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NATURE METHODS, ISSN 1548-7091, 09/2010, Volume 7, Issue 9, pp. 729 - U88
We report ultrasensitive Ca2+ indicators, yellow cameleon-Nano (YC-Nano), developed by engineering the Ca2+-sensing domain of a genetically encoded Ca2+... 
VITRO | DICTYOSTELIUM | CELLS | CALMODULIN | IN-VIVO | FLUORESCENT INDICATORS | BIOCHEMICAL RESEARCH METHODS | CALCIUM INDICATORS | NEURAL ACTIVITY | PROTEINS | PEPTIDE HYBRID MOLECULE | Signal transduction | Scientific imaging | Cellular biology | Neurons | Information processing
Journal Article
Nature Methods, ISSN 1548-7091, 09/2010, Volume 7, Issue 9, pp. 729 - 732
We report ultrasensitive Ca2+ indicators, yellow cameleon-Nano (YC-Nano), developed by engineering the Ca2+-sensing domain of a genetically encoded Ca2+... 
Journal Article
Cell Reports, ISSN 2211-1247, 03/2018, Volume 22, Issue 11, pp. 2873 - 2885
Multisensory integration (MSI) is a fundamental emergent property of the mammalian brain. During MSI, perceptual information encoded in patterned activity is... 
mouse | excitatory neuron | cortical slow waves | multisensory integration | association cortex | fluorescence resonance energy transfer | spontaneous activity | inhibitory neuron | phase locking | wide-field calcium imaging | AUDITORY-CORTEX | IN-VIVO | MICE | FLUORESCENT PROTEINS | CORTICAL ACTIVITY | OSCILLATIONS | PHASE SYNCHRONIZATION | MOUSE VISUAL-CORTEX | CIRCUIT | RANGE | CELL BIOLOGY
Journal Article
Molecular Cell, ISSN 1097-2765, 2006, Volume 22, Issue 6, pp. 795 - 806
The inositol 1,4,5-trisphosphate (IP ) receptors (IP Rs) are IP -gated intracellular Ca channels. We previously identified an IP R binding protein, IRBIT,... 
MOLNEURO | SIGNALING
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1982 - 10
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic intestinal inflammatory condition initiated by... 
COLON-CANCER | ANTIBODIES | MIGRATION | CYTOKINES | PROTEIN | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | CELL-ADHESION | LEUKOCYTE ADHESION | EXPRESSION | MOUSE MODELS | Colon - cytology | Cyclohexanes - pharmacology | Humans | Colon - immunology | Male | Healthy Volunteers | Colitis, Ulcerative - immunology | Cyclohexanes - therapeutic use | T-Lymphocytes - drug effects | Integrin alpha Chains - immunology | Anti-Inflammatory Agents - therapeutic use | Female | Colitis, Ulcerative - drug therapy | Neutrophil Infiltration - drug effects | Disease Models, Animal | Neutrophil Infiltration - immunology | Anti-Inflammatory Agents - pharmacology | Colon - pathology | Jurkat Cells | Neutrophils - drug effects | Neutrophils - immunology | Integrin alpha Chains - metabolism | Piperazines - therapeutic use | Mice, SCID | Piperazines - pharmacology | Dextran Sulfate - toxicity | Animals | Colitis, Ulcerative - chemically induced | Calreticulin - antagonists & inhibitors | Protein Binding | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Calreticulin - immunology | Animal models | Inflammatory bowel diseases | Calcium | Pathogenesis | Lymphocytes T | Leukocytes | Sodium sulfates | Calreticulin | Lymphocytes | Intestine | Rodents | Sodium sulfate | Colon | Binding | Leukocytes (neutrophilic) | Gene expression | Molecular chains | Endothelium | Inflammatory bowel disease | White blood cells | Dextran | Sodium | Infiltration | Microvasculature | Sulfate | Ulcerative colitis | Integrins
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 2004, Volume 1742, Issue 1, pp. 89 - 102
Inositol 1,4,5-trisphosphate receptors (IP R) are intracellular Ca release channels whose opening requires binding of two intracellular messengers IP and Ca .... 
Calcium signaling | IP 3 | IP 3 receptor structure | receptor structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 46, pp. 36081 - 36091
The N-terminal similar to 220-amino acid region of the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)/Ca2+ release channel has been referred to as the... 
CALCIUM RELEASE | SITE | COMPLEX | AFFINITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | XENOPUS EMBRYOS | ENDOPLASMIC-RETICULUM | MOLECULAR-CLONING | MONOCLONAL-ANTIBODIES | DOMAINS | MICE LACKING | Inositol 1,4,5-Trisphosphate Receptors - chemistry | Calcium - metabolism | Inositol 1,4,5-Trisphosphate - chemistry | Molecular Sequence Data | Tryptophan - chemistry | Inositol 1,4,5-Trisphosphate - pharmacology | Tryptophan - metabolism | Ion Channel Gating - physiology | Protein Isoforms - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Protein Isoforms - chemistry | Tyrosine - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Mutagenesis, Site-Directed | Tryptophan - genetics | Models, Molecular | Binding Sites - genetics | Trypsin - metabolism | Blotting, Western | Sequence Homology, Amino Acid | Tyrosine - metabolism | Animals | Ion Channel Gating - genetics | Cell Line, Tumor | Protein Binding | Ligands | Mice | Mutation | Inositol 1,4,5-Trisphosphate - metabolism | Inositol 1,4,5-Trisphosphate Receptors - genetics | Amino Acid Substitution | Ion Channel Gating - drug effects | Protein Isoforms - genetics | Tyrosine - genetics | Index Medicus | Protein Structure and Folding | Calcium | Calcium Channels | Ion Channels | Signal Transduction | Inositol Phosphates | Intracellular Calcium Release
Journal Article
Scientific Reports, 12/2019, Volume 9, Issue 1, p. 4829
In most species, fertilization induces Ca transients in the egg. In mammals, the Ca rises are triggered by phospholipase Cζ (PLCζ) released from the sperm; IP... 
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2007, Volume 27, Issue 32, pp. 8628 - 8635
The abnormal deposition of the amyloid β-protein (Aβ) in the brain appears crucial to the pathogenesis of Alzheimer's disease (AD). Recent studies have... 
ACE | APP transgenic mouse | Aβ degradation | Aβ deposition | Angiotensin-converting enzyme | Amyloid β-protein | Alzheimer's disease | amyloid β-protein | angiotensin-converting enzyme
Journal Article