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1. Full Text Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: Focus on protection against cardiovascular and metabolic diseases
by Bulotta, Stefania and Celano, Marilena and Lepore, Saverio M and Montalcini, Tiziana and Pujia, Arturo and Russo, Diego
Journal of Translational Medicine, ISSN 1479-5876, 08/2014, Volume 12, Issue 1, p. 219
The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two... 
Hydroxytyrosol | Oleuropein | Virgin olive oil | Diabetes mellitus | Phenols | Cardiovascular disease | Antioxidant | HL60 CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE DNA-DAMAGE | CANCER CELLS | MEDITERRANEAN DIET | ANTIOXIDANT ACTIVITIES | LOW-DENSITY-LIPOPROTEIN | BIOLOGICAL-ACTIVITIES | IN-VITRO | SPINAL-CORD-INJURY | LEAF EXTRACT | Diabetes Mellitus - prevention & control | Animals | Iridoids - administration & dosage | Phenylethyl Alcohol - administration & dosage | Iridoids - analysis | Phenylethyl Alcohol - analogs & derivatives | Cardiovascular Diseases - prevention & control | Humans | Metabolic Diseases - prevention & control | Olive Oil | Phenylethyl Alcohol - analysis | Plant Oils - chemistry | Antioxidants | Medicine, Experimental | Medical research | Olive oil | Diabetes | Analysis | Enzymes | Free radicals | Bioavailability | Kinases | Lipoproteins | Metabolites | Atherosclerosis | Metabolic disorders | Functional foods & nutraceuticals | Food
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2. Full Text No evidence of circulating autoantibodies against osteoprotegerin in patients with celiac disease
by Tiziana Larussa Evelina Suraci Immacolata Nazionale Isabella Leone Tiziana Montalcini Ludovico Abenavoli Maria Imeneo Arturo Pujia Francesco Luzza
世界胃肠病学杂志：英文版, ISSN 1007-9327, 2012, Volume 18, Issue 14, pp. 1622 - 1627
AIM：To investigate risk factors for low bone mineral density（BMD） in celiac disease（CD） patients,focusing on circulating autoantibodies against... 
疾病 | 循环抗体 | 腹腔 | 证据 | 骨矿化 | 患者 | 风险因素 | Gluten-free diet | Celiac disease | Osteoporosis | Bone mineral density | Osteopenia | Osteoprotegerin | BONE-MINERAL DENSITY | ADHERENCE | CALCIUM-ABSORPTION | RECOVERY | METABOLISM | LIGAND | GASTROENTEROLOGY & HEPATOLOGY | LONG-TERM TREATMENT | ASSOCIATION | Osteoporosis - immunology | Bone Diseases, Metabolic - immunology | Calcium - metabolism | Humans | Middle Aged | Osteoprotegerin - immunology | Male | Autoantibodies - immunology | Bone Diseases, Metabolic - complications | Celiac Disease - immunology | Osteoporosis - complications | Celiac Disease - complications | Adult | Female | Aged | Diet, Gluten-Free | Brief
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3. Full Text Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
by Dongiovanni, Paola and Petta, Salvatore and Maglio, Cristina and Fracanzani, Anna Ludovica and Pipitone, Rosaria and Mozzi, Enrico and Motta, Benedetta Maria and Kaminska, Dorota and Rametta, Raffaela and Grimaudo, Stefania and Pelusi, Serena and Montalcini, Tiziana and Alisi, Anna and Maggioni, Marco and Kärjä, Vesa and Borén, Jan and Käkelä, Pirjo and Di Marco, Vito and Xing, Chao and Nobili, Valerio and Dallapiccola, Bruno and Craxi, Antonio and Pihlajamäki, Jussi and Fargion, Silvia and Sjöström, Lars and Carlsson, Lena M and Romeo, Stefano and Valenti, Luca and Institute of Medicine, Department of Molecular and Clinical Medicine and Wallenberg Laboratory and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Sahlgrenska akademin and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Wallenberglaboratoriet
Hepatology, ISSN 0270-9139, 02/2015, Volume 61, Issue 2, pp. 506 - 514
Excess hepatic storage of triglycerides is considered a benign condition, but nonalcoholic steatohepatitis (NASH) may progress to fibrosis and promote... 
CONFERS SUSCEPTIBILITY | FIBROSIS | CHOLESTEROL | FATTY LIVER-DISEASE | INSULIN-RESISTANCE | PNPLA3 | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | SEVERITY | ADIPOSE-TISSUE | TM6SF2 | Liver - pathology | Cross-Sectional Studies | Non-alcoholic Fatty Liver Disease - genetics | Membrane Proteins - genetics | Obesity - complications | Humans | Middle Aged | Male | Non-alcoholic Fatty Liver Disease - metabolism | Hepatocytes - metabolism | Biopsy | Lipoproteins, VLDL - metabolism | Carotid Artery Diseases - genetics | Adult | Female | Liver Cirrhosis - genetics | Cohort Studies | Confidence intervals | Heart attacks | Liver | Atherosclerosis | Cardiovascular disease | Drug therapy | Cholesterol | OBESE SUBJECTS | HEPATIC | Gastroenterologi | RISK | Gastroenterology & Hepatology | STEATOSIS | Gastroenterology and Hepatology
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4. Full Text An update on the potential role of C-peptide in diabetes and osteoporosis
by Pujia, Arturo and Gazzaruso, Carmine and Montalcini, Tiziana
Endocrine, ISSN 1355-008X, 12/2017, Volume 58, Issue 3, pp. 408 - 412
C-peptide secretion is deficient or absent in type 1 diabetes mellitus. It is well accepted that insulin replacement therapy cannot prevent the development of... 
Osteoporosis | Fractures | Medicine & Public Health | Intracellular signaling | Science, Humanities and Social Sciences, multidisciplinary | C-peptide | Internal Medicine | Diabetes | Endocrinology | TUBULAR CELLS | GLYCEMIC CONTROL | BONE-MINERAL DENSITY | K+-ATPASE | RENAL-FUNCTION | GLUCOSE-UTILIZATION | MELLITUS | PREVALENCE | INSULIN | ENDOCRINOLOGY & METABOLISM | TYPE-1 | Bone and Bones - pathology | Fractures, Bone - etiology | Osteoporosis - metabolism | Diabetes Complications - metabolism | Humans | Diabetes Mellitus - metabolism | Fractures, Bone - epidemiology | C-Peptide - metabolism | Complications and side effects | Usage | Care and treatment | Peptides | Muscles | Insulin resistance | Research
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5. Full Text The COBLL1 C allele is associated with lower serum insulin levels and lower insulin resistance in overweight and obese children
by Mancina, Rosellina Margherita and Burza, Maria Antonella and Maglio, Cristina and Pirazzi, Carlo and Sentinelli, Federica and Incani, Michela and Montalcini, Tiziana and Pujia, Arturo and Congiu, Tiziana and Loche, Sandro and Pilia, Sabrina and Wiklund, Olov and Borén, Jan and Romeo, Stefano and Baroni, Marco Giorgio
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 07/2013, Volume 29, Issue 5, pp. 413 - 416
Background Childhood obesity is a growing epidemic worldwide, and it is associated with metabolic complications, such as insulin resistance. Recently, a... 
rs7607980 | genetics | children | insulin resistance | COBLL1 | obesity | Obesity | Genetics | Insulin resistance | Children | Rs7607980 | ADOLESCENTS | GLUCOSE | GROWTH | ENDOCRINOLOGY & METABOLISM | BODY-MASS INDEX | PREVALENCE | Humans | Child, Preschool | Male | Insulin - blood | Obesity - blood | Obesity - genetics | Young Adult | Overweight - metabolism | Adult | Female | Child | Body Mass Index | Genetic Association Studies | Down-Regulation | Insulin Resistance | Overweight - genetics | Transcription Factors - genetics | Obesity - metabolism | Transcription Factors - metabolism | Homozygote | Overweight - blood | Adolescent | Alleles | Heterozygote | Italy | Polymorphism, Single Nucleotide | Cohort Studies | Glucose metabolism | Obesity in children | Diabetes | Glucose | Health aspects | Glucose tolerance tests | Dextrose
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6. Full Text Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis
by Bosco, Domenico and Fava, Antonietta and Plastino, Massimiliano and Montalcini, Tiziana and Pujia, Arturo
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 09/2011, Volume 15, Issue 9, pp. 1807 - 1821
Type 2 diabetes mellitus (DM) appears to be a significant risk factor for Alzheimer disease (AD). Insulin and insulin-like growth factor-1 (IGF-1) also have... 
Insulin resistance | Insulin therapy | Dementia and diabetes mellitus | Insulin receptor | Alzheimer's disease | MEDICINE, RESEARCH & EXPERIMENTAL | GLYCATION-ENDPRODUCTS RAGE | AMYLOID PRECURSOR PROTEIN | APOLIPOPROTEIN-E GENOTYPE | BLOOD-BRAIN-BARRIER | A-BETA OLIGOMERS | CELL BIOLOGY | dementia and diabetes mellitus | PROMOTES TAU-PHOSPHORYLATION | CORTICAL-NEURONS | CENTRAL-NERVOUS-SYSTEM | insulin receptor | insulin therapy | TRANSGENIC MOUSE MODEL | insulin resistance | GROWTH-FACTOR-I | Alzheimer Disease - etiology | Brain - metabolism | Oxidative Stress | Signal Transduction | Humans | Alzheimer Disease - metabolism | Insulin Resistance | Brain - pathology | Glucose - metabolism | Alzheimer Disease - pathology
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7. Full Text Role of structured individual patient education in the prevention of vascular complications in newly diagnosed type 2 diabetes: the INdividual Therapeutic Education in Newly Diagnosed type 2 diabetes (INTEND) randomized controlled trial
by Coppola, Adriana and Coppola, Adriana and Luzi, Livio and Luzi, Livio and Montalcini, Tiziana and Montalcini, Tiziana and Giustina, Andrea and Giustina, Andrea and Gazzaruso, Carmine and Gazzaruso, Carmine
Endocrine, ISSN 1355-008X, 4/2018, Volume 60, Issue 1, pp. 46 - 49
Recent studies showed that a structured patient therapeutic education (PTE) may decrease both mortality and the development of diabetes complications.... 
Patient education | Macrovascular complications | Medicine & Public Health | Science, Humanities and Social Sciences, multidisciplinary | Self-management | Internal Medicine | Diabetes | Endocrinology | MANAGEMENT | ENDOCRINOLOGY & METABOLISM | CORONARY-ARTERY-DISEASE | ERECTILE DYSFUNCTION | Type 2 diabetes | Prevention | Complications and side effects | Blood circulation disorders | Care and treatment | Usage | Research | Risk factors
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8. Full Text Effects of acute physical exercise on oxidative stress and inflammatory status in young, sedentary obese subjects
by Accattato, Francesca and Greco, Marta and Pullano, Salvatore A and Caré, Ilaria and Fiorillo, Antonino S and Pujia, Arturo and Montalcini, Tiziana and Foti, Daniela P and Brunetti, Antonio and Gulletta, Elio
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0178900
Circulating oxidative stress and pro-inflammatory markers change after regular physical exercise; however, how a short session of acute physical activity... 
SKELETAL-MUSCLE | METABOLIC SYNDROME | INSULIN-RESISTANCE | OLDER-ADULTS | MULTIDISCIPLINARY SCIENCES | EPIDERMAL-GROWTH-FACTOR | HEART-FAILURE | MEN | GENE-EXPRESSION | HYPOXIA | ADIPOSE-TISSUE | Body Mass Index | Severity of Illness Index | Fasting | Interleukins - blood | Oxidative Stress | Glutathione Peroxidase - blood | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Vascular Endothelial Growth Factor A - blood | Superoxide Dismutase - blood | Male | Obesity - physiopathology | Glutathione Reductase - blood | Sedentary Lifestyle | Biomarkers - blood | Chemokine CCL2 - blood | Obesity - blood | Epidermal Growth Factor - blood | Exercise | Adult | Interferon-gamma - blood | Obesity | Oxidative stress | Usage | Dosage and administration | Health aspects | Vascular endothelial growth factor | Physical exercise | Physical training | Physical activity | Body weight | Cardiovascular disease | Blood | Antioxidants | Glutathione reductase | Physiology | Blood pressure | Bioindicators | Glutathione peroxidase | Free radicals | Cytokines | Gene expression | Diseases | Studies | Physical fitness | Body mass | Tumor necrosis factor | Men | Interleukin 10 | Biomarkers | Hypoxia | Monocyte chemoattractant protein 1 | Reductase | Health sciences | Superoxide dismutase | Metabolic syndrome | Interleukin 6 | Interleukin 4 | Epidermal growth factor | Interleukin 2 | Risk assessment | Interleukin 1 | Tumor necrosis factor-TNF | Peroxidase | Interleukin 8 | Age | Glutathione | Markers | Oxygen consumption | Superoxide | Inflammation | Musculoskeletal system | Weight control | Interferon | Diabetes | Chemokines | Cancer
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9. Full Text Serum calcium level is related to both intima-media thickness and carotid atherosclerosis: A neglect risk factor in obese/overweight subjects
by Montalcini, Tiziana and Gorgone, Gaetano and Pujia, Arturo
Journal of Translational Medicine, ISSN 1479-5876, 06/2012, Volume 10, Issue 1, pp. 114 - 114
Background: Experimental studies suggested that high serum calcium may be important in the pathogenesis of vascular diseases. Since calcium seems to affect... 
Obesity | Calcium | Ultrasound | Carotid | Atherosclerosis | MORTALITY | SURGERY | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | PRIMARY HYPERPARATHYROIDISM | ADULTS | DEATH | ARTERIAL-WALL THICKNESS | STROKE | CARDIOVASCULAR-DISEASE | FETUIN-A | Multivariate Analysis | Disease Susceptibility - blood | Prevalence | Carotid Intima-Media Thickness | Obesity - complications | Humans | Middle Aged | Risk Factors | Carotid Artery Diseases - complications | Carotid Artery Diseases - epidemiology | Male | Obesity - blood | Calcium - blood | Regression Analysis | Carotid Artery Diseases - blood | Female | Italy - epidemiology | Disease Susceptibility - pathology | Blood circulation disorders | Body mass index | Ultrasound imaging | Risk factors | Studies | Hypertension | Cardiovascular disease
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10. Full Text Bergamot polyphenol fraction exerts effects on bone biology by activating ERK 1/2 and Wnt/β-catenin pathway and regulating bone biomarkers in bone cell cultures
by Pujia, Arturo and Russo, Cristina and Maurotti, Samantha and Pujia, Roberta and Mollace, Vincenzo and Romeo, Stefano and Montalcini, Tiziana
Nutrients, ISSN 2072-6643, 09/2018, Volume 10, Issue 9, p. 1305
Epidemiological studies show that fruit consumption may modulate bone mineral density. However, data regarding the effect of the Risso (Bergamot orange), a... 
Citrus fruits | Osteoporosis | β-catenin | Polyphenols | Bone cells | Saos-2 | Bergamot | Phosphorylation | RANK Ligand - metabolism | Plant Extracts - pharmacology | Humans | Polyphenols - pharmacology | Citrus - chemistry | Core Binding Factor Alpha 1 Subunit - metabolism | Bone Remodeling - drug effects | Collagen Type I - genetics | Biomarkers - metabolism | Cell Line | Polyphenols - isolation & purification | Collagen Type I - metabolism | Fruit | Osteoblasts - enzymology | Osteoblasts - drug effects | Plant Extracts - isolation & purification | beta Catenin - metabolism | beta Catenin - genetics | RANK Ligand - genetics | Wnt Signaling Pathway - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Enzyme Activation | Core Binding Factor Alpha 1 Subunit - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Wnt protein | Citrus fruit | Kinases | Epidemiology | Fruits | Bone resorption | Proteins | Biological effects | Biomedical materials | Cell growth | Biocompatibility | TRANCE protein | Growth factors | Cbfa-1 protein | Extracellular signal-regulated kinase | Flavonoids | Bone cancer | Osteoblastogenesis | Collagen | Stem cells | Biomarkers | Bone mineral density | In vivo methods and tests | polyphenols | citrus fruits | bone cells | osteoporosis
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11. Full Text PNPLA3 I148M variant influences circulating retinol in adults with nonalcoholic fatty liver disease or obesity
by Mondul, Alison and Mancina, Rosellina M and Merlo, Andrea and Dongiovanni, Paola and Rametta, Raffaela and Montalcini, Tiziana and Valenti, Luca and Albanes, Demetrius and Romeo, Stefano
Journal of Nutrition, ISSN 0022-3166, 2015, Volume 145, Issue 8, pp. 1687 - 1691
Retinol is a lipid-soluble essential nutrient that is stored as retinyl esters in lipid droplets of hepatic stellate cells. Patatin-like phospholipase... 
PNPLA3 | Obesity | NAFLD | RBP4 | Retinol | Non-alcoholic Fatty Liver Disease - genetics | Membrane Proteins - genetics | Humans | Middle Aged | Overweight - genetics | Male | Lipase - metabolism | Genetic Variation | Non-alcoholic Fatty Liver Disease - blood | Overweight - blood | Female | Aged | Membrane Proteins - metabolism | Vitamin A - blood | Lipase - genetics | Vitamin A | Genetic aspects | Fatty liver | Lipase | Health aspects
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12. Full Text Effect of the replacement of dietary vegetable oils with a low dose of extravirgin olive oil in the Mediterranean Diet on cognitive functions in the elderly
by Mazza, Elisa and Fava, Antonietta and Ferro, Yvelise and Rotundo, Stefania and Romeo, Stefano and Bosco, Domenico and Pujia, Arturo and Montalcini, Tiziana and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
Journal of Translational Medicine, ISSN 1479-5876, 01/2018, Volume 16, Issue 1, pp. 10 - 10
Background: Numerous studies have investigated the role of the monounsaturated fatty acid and other dietary factors in the prevention of cognitive decline but... 
Extravirgin olive oil | Elderly | Cognitive functions | Mediterranean Diet | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | CAROTID ATHEROSCLEROSIS | DEMENTIA | ALZHEIMERS-DISEASE | PERFORMANCE | IMPAIRMENT | HABITS | LDL CHOLESTEROL | IMPACT | ASSOCIATION | Neuropsychological Tests | Olive Oil - pharmacology | Plant Oils - pharmacology | Diet, Mediterranean | Humans | Female | Male | Aged | Cognition - drug effects | Usage | Olive oil | Health aspects | Alzheimer Disease Assessment Scale | food quality | Article | cognitive defect | vegetable oil | extra virgin olive oil | Italian (citizen) | treatment duration | dietary intake | human | human experiment | cognition | disease course | Cell and Molecular Biology | aged | neuropsychological test | randomized controlled trial | controlled study | geriatric patient | neuroprotection | Cell- och molekylärbiologi
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13. Full Text Early effects of a hypocaloric, mediterranean diet on laboratory parameters in obese individuals
by Greco, Marta and Chiefari, Eusebio and Montalcini, Tiziana and Accattato, Francesca and Costanzo, Francesco S and Pujia, Arturo and Foti, Daniela and Brunetti, Antonio and Gulletta, Elio
Mediators of Inflammation, ISSN 0962-9351, 2014, Volume 2014, pp. 750860 - 8
Calorie restriction is a common strategy for weight loss in obese individuals. However, little is known about the impact of moderate hypocaloric diets on... 
METABOLIC SYNDROME | ADIPOKINE CONCENTRATIONS | INSULIN-RESISTANCE | EPIDERMAL-GROWTH-FACTOR | WEIGHT-LOSS | BODY-MASS INDEX | RANDOMIZED-TRIAL | LEPTIN RECEPTOR | IMMUNOLOGY | LOW-CARBOHYDRATE | ADIPOSE-TISSUE | CELL BIOLOGY | Body Mass Index | Obesity - diet therapy | Prospective Studies | Diet, Mediterranean | Caloric Restriction | Anthropometry | Humans | Middle Aged | Insulin Resistance | Male | Biomarkers - blood | Insulin - blood | Obesity - blood | Epidermal Growth Factor - blood | Adipokines - blood | Leptin - blood | Diet | L-Lactate Dehydrogenase - blood | Weight Loss | Female
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14. Full Text Influence of storage conditions on MALDI‐TOF MS profiling of gingival crevicular fluid: Implications on the role of S100A8 and S100A9 for clinical and proteomic based diagnostic investigations
by Preianò, Mariaimmacolata and Maggisano, Giuseppina and Lombardo, Nicola and Montalcini, Tiziana and Paduano, Sergio and Pelaia, Girolamo and Savino, Rocco and Terracciano, Rosa
PROTEOMICS, ISSN 1615-9853, 03/2016, Volume 16, Issue 6, pp. 1033 - 1045
Gingival crevicular fluid (GCF) may be a source of diagnostic biomarkers of periodontitis/gingivitis. However, peptide fingerprints may change, depending on... 
Biomarkers | Biomedicine | MALDI‐TOF‐MS | Peptidomics | Gingival crevicular fluid | MALDI-TOF-MS | WHOLE-SALIVA | ASSISTED-LASER-DESORPTION/IONIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | HPLC-ESI-MS | PERIODONTAL-DISEASE | IDENTIFICATION | SALIVARY PROTEOME | FLIGHT MASS-SPECTROMETRY | SAMPLE COLLECTION | SERUM PEPTIDOME | Cold Temperature | Calgranulin A - analysis | Trifluoroacetic Acid | Humans | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Gingival Crevicular Fluid - chemistry | Proteome - analysis | Proteome - chemistry | Calgranulin A - chemistry | Calgranulin B - analysis | Specimen Handling | Proteomics - methods | Calgranulin B - chemistry | Information storage and retrieval | Peptides | Investigations | Preservation | Change detection | Shelf life | Gingivitis | Molecular chains | Periodontal disease | Periodontitis | Trifluoroacetic acid | Reproducibility | Storage conditions | Paper | Diagnostic systems | In vitro methods and tests
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