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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, ISSN 2157-1422, 01/2018, Volume 8, Issue 1
Osteoporosis is a significant public health problem, and a major cause of the disease is estrogen deficiency following menopause in women. In addition,... 
MEDICINE, RESEARCH & EXPERIMENTAL | CORTICAL BONE | ANDROGEN RECEPTOR | AROMATASE DEFICIENCY | MINERAL DENSITY | TARGET-CELLS | ESTROGEN-RECEPTOR-ALPHA | FEMALE MICE | OSTEOPROGENITOR CELLS | POSTMENOPAUSAL WOMEN | KAPPA-B LIGAND
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1072 - 1079
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities(1). Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SECRETORY PHENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURE | IDENTIFICATION | CELL BIOLOGY | OSTEOCLASTOGENESIS | ACTIVATOR | MASS | ESTROGEN | FRACTURES | DYSFUNCTION | Osteocytes - drug effects | Cancellous Bone - metabolism | beta-Galactosidase | Cellular Senescence - drug effects | Apoptosis - genetics | Cancellous Bone - drug effects | Gene Expression Profiling | Osteoclasts - cytology | Bone and Bones - drug effects | Caspase 8 - genetics | Flow Cytometry | Osteoporosis - metabolism | Bone and Bones - metabolism | Osteoporosis - genetics | Cell Differentiation | Osteoblasts - cytology | Real-Time Polymerase Chain Reaction | Pyrazoles - pharmacology | Cellular Senescence - genetics | Osteoblasts - drug effects | Mice, Transgenic | Absorptiometry, Photon | Cortical Bone - metabolism | Janus Kinases - antagonists & inhibitors | Culture Media, Conditioned | Animals | Cortical Bone - drug effects | Weight-Bearing | Mice | In Vitro Techniques | Osteoclasts - drug effects | Prevention | Osteoporosis | Aging | Physiological aspects | Genetic aspects | Research | Cells | Senescence | Bone (trabecular) | Suicide | Bone resorption | Bone growth | Biomedical materials | Mineralization | Rodents | Computer architecture | Biocompatibility | Inhibition | Conditioning | Bone loss | Bone (cortical) | Suicide genes | Age | Cardiovascular system | Cell survival | Aging (artificial) | Caspase | Pharmacology | Secretome | Inflammation | Insulin | Osteoclastogenesis | Caspase-8 | Bone mass | Cellular biology | Sensitivity enhancement | Bone | In vitro methods and tests | Osteogenesis | Disease prevention | Osteoclast | Drug therapy | Osteocyte
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 01/2019, Volume 34, Issue 1, pp. 135 - 144
ABSTRACT Developing novel approaches to treat skeletal disorders requires an understanding of how critical molecular factors regulate osteoblast... 
OSTEOBLAST | AGING | MicroRNA | Rorβ | OSTEOPOROSIS | PATHWAYS | OSTEOCYTES | PROLIFERATION | MICRORNAS | IDENTIFICATION | GENOMICS | Ror beta | ENDOCRINOLOGY & METABOLISM | ESTROGEN | TARGETS | WNT | Alkaline phosphatase | Bone remodelling | MiRNA | Homeostasis | Bone turnover | Gene expression | Osteoblasts | Bone mass | Osteoblastogenesis | Clonal deletion | Aging | Bone loss | Osteogenesis | RorB
Journal Article
JOURNAL OF BONE AND MINERAL RESEARCH, ISSN 0884-0431, 04/2018, Volume 33, Issue 4, pp. 720 - 731
There is a clinical need to identify new molecular targets for the treatment of osteoporosis, particularly those that simultaneously inhibit bone resorption... 
TRANSCRIPTION FACTORS | CELLS | OSTEOCLASTS | OSTEOBLAST DIFFERENTIATION | AGING | OSTEOPOROSIS | KAPPA-B PATHWAYS | BETA | GENE | BONE-FORMATION | WNT PATHWAY | OSTEOBLASTS | ENDOCRINOLOGY & METABOLISM | PARATHYROID-HORMONE | OSTEOSARCOMA | EXPRESSION | Osteoporosis | Physiological aspects | Genetic research | Bones | T cells | Gene expression | Density
Journal Article
Journal Article