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Pflugers Archiv : European journal of physiology, ISSN 0031-6768, 3/2016, Volume 468, Issue 3, pp. 421 - 441
Volume regulated anion channel (VRAC) is a ubiquitously expressed yet highly enigmatic member of the superfamily of chloride/anion channels. It is activated by... 
cell volume regulation | astrocytes | LRRC8 | neurons | VRAC | central nervous system
Journal Article
Pathophysiology, ISSN 0928-4680, 2007, Volume 14, Issue 3, pp. 183 - 193
The mechanisms of brain tissue damage in stroke are strongly linked to the phenomenon of excitotoxicity, which is defined as damage or death of neural cells... 
Na +,K +,2Cl − cotransport | Na +/Ca 2+ exchange | Volume-regulated anion channels | Na +/H + exchange | Excitotoxicity | Cellular edema | cotransport | exchange | 2Cl | Ca | cellular edema | volume-regulated anion channels | Na+ | 2Cl− cotransport | excitotoxicity | Ca2+ exchange | H+ exchange
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 10/2015, Volume 135, Issue 1, pp. 176 - 185
Journal Article
The Journal of Physiology, ISSN 0022-3751, 11/2017, Volume 595, Issue 22, pp. 6939 - 6951
Journal Article
Neuroscience Letters, ISSN 0304-3940, 01/2019, Volume 689, pp. 33 - 44
It is well known that the electrical signaling in neuronal networks is modulated by chloride (Cl ) fluxes the inhibitory GABA and glycine receptors. Here, we... 
Chloride homeostasis | Neuron-astrocyte communication | WNK | VRAC | Chloride channels | NKCC | KCC | CELL-VOLUME REGULATION | PROTEIN-KINASE-C | AMINO-ACID RELEASE | NA-K-CL | NA-K-2CL COTRANSPORTER | NEUROSCIENCES | MOLECULAR PHYSIOLOGY | REGULATED ANION CHANNELS | WHITE-MATTER EDEMA | ACTIVATED POTASSIUM CHANNEL | RAT-BRAIN
Journal Article
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 04/2019
Volume-regulated anion channel (VRAC) is a glutamate-permeable channel that is activated by physiological and pathological cell swelling and promotes ischemic... 
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2007, Volume 293, Issue 4, pp. 2039 - 2053
High salt consumption contributes to the development of hypertension and is considered an independent risk factor for vascular remodeling, cardiac hypertrophy,... 
Plasma | Chloride | Sodium | Cerebrospinal fluid | Osmolality | Tubular fluid | Salt intake | K-CL COTRANSPORTER | PLASMA SODIUM CONCENTRATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | osmolality | BOVINE ADRENOCORTICAL-CELLS | MACULA DENSA CELLS | DAHL-S RATS | NA+-H+ EXCHANGER | OUABAIN-INDUCED HYPERTENSION | VASCULAR SMOOTH-MUSCLE | sodium | GLOMERULAR-FILTRATION-RATE | cerebrospinal fluid | chloride | salt intake | PERIPHERAL VASCULAR DISEASE | CENTRAL-NERVOUS-SYSTEM | plasma | tubular fluid | Blood Pressure | Hypertension - cerebrospinal fluid | Humans | Supraoptic Nucleus - metabolism | Sodium-Potassium-Chloride Symporters - metabolism | Paraventricular Hypothalamic Nucleus - physiopathology | Hypertension - etiology | Brain - metabolism | Hypertension - blood | TRPV Cation Channels - metabolism | Kidney - metabolism | Sodium Channels - metabolism | Neurons - metabolism | Water-Electrolyte Balance | Kidney - physiopathology | Signal Transduction | Brain - physiopathology | Sodium Chloride, Dietary - adverse effects | Hypertension - physiopathology | Hypertension - metabolism | Sodium Chloride, Dietary - blood | Supraoptic Nucleus - physiopathology | Extracellular Fluid - metabolism | Solute Carrier Family 12, Member 1 | Animals | Sodium Chloride, Dietary - metabolism | Paraventricular Hypothalamic Nucleus - metabolism | Neuroglia - metabolism | Sodium Chloride, Dietary - cerebrospinal fluid
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 01/2013, Volume 83, Issue 1, pp. 22 - 32
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 8, p. e12304
Gliomas are morbid brain tumors that are extremely resistant to available chemotherapy and radiology treatments. Some studies have suggested that... 
BREAST-CANCER CELLS | BRAIN-TUMOR | INHIBITION | MULTIDISCIPLINARY SCIENCES | CA2+-ACTIVATED K+ CHANNELS | GROWTH | CLOTRIMAZOLE | INTERMEDIATE-CONDUCTANCE | EPIDEMIOLOGY | MODULATION | CYCLE | Potassium - metabolism | RNA, Small Interfering - genetics | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Small-Conductance Calcium-Activated Potassium Channels - genetics | Intermediate-Conductance Calcium-Activated Potassium Channels - genetics | Humans | Large-Conductance Calcium-Activated Potassium Channels - deficiency | Molecular Sequence Data | Electric Conductivity | Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism | RNA, Messenger - metabolism | Gene Knockdown Techniques | Glioblastoma - genetics | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Large-Conductance Calcium-Activated Potassium Channels - genetics | Gene Expression Regulation, Neoplastic - drug effects | Potassium Channel Blockers - pharmacology | Amino Acid Sequence | RNA, Messenger - genetics | Down-Regulation - genetics | Glioblastoma - surgery | Glioblastoma - pathology | Intermediate-Conductance Calcium-Activated Potassium Channels - deficiency | Cell Line, Tumor | Cell Proliferation - drug effects | Chemotherapy | Gliomas | Genes | Brain tumors | Genetic engineering | Potassium channels | Cancer | Cell proliferation | Brain | Biotechnology | Neurosciences | Calcium | Brain cancer | Glioblastoma | Smooth muscle | Potassium conductance | Kinases | Cancer therapies | Channels | Potassium channels (calcium-gated) | Proteins | Cell growth | Surgery | Glioma cells | Cell cycle | Physiology | Calcium channels | Channel gating | Tumor cells | Cultures | siRNA | Pharmacology | Glioblastoma multiforme | Resistance | Studies | Polymerase chain reaction | Gene silencing | Inhibitors | Cell lines | Radiology | Conductance | Glioblastoma cells | Potassium | Prostate cancer | Clotrimazole | Tumors
Journal Article