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by Michailidou, Kyriaki and Hall, Per and Gonzalez-Neira, Anna and Ghoussaini, Maya and Dennis, Joe and Milne, Roger L and Schmidt, Marjanka K and Chang-Claude, Jenny and Bojesen, Stig E and Bolla, Manjeet K and Wang, Qin and Dicks, Ed and Lee, Anew and Turnbull, Clare and Rahman, Nazneen and Fletcher, Olivia and Peto, Julian and Gibson, Lorna and dos Santos Silva, Isabel and Nevanlinna, Heli and Muranen, Taru A and Aittomäki, Kristiina and Blomqvist, Carl and Czene, Kamila and Irwanto, Astrid and Liu, Jianjun and Waisfisz, Quinten and Meijers-Heijboer, Hanne and Adank, Muriel and van der Luijt, Rob B and Hein, Rebecca and Dahmen, Norbert and Beckman, Lars and Meindl, Alfons and Schmutzler, Rita K and Müller-Myhsok, Bertram and Lichtner, Peter and Hopper, John L and Southey, Melissa C and Makalic, Enes and Schmidt, Daniel F and Uitterlinden, Ane G and Hofman, Albert and Hunter, David J and Chanock, Stephen J and Vincent, Daniel and Bacot, François and Tessier, Daniel C and Canisius, Sander and Wessels, Lodewyk F. A and Haiman, Christopher A and Shah, Mitul and Luben, Robert and Brown, Judith and Luccarini, Craig and Schoof, Nils and Humphreys, Keith and Li, Jingmei and Nordestgaard, Børge G and Nielsen, Sune F and Flyger, Henrik and Couch, Fergus J and Wang, Xianshu and Vachon, Celine and Stevens, Kristen N and Lambrechts, Diether and Moisse, Matthieu and Paridaens, Robert and Christiaens, Marie-Rose and Rudolph, Anja and Nickels, Stefan and Flesch-Janys, Dieter and Johnson, Nichola and Aitken, Zoe and Aaltonen, Kirsimari and Heikkinen, Tuomas and Broeks, Annegien and van 't Veer, Laura J and van der Schoot, C. Ellen and Guénel, Pascal and Truong, Thérèse and Laurent-Puig, Pierre and Menegaux, Florence and Marme, Frederik and Schneeweiss, Aneas and Sohn, Christof and Burwinkel, Barbara and Zamora, M. Pilar and Perez, Jose Ignacio Arias and Pita, Guillermo and Alonso, M. Rosario and Cox, Angela and Brock, Ian W and Cross, Simon S and Reed, Malcolm W. R and Sawyer, Elinor J and Tomlinson, Ian and Kerin, Michael J and Miller, Nicola and Henderson, Brian E and ... and kConFab Investigators and GENICA Gene Environm Interaction B and Hereditary Breast Ovarian Canc Res and Australian Ovarian Can Study Grp and Breast Ovarian Canc Susceptibility and Australian Ovarian Cancer Study Group and GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network and Breast and Ovarian Cancer Susceptibility Collaboration and Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) and The Breast and Ovarian Cancer Susceptibility Collaboration and The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 4, pp. 353 - 361
Journal Article
by Nicolas, Aude and Kenna, Kevin P and Kenna, Aoife and Kenna, Kevin and Kenna, Brendan J and Renton, Alan E and Ticozzi, Nicola and Faghri, Faraz and Chia, Ruth and Dominov, Janice A and Nalls, Mike A and Keagle, Pamela and Rivera, Alberto M and van Rheenen, Wouter and Murphy, Natalie A and van Vugt, Joke and van Vugt, Joke J.F.A and Geiger, Joshua T and Van der Spek, Rick A and Pliner, Hannah A and Shankaracharya and Smith, Bradley N and Marangi, Giuseppe and Topp, Simon D and Abramzon, Yevgeniya and Gkazi, Athina Soragia and Eicher, John D and Logullo, Francesco O and Simone, Isabella and Simone, Isabella L and Logroscino, Giancarlo and Salvi, Fabrizio and Bartolomei, Ilaria and Borghero, Giuseppe and Murru, Maria Rita and Costantino, Emanuela and Pani, Carla and Puddu, Roberta and Caredda, Carla and Piras, Valeria and Tranquilli, Stefania and Cuccu, Stefania and Corongiu, Daniela and Melis, Maurizio and Milia, Antonio and Marrosu, Francesco and Marrosu, Maria Giovanna and Floris, Gianluca and Cannas, Antonino and Capasso, Margherita and Caponnetto, Claudia and Mancardi, Gianluigi and Origone, Paola and Mandich, Paola and Conforti, Francesca L and Cavallaro, Sebastiano and Mora, Gabriele and Mora, Jesús S and Marinou, Kalliopi and Sideri, Riccardo and Penco, Silvana and Mosca, Lorena and Lunetta, Christian and Pinter, Giuseppe Lauria and Corbo, Massimo and Riva, Nilo and Carrera, Paola and Volanti, Paolo and Mandrioli, Jessica and Fini, Nicola and Fasano, Antonio and Tremolizzo, Lucio and Arosio, Alessandro and Ferrarese, Carlo and Trojsi, Francesca and Tedeschi, Gioacchino and Monsurrò, Maria Rosaria and Piccirillo, Giovanni and Femiano, Cinzia and Ticca, Anna and Ortu, Enzo and La Bella, Vincenzo and Spataro, Rossella and Colletti, Tiziana and Sabatelli, Mario and Zollino, Marcella and Conte, Amelia and Luigetti, Marco and Lattante, Serena and Santarelli, Marialuisa and Petrucci, Antonio and Pugliatti, Maura and Pirisi, Angelo and Parish, Leslie D and Occhineri, Patrizia and Giannini, Fabio and Battistini, Stefania and Ricci, Claudia and Benigni, Michele and Cau, Tea B and ... and Genomic Translation ALS Care GTAC and ALS Sequencing Consortium and Clinical Res ALS Related Disorders and NYGC ALS Consortium and ITALSGEN Consortium and SLAGEN Consortium and French ALS Consortium and Project MinE ALS Sequencing Consor and Answer ALS Fdn and Project MinE ALS Sequencing Consortium and Genomic Translation for ALS Care (GTAC) Consortium and Answer ALS Foundation and Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium and Medicinska fakulteten and Institutionen för farmakologi och klinisk neurovetenskap and Umeå universitet
Neuron, ISSN 0896-6273, 03/2018, Volume 97, Issue 6, pp. 1268 - 1283.e6
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2018, Volume 142, Issue 6, pp. 1230 - 1243
Uterine leiomyosarcomas (uLMS) are rare, aggressive malignancies for which limited treatment options are available. To gain novel molecular insights into uLMS... 
RNA sequencing | uterine leiomyosarcoma | copy number alteration | data integration | molecular profiling | MOLECULAR SUBTYPES | TUMOR PROGRESSION | VARIANTS | DOXORUBICIN | CANCER GENOMES | IMPACT | INHIBITION | ONCOLOGY | EXPRESSION | CARCINOMA | SOFT-TISSUE SARCOMA | Uterine Neoplasms - therapy | Uterine Neoplasms - pathology | Humans | Middle Aged | Receptors, Vasoactive Intestinal Peptide, Type II - genetics | Aged, 80 and over | Leiomyosarcoma - genetics | Uterine Neoplasms - mortality | Adult | Female | Genomics - methods | High-Throughput Nucleotide Sequencing - methods | Genes, Tumor Suppressor | Gene Expression Regulation, Neoplastic - genetics | Uterine Neoplasms - genetics | Oncogenes - genetics | Cell Proliferation - genetics | Leiomyosarcoma - pathology | Myometrium - pathology | Carcinogenesis - genetics | Kaplan-Meier Estimate | Signal Transduction - genetics | Whole Genome Sequencing - methods | Leiomyosarcoma - therapy | Sequence Analysis, RNA - methods | Leiomyosarcoma - mortality | Aged | RNA | Analysis | Genes | Genomics | Estrogen | Leiomyosarcoma | Genetic research | Genomes | Tumor proteins | Gene expression | TOR protein | Cell proliferation | Drugs | Target recognition | Copy number | p53 Protein | Estrogens | DNA damage | Smooth muscle | AKT protein | Gene deletion | Multivariate analysis | Drug development | Alterations | Cell growth | Pathways | Clonal deletion | Uterus | Data integration | Deletion | Deoxyribonucleic acid--DNA | Myometrium | Muscles | Data processing | Patients | 1-Phosphatidylinositol 3-kinase | Signaling | Vasoactive intestinal peptide | Tumor suppressor genes | Mutation | Uterine cancer | PTEN protein | Cancer | Fibroblast growth factor receptors
Journal Article
British Journal of Cancer, ISSN 0007-0920, 09/2015, Volume 113, Issue 7, pp. 1027 - 1034
Background: Aflibercept (ziv-aflibercept) is an anti-angiogenic agent recently approved in combination with FOLFIRI for the treatment of metastatic colorectal... 
anti-angiogenesis; aflibercept; metastatic colorectal cancer; predictive marker; KRAS mutation status; IL8 | aflibercept | ANGIOPOIETIN-2 | ANTITUMOR-ACTIVITY | IDENTIFICATION | CHEMOTHERAPY PLUS BEVACIZUMAB | BIOMARKERS | TRIAL | KRAS mutation status | IL8 | MODELS | ONCOLOGY | anti-angiogenesis | metastatic colorectal cancer | KRAS | predictive marker | BEVACIZUMAB-INDUCED HYPERTENSION | AGENT BEVACIZUMAB | Leucovorin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Recombinant Fusion Proteins - adverse effects | Colorectal Neoplasms - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Fluorouracil - therapeutic use | Angiogenesis Inhibitors - administration & dosage | Neoplasm Metastasis | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Leucovorin - therapeutic use | Interleukin-8 - blood | Angiogenesis Inhibitors - adverse effects | Recombinant Fusion Proteins - administration & dosage | Colorectal Neoplasms - blood | Treatment Outcome | Receptors, Vascular Endothelial Growth Factor - administration & dosage | Biomarkers, Tumor - blood | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Vascular Endothelial Growth Factor B - genetics | Aged | Biomarkers, Tumor - genetics | Polymorphism, Single Nucleotide | Mutation | Organoplatinum Compounds - therapeutic use | Receptors, Vascular Endothelial Growth Factor - adverse effects | Translational Therapeutics
Journal Article