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Nature Reviews Drug Discovery, ISSN 1474-1776, 03/2016, Volume 15, Issue 3, pp. 204 - 216
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2016, Volume 19, Issue 6, pp. 765 - 767
Journal Article
Brain Pathology, ISSN 1015-6305, 11/2015, Volume 25, Issue 6, pp. 753 - 754
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 04/2015, Volume 15, Issue 5, pp. 302 - 310
As tumours evolve, the daughter cells of the initiating cell often become molecularly heterogeneous and develop different functional properties and therapeutic... 
Brain Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | Signal Transduction - genetics | Glioblastoma - genetics | Humans | Genetic Heterogeneity | Care and treatment | Epidermal growth factor | Analysis | Genetic aspects | Diagnosis | Glioblastoma multiforme | Cancer
Journal Article
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, ISSN 1939-5094, 01/2018, Volume 10, Issue 1, p. e1398
Journal Article
Wiley interdisciplinary reviews. Systems biology and medicine, ISSN 1939-5094, 1/2018, Volume 10, Issue 1
The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase (RTK) that is critical for normal development and function. EGFR is... 
TKI | glioblastoma | tyrosine kinase inhibitor | signal transduction | Epidermal growth factor receptor | EGFR
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2011, Volume 121, Issue 8, p. 3357
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. SY26-02 - SY26-02
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2013, Volume 123, Issue 2, pp. 548 - 548
RNA sequencing facilitates the discovery of novel gene fusions in cancer. In this issue of the JCI, Parker et al. identify an FGFR3-TACC3 fusion oncogene in... 
Journal Article
Biochimica et biophysica acta. Reviews on cancer, ISSN 0304-419X, 8/2018, Volume 1870, Issue 1, pp. 76 - 87
Tumors cells reprogram their metabolism to fuel rapid growth. The ability to trace nutrient fluxes in the context of specific alterations has provided new... 
Heterogeneity | Cancer metabolism | ecDNA | Tissue context | Oncogenic signaling | Metabolic co-dependency
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2013, Volume 23, Issue 2, pp. 143 - 158
The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in ∼20% of non-small cell lung cancers (NSCLC). LKB1 is the major upstream kinase... 
LKB1-AMPK PATHWAY | COMPLEX I | SURVIVAL | RESPIRATORY-CHAIN | METFORMIN | ENERGY STRESS | HOMEOSTASIS | ONCOLOGY | PHOSPHORYLATION | KINASE | AMPK ACTIVATION | CELL BIOLOGY | Lung Neoplasms - drug therapy | AMP-Activated Protein Kinases - metabolism | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins p21(ras) - physiology | Phenformin - therapeutic use | Tumor Suppressor Protein p53 - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Eukaryotic Initiation Factor-2 - metabolism | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | Hypoglycemic Agents - therapeutic use | Protein-Serine-Threonine Kinases - physiology | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Cells, Cultured | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Animals | Eukaryotic Initiation Factor-2 - genetics | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | AMP-Activated Protein Kinases - genetics | Drugs | Care and treatment | Analysis | Physiological aspects | Diabetes | Tumor proteins | Drug therapy | Lung cancer, Non-small cell | Health aspects | Cells | Tumors | Cancer
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 12/2019
Journal Article
Cell Metabolism, ISSN 1550-4131, 08/2019, Volume 30, Issue 2, pp. 229 - 230
Altered lipid metabolism is common in glioblastoma, but its role in tumorigenesis is not well understood. In this issue of , provide new insight into this... 
METABOLISM | INHIBITOR | ENDOCRINOLOGY & METABOLISM | CELL BIOLOGY | Physiological aspects | Medical colleges | Gliomas | Protein binding
Journal Article