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Science, ISSN 0036-8075, 12/2016, Volume 354, Issue 6319, pp. aaf6814 - aaf6814
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2012, Volume 53, Issue 1, pp. 51 - 65
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2011, Volume 52, Issue 1, pp. 78 - 86
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 06/2011, Volume 52, Issue 6, pp. 1084 - 1097
Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE(-/-) and low density... 
Low density lipoprotein receptor | Low density lipoprotein cholesterol | Short-interfering RNA | Cholesteryl ester transfer protein | FAMILIAL HYPERCHOLESTEROLEMIA | RNAI | HYPOBETALIPOPROTEINEMIA | cholesteryl ester transfer protein | BIOCHEMISTRY & MOLECULAR BIOLOGY | low density lipoprotein receptor | APOLIPOPROTEIN-E | AGGRAVATES ATHEROSCLEROSIS | TRANSFER PROTEIN | HYPERLIPOPROTEINEMIA | GENE | short-interfering RNA | DENSITY-LIPOPROTEIN | MICE | low density lipoprotein cholesterol | Atherosclerosis - genetics | Humans | RNA, Messenger - analysis | Apolipoproteins B - blood | Gene Expression Profiling | Gene Knockdown Techniques | Founder Effect | RNA, Messenger - biosynthesis | Liver - drug effects | Cholesterol Ester Transfer Proteins - genetics | Cholesterol, LDL - blood | Lipid Metabolism - genetics | Disease Models, Animal | Receptors, LDL - genetics | Atherosclerosis - pathology | Liver - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Receptors, LDL - metabolism | Mice, Transgenic | Apolipoproteins B - genetics | Atherosclerosis - metabolism | Hemizygote | Animals | Apolipoproteins E - blood | Apolipoproteins E - genetics | Triglycerides - blood | Cell Line, Tumor | Liposomes - metabolism | Mice | Nanoparticles - administration & dosage | Cholesterol Ester Transfer Proteins - metabolism | RNA, Small Interfering - metabolism | Lipoproteins (low density) | Animal models | Liver | Lipids | Triglycerides | mRNA | siRNA | Serum lipids | nanoparticles | Arteriosclerosis | Lipoprotein (low density) receptors | Mutation | Transgenes | Heart diseases | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2006, Volume 71, Issue 4, pp. 453 - 463
Liver X receptor (LXR) α and LXRβ are closely related nuclear receptors that respond to elevated levels of intracellular cholesterol by enhancing transcription... 
Nuclear receptor | High density lipoprotein | Sterol regulatory element-binding protein-1c | Triglycerides | ATP-binding cassette transporter A1 | Macrophages | Cholesterol | MACROPHAGE CELL-LINE | NUCLEAR RECEPTORS | triglycerides | POTENTIAL THERAPEUTIC TARGETS | sterol regulatory element-binding | LXR-ALPHA | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-E | macrophages | OXYSTEROL RECEPTORS | protein-1c | GENE-EXPRESSION | nuclear receptor | cholesterol | PHARMACOLOGY & PHARMACY | high density lipoprotein | CHOLESTEROL HOMEOSTASIS | ADIPOSE-TISSUE | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | ATP-Binding Cassette Transporters - genetics | DNA-Binding Proteins - agonists | Liver - drug effects | Protein Isoforms - agonists | Liver X Receptors | ATP-Binding Cassette Transporters - metabolism | Molecular Structure | Orphan Nuclear Receptors | ATP Binding Cassette Transporter 1 | Macrophages, Peritoneal - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | DNA-Binding Proteins - physiology | Administration, Oral | Cholesterol, HDL - metabolism | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Cholesterol - metabolism | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Protein Isoforms - physiology | Mice, Knockout | Triglycerides - metabolism | Cyclic AMP - pharmacology | Gene Expression Regulation - drug effects | Isoxazoles - pharmacology | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Triglycerides - blood | Cholesterol, HDL - blood | Mice | Phenylurea Compounds - pharmacology | Macrophages, Peritoneal - metabolism | Pyrazines - pharmacology | Lipid Metabolism - physiology | Protein Isoforms - genetics | Index Medicus
Journal Article
Lipids, ISSN 0024-4201, 11/2011, Volume 46, Issue 11, pp. 991 - 1003
Journal Article
International Journal of Biological Sciences, ISSN 1449-2288, 02/2012, Volume 8, Issue 3, pp. 310 - 327
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20... 
Low density lipoprotein cholesterol (LDL-C) | PCSK9 | Sterol regulatory element binding protein (SREBP) | Hypercholesterolemia | Primary hepatocytes | LDL receptor | NONHUMAN-PRIMATES | primary hepatocytes | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE VARIATIONS | low density lipoprotein cholesterol (LDL-C) | hypercholesterolemia | PLASMA-CHOLESTEROL | METABOLISM | DEGRADATION | TARGETING PCSK9 | ASSOCIATION | BINDING | sterol regulatory element binding protein (SREBP) | DENSITY-LIPOPROTEIN RECEPTOR | Proprotein Convertases - antagonists & inhibitors | Simvastatin - therapeutic use | Humans | Antibodies, Monoclonal - therapeutic use | Gene Expression Profiling | Macaca mulatta | Hepatocytes - metabolism | RNA, Messenger - metabolism | Metabolic Syndrome - drug therapy | Proprotein Convertases - genetics | Hep G2 Cells - drug effects | Liver - drug effects | Proprotein Convertases - biosynthesis | Cholesterol Ester Transfer Proteins - genetics | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Cholesterol, LDL - blood | Lipid Metabolism - genetics | Hepatocytes - drug effects | Recombinant Proteins - metabolism | Receptors, LDL - genetics | Cells, Cultured - drug effects | Serine Endopeptidases - biosynthesis | Simvastatin - administration & dosage | Antibodies, Monoclonal - pharmacology | Liver - metabolism | Antibody Affinity | Metabolic Syndrome - therapy | Mice, Transgenic | Proprotein Convertases - immunology | Gene Expression Regulation - drug effects | Animals | Anticholesteremic Agents - therapeutic use | Metabolic Syndrome - genetics | Anticholesteremic Agents - administration & dosage | Hep G2 Cells - metabolism | Receptors, LDL - biosynthesis | Immunization, Passive | Cells, Cultured - metabolism | Mice | Sterol Regulatory Element Binding Proteins - physiology | Cholesterol Ester Transfer Proteins - metabolism | Proprotein Convertase 9 | Index Medicus
Journal Article
Journal Article
Atherosclerosis, ISSN 0021-9150, 2005, Volume 181, Issue 2, pp. 251 - 259
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 1/2011, Volume 52, Issue 1, pp. 78 - 86
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We... 
low density lipoprotein metabolism | kexin type 9 | drug therapy | proprotein convertase subtilisin-like | cholesterol | antibodies | metabolism | lipoprotein receptors
Journal Article