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1. Full Text Discovery of Transdermal Penetration Enhancers for Drug Delivery Samir Mitragotri
by Mitragotri, S
BIOPHYSICAL JOURNAL, ISSN 0006-3495, 01/2010, Volume 98, Issue 3, pp. 436A - 436A
BIOPHYSICS
Conference Proceeding
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2. Full Text Shape Induced Inhibition of Phagocytosis of Polymer Particles
by Champion, Julie A and Mitragotri, Samir
Pharmaceutical Research, ISSN 0724-8741, 1/2009, Volume 26, Issue 1, pp. 244 - 249
To determine if particle shape can be engineered to inhibit phagocytosis of drug delivery particles by macrophages, which can be a significant barrier to... 
Biomedical Engineering | Biochemistry, general | aspect ratio | Biomedicine | Pharmacy | polystyrene | Medical Law | macrophage | drug delivery | Pharmacology/Toxicology | curvature | Drug delivery | Aspect ratio | Polystyrene | Curvature | Macrophage | TARGET | NANOPARTICLES | DRUG-DELIVERY | SIZE | PHARMACOLOGY & PHARMACY | CHEMISTRY, MULTIDISCIPLINARY | Excipients | Microscopy, Electron, Scanning | Emulsions | Nanoparticles - chemistry | Polyethylene Glycols - chemistry | Chemistry, Pharmaceutical | Freezing | Peptide Hydrolases - chemistry | Drug Carriers | Hydrogen Peroxide - chemistry | Nanotubes - chemistry | Particle Size | Tissue Distribution | Catalase - administration & dosage | Animals | Drug Compounding | Indicators and Reagents | Mice | Catalase - pharmacokinetics | Catalase - chemistry | Drugs and athletes | Drugs | Drug delivery systems | Analysis | Fluorescence | Polymers | Macrophages | Vehicles | Nanoparticles | Membranes | Cellular biology | Index Medicus
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3. Full Text In Drug Delivery, Shape Does Matter
by Mitragotri, Samir
Pharmaceutical Research, ISSN 0724-8741, 1/2009, Volume 26, Issue 1, pp. 232 - 234
  Drug delivery continues to be a challenge in the field. Many of these challenges have been identified and significant progress has been made in the last... 
Biomedical Engineering | Biochemistry, general | Medical Law | Biomedicine | Pharmacology/Toxicology | Pharmacy | NANOPARTICLES | PHARMACOLOGY & PHARMACY | NONSPHERICAL PARTICLES | CHEMISTRY, MULTIDISCIPLINARY | Particle Size | Drug Industry | Drug Design | Particulate Matter | Research | Chemistry, Pharmaceutical - trends | Chemistry, Pharmaceutical - education | Drug Carriers | Drug Delivery Systems | Drugs | Drug delivery systems | Vehicles | Pharmaceutical sciences | Index Medicus
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4. Full Text Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer
by Tracy Hsu and Samir Mitragotri
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 15816 - 15821
Delivery of macromolecules into cells and tissues such as skin is a major challenge. This obstacle poses a particular challenge for the delivery of siRNA where... 
Bacteriophages | Atopic dermatitis | Internalization | Macromolecules | Small interfering RNA | Transdermal application | Keratinocytes | Skin diseases | Skin | Endothelial cells | Drug delivery | Topical | Transdermal | Dermatology | Cell-penetrating peptide | PATHWAYS | topical | PERMEABILITY | FILAGGRIN | MULTIDISCIPLINARY SCIENCES | drug delivery | cell-penetrating peptide | PATHOGENESIS | ATOPIC-DERMATITIS | PENETRATION ENHANCERS | TRANSPORT | dermatology | transdermal | MACROPINOCYTOSIS | TRANSDERMAL DRUG-DELIVERY | PROTEIN DELIVERY | RNA, Small Interfering - genetics | Skin - metabolism | Humans | Peptides - genetics | Administration, Cutaneous | Peptide Library | Spectroscopy, Fourier Transform Infrared | Peptides - administration & dosage | RNA, Small Interfering - chemistry | Macromolecular Substances - chemistry | RNA Interference | Swine | Female | Fluorescent Dyes - chemistry | Peptides - chemistry | Macromolecular Substances - administration & dosage | Cells, Cultured | Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - genetics | Microscopy, Confocal | Animals | Interleukin-10 - genetics | Cell Line, Tumor | Mice | Mice, Inbred BALB C | RNA, Small Interfering - administration & dosage | Drug Delivery Systems - methods | Development and progression | Research | Risk factors | Proteins | Tissue | Peptides | Ribonucleic acid--RNA | Cells | Index Medicus | Biological Sciences
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5. Full Text Macrophages recognize size and shape of their targets
by Doshi, Nishit and Mitragotri, Samir
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 4, pp. e10051 - e10051
Recognition by macrophages is a key process in generating immune response against invading pathogens. Previous studies have focused on recognition of pathogens... 
SYSTEM | CLEARANCE | PHAGOCYTOSIS | INTERNALIZATION | POLYMERIC NANOPARTICLES | DRUG-DELIVERY | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | INNATE | PARTICLE-SIZE | BIODISTRIBUTION | Particle Size | Cell Line | Bacteria - immunology | Models, Immunological | Animals | Adhesiveness | Polystyrenes | Mice | Fluorescent Dyes | Macrophages - immunology | Drug Carriers | Macrophages | Bacteria | Pneumonia | Drug delivery systems | Target recognition | Laboratories | Chemical engineering | Drug delivery | Data mining | Blood | Receptors | Cooperation | Libraries | Public health | Immune system | Scanning electron microscopy | Pathogens | Immune response | Fetuses | Particulates | Pattern recognition | Disease control | Pathogenicity | Immune systems | Studies | Geometry | Disease prevention | Tuberculosis | Infectious diseases | Surveillance | Cholera | Web sites | Shape recognition | Index Medicus
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6. Full Text Mechanistic study of transdermal delivery of macromolecules assisted by ionic liquids
Journal of controlled release : official journal of the Controlled Release Society, 08/2019
Index Medicus
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7. Full Text Role of Particle Size in Phagocytosis of Polymeric Microspheres
by Champion, Julie A and Walker, Amanda and Mitragotri, Samir
Pharmaceutical Research, ISSN 0724-8741, 8/2008, Volume 25, Issue 8, pp. 1815 - 1821
Polymeric microspheres are extensively researched for applications in drug and vaccine delivery. However, upon administration into the body, microspheres are... 
Biomedical Engineering | Biochemistry, general | phagocytosis | Biomedicine | size | Pharmacy | Medical Law | macrophage | microsphere | drug delivery | Pharmacology/Toxicology | Drug delivery | Microsphere | Size | Phagocytosis | Macrophage | TARGET | MECHANISMS | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | NANOPARTICLES | LEUKOCYTES | PHARMACOLOGY & PHARMACY | RECEPTORS | INNATE IMMUNITY | Particle Size | Cell Line | Microspheres | Microscopy, Electron, Scanning | Algorithms | Animals | Flow Cytometry | Phagocytosis - physiology | Macrophages, Alveolar - physiology | Rats | Microscopy, Video | Polymers | Drugs and athletes | Drugs | Drug delivery systems | Macrophages | Analysis | Vehicles | Pharmacology | Biochemistry | Models | Cellular biology | Rodents | Index Medicus
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8. Full Text Role of Target Geometry in Phagocytosis
by Julie A. Champion and Samir Mitragotri
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2006, Volume 103, Issue 13, pp. 4930 - 4934
Phagocytosis is a principal component of the body's innate immunity in which macrophages internalize targets in an actin-dependent manner. Targets vary widely... 
Phagocytes | Microscopy | Internalization | Geometric shapes | Actins | Cell membranes | Macrophages | Aspect ratio | Radius of a sphere | Phagocytosis | Membrane | Drug delivery | Shape | membrane | shape | MULTIDISCIPLINARY SCIENCES | MACROPHAGE | drug delivery | MODEL | SURFACE-CHARGE | DICTYOSTELIUM | macrophages | IN-VITRO | DYNAMICS | PARTICLE-SIZE | BINDING | Particle Size | Cell Line | Microscopy, Electron, Scanning | Animals | Polystyrenes | Actins - metabolism | Phagocytosis - physiology | Rats | Cell Membrane - metabolism | Research | Proteins | Membranes | Biophysics | Cellular biology | Molecular structure | Immune system | Index Medicus | Biological Sciences
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9. Full Text Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium
by Poornima Kolhar and Aaron C. Anselmo and Vivek Gupta and Kapil Pant and Balabhaskar Prabhakarpandian and Erkki Ruoslahti and Samir Mitragotri
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 26, pp. 10753 - 10758
Vascular endothelium offers a variety of therapeutic targets for the treatment of cancer, cardiovascular diseases, inflammation, and oxidative stress.... 
Nanoparticles | Cell culture techniques | Lungs | Particle interactions | Antibodies | Surface science | Nanorods | Endothelial cells | Endothelium | Tumors | Cylinder | Drug delivery | SMN | Biodistribution | Morphology | POLYMER PARTICLES | biodistribution | INTERCELLULAR-ADHESION MOLECULE-1 | morphology | DRUG-DELIVERY | MULTIDISCIPLINARY SCIENCES | CELL-ADHESION | drug delivery | NONSPHERICAL PARTICLES | IN-VITRO | SHEAR-STRESS | SYNTHETIC MICROVASCULAR NETWORKS | cylinder | VASCULAR ZIP CODES | BLOOD | Endothelium, Vascular - ultrastructure | Nanospheres - ultrastructure | Brain - blood supply | Female | Endothelium, Vascular - immunology | Nanotubes - ultrastructure | Cell Line | Microscopy, Electron, Scanning | Adhesiveness | Nanoparticles - ultrastructure | Antibodies, Monoclonal - pharmacokinetics | Rats | Particle Size | Animals | Antibodies, Monoclonal - administration & dosage | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Lung - blood supply | Brain - immunology | Drug Delivery Systems - methods | Lung - immunology | Microfluidics | Nanotechnology | Nanospheres - administration & dosage | Drugs | Drug delivery systems | Usage | Physiological aspects | Genetic aspects | Research | Vehicles | Brain | Molecules | Cell adhesion & migration | Index Medicus | Biological Sciences
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10. Full Text Particle shape enhances specificity of antibody-displaying nanoparticles
by Sutapa Barua and Jin-Wook Yoo and Poornima Kolhar and Aditya Wakankar and Yatin R. Gokarn and Samir Mitragotri
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 9, pp. 3270 - 3275
Monoclonal antibodies are used in numerous therapeutic and diagnostic applications; however, their efficacy is contingent on specificity and avidity. Here, we... 
Nanoparticles | Cell growth | Particle interactions | Medical treatment | Cell lines | Antibodies | Fluorescence | Breast cancer | Cell membranes | Nanorods | Drug delivery | Nanomedicine | Morphology | Nanotechnology | CELLS | morphology | TRASTUZUMAB | MULTIDISCIPLINARY SCIENCES | nanomedicine | MULTIVALENT LIGANDS | MONOCLONAL-ANTIBODY | drug delivery | ENDOCYTOSIS | BREAST-CANCER | SEMICONDUCTOR QUANTUM DOTS | nanotechnology | SURFACE | LOADED NANOPARTICLES | TARGETED DELIVERY | Temperature | Antibodies, Monoclonal, Humanized - therapeutic use | Nanoparticles - chemistry | Antibodies, Monoclonal - pharmacology | Endocytosis - drug effects | Humans | Nanoparticles - ultrastructure | Antibodies, Monoclonal - therapeutic use | Breast Neoplasms - drug therapy | Antibody Specificity - immunology | Breast Neoplasms - pathology | Antibodies, Monoclonal, Humanized - pharmacology | Antibody Specificity - drug effects | Cell Line, Tumor | Female | Cell Proliferation - drug effects | Antibodies, Monoclonal, Humanized - immunology | Antibodies, Monoclonal - immunology | Trastuzumab | Care and treatment | Monoclonal antibodies | Atomic properties | Research | Drug therapy | Properties | Health aspects | Cancer | Polystyrene | Cells | Binding sites | Index Medicus | Physical Sciences
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11. Full Text Polymer particles that switch shape in response to a stimulus
by Jin-Wook Yoo and Samir Mitragotri and David A. Tirrell
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 25, pp. 11205 - 11210
Particle engineering for biomedical applications has unfolded the roles of attributes such as size, surface chemistry, and shape for modulating particle... 
Viscosity | Nanoparticles | Particle interactions | Interfacial tension | Geometric shapes | Particle mass | pH | Polymers | Macrophages | Phagocytosis | Geometry | Drug delivery | Carrier | Nanotechnology | phagocytosis | SHEAR VISCOSITY | DRUG-DELIVERY | MULTIDISCIPLINARY SCIENCES | SIZE | drug delivery | NONSPHERICAL PARTICLES | CARRIERS | POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES | NANOPARTICLES | carrier | IN-VIVO | nanotechnology | INORGANIC GLASSES | geometry | SUSTAINED-RELEASE | Microscopy, Video - methods | Biocompatible Materials - chemistry | Materials Testing | Equipment Design | Drug Carriers | Drug Delivery Systems | Particle Size | Macrophages - metabolism | Animals | Microscopy, Electron, Scanning - methods | Time Factors | Polymers - chemistry | Mice | Drugs | Drug delivery systems | Innovations | Research | Properties | Observations | Biomedical engineering | Vehicles | Biomedical materials | Cellular biology | Cells | Index Medicus | Physical Sciences
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12. Full Text Making Polymeric Micro- and Nanoparticles of Complex Shapes
by Julie A. Champion and Yogesh K. Katare and Samir Mitragotri
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2007, Volume 104, Issue 29, pp. 11901 - 11904
Polymeric micro- and nanoparticles play a central role in varied applications such as drug delivery, medical imaging, and advanced materials, as well as in... 
Viscosity | Solvents | Stretchers | Liquefaction | Particle interactions | Geometric shapes | Polymers | Aspect ratio | Nanotechnology | Ellipsoids | Geometry | Drug delivery | Nonspherical | Morphology | morphology | PARTICLES | DRUG-DELIVERY | MONODISPERSE | MULTIDISCIPLINARY SCIENCES | nonspherical | nanotechnology | geometry | drug delivery | FLOW | MICROFLUIDICS | Nanoparticles | Usage | Chemical properties | Innovations | Medical imaging | Physical Sciences
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13. Full Text Synergistic targeting of cell membrane, cytoplasm, and nucleus of cancer cells using rod-shaped nanoparticles
by Barua, Sutapa and Mitragotri, Samir
ACS Nano, ISSN 1936-0851, 11/2013, Volume 7, Issue 11, pp. 9558 - 9570
Design of carriers for effective delivery and targeting of drugs to cellular and subcellular compartments is an unmet need in medicine. Here, we report pure... 
camptothecin | morphology | shape | nanoparticle | synergistic | doxorubicin | herceptin | GOLD NANOPARTICLES | 1ST-LINE TREATMENT | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | TOPOISOMERASE-I | NANOSCIENCE & NANOTECHNOLOGY | MONOCLONAL-ANTIBODY | NONSPHERICAL PARTICLES | ANTITUMOR-ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | RECEPTOR-MEDIATED ENDOCYTOSIS | METASTATIC BREAST-CANCER | PACLITAXEL-LOADED NANOPARTICLES | INTRACELLULAR DELIVERY | Breast Neoplasms - ultrastructure | Nanoparticles - chemistry | Humans | Nanoparticles - ultrastructure | Breast Neoplasms - drug therapy | Drug Carriers | Nanotubes - chemistry | Antibodies, Monoclonal, Humanized - administration & dosage | Cell Cycle | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Nanomedicine - methods | Cell Line, Tumor | Inhibitory Concentration 50 | Camptothecin - administration & dosage | Female | Cell Nucleus - drug effects | Cytoplasm - drug effects | Cell Membrane - drug effects | Trastuzumab | Doxorubicin - administration & dosage | Index Medicus | Nanoparticles | Drugs | Membranes | Drug delivery systems | Breast | Inhibition | Nuclei | Nanorods | Cancer | Camptothecin
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14. Full Text Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization
by Niu, Jia and Lunn, David J and Pusuluri, Anusha and Yoo, Justin I and O'Malley, Michelle A and Mitragotri, Samir and Soh, H. Tom and Hawker, Craig J
Nature Chemistry, ISSN 1755-4330, 06/2017, Volume 9, Issue 6, pp. 537 - 545
The capability to graft synthetic polymers onto the surfaces of live cells offers the potential to manipulate and control their phenotype and underlying... 
WALL | HYBRID MATERIALS | BRUSHES | GROWTH | COATINGS | FREE CLICK CHEMISTRY | SACCHAROMYCES-CEREVISIAE | CHEMISTRY, MULTIDISCIPLINARY | LIVING CELLS | Cell Survival | Free Radicals - chemistry | Jurkat Cells | Humans | Cells, Cultured | Cell Communication | Polymerization | Saccharomyces cerevisiae - chemistry | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | Surface Properties | Free Radicals - metabolism | Cell Engineering | Polymers - chemistry | Polymers - metabolism | Yeast | Addition polymerization | Surface chemistry | Electron transfer | Polyethylene terephthalate | Chains (polymeric) | Grafting | Cell surface | Mammalian cells | Covalence | Temperature effects | Polydispersity | Control surfaces | Polymers | Viability | Manganese | Index Medicus
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15. Full Text Designer biomaterials for nanomedicine
by Doshi, Nishit and Mitragotri, Samir
Advanced Functional Materials, ISSN 1616-301X, 12/2009, Volume 19, Issue 24, pp. 3843 - 3854
Nanotechnology has had tremendous impact on medical science and has resulted in phenomenal progress in the field of drug delivery and diagnostics. A wide... 
CELLS | PHYSICS, CONDENSED MATTER | PHAGOCYTOSIS | PHYSICS, APPLIED | TARGETED DRUG-DELIVERY | MONODISPERSE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | BIODEGRADABLE NANOPARTICLES | MICROPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | SHAPE | SYSTEMS | PARTICLE-SIZE | LIPOSOMES
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