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Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2018, Volume 14, Issue 5, pp. e1007116 - e1007116
De novo biosynthesis of lipids is essential for Trypanosoma brucei, a protist responsible for the sleeping sickness. Here, we demonstrate that the ketogenic... 
MOLECULAR CHARACTERIZATION | ACETYL-COA | DEPENDENT ENZYME | MICROBIOLOGY | PROLINE METABOLISM | VIROLOGY | SUCCINATE COA-TRANSFERASE | LEISHMANIA-MEXICANA | LIPID BIOSYNTHESIS | BLOOD-STREAM FORMS | CELL-CYCLE | ENERGY-METABOLISM | PARASITOLOGY | Sterols | Analysis | Physiological aspects | Amino acids | Glucose | Gene expression | Fatty acids | Dextrose | Biosynthesis | Genetic aspects | Virulence (Microbiology) | Trypanosoma brucei | Health aspects | Dehydrogenases | Laboratories | Funding | Midgut | Lipids | Biology | Biochemistry | Leucine | Parasites | Gene deletion | Dehydrogenase | Degradation | Proteins | Metabolic flux | Mevalonic acid | Clonal deletion | Metabolites | Precursors | Cell cycle | Deletion | Isovaleryl-CoA dehydrogenase | Genetics | Lipid metabolism | Digestive tract | Supervision | African trypanosomiasis | Carbon sources | Vector-borne diseases | Protozoa | Enzymes | Threonine | RNA-mediated interference | Thiolase | Metabolism | Carbon | Insects | Acetic acid | Index Medicus | Alcohol Oxidoreductases | Mevalonic Acid | Parasitology | Fatty Acids | Insect Vectors | Gene Expression Regulation | Proline | Gene Knockout Techniques | Acetates | Acetyl Coenzyme A | Trypanosoma brucei brucei | Life Sciences | Microbiology and Parasitology | Animals | Tsetse Flies | Acyl Coenzyme A | Acetyltransferases
Journal Article
PLoS Pathogens, ISSN 1553-7366, 12/2018, Volume 14, Issue 12, pp. e1007502 - e1007502
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 03/2015, Volume 11, Issue 3
  Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form... 
Proteins | Enzymes | Metabolites | Glycerol | Biosynthesis | Parasites | Metabolism | Carbon
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2014, Volume 289, Issue 25, pp. 17365 - 17378
Journal Article
Current Genetics, ISSN 0172-8083, 8/2012, Volume 58, Issue 4, pp. 245 - 254
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 21, pp. 17186 - 17197
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 12/2013, Volume 7, Issue 12
  Background The bloodstream forms of Trypanosoma brucei, the causative agent of sleeping sickness, rely solely on glycolysis for ATP production. It is... 
Studies | Enzymes | Genotype & phenotype | Dehydrogenases | Amino acids | Biosynthesis | Metabolism | Fatty acids | Carbon | Apoptosis
Journal Article