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Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. C116 - C116
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 01/2016, Volume 14, Issue 1 Supplement, pp. B37 - B37
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 3726 - 3726
Journal Article
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 07/2013, Volume 10, Issue 7, pp. 372 - 374
Tivantinib is being tested in a variety of phase II and phase III clinical trials as a highly selective, non ATP-competitive MET tyrosine kinase inhibitor. Its... 
ARQ 197 | PLACEBO | ONCOLOGY | INIPARIB | KINASE | Proto-Oncogene Proteins c-met - metabolism | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Tubulin Modulators - pharmacology | Humans | Pyrrolidinones - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Quinolines - pharmacology | Index Medicus
Journal Article
Molecular Oncology, ISSN 1574-7891, 06/2016, Volume 10, Issue 6, pp. 938 - 948
The kinase receptor encoded by the Met oncogene is a sensible target for cancer therapy. The chimeric monovalent Fab fragment of the DN30 monoclonal antibody... 
Cancer targeted therapy | Protein engineering | Half-life | Antibody | Met | Fab | Half‐life | HEPATOCYTE GROWTH-FACTOR | ACQUIRED-RESISTANCE | SOMATIC MUTATIONS | LUNG-CANCER | AMPLIFICATION | ONCOLOGY | COLORECTAL-CANCER | C-MET | INHIBITORS | SCATTER-FACTOR | RECEPTOR TYROSINE KINASE | Proto-Oncogene Proteins c-met - metabolism | Colonic Neoplasms - drug therapy | Humans | Colon - drug effects | Half-Life | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Immunoglobulin Fab Fragments - therapeutic use | Colonic Neoplasms - metabolism | Antibodies, Monoclonal - blood | HEK293 Cells | Protein Engineering | Protein Domains | Female | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Antibodies, Monoclonal - chemistry | Immunoglobulin Fab Fragments - blood | A549 Cells | Colon - pathology | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Colon - metabolism | Immunoglobulin Fab Fragments - pharmacology | Animals | Signal Transduction - drug effects | Colonic Neoplasms - pathology | Immunoglobulin Fab Fragments - chemistry | Antineoplastic Agents - blood | Cell Line, Tumor | Mice, Inbred NOD | Monoclonal antibodies | Proteases | Health aspects | Analysis | Biopharmaceutics | Cells | Index Medicus
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 1/2014, Volume 92, Issue 1, pp. 65 - 76
Due to the key role played in critical sub-populations, Met is considered a relevant therapeutic target for glioblastoma multiforme and lung cancers. The... 
Human Genetics | Lentiviral vector | Biomedicine | Targeted therapy | Antibody | Internal Medicine | Molecular Medicine | Gene therapy | Met | Cancer | MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCYTE GROWTH-FACTOR | DOWN-REGULATION | LENTIVIRAL VECTORS | LUNG-CANCER | AMPLIFICATION | IN-VIVO | C-MET | GENETICS & HEREDITY | RESISTANCE | MONOCLONAL-ANTIBODIES | EXPRESSION | Proto-Oncogene Proteins c-met - metabolism | Genetic Therapy | Genetic Vectors - administration & dosage | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Immunoglobulin Fab Fragments - metabolism | Female | Lentivirus - genetics | Tumor Burden - genetics | Disease Models, Animal | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Gene Transfer Techniques | Gene Expression | Transduction, Genetic | Immunoglobulin Fab Fragments - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Carcinoma, Non-Small-Cell Lung - mortality | Genetic Vectors - genetics | Proto-Oncogene Proteins c-met - genetics | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Mice | Viral antibodies | Care and treatment | Lung cancer | Antibodies | Genetic aspects | Research | Health aspects | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 46, pp. 36149 - 36157
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2008, Volume 3, Issue 9, pp. e3223 - e3223
Journal Article
Cancer Cell, ISSN 1535-6108, 2004, Volume 6, Issue 1, pp. 61 - 73
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 07/2013, Volume 10, Issue 7, pp. 372 - 374
Tivantinib is being tested in a variety of phase II and phase III clinical trials as a highly selective, non ATP-competitive MET tyrosine kinase inhibitor. Its... 
Usage | Control | Cancer cells | Monoclonal antibodies | Clinical trials | Research | Management | Health aspects
Journal Article