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Cancer Cell, ISSN 1535-6108, 06/2014, Volume 25, Issue 6, pp. 735 - 747
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 08/2019, Volume 294, Issue 38, pp. 13864 - 13875
Asparaginase is an amino acid-depleting agent used to treat blood cancers. Metabolic complications due to asparaginase affect liver function in humans. To... 
Editors' Picks | triglyceride | development | amino acid | asparaginase | eukaryotic initiation factor 2 (eIF2) | age-dependent response | integrated stress response (ISR) | mRNA | hepatic metabolism | integrated stress response
Journal Article
The Journal of Nutrition, ISSN 0022-3166, 6/2017, Volume 147, Issue 6, pp. 1031 - 1040
Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene... 
GCN2 | eIF2B | Biochemical, Molecular, and Genetic Mechanisms | PERK | ATF4 | integrated stress response
Journal Article
Journal of Nutrition, ISSN 0022-3166, 06/2017, Volume 147, Issue 6, pp. 1031 - 1040
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2016, Volume 310, Issue 11, pp. G1061 - G1070
Treatment with the antileukemic agent asparaginase can induce acute pancreatitis, but the pathophysiology remains obscure. In the liver of mice, eukaryotic... 
Protein kinase R-like ER kinase | Amino acid response | Eukaryotic initiation factor 2 | Endoplasmic reticulum stress | Unfolded protein response | eukaryotic initiation factor 2 | protein kinase R-like ER kinase | PHYSIOLOGY | INCREASING SECRETION | ENDOPLASMIC-RETICULUM STRESS | TRYPSIN ACTIVATION | endoplasmic reticulum stress | ACINAR-CELL APOPTOSIS | unfolded protein response | ACUTE LYMPHOBLASTIC-LEUKEMIA | COLI-DERIVED ASPARAGINASE | GASTROENTEROLOGY & HEPATOLOGY | amino acid response | AMINO-ACID DEPRIVATION | GENOME-WIDE ASSOCIATION | EIF2 KINASE GCN2 | Sirtuin 1 - metabolism | Tumor Necrosis Factor-alpha - metabolism | Pancreatitis - etiology | eIF-2 Kinase - metabolism | Pancreas - cytology | Tumor Necrosis Factor-alpha - genetics | Fibroblast Growth Factors - genetics | Male | Autophagy | Sirtuin 1 - genetics | Fibroblast Growth Factors - metabolism | Heat-Shock Proteins - genetics | Pancreatitis - genetics | Gene Deletion | Female | Protein-Serine-Threonine Kinases - metabolism | Acinar Cells - metabolism | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Pancreas - metabolism | Transcription Factors - genetics | Pancreatitis-Associated Proteins | Triglycerides - metabolism | Transcription Factors - metabolism | Asparaginase - toxicity | Acinar Cells - pathology | Animals | X-Box Binding Protein 1 - metabolism | Endoplasmic Reticulum Stress | Mice | Acinar Cells - drug effects | Pancreatitis - metabolism | X-Box Binding Protein 1 - genetics | Physiological aspects | Complications and side effects | Endoplasmic reticulum | Asparaginase | Pancreatitis | Index Medicus | Pathophysiology | Pancreatic Physiology
Journal Article
Cancer Research, ISSN 0008-5472, 07/2012, Volume 72, Issue 14 Supplement, pp. IA5 - IA5
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2015, Volume 308, Issue 4, pp. E283 - E293
The antileu-kemic agent asparaginase triggers the amino acid response (AAR) in the liver by activating the eukaryotic initiation factor 2 (eIF2) kinase general... 
General control nonderepressible 2 | Oxidative stress | Adipose | Amino acid response | Fibroblast growth factor 21 | Antithrombin III | Liver | Apolipoprotein B-100 | Mice | Eukaryotic initiation factor 2 | Steatosis | fibroblast growth factor 21 | eukaryotic initiation factor 2 | PHYSIOLOGY | liver | general control nonderepressible 2 | antithrombin III | adipose | ENDOPLASMIC-RETICULUM STRESS | APOLIPOPROTEIN-B | LIVER-DISEASE | mice | MAMMALIAN-CELLS | TRANSLATIONAL CONTROL | apolipoprotein B-100 | ACUTE LYMPHOBLASTIC-LEUKEMIA | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | steatosis | amino acid response | oxidative stress | AMINO-ACID DEPRIVATION | EIF2 KINASE GCN2 | Liver - pathology | Adipose Tissue, White - metabolism | Male | Antineoplastic Agents - administration & dosage | RNA, Messenger - metabolism | Escherichia coli Proteins - adverse effects | Asparaginase - adverse effects | Escherichia coli Proteins - administration & dosage | Liver - drug effects | Antineoplastic Agents - adverse effects | Lipid Peroxidation - drug effects | Female | Fibroblast Growth Factors - agonists | Homeostasis - drug effects | Chemical and Drug Induced Liver Injury - pathology | Protein-Serine-Threonine Kinases - metabolism | Biomarkers - metabolism | Adipose Tissue, White - pathology | Liver - metabolism | Mice, Inbred C57BL | Injections, Intraperitoneal | Protein-Serine-Threonine Kinases - genetics | Biomarkers - blood | Mice, Knockout | Triglycerides - metabolism | Asparaginase - administration & dosage | Gene Expression Regulation - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Fibroblast Growth Factors - blood | Adipose Tissue, White - drug effects | Homeostasis | Fibroblast growth factors | Dosage and administration | Triglycerides | Health aspects | Protein kinases | Asparaginase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 16, pp. 6786 - 6798
Obesity increases risk for liver toxicity by the anti-leukemic agent asparaginase, but the mechanism is unknown. Asparaginase activates the integrated stress... 
INSULIN | INDUCED GENE-EXPRESSION | GCN2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | LEUCINE DEPRIVATION | HYDROGEN-SULFIDE | TRANSLATION | PROTEIN-SYNTHESIS | PEGYLATED ARGINASE I | AMINO-ACID DEPRIVATION | Liver - pathology | TOR Serine-Threonine Kinases - metabolism | Fatty Liver - pathology | eIF-2 Kinase - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Apolipoprotein B-100 - metabolism | Liver - drug effects | Activating Transcription Factors - metabolism | Gene Deletion | Eukaryotic Initiation Factor-2 - metabolism | Nuclear Proteins - genetics | Disease Models, Animal | Asparaginase - metabolism | Fatty Liver - metabolism | Hydrogen Sulfide - chemistry | Liver - metabolism | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Activating Transcription Factor 4 - genetics | Mice, Transgenic | Obesity - metabolism | Animals | Mice, Obese | Glutathione - chemistry | Mice | Index Medicus | general control nonderepressible 2 (GCN2) | Molecular Bases of Disease | hydrogen sulfide | liver | PKR-like endoplasmic reticulum kinase (PERK) | eukaryotic initiation factor 2 (eIF2) | mammalian target of rapamycin (mTOR) | activating transcription factor 4 (ATF4) | obesity | integrated stress response | sestrin2
Journal Article
American Journal of Physiology, ISSN 0193-1849, 02/2015, Volume 308, Issue 4, p. E283
  The antileukemic agent asparaginase triggers the amino acid response (AAR) in the liver by activating the eukaryotic initiation factor 2 (eIF2) kinase... 
Enzymes | Liver | Homeostasis | Protein expression | Amino acids | Triglycerides | Gene expression
Journal Article
Journal Article