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1. Full Text Targeting coagulation factor XII as a novel therapeutic option in brain trauma
by Hopp, Sarah and Albert‐Weissenberger, Christiane and Mencl, Stine and Bieber, Michael and Schuhmann, Michael K and Stetter, Christian and Nieswandt, Bernhard and Schmidt, Peter M and Monoranu, Camelia‐Maria and Alafuzoff, Irina and Marklund, Niklas and Nolte, Marc W and Sirén, Anna‐Leena and Kleinschnitz, Christoph
Annals of neurology, ISSN 0364-5134, 06/2016, Volume 79, Issue 6, pp. 970 - 982
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neuroimaging | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Case-Control Studies | Serum Albumin, Human | Young Adult | Brain Injuries, Traumatic - physiopathology | Adult | Female | Insect Proteins - therapeutic use | Intracranial Thrombosis - drug therapy | Factor XII - therapeutic use | Disease Models, Animal | Factor XII - genetics | Brain Injuries, Traumatic - drug therapy | Platelet Aggregation - physiology | Mice, Knockout | Serum Albumin - therapeutic use | Magnetic Resonance Imaging | Animals | Factor XIIa - antagonists & inhibitors | Aged | Mice | Brain damage | Traumatic brain injury | Catheters | Blood clots | Brain | Animal models | Drug delivery systems | Medical innovations | Coagulation | Motor task performance | Bleeding | Head injuries | Ischemia | Neurodegeneration | Inhibition | Public health | Human motion | Therapeutic applications | Albumin | Thrombosis | Trauma | Coagulation factors | Microvasculature | Coagulation factor XII | Index Medicus
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2. Full Text DNA methylation-based classification of central nervous system tumours
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Aiana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Henik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Roiguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, J. rgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Aneas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and ever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Guun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature (London), ISSN 0028-0836, 2018, Volume 555, Issue 7697, pp. 469 - 474
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Central Nervous System Neoplasms - classification | Reproducibility of Results | Central Nervous System Neoplasms - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Unsupervised Machine Learning | Young Adult | Central Nervous System Neoplasms - pathology | DNA Methylation | Adolescent | Aged, 80 and over | Adult | Female | Aged | Central Nervous System Neoplasms - diagnosis | Child | Cohort Studies | Medical colleges | Usage | DNA | Central nervous system | Diagnosis | Comparative analysis | Methylation | Tumors | Genetic aspects | Nucleotide sequencing | Observations | Methods | DNA sequencing | Cancer | Medical examination | Identification and classification | Analysis | Machine learning | Classifiers | Brain cancer | Standardization | Clinical trials | Probability | Data processing | Nervous system | Genomes | Gene expression | Generalized linear models | Learning algorithms | Classification | Diagnostic software | DNA methylation | Diagnostic systems | Bioinformatics | Deoxyribonucleic acid--DNA | Index Medicus
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3. Full Text Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations
by Reinhardt, Annekathrin and Stichel, Damian and Schrimpf, Daniel and Sahm, Felix and Korshunov, Andrey and Reuss, David E and Koelsche, Christian and Huang, Kristin and Wefers, Annika K and Hovestadt, Volker and Sill, Martin and Gramatzki, Dorothee and Felsberg, Joerg and Reifenberger, Guido and Koch, Arend and Thomale, Ulrich-W and Becker, Albert and Hans, Volkmar H and Prinz, Marco and Staszewski, Ori and Acker, Till and Dohmen, Hildegard and Hartmann, Christian and Mueller, Wolf and Tuffaha, Muin S. A and Paulus, Werner and Heß, Katharina and Brokinkel, Benjamin and Schittenhelm, Jens and Monoranu, Camelia-Maria and Kessler, Almuth Friederike and Loehr, Mario and Buslei, Rolf and Deckert, Martina and Mawrin, Christian and Kohlhof, Patricia and Hewer, Ekkehard and Olar, Adriana and Rodriguez, Fausto J and Giannini, Caterina and NageswaraRao, Amulya A and Tabori, Uri and Nunes, Nuno Miguel and Weller, Michael and Pohl, Ute and Jaunmuktane, Zane and Brandner, Sebastian and Unterberg, Andreas and Hänggi, Daniel and Platten, Michael and Pfister, Stefan M and Wick, Wolfgang and Herold-Mende, Christel and Jones, David T. W and von Deimling, Andreas and Capper, David
Acta neuropathologica, ISSN 0001-6322, 8/2018, Volume 136, Issue 2, pp. 273 - 291
Neurosciences | MGMT | ATRX | Methylation profile based classification | Panel sequencing | BRAF | Anaplastic pilocytic astrocytoma | Pilocytic astrocytoma with anaplasia | Pathology | CDKN2A/B | DNA copy number alterations | Medicine & Public Health | NF1 | Molecular characterization | FGFR1 | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Medical colleges | Methylation | Gliomas | Health aspects | Analysis | Brain tumors | Glioblastoma | MAP kinase | Embedding | Glioma | DNA methylation | Microvasculature | Stochasticity | Mutation | DNA fingerprinting | Localization | Fibroblast growth factor receptor 1 | Astrocytoma | Deoxyribonucleic acid--DNA
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4. Full Text Human brain endothelial CXCR2 is inflammation-inducible and mediates CXCL5-and CXCL8-triggered paraendothelial barrier breakdown
by Haarmann, Axel and Schuhmann, Michael K and Schuhmann, Michael K and Silwedel, Christine and Silwedel, Christine and Monoranu, Camelia-Maria and Stoll, Guido and Buttmann, Mathias and Buttmann, Mathias
International journal of molecular sciences, ISSN 1661-6596, 02/2019, Volume 20, Issue 3, p. 602
Multiple sclerosis | CXCL8 | blood–brain barrier | Blood-brain barrier | CXCR2 | Human cerebral endothelial cells | SB332235 | Interleukin-8 | CXCL5 | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Brain | Spinal cord | Phosphorylation | Nuclear magnetic resonance--NMR | Oligodendrocyte-myelin glycoprotein | Pathogenesis | Intracellular signalling | AKT protein | Activation | Kinases | Experiments | Western blotting | Proteins | Actin | CXC chemokines | Extravasation | Von Willebrand factor | Capillaries | Plaques | Immunization | Myelin | CXCR2 protein | Neutrophils | Blood vessels | Inflammation | Glycoproteins | Experimental allergic encephalomyelitis | Endothelium | Organic chemistry | Biopsy | Morphology | Protein expression | Immunofluorescence | Adapter proteins | Chemokines | Histochemistry | Index Medicus | human cerebral endothelial cells | multiple sclerosis | interleukin-8
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5. Full Text Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
by Bender, Sebastian and Tang, Yujie and Lindroth, Anders M and Hovestadt, Volker and Jones, David T.W and Kool, Marcel and Zapatka, Marc and Northcott, Paul A and Sturm, Dominik and Wang, Wei and Radlwimmer, Bernhard and Højfeldt, Jonas W and Truffaux, Nathalène and Castel, David and Schubert, Simone and Ryzhova, Marina and Şeker-Cin, Huriye and Gronych, Jan and Johann, Pascal David and Stark, Sebastian and Meyer, Jochen and Milde, Till and Schuhmann, Martin and Ebinger, Martin and Monoranu, Camelia-Maria and Ponnuswami, Anitha and Chen, Spenser and Jones, Chris and Witt, Olaf and Collins, V. Peter and von Deimling, Andreas and Jabado, Nada and Puget, Stephanie and Grill, Jacques and Helin, Kristian and Korshunov, Andrey and Lichter, Peter and Monje, Michelle and Plass, Christoph and Cho, Yoon-Jae and Pfister, Stefan M
Cancer cell, ISSN 1535-6108, 11/2013, Volume 24, Issue 5, pp. 660 - 672
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Brain Neoplasms - genetics | Molecular Sequence Data | Mutation, Missense | Brain Neoplasms - metabolism | Brain Stem Neoplasms - metabolism | DNA Methylation | Brain Stem Neoplasms - genetics | Histones - genetics | Genes, Dominant | Glioblastoma - genetics | Histone-Lysine N-Methyltransferase - metabolism | Cell Line, Tumor | Protein Binding | Glioblastoma - metabolism | Transcription, Genetic | Protein Processing, Post-Translational | Histones - metabolism | Methylation | Polycomb Repressive Complex 2 - metabolism | Child | Pediatrics | Genetic aspects | Gene expression | Gliomas | DNA | Cancer | Index Medicus
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6. Full Text Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features
by Deng, Maximilian Y and Sill, Martin and Chiang, Jason and Schittenhelm, Jens and Ebinger, Martin and Schuhmann, Martin U and Monoranu, Camelia-Maria and Milde, Till and Wittmann, Andrea and Hartmann, Christian and Sommer, Clemens and Paulus, Werner and Gärtner, Jutta and Brück, Wolfgang and Rüdiger, Thomas and Leipold, Alfred and Jaunmuktane, Zane and Brandner, Sebastian and Giangaspero, Felice and Nozza, Paolo and Mora, Jaume and Morales la Madrid, Andres and Cruz Martinez, Ofelia and Hansford, Jordan R and Pietsch, Torsten and Tietze, Anna and Hernáiz-Driever, Pablo and Stoler, Iris and Capper, David and Korshunov, Andrey and Ellison, David W and von Deimling, Andreas and Pfister, Stefan M and Sahm, Felix and Jones, David T. W
Acta neuropathologica, ISSN 0001-6322, 8/2018, Volume 136, Issue 2, pp. 239 - 253
Brain tumor | Pathology | Neurosciences | Medicine & Public Health | Subgroup | Diffuse leptomeningeal glioneuronal tumor | Methylation | Pediatric | Prognostic | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Diagnosis | Brain tumors | Genomics | Biomarkers | Therapeutic applications | Physical characteristics
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7. Full Text New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
by Sturm, Dominik and Orr, Brent A and Toprak, Umut H and Hovestadt, Volker and Jones, David T.W and Capper, David and Sill, Martin and Buchhalter, Ivo and Northcott, Paul A and Leis, Irina and Ryzhova, Marina and Koelsche, Christian and Pfaff, Elke and Allen, Sariah J and Balasubramanian, Gnanaprakash and Worst, Barbara C and Pajtler, Kristian W and Brabetz, Sebastian and Johann, Pascal D and Sahm, Felix and Reimand, Jüri and Mackay, Alan and Carvalho, Diana M and Remke, Marc and Phillips, Joanna J and Perry, Arie and Cowdrey, Cynthia and Drissi, Rachid and Fouladi, Maryam and Giangaspero, Felice and Łastowska, Maria and Grajkowska, Wiesława and Scheurlen, Wolfram and Pietsch, Torsten and Hagel, Christian and Gojo, Johannes and Lötsch, Daniela and Berger, Walter and Slavc, Irene and Haberler, Christine and Jouvet, Anne and Holm, Stefan and Hofer, Silvia and Prinz, Marco and Keohane, Catherine and Fried, Iris and Mawrin, Christian and Scheie, David and Mobley, Bret C and Schniederjan, Matthew J and Santi, Mariarita and Buccoliero, Anna M and Dahiya, Sonika and Kramm, Christof M and von Bueren, André O and von Hoff, Katja and Rutkowski, Stefan and Herold-Mende, Christel and Frühwald, Michael C and Milde, Till and Hasselblatt, Martin and Wesseling, Pieter and Rößler, Jochen and Schüller, Ulrich and Ebinger, Martin and Schittenhelm, Jens and Frank, Stephan and Grobholz, Rainer and Vajtai, Istvan and Hans, Volkmar and Schneppenheim, Reinhard and Zitterbart, Karel and Collins, V. Peter and Aronica, Eleonora and Varlet, Pascale and Puget, Stephanie and Dufour, Christelle and Grill, Jacques and Figarella-Branger, Dominique and Wolter, Marietta and Schuhmann, Martin U and Shalaby, Tarek and Grotzer, Michael and van Meter, Timothy and Monoranu, Camelia-Maria and Felsberg, Jörg and Reifenberger, Guido and Snuderl, Matija and Forrester, Lynn Ann and Koster, Jan and Versteeg, Rogier and Volckmann, Richard and van Sluis, Peter and Wolf, Stephan and Mikkelsen, Tom and Gajjar, Amar and Aldape, Kenneth and Moore, Andrew S and Taylor, Michael D and Jones, Chris and ...
Cell (Cambridge), ISSN 0092-8674, 02/2016, Volume 164, Issue 5, pp. 1060 - 1072
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amino Acid Sequence | Central Nervous System Neoplasms - classification | Repressor Proteins - chemistry | Signal Transduction | Central Nervous System Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Gene Expression Profiling | Proto-Oncogene Proteins - chemistry | Forkhead Transcription Factors - genetics | Neuroectodermal Tumors - diagnosis | Central Nervous System Neoplasms - pathology | DNA Methylation | Neuroectodermal Tumors - genetics | Tumor Suppressor Proteins - genetics | Neuroectodermal Tumors - classification | Neuroectodermal Tumors - pathology | Central Nervous System Neoplasms - diagnosis | Child | Brain tumors | Index Medicus | Life Sciences | Neurons and Cognition | Neurobiology | Cancer
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8. Full Text Expression of D-amino acid oxidase (DAO/DAAO) and D-amino acid oxidase activator (DAOA/G72) during development and aging in the human post-mortem brain
by Jagannath, Vinita and Marinova, Zoya and Monoranu, Camelia-Maria and Walitza, Susanne and Grünblatt, Edna
Frontiers in neuroanatomy, ISSN 1662-5129, 04/2017, Volume 11, pp. 31 - 31
Human post-mortem brain regions | DNA methylation | DAO/DAAO | DAOA/G72 | Gene and protein expression | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Anatomy & Morphology | Science & Technology | Oxidases | Aging | Brain research | Research | Cerebellum | Brain | Post-transcription | Amygdala | Mental disorders | Working groups | Glutamic acid receptors (ionotropic) | Gene regulation | Genomics | Schizophrenia | Reverse transcription | Amino acids | Genomes | Gestation | Proteins | Consortia | Autopsy | Cortex (frontal) | Amino acid oxidase | Enzyme-linked immunosorbent assay | Deoxyribonucleic acid--DNA | CpG islands | D-Serine | Attention deficit hyperactivity disorder | D-Amino-acid oxidase | N-Methyl-D-aspartic acid receptors | Gene expression | Polymerase chain reaction | Life span | Epigenetics | Protein expression | Receptor mechanisms | Age composition | Child & adolescent psychiatry
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