Nature Biotechnology, ISSN 1087-0156, 08/2014, Volume 32, Issue 8, p. 750
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2014, Volume 371, Issue 26, pp. 2477 - 2487
In this study, clonal hematopoiesis with somatic mutations was found in 10% of otherwise healthy people older than 65. The risk of hematologic cancer was...
EPIGENETIC REGULATORS | ASXL1 | MEDICINE, GENERAL & INTERNAL | STEM-CELLS | PPM1D MUTATIONS | EVOLUTION | DNMT3A | TET2 | JAK2 | GENOME | MOSAICISM | Age Factors | Humans | Middle Aged | Risk Factors | Blood | Exome | Young Adult | Cell Transformation, Neoplastic - genetics | DNA Mutational Analysis | Aged, 80 and over | Hematopoietic Stem Cells - physiology | Adult | Hematopoiesis - physiology | Aged | Clone Cells | Hematologic Neoplasms - genetics | Mutation | Hematologic Neoplasms - physiopathology | Phenotype | Nucleotide sequence | Hematopoiesis | Leukemia | Analysis | Research | Risk factors | Phenotypes | Myeloid leukemia | Pathogenesis | Blood cells | Data processing | Genomes | Hemopoiesis | Bone cancer | Developmental stages | Biopsy | Peripheral blood | Stem cells | Bone marrow | Diagnosis | Blood diseases | Sampling | Acute myeloid leukemia | Age | Deoxyribonucleic acid--DNA | Cancer | DNA sequencing | Annan medicinsk grundvetenskap | Basic Medicine | Other Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
EPIGENETIC REGULATORS | ASXL1 | MEDICINE, GENERAL & INTERNAL | STEM-CELLS | PPM1D MUTATIONS | EVOLUTION | DNMT3A | TET2 | JAK2 | GENOME | MOSAICISM | Age Factors | Humans | Middle Aged | Risk Factors | Blood | Exome | Young Adult | Cell Transformation, Neoplastic - genetics | DNA Mutational Analysis | Aged, 80 and over | Hematopoietic Stem Cells - physiology | Adult | Hematopoiesis - physiology | Aged | Clone Cells | Hematologic Neoplasms - genetics | Mutation | Hematologic Neoplasms - physiopathology | Phenotype | Nucleotide sequence | Hematopoiesis | Leukemia | Analysis | Research | Risk factors | Phenotypes | Myeloid leukemia | Pathogenesis | Blood cells | Data processing | Genomes | Hemopoiesis | Bone cancer | Developmental stages | Biopsy | Peripheral blood | Stem cells | Bone marrow | Diagnosis | Blood diseases | Sampling | Acute myeloid leukemia | Age | Deoxyribonucleic acid--DNA | Cancer | DNA sequencing | Annan medicinsk grundvetenskap | Basic Medicine | Other Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 11, p. 1166
Journal Article
Nature Biotechnology, ISSN 1087-0156, 11/2014, Volume 32, Issue 11, pp. 1166 - 1166
Journal Article
Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 8, pp. 750 - 751
The structure of complex microbial communities is resolved by considering co-variation of gene abundance.
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Metagenomics | Microbiota | Genomics | Deoxyribonucleic acid--DNA | Meta-analysis
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Metagenomics | Microbiota | Genomics | Deoxyribonucleic acid--DNA | Meta-analysis
Journal Article
Genome Research, ISSN 1088-9051, 10/2012, Volume 22, Issue 10, pp. 1985 - 1994
The bacterial community in the human gut has crucial health roles both in metabolic functions and in protection against pathogens. Phages, which are known to...
SYSTEM | BACTERIA | VIRAL COMMUNITY | PERSPECTIVE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROVIDES ACQUIRED-RESISTANCE | IDENTIFICATION | HUMAN FECES | ARCHAEA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | DIVERSITY | VIRUSES | Metagenome - genetics | Intestines - microbiology | Bacteriophages - classification | Genomics | Humans | Bacteriophages - physiology | Bacteria - genetics | Bacteria - virology | Bacteriophages | Genetic aspects | Immune response | Research | Microbiota (Symbiotic organisms) | Health aspects
SYSTEM | BACTERIA | VIRAL COMMUNITY | PERSPECTIVE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROVIDES ACQUIRED-RESISTANCE | IDENTIFICATION | HUMAN FECES | ARCHAEA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | DIVERSITY | VIRUSES | Metagenome - genetics | Intestines - microbiology | Bacteriophages - classification | Genomics | Humans | Bacteriophages - physiology | Bacteria - genetics | Bacteria - virology | Bacteriophages | Genetic aspects | Immune response | Research | Microbiota (Symbiotic organisms) | Health aspects
Journal Article
Cell Reports, ISSN 2211-1247, 04/2019, Volume 27, Issue 5, pp. 1364 - 1375.e5
The mitochondrial calcium uniporter has been proposed to coordinate the organelle’s energetics with calcium signaling. Uniporter current has previously been...
thermogenesis | calcium | brown fat | GDF15 | mitochondria | uniporter | MCU | ATF4 | integrated stress response | FGF21 | SKELETAL-MUSCLE | BEIGE ADIPOCYTES | ESSENTIAL COMPONENT | CA2+ RELEASE | GLUTATHIONE TRANSFERASE A3-3 | DIET-INDUCED THERMOGENESIS | ENDOPLASMIC-RETICULUM | NEGATIVE-FEEDBACK | INTEGRATED STRESS-RESPONSE | ADIPOSE-TISSUE | CELL BIOLOGY
thermogenesis | calcium | brown fat | GDF15 | mitochondria | uniporter | MCU | ATF4 | integrated stress response | FGF21 | SKELETAL-MUSCLE | BEIGE ADIPOCYTES | ESSENTIAL COMPONENT | CA2+ RELEASE | GLUTATHIONE TRANSFERASE A3-3 | DIET-INDUCED THERMOGENESIS | ENDOPLASMIC-RETICULUM | NEGATIVE-FEEDBACK | INTEGRATED STRESS-RESPONSE | ADIPOSE-TISSUE | CELL BIOLOGY
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 2016, Volume 44, Issue 1, pp. W46 - W53
Whole-transcriptome sequencing studies from recent years revealed an unexpected complexity in transcriptomes of bacteria and archaea, including abundant...
BACTERIA | ARCHAEA | START SITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANDIDATE STRUCTURED RNAS | COMPLEXITY | ANTISENSE | GENE-REGULATION | SEQ | User-Computer Interface | Riboswitch | Transcriptome | Chromosome Mapping | Phylogeny | Archaea - classification | Bacteria - genetics | RNA, Untranslated - genetics | Computer Graphics | Sequence Analysis, RNA | 5' Untranslated Regions | Bacteria - classification | RNA, Bacterial - genetics | Archaea - genetics | RNA, Archaeal - genetics | Web Server issue
BACTERIA | ARCHAEA | START SITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANDIDATE STRUCTURED RNAS | COMPLEXITY | ANTISENSE | GENE-REGULATION | SEQ | User-Computer Interface | Riboswitch | Transcriptome | Chromosome Mapping | Phylogeny | Archaea - classification | Bacteria - genetics | RNA, Untranslated - genetics | Computer Graphics | Sequence Analysis, RNA | 5' Untranslated Regions | Bacteria - classification | RNA, Bacterial - genetics | Archaea - genetics | RNA, Archaeal - genetics | Web Server issue
Journal Article
Science Translational Medicine, ISSN 1946-6234, 04/2018, Volume 10, Issue 436, p. eaao5931
We conducted a pilot clinical trial testing a personalized vaccine generated by autologous dendritic cells (DCs) pulsed with oxidized autologous whole-tumor...
TUMOR-INFILTRATING LYMPHOCYTES | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | II CLINICAL-TRIAL | GYNECOLOGIC-ONCOLOGY-GROUP | IMMUNOTHERAPY | BEVACIZUMAB | COMPLETE RESPONSE | PHASE-II | RESISTANT PROSTATE-CANCER | CARCINOMA | CELL BIOLOGY
TUMOR-INFILTRATING LYMPHOCYTES | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | II CLINICAL-TRIAL | GYNECOLOGIC-ONCOLOGY-GROUP | IMMUNOTHERAPY | BEVACIZUMAB | COMPLETE RESPONSE | PHASE-II | RESISTANT PROSTATE-CANCER | CARCINOMA | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 27, p. E6283
Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis...
NADH-ubiquinone oxidoreductase | Transcription factors | Kidneys | Positive selection | Heuristic methods | Genomes | Biosynthesis | Mitochondrial DNA | Gene expression | Metabolism | Cyclin D1 | Glycine | Chromosome 1 | Intermediates | Antioxidants | Electron transport chain | Mitochondria | Rewiring | Kidney diseases | Mutation | Viability | Glutathione | Tumors
NADH-ubiquinone oxidoreductase | Transcription factors | Kidneys | Positive selection | Heuristic methods | Genomes | Biosynthesis | Mitochondrial DNA | Gene expression | Metabolism | Cyclin D1 | Glycine | Chromosome 1 | Intermediates | Antioxidants | Electron transport chain | Mitochondria | Rewiring | Kidney diseases | Mutation | Viability | Glutathione | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 27, pp. E6283 - E6290
Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis...
Oncocytoma | γ-glutamyl cycle | Complex I | mtDNA | Glutathione | glutathione | MULTIDISCIPLINARY SCIENCES | oncocytoma | SIGNALS | DISORDERS | CANCER | GENOMIC LANDSCAPE | DNA | complex I | TUMOR-SUPPRESSOR | gamma-glutamyl cycle | GENERATION | PROMOTES TUMORIGENESIS | Cyclin D1 - metabolism | Kidney Neoplasms - genetics | Adenoma, Oxyphilic - pathology | DNA, Neoplasm - metabolism | Glutathione - metabolism | Electron Transport Complex I - deficiency | Humans | Cell Survival - genetics | Adenoma, Oxyphilic - genetics | Male | Gene Expression Profiling | Kidney Neoplasms - metabolism | Glutathione - genetics | DNA, Mitochondrial - genetics | Mitochondria - genetics | Adenoma, Oxyphilic - metabolism | Female | Chromosomes, Human, Pair 1 - genetics | DNA, Mitochondrial - metabolism | Chromosomes, Human, Pair 1 - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Cyclin D1 - genetics | Kidney Neoplasms - pathology | Neoplasm Proteins - deficiency | DNA, Neoplasm - genetics | Genetic aspects | Mitochondrial DNA | Nucleotide sequencing | Carcinoma, Renal cell | Health aspects | Methods | DNA sequencing | Biological Sciences | PNAS Plus
Oncocytoma | γ-glutamyl cycle | Complex I | mtDNA | Glutathione | glutathione | MULTIDISCIPLINARY SCIENCES | oncocytoma | SIGNALS | DISORDERS | CANCER | GENOMIC LANDSCAPE | DNA | complex I | TUMOR-SUPPRESSOR | gamma-glutamyl cycle | GENERATION | PROMOTES TUMORIGENESIS | Cyclin D1 - metabolism | Kidney Neoplasms - genetics | Adenoma, Oxyphilic - pathology | DNA, Neoplasm - metabolism | Glutathione - metabolism | Electron Transport Complex I - deficiency | Humans | Cell Survival - genetics | Adenoma, Oxyphilic - genetics | Male | Gene Expression Profiling | Kidney Neoplasms - metabolism | Glutathione - genetics | DNA, Mitochondrial - genetics | Mitochondria - genetics | Adenoma, Oxyphilic - metabolism | Female | Chromosomes, Human, Pair 1 - genetics | DNA, Mitochondrial - metabolism | Chromosomes, Human, Pair 1 - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Cyclin D1 - genetics | Kidney Neoplasms - pathology | Neoplasm Proteins - deficiency | DNA, Neoplasm - genetics | Genetic aspects | Mitochondrial DNA | Nucleotide sequencing | Carcinoma, Renal cell | Health aspects | Methods | DNA sequencing | Biological Sciences | PNAS Plus
Journal Article
Journal of Computational Biology, ISSN 1066-5277, 05/2013, Volume 20, Issue 5, pp. 375 - 382
The novel high-throughput technology of protein-binding microarrays (PBMs) measures binding intensity of a transcription factor to thousands of DNA probe...
Research Articles | Protein-binding microarray | Protein-binding site | Motif finding | TRANSCRIPTION FACTORS | SPECIFICITY | protein-binding microarray | RESOLUTION | BIOCHEMICAL RESEARCH METHODS | protein-binding site | STATISTICS & PROBABILITY | GENOME | DNA INTERACTIONS | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | motif finding | SITES | UPDATE | TOOLS | Sequence Analysis, Protein - methods | Algorithms | Databases, Protein | Software | Binding Sites | Protein Array Analysis - methods | Amino Acid Motifs | Binding | Biomedical materials | In vivo testing | In vivo tests | Mathematical models | In vitro testing | Biology
Research Articles | Protein-binding microarray | Protein-binding site | Motif finding | TRANSCRIPTION FACTORS | SPECIFICITY | protein-binding microarray | RESOLUTION | BIOCHEMICAL RESEARCH METHODS | protein-binding site | STATISTICS & PROBABILITY | GENOME | DNA INTERACTIONS | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | motif finding | SITES | UPDATE | TOOLS | Sequence Analysis, Protein - methods | Algorithms | Databases, Protein | Software | Binding Sites | Protein Array Analysis - methods | Amino Acid Motifs | Binding | Biomedical materials | In vivo testing | In vivo tests | Mathematical models | In vitro testing | Biology
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. 5519 - 5519
Journal Article
14.
Full Text
Holding a grudge
: Persisting anti-phage CRISPR immunity in multiple human gut microbiomes
RNA Biology, ISSN 1547-6286, 05/2013, Volume 10, Issue 5, pp. 900 - 906
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated) system of bacteria and archaea constitutes a mechanism of...
lysogeny | CRISPR | human gut | phages | prophages | human microbiome | Human microbiome | Prophages | Phages | Human gut | Lysogeny | SYSTEM | DEFENSE | BACTERIA | DIVERSIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROVIDES ACQUIRED-RESISTANCE | SHORT PALINDROMIC REPEATS | DNA | DYNAMICS | DIVERSITY | VIRUSES | DNA, Intergenic | Gene Targeting | Metagenomics | CRISPR-Associated Proteins - genetics | Humans | Middle Aged | Gastrointestinal Tract - microbiology | Male | Bacteria - genetics | Microbiota | CRISPR-Associated Proteins - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Bacteriophages - genetics | Adult | Female | Archaea - genetics | Bacteriophages - physiology | Bacteria - virology
lysogeny | CRISPR | human gut | phages | prophages | human microbiome | Human microbiome | Prophages | Phages | Human gut | Lysogeny | SYSTEM | DEFENSE | BACTERIA | DIVERSIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROVIDES ACQUIRED-RESISTANCE | SHORT PALINDROMIC REPEATS | DNA | DYNAMICS | DIVERSITY | VIRUSES | DNA, Intergenic | Gene Targeting | Metagenomics | CRISPR-Associated Proteins - genetics | Humans | Middle Aged | Gastrointestinal Tract - microbiology | Male | Bacteria - genetics | Microbiota | CRISPR-Associated Proteins - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Bacteriophages - genetics | Adult | Female | Archaea - genetics | Bacteriophages - physiology | Bacteria - virology
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2014, Volume 371, Issue 26, p. 2477
Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before...
Psykiatri | Psychiatry
Psykiatri | Psychiatry
Journal Article
El Norte, 09/1995
Hace 50 anos, Mujer Bonita (Pretty Woman) se habria llamado Mujer Bonita del Sur, y la "femme fatal" de [Nicole Kidman] en Malicia (Malice) y su papel de...
Newspaper Article
Journal of Comparative Family Studies, ISSN 0047-2328, 1/2017, Volume 48, Issue 1, pp. 41 - 65
The study investigates attitudes about the gendered division of labor in families in Northern Ireland. There is a paucity of existing research on this topic,...
UNITED-STATES | CONFLICT | IDEOLOGY | IMPACT | IRELAND | WELFARE STATES | WOMENS EMPLOYMENT | INEQUALITY | WAR | FAMILY STUDIES | FERTILITY
UNITED-STATES | CONFLICT | IDEOLOGY | IMPACT | IRELAND | WELFARE STATES | WOMENS EMPLOYMENT | INEQUALITY | WAR | FAMILY STUDIES | FERTILITY
Journal Article
Bulletin of the World Health Organization, ISSN 0042-9686, 01/2010, Volume 88, Issue 1, p. 66
Since its widespread introduction, the hepatitis B vaccine has become an essential part of infant immunization programmes globally. The vaccine has been...
Care and treatment | Control | Usage | Hepatitis B vaccine | Dosage and administration | Hepatitis B virus | Research | Drug therapy | Hepatitis B
Care and treatment | Control | Usage | Hepatitis B vaccine | Dosage and administration | Hepatitis B virus | Research | Drug therapy | Hepatitis B
Journal Article
Revista Finlay, 02/2011, Volume 1, Issue 1, pp. 17 - 25
Fundamento: La hiperreactividad cardiovascular se ha asociado a diferentes factores de riesgo, sin embargo no está claro cómo se asocia al síndrome metabólico....
prevalencia | factores de riesgo | síndrome X metabólico
prevalencia | factores de riesgo | síndrome X metabólico
Journal Article
Revista Finlay, 02/2011, Volume 1, Issue 1, pp. 17 - 25
Fundamento: La hiperreactividad cardiovascular se ha asociado a diferentes factores de riesgo, sin embargo no está claro cómo se asocia al síndrome metabólico....
prevalencia | factores de riesgo | síndrome X metabólico
prevalencia | factores de riesgo | síndrome X metabólico
Journal Article
No results were found for your search.
Cannot display more than 1000 results, please narrow the terms of your search.