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Angewandte Chemie - International Edition, ISSN 1433-7851, 04/2009, Volume 48, Issue 18, pp. 3221 - 3223
Adding up: A recent total synthesis of bryostatin 16 is highlighted by two transition-metal-catalyzed addition reactions. The first forges the B ring while... 
lactones | bryostatins | homogeneous catalysis | ANALOG | macrocycles | total synthesis | CHEMISTRY, MULTIDISCIPLINARY | Catalysis | Cyclization | Isomerism | Bryostatins - chemical synthesis
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7567, pp. 124 - 128
Mitochondria are involved in a variety of cellular functions, including ATP production, amino acid and lipid biogenesis and breakdown, signalling and... 
APOPTOSIS | MUTANTS | ACID | MITOFUSIN 2 | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DYNAMICS | DYSFUNCTION | STRESS | DROSOPHILA | PARKINSONS-DISEASE | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Antigens, CD - metabolism | Stearic Acids - metabolism | Drosophila melanogaster - metabolism | Ubiquitination - drug effects | Acetyltransferases - deficiency | Mitochondria - genetics | Larva - drug effects | Larva - genetics | Membrane Proteins - metabolism | Stearic Acids - administration & dosage | Larva - metabolism | Drosophila melanogaster - cytology | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Receptors, Transferrin - metabolism | Drosophila melanogaster - drug effects | Animals | Mitochondrial Dynamics - drug effects | Diet | Signal Transduction - drug effects | Drosophila Proteins - deficiency | Ubiquitin-Protein Ligases - deficiency | Drosophila Proteins - genetics | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Stearic Acids - pharmacology | Tumor Suppressor Proteins | Mitochondria | Cell receptors | Genetic aspects | Stearic acid | Genetic regulation | Health aspects | Proteins | Insects | Acids | Morphology | Parkinsons disease | Pink | Parkinsons | Drosophila | mitochondria | metabolism | mitofusin | Parkin
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2016, Volume 26, Issue 21, pp. 5260 - 5262
The use of small molecules to regulate cellular levels of specific proteins is poised to become a powerful technique in the coming years. Critical to the... 
PROTACs | E3 ligase | Cereblon | Thalidomide | DESIGN | CHEMISTRY, MEDICINAL | ACID | CHEMISTRY, ORGANIC | MEDIATED DEGRADATION | RECEPTOR | INDUCERS | SMALL-MOLECULE PROTACS | PROTEIN-DEGRADATION | KNOCKDOWN | E3 UBIQUITIN LIGASE | BRD4 | Ligands | Phthalimides - chemistry | Phthalimides - chemical synthesis | Proteolysis | Humans | Peptide Hydrolases - chemistry
Journal Article
ChemMedChem, ISSN 1860-7179, 10/2017, Volume 12, Issue 19, pp. 1652 - 1654
The picturesque city of Heidelberg was host to last December′s conference, Drug Innovation in Academia , organized by the partner institutions of the Helmholtz... 
RNA-based treatments | drug screening | academic drug research | epigenetics | medicinal chemistry | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY | Drug Discovery | Humans | Pharmaceutical Research | Conferences, meetings and seminars | Epigenetic inheritance | Conferences and conventions | Institutions | Innovations
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 10/2012, Volume 51, Issue 43, pp. 10704 - 10707
Journal Article
Angewandte Chemie, ISSN 0044-8249, 10/2012, Volume 124, Issue 43, p. 10862
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 04/2016, Volume 11, Issue 4, pp. 1001 - 1011
Methionine aminopeptidases (MetAPs) are responsible for the cotranslational cleavage of initiator methionines from nascent proteins. The MetAP2 subtype is... 
Metalloendopeptidases - antagonists & inhibitors | Triazoles - pharmacology | Cell Line | Cyclohexanes - pharmacology | Humans | Crystallography, X-Ray | Fatty Acids, Unsaturated - pharmacology | Aminopeptidases - antagonists & inhibitors | Sesquiterpenes - pharmacology
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4426 - 4443
The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biological functions of individual HDACs and for... 
POTENT | DESIGN | CHEMISTRY, MEDICINAL | ANALOGS | AUTOPHAGY | CANCER | HDAC6
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 19, pp. 8859 - 8874
Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins (KLKs). Many KLKs are investigated as... 
NERVOUS-SYSTEM | PROTEOLYTIC CASCADE | CHEMISTRY, MEDICINAL | FACTOR VIIA INHIBITORS | BIOLOGICAL-FLUIDS | PROSTATE-SPECIFIC ANTIGEN | STRATUM-CORNEUM | SERINE-PROTEASE | OVARIAN-CANCER | CANCER PROGRESSION | ACTIVITY-BASED PROBES
Journal Article
Journal Article
Synlett, ISSN 0936-5214, 9/2006, Volume 2006, Issue 14, pp. 2295 - 2316
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2006, Volume 128, Issue 51, pp. 17057 - 17062
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 10/2014, Volume 25, Issue 20-21, pp. 1355 - 1359
The configuration at C6 of the epimeric bisulfite adducts of deoxyuridine was determined by means of NMR in conjunction with DFT calculations. The preferred... 
DENSITY FUNCTIONALS | PURINE NUCLEOSIDES | NUCLEOTIDES | 5-METHYLCYTOSINE | SODIUM BISULFITE | DNA | THERMOCHEMISTRY | EQUILIBRIUM | CHEMISTRY, PHYSICAL | 5-HYDROXYMETHYLCYTOSINE | 5-FORMYLCYTOSINE | Sulfites | Nuclear magnetic resonance
Journal Article
Organic Letters, ISSN 1523-7060, 07/2005, Volume 7, Issue 14, pp. 2901 - 2903
[reaction: see text] The total synthesis of bicyclo[4.2.0]octane natural products elysiapyrones A and B is described. 
Molecular Structure | Animals | Cyclization | Mollusca - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis
Journal Article
Organic Letters, ISSN 1523-7060, 03/2005, Volume 7, Issue 5, pp. 819 - 821
Members of a family of alpha-methoxy-gamma-pyrone-containing polypropionate natural products have been stereoselectively synthesized. Two key iodovinyl pyrone... 
Biological Products - chemical synthesis | Indicators and Reagents | Molecular Structure | Catalysis | Pyrones - chemical synthesis | Stereoisomerism
Journal Article