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Neuron, ISSN 0896-6273, 09/2012, Volume 75, Issue 6, pp. 1008 - 1021
LRRK2 is a kinase mutated in Parkinson’s disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical... 
DROSOPHILA NEUROMUSCULAR-JUNCTION | FUSION | VESICLE ENDOCYTOSIS | MEMBRANE CURVATURE | ENDOPHILIN-A | SNARE-PROTEINS | MUTATIONS | BAR DOMAIN | NEUROSCIENCES | PARKINSONS-DISEASE | DEGENERATION | RNA, Small Interfering - genetics | Calcium - metabolism | Neuromuscular Junction - drug effects | Humans | Synaptic Potentials - drug effects | Green Fluorescent Proteins - genetics | Acyltransferases - metabolism | Drosophila Proteins - metabolism | Acyltransferases - genetics | Brain - metabolism | Phosphorylation - genetics | Transfection | Mass Spectrometry | Endocytosis - genetics | Synaptic Vesicles - physiology | Protein-Serine-Threonine Kinases - metabolism | CHO Cells | Green Fluorescent Proteins - metabolism | Microscopy, Electron, Transmission | Brain - cytology | Cricetinae | Animals, Genetically Modified | Gene Expression Regulation - genetics | Synaptic Potentials - genetics | Drosophila | Protein-Serine-Threonine Kinases - genetics | Models, Molecular | Serine - genetics | Mutation - genetics | Neuromuscular Junction - ultrastructure | Serine - metabolism | Clathrin - metabolism | Endocytosis - physiology | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Sequence Alignment | Animals | Synaptic Vesicles - drug effects | Mice | Drosophila Proteins - genetics | Neuromuscular Junction - physiology | RNA, Small Interfering - metabolism | Neurosciences | Parkinson's disease | Proteins | Endocytosis | Phosphorylation | Membranes | Insects | Grants | Kinases | Defects
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2009, Volume 106, Issue 27, pp. 11318 - 11323
The stomach-derived hormone ghrelin interacts with key CNS circuits regulating energy balance and body weight. Here we provide evidence that the central... 
Knockout mice | Receptors | Food intake | Alcoholic beverages | Alcohol drinking | Drug design | Mice | Pharmacology | Alcohols | Vehicles | Appetite | Mesolimbic dopamine system | Reinforcing | GHS-R1A | Ethanol | CONDITIONED PLACE PREFERENCE | FOOD-INTAKE | MULTIDISCIPLINARY SCIENCES | RATS | STIMULATES LOCOMOTOR-ACTIVITY | ethanol | reinforcing | DOPAMINE-OVERFLOW | NUCLEUS-ACCUMBENS | appetite | mesolimbic dopamine system | HORMONE SECRETAGOGUE RECEPTOR | BRAIN | Ventral Tegmental Area - drug effects | Central Nervous System - metabolism | Ghrelin - administration & dosage | Conditioning, Classical - drug effects | Mice, Inbred C57BL | Nucleus Accumbens - metabolism | Injections, Intraperitoneal | Injections, Intraventricular | Ethanol - administration & dosage | Motor Activity - drug effects | Receptors, Ghrelin - antagonists & inhibitors | Ghrelin - pharmacology | Ghrelin - metabolism | Animals | Signal Transduction - drug effects | Models, Biological | Central Nervous System - drug effects | Models, Genetic | Reward | Nucleus Accumbens - drug effects | Dopamine - metabolism | Psychological aspects | Physiological aspects | Drinking of alcoholic beverages | Research | Ghrelin | Reinforcement (Psychology) | Biological Sciences | Genetic | Motor Activity | Intraperitoneal | administration & dosage | Ventral Tegmental Area | pharmacology | Physiology | Conditioning | Nucleus Accumbens | Dopamine | Signal Transduction | Fysiologi | drug effects | Biological | Inbred C57BL | antagonists & inhibitors | Injections | Central Nervous System | Intraventricular | metabolism | Classical | Models
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 4/2016, Volume 131, Issue 4, pp. 549 - 569
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 06/2015, Volume 129, Issue 6, pp. 875 - 894
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 03/2016, Volume 39, Issue 3, p. 158
  The protease β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is required for the production of the amyloid-β (Aβ) peptide, which is central... 
Enzymes | Proteases | Pathogenesis | Alzheimers disease | Knowledge
Journal Article