via Toll-like receptors, the cytosol of the cell is also under surveillance for... 
LISTERIA-MONOCYTOGENES | BACILLUS-CALMETTE-GUERIN | HUMAN MACROPHAGES | MICROBIOLOGY | INNATE IMMUNE-SYSTEM | ENHANCED PROTECTION | BACTERIAL PEPTIDOGLYCAN | CUTTING EDGE | VIROLOGY | TOLL-LIKE RECEPTORS | INTRACELLULAR BACTERIA | NF-KAPPA-B | PARASITOLOGY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Interferon Regulatory Factors - metabolism | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | Tuberculosis - microbiology | Interferon Type I - immunology | Interferon Type I - biosynthesis | Interferon Type I - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Tuberculosis - metabolism | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Interferon Regulatory Factor-3 - immunology | Cell Line | Mice, Inbred C57BL | Bacterial Proteins - genetics | Nod2 Signaling Adaptor Protein - immunology | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | Tuberculosis - immunology | Interferon Regulatory Factors - immunology | Macrophages - metabolism | Animals | Nod2 Signaling Adaptor Protein - metabolism | Interferon Regulatory Factor-3 - metabolism | Protein-Serine-Threonine Kinases - immunology | Mice | Mutation | Ubiquitin - immunology | Mycobacterium tuberculosis - genetics | Immune response | Tuberculosis | Mycobacterium tuberculosis | Physiological aspects | Causes of | Development and progression | Genetic aspects | Interferon | Research | Proteins | Microbiology | Listeria | Gram-positive bacteria | Bacteria | Standard deviation | Kinases | Gene expression | Real time | Experiments | Apoptosis
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 08/2018, Volume 9, p. 1718
The NOTCH (14) family of receptors are highly conserved and are critical in regulating many developmental processes and in the maintenance of tissue... 
T lymphocytes | TARGETED THERAPY | STEM-CELLS | SOLID TUMORS | NOTCH | IMMUNOLOGY | LUNG-CANCER | CANCER IMMUNOSURVEILLANCE | ADOPTIVE TRANSFER | immunotherapy | IN-VIVO | anti-tumor response | CHRONIC LYMPHOCYTIC-LEUKEMIA | TUMOR-SUPPRESSOR | cancer | SUPPRESSOR-CELLS | Usage | Immunotherapy | Oncology, Experimental | Cellular signal transduction | Research | T cells | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2014, Volume 111, Issue 40, pp. 14436 - 14441
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is recruited to the TNF receptor 1 to mediate proinflammatory signaling and to regulate... 
Cytokines | Cell death | Bone marrow | Inflammation | Gene expression regulation | Bone marrow cells | Liver cells | Progenitor cells | Apoptosis | Necrosis | Tumor necrosis factor | Programmed necrosis | Hematopoietic failure | PROGENITOR CELLS | KAPPA-B ACTIVATION | DOMAIN KINASE RIP | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | hematopoietic failure | CELL-DEATH | programmed necrosis | tumor necrosis factor | RECEPTOR-INTERACTING PROTEIN | FANCONI-ANEMIA PATIENTS | TNF-ALPHA | APLASTIC-ANEMIA | Intestinal Mucosa - metabolism | Epithelial Cells - metabolism | Apoptosis - drug effects | Apoptosis - genetics | Estrogen Antagonists - pharmacology | Intestinal Mucosa - cytology | Flow Cytometry | Bone Marrow - metabolism | Epithelial Cells - cytology | Thymus Gland - metabolism | Cytokines - blood | Mice, Inbred C57BL | Cells, Cultured | Inflammation Mediators - blood | Thymus Gland - cytology | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Spleen - cytology | Mice, Knockout | Tumor Necrosis Factor-alpha - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Spleen - metabolism | Bone Marrow - pathology | Hematopoietic Stem Cells - cytology | Tamoxifen - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Apoptosis - physiology | Protein research | Physiological aspects | Research | Protein kinases | Health aspects | Diseases | Biological Sciences
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 50, pp. 36223 - 36229
The Rip2 kinase contains a caspase recruitment domain and has been implicated in the activation of the transcriptional factor NF-κB downstream of Toll-like... 
PEPTIDOGLYCAN | PROTEIN | INNATE IMMUNE-RESPONSES | HOST RECOGNITION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTOR | SYSTEMS | NF-KAPPA-B | TLR4 | MYD88 | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Ubiquitination - drug effects | TNF Receptor-Associated Factor 6 - genetics | Toll-Like Receptors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - microbiology | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Protein Ligases - metabolism | Nod2 Signaling Adaptor Protein - immunology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ubiquitin - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Adjuvants, Immunologic - pharmacology | NF-kappa B - immunology | TNF Receptor-Associated Factor 6 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Enzyme Activation - immunology | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | I-kappa B Kinase - metabolism | Myeloid Differentiation Factor 88 - immunology | Ubiquitin-Conjugating Enzymes - immunology | Tuberculosis - metabolism | Macrophages - immunology | Cells, Cultured | Ubiquitination - immunology | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Tuberculosis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | NF-kappa B - genetics | Tuberculosis - genetics | TNF Receptor-Associated Factor 6 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2011, Volume 31, Issue 14, pp. 2774 - 2786
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
PATHWAY ACTIVATION | MULTIPLE-MYELOMA | UBIQUITINATION | CYLD | DOMAIN | ENZYME | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATM | TAB2 | NEMO | CELL BIOLOGY
Journal Article
Leukemia, ISSN 0887-6924, 2014, Volume 28, Issue 9, pp. 1819 - 1827
Journal Article
Journal Article