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Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1591 - 1602
The mechanistic target of rapamycin (mTOR) is hyperactivated in many types of cancer, rendering it a compelling drug-target; however, the impact of mTOR... 
RAPAMYCIN | MEDICINE, RESEARCH & EXPERIMENTAL | PATHWAY | MUTATION | KINASE INHIBITORS | PROLIFERATION | CELL-GROWTH | PTEN-DEFICIENT | CANCER | CONTRIBUTES | Gas Chromatography-Mass Spectrometry | Humans | Glutamine - metabolism | Male | Neoplasm Proteins - antagonists & inhibitors | Purines - administration & dosage | Indoles - administration & dosage | Benzophenanthridines - therapeutic use | Glioblastoma - metabolism | Purines - therapeutic use | Neoplasm Proteins - genetics | Glutaminase - biosynthesis | Magnetic Resonance Spectroscopy | Benzophenanthridines - administration & dosage | Brain Neoplasms - drug therapy | Benzophenanthridines - pharmacology | Drug Synergism | Energy Metabolism | Signal Transduction - drug effects | Mice, Nude | Glioblastoma - pathology | Cell Line, Tumor | Indoles - therapeutic use | Mice | Mice, Inbred BALB C | Glioblastoma - drug therapy | Glutaminase - physiology | Neoplasm Proteins - physiology | Brain Neoplasms - pathology | Molecular Targeted Therapy | Brain Neoplasms - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Ketoglutaric Acids - metabolism | Neoplasm Proteins - biosynthesis | Purines - pharmacology | RNA, Small Interfering - pharmacology | Temporal Lobe - metabolism | Glutaminase - antagonists & inhibitors | Citric Acid Cycle | Xenograft Model Antitumor Assays | Rotarod Performance Test | Animals | Metabolome - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Glycolysis | Signal Transduction - physiology | Aged | Glutamic Acid - metabolism | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - physiology | Glutaminase - genetics | Pharmacology, Experimental | Oncology, Experimental | Glutamine metabolism | Research | Drug therapy | Drug resistance | Health aspects | Glioblastoma multiforme | Cancer | Medical research | Enzymes | Brain cancer | Neurosurgery | Glucose | Kinases | Metabolism | Carbon | Cancer therapies | Medicine | Cell growth | Brain research | Laboratory animals | Tumors | University graduates | Oncology
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