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Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1318 - 1325
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 603 - 607
Journal Article
Science Translational Medicine, ISSN 1946-6234, 09/2010, Volume 2, Issue 51, pp. 51ra70 - 51ra70
Journal Article
Cancer Discovery, ISSN 2159-8274, 12/2012, Volume 2, Issue 12, pp. 1118 - 1133
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5255 - 5264
The emergence of drug resistance is a primary concern in any cancer treatment, including with targeted kinase inhibitors as exemplified by the appearance of... 
TYROSINE KINASE INHIBITORS | LUNG-CANCER | ONCOLOGY | PAPILLARY RENAL-CARCINOMAS | BCR-ABL | ACQUIRED-RESISTANCE | CLINICAL RESISTANCE | GENE AMPLIFICATION | GEFITINIB RESISTANCE | SOMATIC MUTATIONS | CHRONIC MYELOID-LEUKEMIA | Humans | Receptors, Growth Factor - antagonists & inhibitors | Crystallography, X-Ray | Aminopyridines - metabolism | Mutation, Missense | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Receptors, Growth Factor - genetics | Neoplasms - genetics | DNA Mutational Analysis | Antineoplastic Agents - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - metabolism | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Models, Molecular | Pyrazoles - metabolism | Receptors, Growth Factor - chemistry | Neoplasms - drug therapy | Proto-Oncogene Proteins c-met - genetics | Quinolines - metabolism | Point Mutation | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Drug Resistance, Neoplasm - genetics | Tyrosine - metabolism | Animals | Mutagenesis | Aminopyridines - pharmacology | Cell Line, Tumor | Protein Binding | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | DNA, Neoplasm - genetics | Proto-Oncogene Proteins c-met - chemistry | Enzyme Activation - genetics | Cell Line, Transformed | Amino Acid Substitution | Protein Kinase Inhibitors - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0138486 - e0138486
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2015, Volume 5, Issue 4, pp. 438 - 451
Journal Article