Jama : Journal of the American Medical Association, ISSN 0098-7484, 2015, Volume 313, Issue 19, pp. 1924 - 1938
IMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of...
OLDER PERSONS | POPULATION | MEDICINE, GENERAL & INTERNAL | CEREBROSPINAL-FLUID BIOMARKERS | COHORT | MILD COGNITIVE IMPAIRMENT | DIAGNOSTIC-CRITERIA | BETA-AMYLOIDOSIS | ASSOCIATION | PIB PET | ALZHEIMER-DISEASE PATHOLOGY | Apolipoprotein E4 - genetics | Dementia - pathology | Prevalence | Age Factors | Humans | Middle Aged | Risk Factors | Biomarkers - analysis | Genotype | Male | Positron-Emission Tomography | Cognitive Dysfunction - pathology | Cerebrospinal Fluid - chemistry | Aged, 80 and over | Amyloid beta-Peptides - analysis | Brain - pathology | Adult | Female | Aged | Usage | Analysis | Amyloidosis | Cognition | Research | Biological markers | Risk factors | Meta-analysis | Prevalence studies (Epidemiology) | Pathology | Medical research | Neurological disorders | Dementia | Brain | Neurosciences | pathology | Biological Markers | 80 and over | genetics | Amyloid beta-Peptides | Neurovetenskaper | chemistry | Apolipoprotein E4 | Cerebrospinal Fluid | analysis | Mild Cognitive Impairment
OLDER PERSONS | POPULATION | MEDICINE, GENERAL & INTERNAL | CEREBROSPINAL-FLUID BIOMARKERS | COHORT | MILD COGNITIVE IMPAIRMENT | DIAGNOSTIC-CRITERIA | BETA-AMYLOIDOSIS | ASSOCIATION | PIB PET | ALZHEIMER-DISEASE PATHOLOGY | Apolipoprotein E4 - genetics | Dementia - pathology | Prevalence | Age Factors | Humans | Middle Aged | Risk Factors | Biomarkers - analysis | Genotype | Male | Positron-Emission Tomography | Cognitive Dysfunction - pathology | Cerebrospinal Fluid - chemistry | Aged, 80 and over | Amyloid beta-Peptides - analysis | Brain - pathology | Adult | Female | Aged | Usage | Analysis | Amyloidosis | Cognition | Research | Biological markers | Risk factors | Meta-analysis | Prevalence studies (Epidemiology) | Pathology | Medical research | Neurological disorders | Dementia | Brain | Neurosciences | pathology | Biological Markers | 80 and over | genetics | Amyloid beta-Peptides | Neurovetenskaper | chemistry | Apolipoprotein E4 | Cerebrospinal Fluid | analysis | Mild Cognitive Impairment
Journal Article
JAMA Psychiatry, ISSN 2168-622X, 2018, Volume 75, Issue 1, pp. 84 - 95
Importance: Cerebral amyloid-beta aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and...
INDIVIDUALS | LIFE-SPAN | MEMORY PERFORMANCE | METAANALYSIS | PSYCHIATRY | PRECLINICAL ALZHEIMERS-DISEASE | APOE | BURDEN | DECLINE | AGE | IMPAIRMENT | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Cross-Sectional Studies | Brain - physiopathology | Humans | Middle Aged | Memory, Episodic | Male | Reference Values | Mental Status and Dementia Tests | Positron-Emission Tomography | Cognitive Dysfunction - physiopathology | Alzheimer Disease - diagnosis | Cognition Disorders - diagnosis | Amyloid beta-Peptides - cerebrospinal fluid | Cognitive Dysfunction - psychology | Female | Aged | Cognitive Dysfunction - diagnosis | Alzheimer Disease - psychology | Cognition Disorders - psychology | Online First | Original Investigation | Research | Clinical Medicine | No dementia | Medical and Health Sciences | Medicin och hälsovetenskap | amyloid-β | cognitive functioning | Klinisk medicin | Geriatrik | Geriatrics
INDIVIDUALS | LIFE-SPAN | MEMORY PERFORMANCE | METAANALYSIS | PSYCHIATRY | PRECLINICAL ALZHEIMERS-DISEASE | APOE | BURDEN | DECLINE | AGE | IMPAIRMENT | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Cross-Sectional Studies | Brain - physiopathology | Humans | Middle Aged | Memory, Episodic | Male | Reference Values | Mental Status and Dementia Tests | Positron-Emission Tomography | Cognitive Dysfunction - physiopathology | Alzheimer Disease - diagnosis | Cognition Disorders - diagnosis | Amyloid beta-Peptides - cerebrospinal fluid | Cognitive Dysfunction - psychology | Female | Aged | Cognitive Dysfunction - diagnosis | Alzheimer Disease - psychology | Cognition Disorders - psychology | Online First | Original Investigation | Research | Clinical Medicine | No dementia | Medical and Health Sciences | Medicin och hälsovetenskap | amyloid-β | cognitive functioning | Klinisk medicin | Geriatrik | Geriatrics
Journal Article
Neurology, ISSN 0028-3878, 08/2006, Volume 67, Issue 3, pp. 446 - 452
Background: Beta- amyloid (A beta) plaques are the hallmark of Alzheimer disease (AD). A PET imaging tracer that binds to A beta plaques in vivo,...
GRAPHICAL ANALYSIS | POSITRON-EMISSION-TOMOGRAPHY | BETA-AMYLOID PLAQUES | AUTOMATED ALGORITHM | DEMENTIA RATING CDR | MILD COGNITIVE IMPAIRMENT | BINDING | PITTSBURGH COMPOUND-B | PET | BRAIN | CLINICAL NEUROLOGY | Alzheimer Disease - diagnosis | Humans | Middle Aged | Alzheimer Disease - metabolism | Aged, 80 and over | Biomarkers | Adult | Aged | Radiopharmaceuticals | Benzothiazoles | Carbon Radioisotopes
GRAPHICAL ANALYSIS | POSITRON-EMISSION-TOMOGRAPHY | BETA-AMYLOID PLAQUES | AUTOMATED ALGORITHM | DEMENTIA RATING CDR | MILD COGNITIVE IMPAIRMENT | BINDING | PITTSBURGH COMPOUND-B | PET | BRAIN | CLINICAL NEUROLOGY | Alzheimer Disease - diagnosis | Humans | Middle Aged | Alzheimer Disease - metabolism | Aged, 80 and over | Biomarkers | Adult | Aged | Radiopharmaceuticals | Benzothiazoles | Carbon Radioisotopes
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 09/2014, Volume 19, Issue 9, pp. 1044 - 1051
This study was designed to evaluate whether subjects with amyloid beta (A beta) pathology, detected using florbetapir positron emission tomorgraphy (PET),...
alzheimer's disease | florbetapir | MCI | amyloid | cognitive decline | PET | NEUROIMAGING INITIATIVE PROGRESS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALZHEIMERS ASSOCIATION WORKGROUPS | NEUROSCIENCES | PITTSBURGH COMPOUND-B | IMPAIRMENT | NATIONAL INSTITUTE | RECOMMENDATIONS | DISEASE | DIAGNOSTIC GUIDELINES | A-BETA | PLACEBO-CONTROLLED TRIAL | Brain - diagnostic imaging | Prospective Studies | Follow-Up Studies | Aniline Compounds | Humans | Male | Positron-Emission Tomography | Alzheimer Disease - diagnosis | Brain - metabolism | Ethylene Glycols | Amyloid beta-Peptides - metabolism | Female | Cognitive Dysfunction - diagnosis | Cognitive Dysfunction - diagnostic imaging | Radiopharmaceuticals | Cognitive Dysfunction - drug therapy | Cognitive Dysfunction - metabolism | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Disease Progression | Neuropsychological Tests | Alzheimer Disease - metabolism | Aged | Alzheimer Disease - diagnostic imaging | Longitudinal Studies | Usage | PET imaging | Amyloid beta-protein | Physiological aspects | Development and progression | Cognition disorders | Health aspects | Original
alzheimer's disease | florbetapir | MCI | amyloid | cognitive decline | PET | NEUROIMAGING INITIATIVE PROGRESS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALZHEIMERS ASSOCIATION WORKGROUPS | NEUROSCIENCES | PITTSBURGH COMPOUND-B | IMPAIRMENT | NATIONAL INSTITUTE | RECOMMENDATIONS | DISEASE | DIAGNOSTIC GUIDELINES | A-BETA | PLACEBO-CONTROLLED TRIAL | Brain - diagnostic imaging | Prospective Studies | Follow-Up Studies | Aniline Compounds | Humans | Male | Positron-Emission Tomography | Alzheimer Disease - diagnosis | Brain - metabolism | Ethylene Glycols | Amyloid beta-Peptides - metabolism | Female | Cognitive Dysfunction - diagnosis | Cognitive Dysfunction - diagnostic imaging | Radiopharmaceuticals | Cognitive Dysfunction - drug therapy | Cognitive Dysfunction - metabolism | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Disease Progression | Neuropsychological Tests | Alzheimer Disease - metabolism | Aged | Alzheimer Disease - diagnostic imaging | Longitudinal Studies | Usage | PET imaging | Amyloid beta-protein | Physiological aspects | Development and progression | Cognition disorders | Health aspects | Original
Journal Article
Journal of the Neurological Sciences, ISSN 0022-510X, 2013, Volume 333, pp. e337 - e338
Journal Article
Neurology, ISSN 0028-3878, 07/2010, Volume 75, Issue 1, pp. 42 - 48
Objective: Several factors may influence the relationship between Alzheimer disease (AD) lesions and the expression of dementia, including those related to...
COGNITIVE RESERVE | OLDER PERSONS | DIAGNOSIS | DEMENTIA | OCCUPATION | DISORDERS | EDUCATION | PITTSBURGH COMPOUND-B | CLINICAL NEUROLOGY | DECLINE | IMPAIRMENT | Amyloid - metabolism | Humans | Middle Aged | Alzheimer Disease - metabolism | Female | Male | Aged | Retrospective Studies | Alzheimer Disease - diagnostic imaging | Positron-Emission Tomography - methods | Alzheimer Disease - psychology
COGNITIVE RESERVE | OLDER PERSONS | DIAGNOSIS | DEMENTIA | OCCUPATION | DISORDERS | EDUCATION | PITTSBURGH COMPOUND-B | CLINICAL NEUROLOGY | DECLINE | IMPAIRMENT | Amyloid - metabolism | Humans | Middle Aged | Alzheimer Disease - metabolism | Female | Male | Aged | Retrospective Studies | Alzheimer Disease - diagnostic imaging | Positron-Emission Tomography - methods | Alzheimer Disease - psychology
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2001, Volume 49, Issue 4, pp. 1171 - 1182
Purpose: Locoregional tumor control for locally advanced cancers with radiation therapy has been unsatisfactory. This is in part associated with the phenomenon...
Hypoxia | Cu-ATSM | IMRT | PET | hypoxia | HEAD | NECK REGION | UTERINE CERVIX | IN-VITRO | TENSION MEASUREMENTS | ONCOLOGY | CONFORMAL THERAPY | LOCAL-CONTROL | MULTILEAF COLLIMATOR | DISTANT METASTASES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | METASTATIC DISSEMINATION | Carcinoma, Squamous Cell - metabolism | Head and Neck Neoplasms - diagnostic imaging | Humans | Organometallic Compounds - pharmacokinetics | Tomography, X-Ray Computed | Carcinoma, Squamous Cell - diagnostic imaging | Carcinoma, Squamous Cell - radiotherapy | Feasibility Studies | Cell Hypoxia | Thiosemicarbazones - pharmacokinetics | Head and Neck Neoplasms - radiotherapy | Algorithms | Tomography, Emission-Computed | Phantoms, Imaging | Dose-Response Relationship, Radiation
Hypoxia | Cu-ATSM | IMRT | PET | hypoxia | HEAD | NECK REGION | UTERINE CERVIX | IN-VITRO | TENSION MEASUREMENTS | ONCOLOGY | CONFORMAL THERAPY | LOCAL-CONTROL | MULTILEAF COLLIMATOR | DISTANT METASTASES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | METASTATIC DISSEMINATION | Carcinoma, Squamous Cell - metabolism | Head and Neck Neoplasms - diagnostic imaging | Humans | Organometallic Compounds - pharmacokinetics | Tomography, X-Ray Computed | Carcinoma, Squamous Cell - diagnostic imaging | Carcinoma, Squamous Cell - radiotherapy | Feasibility Studies | Cell Hypoxia | Thiosemicarbazones - pharmacokinetics | Head and Neck Neoplasms - radiotherapy | Algorithms | Tomography, Emission-Computed | Phantoms, Imaging | Dose-Response Relationship, Radiation
Journal Article
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Full Text
Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease
Neurology, ISSN 0028-3878, 02/2011, Volume 76, Issue 6, pp. 501 - 510
Objective: To investigate factors, including cognitive and brain reserve, which may independently predict prevalent and incident dementia of the Alzheimer type...
BRAIN RESERVE | DEMENTIA | COGNITIVE RESERVE HYPOTHESIS | OCCUPATION | RELIABILITY | CEREBROSPINAL-FLUID A-BETA | EDUCATION | PITTSBURGH COMPOUND-B | CLINICAL NEUROLOGY | DECLINE | IMPAIRMENT | Predictive Value of Tests | Prevalence | Prospective Studies | Age Factors | Cross-Sectional Studies | Follow-Up Studies | Humans | Middle Aged | Male | tau Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Incidence | Alzheimer Disease - diagnosis | Aged, 80 and over | Alzheimer Disease - epidemiology | Apolipoprotein E4 - cerebrospinal fluid | Female | Aged | Biomarkers - cerebrospinal fluid | Longitudinal Studies
BRAIN RESERVE | DEMENTIA | COGNITIVE RESERVE HYPOTHESIS | OCCUPATION | RELIABILITY | CEREBROSPINAL-FLUID A-BETA | EDUCATION | PITTSBURGH COMPOUND-B | CLINICAL NEUROLOGY | DECLINE | IMPAIRMENT | Predictive Value of Tests | Prevalence | Prospective Studies | Age Factors | Cross-Sectional Studies | Follow-Up Studies | Humans | Middle Aged | Male | tau Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Incidence | Alzheimer Disease - diagnosis | Aged, 80 and over | Alzheimer Disease - epidemiology | Apolipoprotein E4 - cerebrospinal fluid | Female | Aged | Biomarkers - cerebrospinal fluid | Longitudinal Studies
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 1989, Volume 30, Issue 2, pp. 141 - 149
Journal Article
Magnetic Resonance in Medicine, ISSN 0740-3194, 05/1995, Volume 33, Issue 5, pp. 636 - 647
The typical functional magnetic resonance (fMRI) study presents a formidable problem of multiple statistical comparisons (i.e, > 10,000 in a 128 x 128 image)....
significance | NMR | spatial correlation | spatial extent | SIGNIFICANCE | SPATIAL EXTENT | RADIOLOGY & NUCLEAR MEDICINE | SPATIAL CORRELATION | Data Interpretation, Statistical | Brain - anatomy & histology | Humans | Magnetic Resonance Imaging - methods | Probability | False Positive Reactions | Brain - physiology | Monte Carlo Method
significance | NMR | spatial correlation | spatial extent | SIGNIFICANCE | SPATIAL EXTENT | RADIOLOGY & NUCLEAR MEDICINE | SPATIAL CORRELATION | Data Interpretation, Statistical | Brain - anatomy & histology | Humans | Magnetic Resonance Imaging - methods | Probability | False Positive Reactions | Brain - physiology | Monte Carlo Method
Journal Article
Neurology, ISSN 0028-3878, 07/2010, Volume 75, Issue 2, pp. 111 - 115
Diagnostic challenges exist for differentiating HIV dementia from Alzheimer disease (AD) in older HIV-infected (HIV+) individuals. Similar abnormalities in...
HIV Infections - diagnostic imaging | Brain - diagnostic imaging | Cognition Disorders - diagnostic imaging | Humans | Middle Aged | Cognition Disorders - metabolism | Male | Chi-Square Distribution | Case-Control Studies | Brain - metabolism | Neuropsychological Tests | Analysis of Variance | HIV | Image Processing, Computer-Assisted | Amyloid beta-Peptides - metabolism | Radionuclide Imaging | Brain Mapping | Adult | Female | Benzothiazoles - metabolism | Carbon Radioisotopes | HIV Infections - metabolism
HIV Infections - diagnostic imaging | Brain - diagnostic imaging | Cognition Disorders - diagnostic imaging | Humans | Middle Aged | Cognition Disorders - metabolism | Male | Chi-Square Distribution | Case-Control Studies | Brain - metabolism | Neuropsychological Tests | Analysis of Variance | HIV | Image Processing, Computer-Assisted | Amyloid beta-Peptides - metabolism | Radionuclide Imaging | Brain Mapping | Adult | Female | Benzothiazoles - metabolism | Carbon Radioisotopes | HIV Infections - metabolism
Journal Article
European Psychiatry, ISSN 0924-9338, 2002, Volume 17, Issue 3, pp. 300 - 305
The effect of depression on the hippocampus has become the focus of a number of structural and functional neuroimaging studies. In the past two decades,...
Neuroimaging | Depression | Volumetric change | Serotonin | Hippocampus | F-18 SETOPERONE | hippocampus | PSYCHIATRY | ALZHEIMERS-DISEASE | GERIATRIC DEPRESSION | VOLUME | SEROTONIN RECEPTORS | SCHIZOPHRENIA | volumetric change | neuroimaging | serotonin | POSITRON-EMISSION-TOMOGRAPHY | RECURRENT MAJOR DEPRESSION | depression | BRAIN | AMYGDALA | Depressive Disorder, Major - physiopathology | Hypothalamo-Hypophyseal System - blood supply | Alzheimer Disease - physiopathology | Pituitary-Adrenal System - physiopathology | Pituitary-Adrenal System - anatomy & histology | Depressive Disorder, Major - metabolism | Humans | Hypothalamo-Hypophyseal System - anatomy & histology | Hippocampus - metabolism | Magnetic Resonance Imaging | Serotonin - metabolism | Hemodynamics - drug effects | Tomography, Emission-Computed | Hippocampus - physiopathology | Hypothalamo-Hypophyseal System - physiopathology | Pituitary-Adrenal System - blood supply
Neuroimaging | Depression | Volumetric change | Serotonin | Hippocampus | F-18 SETOPERONE | hippocampus | PSYCHIATRY | ALZHEIMERS-DISEASE | GERIATRIC DEPRESSION | VOLUME | SEROTONIN RECEPTORS | SCHIZOPHRENIA | volumetric change | neuroimaging | serotonin | POSITRON-EMISSION-TOMOGRAPHY | RECURRENT MAJOR DEPRESSION | depression | BRAIN | AMYGDALA | Depressive Disorder, Major - physiopathology | Hypothalamo-Hypophyseal System - blood supply | Alzheimer Disease - physiopathology | Pituitary-Adrenal System - physiopathology | Pituitary-Adrenal System - anatomy & histology | Depressive Disorder, Major - metabolism | Humans | Hypothalamo-Hypophyseal System - anatomy & histology | Hippocampus - metabolism | Magnetic Resonance Imaging | Serotonin - metabolism | Hemodynamics - drug effects | Tomography, Emission-Computed | Hippocampus - physiopathology | Hypothalamo-Hypophyseal System - physiopathology | Pituitary-Adrenal System - blood supply
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 01/1996, Volume 75, Issue 1, pp. 454 - 468
J. A. Sweeney, M. A. Mintun, S. Kwee, M. B. Wiseman, D. L. Brown, D. R. Rosenberg and J. R. Carl Department of Psychiatry, University of Pittsburgh School of...
SUPERIOR COLLICULUS | DORSOLATERAL PREFRONTAL CORTEX | NEURONAL-ACTIVITY | PHYSIOLOGY | CEREBRAL BLOOD-FLOW | BASAL GANGLIA | RHESUS-MONKEY | AUTOMATED ALGORITHM | VISUALLY GUIDED SACCADES | NEUROSCIENCES | SUPPLEMENTARY MOTOR AREA | FUNCTIONAL-PROPERTIES | Cerebral Cortex - blood supply | Humans | Male | Reference Values | Orientation - physiology | Visual Pathways - diagnostic imaging | Visual Pathways - blood supply | Nerve Net - physiology | Cerebral Cortex - diagnostic imaging | Brain - blood supply | Mental Recall - physiology | Brain Mapping | Adult | Female | Saccades - physiology | Tomography, Emission-Computed | Regional Blood Flow - physiology
SUPERIOR COLLICULUS | DORSOLATERAL PREFRONTAL CORTEX | NEURONAL-ACTIVITY | PHYSIOLOGY | CEREBRAL BLOOD-FLOW | BASAL GANGLIA | RHESUS-MONKEY | AUTOMATED ALGORITHM | VISUALLY GUIDED SACCADES | NEUROSCIENCES | SUPPLEMENTARY MOTOR AREA | FUNCTIONAL-PROPERTIES | Cerebral Cortex - blood supply | Humans | Male | Reference Values | Orientation - physiology | Visual Pathways - diagnostic imaging | Visual Pathways - blood supply | Nerve Net - physiology | Cerebral Cortex - diagnostic imaging | Brain - blood supply | Mental Recall - physiology | Brain Mapping | Adult | Female | Saccades - physiology | Tomography, Emission-Computed | Regional Blood Flow - physiology
Journal Article
Human Brain Mapping, ISSN 1065-9471, 1997, Volume 5, Issue 2, pp. 84 - 92
The purpose of this study was to examine changes in regional cerebral blood flow (rCBF) using positron emission tomography (PET) during overt word and nonword...
fusiform gyrus | frontal cortex | cognition | positron emission tomography | Cognition | Fusiform gyrus | Frontal cortex | Positron emission tomography | LOCALIZATION | DEMENTIA | PET IMAGES | ABNORMALITIES | ALZHEIMERS-DISEASE | PURE ALEXIA | NEUROSCIENCES | DETERIORATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | TEMPORAL LANGUAGE AREA | Reading | Cerebrovascular Circulation - physiology | Semantics | Humans | Adolescent | Phonetics | Adult | Female | Male | Tomography, Emission-Computed | Brain Mapping - methods | Child
fusiform gyrus | frontal cortex | cognition | positron emission tomography | Cognition | Fusiform gyrus | Frontal cortex | Positron emission tomography | LOCALIZATION | DEMENTIA | PET IMAGES | ABNORMALITIES | ALZHEIMERS-DISEASE | PURE ALEXIA | NEUROSCIENCES | DETERIORATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | TEMPORAL LANGUAGE AREA | Reading | Cerebrovascular Circulation - physiology | Semantics | Humans | Adolescent | Phonetics | Adult | Female | Male | Tomography, Emission-Computed | Brain Mapping - methods | Child
Journal Article