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1. Full Text The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)
by Yamagami, Keitaro and Kurogi, Ryota and Kurogi, Ai and Nishimura, Kunihiro and Onozuka, Daisuke and Ren, Nice and Kada, Akiko and Nishimura, Ataru and Arimura, Koichi and Ido, Keisuke and Mizoguchi, Masahiro and Sakamoto, Tetsuya and Kayama, Takamasa and Suzuki, Michiyasu and Arai, Hajime and Hagihara, Akihito and Iihara, Koji and Masayoshi, Takigami and Kenji, Kamiyama and Kiyohiro, Houkin and Shougo, Nishi and Tetsuyuki, Yoshimoto and Sadao, Kaneko and Koji, Oka and Hiroshi, Ooyama and Kyousuke, Kamada and Kenichi, Makino and Naoki, Tokumitsu and Kazuhiro, Sako and Susumu, Suzuki and Nozomi, Suzuki and Naoto, Izumi and Kazumi, Nitta and Masahumi, Ootaki and Masanori, Isobe and Mikio, Nishiya and Takaaki, Yamazaki and Syouji, Mabuchi and Kuniaki, Ogasawara and Naohiko, Kubo and Yukihiko, Shimizu and Keiichi, Saito and Tatumi, Yamanome and Atsuo, Yoshino and Mitsuyuki, Fujitsuka and Masaaki, Takami and Hirotoshi, Ohtaka and Teruyuki, Hirano and Yosiaki, Shiokawa and Takaharu, Okada and Ichiro, Suzuki and Michihiro, Kohno and Jou, Haraoka and Yoshinori, Arai and Noriyoshi, Kawamura and Akira, Isoshima and Masaharu, Yasue and Mitsuhiko, Hokari and Takayoshi, Kobayashi and Kensuke, Kawai and Taketoshi, Maehara and Hajime, Arai and Makoto, Noguchi and Haruhiko, Hoshino and Hirofumi, Hiyama and Kensaku, Yoshida and Osamu, Utsugi and Yasuaki, Takeda and Kouichi, Tamaki and Hirohide, Karasudani and Takao, Urabe and Shiro, Kobayashi and Michio, Nakamura and Yorio, Koguchi and Junichi, Ono and Sumio, Suda and Hiromu, Hadeishi and Toshio, Fukutake and Kenji, Wakui and Hirokazu, Tanno and Naoki, Ishige and Takashi, Ohasi and Hideki, Sakai and Yasuaki, Nishimura and Takayuki, Watanabe and Takashi, Matsumoto and Naoki, Koketsu and Yuichi, Hirose and Manabu, Doyu and Toshinori, Hasegawa and Naoto, Kuwayama and Shinichi, Terao and Nobuhiko, Mizutani and Noriyuki, Suzaki and Satoshi, Okuda and Keizo, Yasui and Yukio, Seki and Yasuhiro, Hasegawa and Akira, Ikeda and Youtarou, Takeuchi and ... and J-ASPECT Study Collaborators
World Neurosurgery, ISSN 1878-8750, 2019
Background: The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging... 
Aging | Hospital mortality | Prognosis | Traumatic brain injury | Subdural hematoma | Index Medicus
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2. Full Text A 28-nm 1R1W Two-Port 8T SRAM Macro With Screening Circuitry Against Read Disturbance and Wordline Coupling Noise Failures
by Yabuuchi, Makoto and Tsukamoto, Yasumasa and Fujiwara, Hidehiro and Tanaka, Miki and Shinji, Shinji and Nii, Koji
IEEE Transactions on Very Large Scale Integration (VLSI) Systems, ISSN 1063-8210, 11/2018, Volume 26, Issue 11, pp. 2335 - 2344
We demonstrate a 1-read/1-write two-port (2P) embedded static random access memory macro based on 8T SRAM bitcell with an effective scheme for design of... 
Couplings | Degradation | Monte Carlo methods | wordline (WL) coupling noise | Random access memory | read disturbance | screening test circuit | Logic gates | Very large scale integration | Timing | two-port (2P) static random access memory | 1-read/1-write (1R1W) | BITLINE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE | DUAL-PORT | 8T-SRAM | read/1-write (1R1W) | ENGINEERING, ELECTRICAL & ELECTRONIC | Static random access memory | CMOS | Electric potential | Screening | Testability | Circuits | Coupling | Sense amplifiers
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3. Full Text Metabolomic analysis of the skeletal muscle mice overexpressing PGC-1α
by Hatazawa, Yukino and Senoo, Nanami and Tadaishi, Miki and Ogawa, Yoshihiro and Ezaki, Osamu and Kamei, Yasutomi and Miura, Shinji
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0129084 - e0129084
Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α) is a coactivator of various nuclear receptors and other transcription factors whose... 
Gene Expression | Metabolome | Male | Mice, Transgenic | Muscle, Skeletal - metabolism | Transcription Factors - genetics | Metabolomics - methods | Citric Acid Cycle | Amino Acids - metabolism | Animals | Energy Metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Nucleotides - biosynthesis | Female | Mice | Pentose Phosphate Pathway | Cluster Analysis | Cluster analysis | Tricarboxylic acid cycle | Energy metabolism | Transcription factors | Dehydrogenases | Biochemistry | Creatine | Receptors | Mitochondria | Pentose | Electrophoresis | Physiology | Life sciences | Mass spectroscopy | Metabolism | Gene expression | Nuclear receptors | Fatty acids | Environmental science | Malate | Scientific imaging | Metabolic pathways | Mass spectrometry | Endocrinology | Phosphates | Metabolomics | Laboratories | Chain branching | Amino acids | Biosynthesis | Fibers | Metabolites | Rodents | Oxidation | Analytical chemistry | Pentose phosphate | Alanine | Nutrition | Capillary electrophoresis | Transgenic mice | Muscles | Principal components analysis | Citric acid | Skeletal muscle | Musculoskeletal system | Ionization | Pentose phosphate pathway | Peroxisome proliferator-activated receptors | Index Medicus
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4. Full Text Effects of Extracranial–Intracranial Bypass for Patients With Hemorrhagic Moyamoya Disease: Results of the Japan Adult Moyamoya Trial
by Miyamoto, Susumu and Yoshimoto, Takashi and Hashimoto, Nobuo and Okada, Yasushi and Tsuji, Ichiro and Tominaga, Teiji and Nakagawara, Jyoji and Takahashi, Jun C and Yamada, Keisuke and Tomata, Yasutake and Fukui, Tsuguya and Fukuuchi, Yasuo and Ohmoto, Takashi and Kuwabara, Yasuo and Nagata, Izumi and Ono, Junichi and Machida, Toshio and Sakakibara, Ryuji and Yamane, Kanji and Okita, Shinji and Iwama, Toru and Kaku, Yasuhiko and Saito, Nobuhito and Fukuyama, Hidenao and Houkin, Kiyohiro and Kuroda, Satoshi and Yabe, Ichiro and Moriwaka, Fumio and Ogawa, Akira and Ogasawara, Kuniaki and Yoshida, Kenji and Fujii, Kiyotaka and Yamada, Masaru and Sato, Kimitoshi and Akutsu, Tsugio and Yamagata, Sen and Takeuchi, Shigekazu and Hayashi, Kentaro and Horie, Nobutaka and Yamada, Kazuo and Osato, Toshiaki and Watanabe, Toshiichi and Honjo, Kaori and Sako, Kazuya and Nakase, Hiroyuki and Kawaguchi, Shoichiro and Nisimura, Fumihiko and Yamao, Junichi and Naritomi, Hiroaki and Inoue, Tooru and Abe, Hiroshi and Suzuki, Akifumi and Ishikawa, Tatsuya and Akiyama, Yoshinori and Suenaga, Toshihiko and Fujimura, Miki and Nagahiro, Shinji and Uno, Masaaki and Nishi, Kyoko and Satomi, Junichiro and Okada, Yoshikazu and Kawashima, Akiji and Yamaguchi, Kohji and Tsutsumi, Yukiko and JAM Trial Investigators
Stroke, ISSN 0039-2499, 05/2014, Volume 45, Issue 5, pp. 1415 - 1421
BACKGROUND AND PURPOSE—About one half of those who develop adult-onset moyamoya disease experience intracranial hemorrhage. Despite the extremely high... 
Hemorrhage | Cerebral revascularization | Moyamoya disease | SURGERY | STROKE | ANEURYSMS | INTRACEREBRAL HEMORRHAGE | cerebral revascularization | PERIPHERAL VASCULAR DISEASE | SURGICAL REVASCULARIZATION | CLINICAL NEUROLOGY | hemorrhage | moyamoya disease | Postoperative Complications - etiology | Prospective Studies | Humans | Japan | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Moyamoya Disease - surgery | Male | Treatment Outcome | Secondary Prevention | Moyamoya Disease - complications | Cerebral Hemorrhage - prevention & control | Adult | Cerebral Revascularization - methods | Female | Cerebral Revascularization - adverse effects | Cerebral Hemorrhage - etiology | Index Medicus
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5. Full Text Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake
by Tadaishi, Miki and Miura, Shinji and Kai, Yuko and Kano, Yutaka and Oishi, Yuichi and Ezaki, Osamu
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, pp. e28290 - e28290
Background: Maximal oxygen uptake (VO2max) predicts mortality and is associated with endurance performance. Trained subjects have a high VO2max due to a high... 
ALL-CAUSE MORTALITY | CARDIORESPIRATORY FITNESS | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | INDUCED ANGIOGENESIS | MESSENGER-RNA | TRAINED MEN | FATTY-ACID OXIDATION | BIOLOGY | RECEPTOR ACTIVATION | UNTRAINED MEN | INTENSITY EXERCISE | Fasting - physiology | Lactic Acid - blood | Humans | Mice, Inbred C57BL | Carbohydrate Metabolism | Gene Expression Regulation | Oxygen Consumption | Male | Mice, Transgenic | Muscle, Skeletal - metabolism | Mitochondria - metabolism | Organ Specificity | Organelle Size | Animals | Glycogen - metabolism | Protein Isoforms - metabolism | Myocardium - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - metabolism | Mice | Transcription Factors | Physical Conditioning, Animal | Body Composition - physiology | Heart | Science | Lipid peroxidation | Amino acids | Cardiovascular disease | Biosynthesis | mRNA | Proteins | Angiogenesis | Mitochondria | Exercise | Transgenic animals | Rodents | Oxidation | Endurance | Capillaries | Heart diseases | Deoxyribonucleic acid--DNA | Maximum oxygen consumption | Oxygen | Nutrition | Cardiac muscle | Glycogen | Mortality | Transgenic mice | Muscles | Oxygen consumption | Oxygen uptake | Metabolism | Fatty acids | Skeletal muscle | Musculoskeletal system | Nuclear fuels | Life span | Isoforms | Cardiac output | Laboratory animals | Dietary fiber | Index Medicus | Deoxyribonucleic acid | DNA
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6. Full Text Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features
by Kawai-Kitahata, Fukiko and Asahina, Yasuhiro and Tanaka, Shinji and Kakinuma, Sei and Murakawa, Miyako and Nitta, Sayuri and Watanabe, Takako and Otani, Satoshi and Taniguchi, Miki and Goto, Fumio and Nagata, Hiroko and Kaneko, Shun and Tasaka-Fujita, Megumi and Nishimura-Sakurai, Yuki and Azuma, Seishin and Itsui, Yasuhiro and Nakagawa, Mina and Tanabe, Minoru and Takano, Shinichi and Fukasawa, Mitsuharu and Sakamoto, Minoru and Maekawa, Shinya and Enomoto, Nobuyuki and Watanabe, Mamoru
Journal of Gastroenterology, ISSN 0944-1174, 5/2016, Volume 51, Issue 5, pp. 473 - 486
Genetic alterations in specific genes are critical events in carcinogenesis and hepatocellular carcinoma (HCC) progression. However, the genetic alterations... 
Medicine & Public Health | TERT | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | CTNNB1 | Surgical Oncology | TP53 | Follow-Up Studies | Humans | Middle Aged | Male | Tumor Suppressor Protein p53 - genetics | Hepatitis B Surface Antigens - blood | Hepatitis B - complications | Telomerase - genetics | Carcinoma, Hepatocellular - genetics | Aged, 80 and over | Adult | Female | Hepatitis C - complications | Liver Neoplasms - pathology | Liver Neoplasms - virology | Promoter Regions, Genetic | Liver Neoplasms - genetics | Survival Rate | Carcinoma, Hepatocellular - virology | Virus Integration | beta Catenin - genetics | Disease-Free Survival | Carcinoma, Hepatocellular - pathology | Aged | High-Throughput Nucleotide Sequencing | Mutation | Analysis | Development and progression | Genetic aspects | Hepatitis B virus | Hepatoma | Hepatitis C virus | Tumor proteins | Health aspects | Telomerase | Hepatitis B | Index Medicus
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7. Full Text Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway
by Ito, Miki and Kanno, Shinichi and Nosho, Katsuhiko and Sukawa, Yasutaka and Mitsuhashi, Kei and Kurihara, Hiroyoshi and Igarashi, Hisayoshi and Takahashi, Taiga and Tachibana, Mami and Takahashi, Hiroaki and Yoshii, Shinji and Takenouchi, Toshinao and Hasegawa, Tadashi and Okita, Kenji and Hirata, Koichi and Maruyama, Reo and Suzuki, Hiromu and Imai, Kohzoh and Yamamoto, Hiroyuki and Shinomura, Yasuhisa
International Journal of Cancer, ISSN 0020-7136, 09/2015, Volume 137, Issue 6, pp. 1258 - 1268
Human gut microbiota is being increasingly recognized as a player in colorectal cancers (CRCs). Evidence suggests that Fusobacterium nucleatum ( F. nucleatum )... 
colorectum | dysplasia | colon polyp | Fusobacterium | serrated neoplasia pathway | BRAF | KRAS | MLH1 | microbiome | miR‐31 | miR-31 | 2 SIDES | MICROBIOTA | LESIONS | ISLAND METHYLATOR PHENOTYPE | REAL-TIME PCR | COLON-CANCER | ONCOLOGY | BRAF MUTATION | NEOPLASIA | DISEASE | EXPRESSION | Microsatellite Instability | Colon - pathology | Colorectal Neoplasms - genetics | Humans | Carcinogenesis - genetics | Fusobacterium Infections - microbiology | Colorectal Neoplasms - microbiology | Male | DNA Methylation - genetics | Cecum - microbiology | Fusobacterium Infections - pathology | Cecum - pathology | CpG Islands - genetics | Fusobacterium Infections - genetics | Female | Aged | Colon - microbiology | MicroRNAs - genetics | Colorectal Neoplasms - pathology | Fusobacterium nucleatum - isolation & purification | Development and progression | Dysplasia | Gram-negative bacteria | Microbiota (Symbiotic organisms) | Colorectal cancer | Bacteria | Microbiology | Tumors | Index Medicus
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8. Full Text Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: A role of β2-adrenergic receptor activation
by Tadaishi, Miki and Miura, Shinji and Kai, Yuko and Kawasaki, Emi and Koshinaka, Keiichi and Kawanaka, Kentaro and Nagata, Junichi and Oishi, Yuichi and Ezaki, Osamu
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 02/2011, Volume 300, Issue 2, pp. E341 - E349
There are three isoforms of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) mRNA, which promotes mitochondrial biogenesis in skeletal... 
Sympathetic nerve | Peroxisome proliferator-activated receptor-γ coactivator 1α | β-adrenergic receptor | 5-amino-imidazole-4-carboxamide-1β-D-ribofuranoside | AMP-activated protein kinase | Catecholamine | Motor Activity - physiology | AMP-Activated Protein Kinases - metabolism | Male | Muscle, Skeletal - metabolism | RNA, Messenger - metabolism | Isomerism | Aminoimidazole Carboxamide - pharmacology | Ribonucleotides - pharmacology | Adrenergic beta-Antagonists - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Trans-Activators - biosynthesis | Receptors, Adrenergic, beta-2 - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Exons - genetics | Catecholamines - blood | Physical Conditioning, Animal - physiology | Receptors, Adrenergic, beta-2 - metabolism | Hypoglycemic Agents - pharmacology | Receptors, Adrenergic, beta-2 - biosynthesis | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Mice | Models, Genetic | Transcription Factors | Propanolamines - pharmacology | Index Medicus
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9. Full Text Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
by Goto, Koji, MD and Nakai, Kentaro, MD and Shizuta, Satoshi, MD and Morimoto, Takeshi, MD and Shiomi, Hiroki, MD and Natsuaki, Masahiro, MD and Yahata, Mitsuhiko, MD and Ota, Chihiro, MD and Ono, Koh, MD and Makiyama, Takeru, MD and Nakagawa, Yoshihisa, MD and Furukawa, Yutaka, MD and Kadota, Kazushige, MD and Takatsu, Yoshiki, MD and Tamura, Takashi, MD and Takizawa, Akinori, MD and Inada, Tsukasa, MD and Doi, Osamu, MD and Nohara, Ryuji, MD and Matsuda, Mitsuo, MD and Takeda, Teruki, MD and Kato, Masayuki, MD and Shirotani, Manabu, MD and Eizawa, Hiroshi, MD and Ishii, Katsuhisa, MD and Lee, Jong-Dae, MD and Takahashi, Masaaki, MD and Horie, Minoru, MD and Takahashi, Mamoru, MD and Miki, Shinji, MD and Aoyama, Takeshi, MD and Suwa, Satoru, MD and Hamasaki, Shuichi, MD and Ogawa, Hisao, MD and Mitsudo, Kazuaki, MD and Nobuyoshi, Masakiyo, MD and Kita, Toru, MD and Kimura, Takeshi, MD and CREDO-Kyoto Registry Cohort-2 and CREDO-Kyoto Registry Cohort-2 Investigators
American Journal of Cardiology, The, ISSN 0002-9149, 2014, Volume 114, Issue 1, pp. 70 - 78
The prevalence, intensity, safety, and efficacy of oral anticoagulation (OAC) in addition to dual antiplatelet therapy (DAPT) in “real-world” patients with... 
Cardiovascular | TRIPLE ANTITHROMBOTIC THERAPY | STENT IMPLANTATION | CARDIAC & CARDIOVASCULAR SYSTEMS | WARFARIN THERAPY | CLOPIDOGREL | EVENTS | MYOCARDIAL-INFARCTION | ORAL ANTICOAGULATION | OPTIMAL INTENSITY | BLEEDING RISK | SECONDARY PREVENTION | Japan - epidemiology | Follow-Up Studies | Comorbidity | Atrial Fibrillation - therapy | Humans | Anticoagulants - therapeutic use | Male | Treatment Outcome | Combined Modality Therapy | Incidence | Atrial Fibrillation - epidemiology | Female | Registries | Stroke - epidemiology | Aged | Platelet Aggregation Inhibitors - therapeutic use | Percutaneous Coronary Intervention | Transluminal angioplasty | Care and treatment | Anticoagulants (Medicine) | Atrial fibrillation | Analysis | Studies | Confidence intervals | Cardiac arrhythmia | Anticoagulants | Stroke | Aspirin | Heart attacks | Hospitalization | Drug therapy | Thrombosis | Methods | Index Medicus | Abridged Index Medicus
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10. Full Text Clinical significance of an elevated ankle-brachial index differs depending on the amount of appendicular muscle mass: the J-SHIPP and Nagahama studies
by Tabara, Y and Igase, M and Setoh, K and Kawaguchi, T and Okada, Y and Ohara, M and Takahashi, Y and Kosugi, S and Ohyagi, Y and Miki, T and Nakayama, T and Kohara, K and Matsuda, F and Nagahama Sudy Grp and J-SHIPP Sudy Grp and J-SHIPP and Nagahama study groups and the J-SHIPP and Nagahama study groups
HYPERTENSION RESEARCH, ISSN 0916-9636, 05/2018, Volume 41, Issue 5, pp. 354 - 362
Clinical implication of a high ankle-brachial index (ABI) is not well known. Based on our previous study, we suspected that body composition may be a... 
MULTIFREQUENCY BIOIMPEDANCE | PULSE-WAVE VELOCITY | ARTERIAL STIFFNESS | CARDIOVASCULAR-DISEASE | ATHEROSCLEROSIS | RISK | PERIPHERAL VASCULAR DISEASE | BODY-COMPOSITION | CHRONIC KIDNEY-DISEASE | ASSOCIATION | BLOOD-PRESSURE | Carotid Intima-Media Thickness | Ankle Brachial Index | Humans | Japan | Middle Aged | Insulin Resistance | Cardiomegaly - physiopathology | Male | Tomography, X-Ray Computed | Electric Impedance | Aging | Adult | Female | Aged | Vascular Stiffness | Longitudinal Studies | Adipose Tissue - anatomy & histology | Cohort Studies | Muscle, Skeletal - anatomy & histology | Ankle | Insulin resistance
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11. Full Text Epidemiology of invasive fungal infections after liver transplantation and the risk factors of late-onset invasive aspergillosis
by Nagao, Miki and Fujimoto, Yasuhiro and Yamamoto, Masaki and Matsumura, Yasufumi and Kaido, Toshimi and Takakura, Shunji and Uemoto, Shinji and Ichiyama, Satoshi
Journal of Infection and Chemotherapy, ISSN 1341-321X, 2015, Volume 22, Issue 2, pp. 84 - 89
Abstract Invasive fungal infection (IFI) in liver transplant recipients is associated with poor outcomes. Targeted antifungal prophylaxis is recommended for... 
Hematology, Oncology and Palliative Medicine | Antifungal prophylaxis | Invasive aspergillosis | Risk factor | Liver transplantation | INFECTIOUS DISEASES | DISEASE | PHARMACOLOGY & PHARMACY | RECIPIENTS | Liver Transplantation - adverse effects | Humans | Middle Aged | Risk Factors | Male | Treatment Outcome | Aspergillosis - epidemiology | Case-Control Studies | Antifungal Agents - therapeutic use | Young Adult | Aspergillosis - etiology | Adolescent | Adult | Female | Aged | Retrospective Studies | Aspergillosis - drug therapy | Index Medicus
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