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American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2007, Volume 293, Issue 4, pp. 2210 - 2218
Targeting cannabinoid-2 (CB2) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms... 
Adhesion molecules | Inflammation | RhoA | Endothelial activation | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Inflammation - chemically induced | Leukocyte Rolling - drug effects | Tumor Necrosis Factor-alpha - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Monocytes - metabolism | NF-kappa B - metabolism | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Coronary Vessels - metabolism | Lipopolysaccharides | Dose-Response Relationship, Drug | Inflammation - metabolism | Anti-Inflammatory Agents - therapeutic use | Chemokine CCL2 - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Cannabinoids - pharmacology | Monocytes - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - drug effects | Index Medicus | inflammation | adhesion molecules | endothelial activation
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2009, Volume 296, Issue 5, pp. 1466 - 1483
Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited because of its cardiotoxicity. Cell death is a key component in... 
Heart failure | Hemodynamics | Inducible nitric oxide synthase | Apoptosis | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Free Radical Scavengers - pharmacology | Antibiotics, Antineoplastic - toxicity | Mitochondria, Heart - metabolism | Heart Diseases - metabolism | Apoptosis - drug effects | Mitochondria, Heart - pathology | Antioxidants - metabolism | Myocardial Contraction - drug effects | Heart Diseases - prevention & control | Male | Mitochondria, Heart - drug effects | Tyrosine - analogs & derivatives | Necrosis | Dose-Response Relationship, Drug | Matrix Metalloproteinase 9 - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Superoxides - metabolism | Nitric Oxide Donors - pharmacology | Heart Diseases - chemically induced | Cell Line | Heart Diseases - physiopathology | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Ventricular Function, Left - drug effects | Enzyme Inhibitors - pharmacology | Ventricular Pressure - drug effects | Doxorubicin - toxicity | Mice, Knockout | Myocytes, Cardiac - pathology | Poly(ADP-ribose) Polymerases - metabolism | Tyrosine - metabolism | Animals | Myocytes, Cardiac - drug effects | Nitric Oxide Synthase Type II - genetics | Peroxynitrous Acid - metabolism | Myocytes, Cardiac - metabolism | Mice | Nitric Oxide - metabolism | Heart Diseases - pathology | Toxicity | Nitric oxide | Rodents | Permeability | Cells | Tumors | Index Medicus | heart failure | apoptosis | hemodynamics | inducible nitric oxide synthase
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 12/2007, Volume 82, Issue 6, pp. 1382 - 1389
In this study, we have investigated the role of the cannabinoid CB2 (CB2) receptor in an in vivo mouse model of hepatic ischemia/reperfusion (I/R) injury. In... 
adhesion | inflammation | TNF‐α | endothelial activation | Inflammation | TNF-α | Adhesion | Endothelial activation | Immunology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Biology
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 2017, Volume 24, Issue 16, pp. 1645 - 1670
Inflammasomes are multiprotein complexes having nucleotide-binding domain and leucine-rich repeat consisting members along with pyrin and HIN domain family. An... 
Herbs | inflammation | inflammasome | inflammatory diseases | NLRP3 | phytochemicals | interleukins-1β | medicinal plants | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Phytochemicals - chemistry | Metabolic Diseases - pathology | Plants, Medicinal - chemistry | Inflammasomes - metabolism | Neurodegenerative Diseases - pathology | Phytochemicals - therapeutic use | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Humans | Metabolic Diseases - drug therapy | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Biological Products - isolation & purification | Phytochemicals - isolation & purification | Biological Products - chemistry | Animals | Metabolic Diseases - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - chemistry | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | Plants, Medicinal - metabolism | Autoimmune Diseases - drug therapy | Biological Products - therapeutic use | Drugs | Animal models | Drug delivery systems | Interleukin | Central nervous system | Inflammatory response | Activation | Leucine | Drug development | Inflammatory diseases | Immunosuppressive agents | Caspase-1 | Microorganisms | Immunology | Pathways | Cost effectiveness | Cytokines | Immunoregulation | Therapeutic applications | Caspase | Hazards | Interleukin 18 | Phytochemicals | Pyrin protein | Natural products | Cell lines
Journal Article