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Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2015, Volume 45, Issue 6, pp. 1772 - 1782
Journal Article
Cells, ISSN 2073-4409, 07/2019, Volume 8, Issue 7, p. 757
The high metabolic needs of T lymphocytes in response to activation make them particularly vulnerable to modifications of their biochemical milieu.... 
IL4I1 | immunosuppression enzyme | phenylalanine | tumor
Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2011, Volume 41, Issue 6, pp. 1629 - 1638
The L-phenylalanine oxidase IL4I1 inhibits T-cell proliferation in vitro through H2O2 production, and is highly expressed in tumor-associated macrophages.... 
Immunoediting | IL4I1 | Tumor escape | Mice | Phenylalanine oxidase | MECHANISM | MACROPHAGES | INDOLEAMINE 2,3-DIOXYGENASE | PROLIFERATION | IMMUNOLOGY | TUMOR-INDUCED TOLERANCE | IMMUNE-SYSTEM | MELANOMA | GENE-EXPRESSION | SUPPRESSOR-CELLS | LYMPHOCYTES | Cell Growth Processes - immunology | Tumor Escape | Antigens, Viral - metabolism | CD8-Positive T-Lymphocytes - pathology | Humans | Glycoproteins - metabolism | Viral Proteins - immunology | Antigens, Viral - genetics | Interferon-gamma - metabolism | Amino Acid Oxidoreductases - metabolism | Viral Proteins - metabolism | Amino Acid Oxidoreductases - genetics | Lymphocyte Activation - genetics | Melanoma, Experimental | Neoplasms, Experimental - immunology | Peptide Fragments - immunology | Antigens, Neoplasm - metabolism | CD8-Positive T-Lymphocytes - metabolism | Interferon-gamma - genetics | Cell Growth Processes - genetics | Peptide Fragments - genetics | Glycoproteins - genetics | Antigens, Neoplasm - genetics | Immunization | Peptide Fragments - metabolism | Antigens, Neoplasm - immunology | Transgenes - genetics | Viral Proteins - genetics | Mice, Transgenic | Amino Acid Oxidoreductases - immunology | Hydrogen Peroxide - metabolism | Antigens, Viral - immunology | Glycoproteins - immunology | Immunosuppression | Animals | CD8-Positive T-Lymphocytes - immunology | T cell receptors | Melanoma | Tumors | Index Medicus | Peptide Fragments | pathology | Hydrogen Peroxide | phenylalanine oxidase | Viral Proteins | Amino Acid Oxidoreductases | CD8-Positive T-Lymphocytes | genetics | Antigens, Viral | Neoplasms, Experimental | Transgenes | immunology | Interferon-gamma | Antigens, Neoplasm | Lymphocyte Activation | Glycoproteins | Cell Growth Processes | metabolism | immunoediting
Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2015, Volume 45, Issue 6, pp. 1772 - 1782
Journal Article
European Journal of Immunology, ISSN 0014-2980, 2010, Volume 40, Issue 9, pp. 2557 - 2568
M Phi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that M Phi and DC are the major... 
Granuloma | NF-κB | STAT | Inflammation | Immunosuppressive enzyme | APOPTOSIS | ACTIVATION | DENDRITIC CELLS | STAT1 | TUBERCULOSIS | IMMUNOLOGY | FIG1 | Immunosuppressive Enzyme | NF-kappa B | TUMOR-ASSOCIATED MACROPHAGES | LYMPHOMA | POLARIZATION | EXPRESSION | Th1 Cells - pathology | Mononuclear Phagocyte System - immunology | RNA, Small Interfering - genetics | Cell Proliferation | Coculture Techniques | Humans | Mononuclear Phagocyte System - pathology | NF-kappa B - metabolism | Th2 Cells - immunology | Th1 Cells - immunology | Th1 Cells - metabolism | STAT1 Transcription Factor - metabolism | B-Lymphocytes - pathology | Mononuclear Phagocyte System - metabolism | B-Lymphocytes - metabolism | Th2 Cells - pathology | Cell Line | Flavoproteins - genetics | Interleukin-4 - metabolism | Immune Tolerance | STAT6 Transcription Factor - metabolism | Th2 Cells - metabolism | B-Lymphocytes - drug effects | Interleukin-4 - immunology | B-Lymphocytes - immunology | CD40 Ligand - pharmacology | Flavoproteins - immunology | Mononuclear Phagocyte System - drug effects | Interferon-gamma - pharmacology | Flavoproteins - biosynthesis | Enzymes | Rodents | Index Medicus | Interleukin-4 | Interferon-gamma | Mononuclear Phagocyte System | Biochemistry, Molecular Biology | B-Lymphocytes | STAT6 Transcription Factor | Th2 Cells | Life Sciences | Th1 Cells | STAT1 Transcription Factor | RNA, Small Interfering | CD40 Ligand | Flavoproteins | pathology | NFkB | genetics | pharmacology | biosynthesis | granuloma | immunology | immunosuppressive enzyme | drug effects | metabolism
Journal Article
OncoImmunology, ISSN 2162-4011, 03/2017, Volume 6, Issue 3, pp. e1278331 - e1278331
Amino acid catabolizing enzymes emerged as a crucial mechanism used by tumors to dampen immune responses. The L-phenylalanine oxidase IL-4 induced gene 1... 
IL4I1 | T cells | tumor escape | CD8 | primary melanoma | LYMPHOCYTE RATIO | CELLS | ONCOLOGY | MOUSE MODEL | CD8(+) T cells | melanoma | IMMUNOLOGY | IMMUNOSUPPRESSIVE ENZYME IL4I1 | EXPRESSION | primary
Journal Article
Blood, ISSN 0006-4971, 10/2008, Volume 112, Issue 7, pp. 2956 - 2964
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2018, Volume 200, Issue 3, pp. 1027 - 1038
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 12/2018, Volume 138, Issue 12, pp. 2625 - 2634
Several studies have emphasized the importance of immune composition of the melanoma microenvironment for clinical outcome. The contribution of IL4I1, a... 
MARKER | TUMOR | INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION | INFILTRATING IMMUNE CELLS | IMMUNOSUPPRESSIVE ENZYME IL4I1 | LYMPHOCYTES | DERMATOLOGY
Journal Article
The American journal of surgical pathology, ISSN 0147-5185, 2012, Volume 36, Issue 11, pp. 1636 - 1646
Epstein-Barr virus (EBV)-infected B cells with Reed-Sternberg-like cell (RS) features may occur in peripheral T-cell lymphomas (PTCLs), especially in... 
EUROPEAN TASK-FORCE | HELPER-CELL | SURGERY | follicular peripheral T-cell lymphoma | follicular helper T cells | STERNBERG-LIKE CELLS | angioimmunoblastic T-cell lymphoma | classical Hodgkin lymphoma | PATHOLOGY | NEOPLASTIC-CELLS | PROTEIN EXPRESSION | CHRONIC LYMPHOCYTIC-LEUKEMIA | LYMPHOPROLIFERATIVE DISORDERS | GROWTH-PATTERN | EPSTEIN-BARR-VIRUS | Reed-Sternberg cell | CENTER B-CELL | Lymphoma, Follicular - metabolism | Recurrence | Lymph Nodes - pathology | Lymphoma, Follicular - drug therapy | Hodgkin Disease - genetics | Humans | Middle Aged | Lymphoma, Follicular - diagnosis | Male | Antigens, CD - metabolism | Lymphatic Diseases - genetics | Herpesvirus 4, Human - isolation & purification | Flow Cytometry | Genes, T-Cell Receptor gamma - genetics | Lymphoma, Follicular - genetics | Lymphoma, T-Cell, Peripheral - metabolism | Aged, 80 and over | B-Lymphocytes - virology | Biomarkers, Tumor - metabolism | Adult | Female | Clone Cells | DNA, Neoplasm - analysis | T-Lymphocytes, Helper-Inducer - pathology | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Diagnosis, Differential | Lymphoma, T-Cell, Peripheral - drug therapy | T-Lymphocytes, Helper-Inducer - metabolism | Hodgkin Disease - metabolism | Hodgkin Disease - diagnosis | Lymphoma, T-Cell, Peripheral - genetics | Lymph Nodes - metabolism | Immunophenotyping | In Situ Hybridization, Fluorescence | Lymph Nodes - virology | Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - genetics | Reed-Sternberg Cells - metabolism | Lymphatic Diseases - metabolism | Reed-Sternberg Cells - pathology | Lymphoma, T-Cell, Peripheral - diagnosis | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Lymphatic Diseases - pathology | Aged | Biomarkers, Tumor - genetics | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 05/2009, Volume 23, Issue 5, pp. 952 - 960
Journal Article