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Journal Article
FASEB JOURNAL, ISSN 0892-6638, 03/2019, Volume 33, Issue 3, pp. 3437 - 3450
Sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) is a cholesterol sensor that plays a critical role in regulating... 
OXIDATIVE STRESS | ACTIVATION | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROPHAGE | LOW-DENSITY-LIPOPROTEIN | MECHANISMS | AMPK pathway | LESIONS | CELL BIOLOGY | REACTIVE OXYGEN | INFLAMMATION | ROS | BIOLOGY | foam cell | VSMC
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 04/2019, Volume 60, Issue 4, pp. 844 - 855
Fatty acid translocase cluster of differentiation (CD36) is a multifunctional membrane protein that facilitates the uptake of long-chain fatty acids. Lipophagy... 
autophagy | ACTIVATED PROTEIN-KINASE | UPSTREAM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROPHAGE | cluster of differentiation 36 | lipid droplets | LIVER AUTOPHAGY | hepatic steatosis | beta-oxidation | SIGNALING PATHWAY | INFLAMMATION | DISEASE | adenosine monophosphate-activated protein kinase | STEATOHEPATITIS | AUTOPHAGIC FLUX | REVEALS
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 03/2003, Volume 14, Issue 3, pp. 593 - 600
Previous studies have demonstrated that inflammatory cytokines such as interleukin-1beta (IL-1beta) promote lipid accumulation in human mesangial cells (HMC)... 
GAMMA | TANGIER-DISEASE | SCAVENGER RECEPTOR | GENE | LDL RECEPTOR | X RECEPTOR | CASSETTE TRANSPORTER 1 | LOW-DENSITY-LIPOPROTEIN | UROLOGY & NEPHROLOGY | ALPHA | INFLAMMATORY CYTOKINES
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e103071 - e103071
Journal Article
Journal of Gastroenterology and Hepatology, ISSN 0815-9319, 05/2012, Volume 27, Issue 5, pp. 974 - 984
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, pp. e0159512 - e0159512
Statins, which are revolutionized cholesterol-lowing agents, have been reported to have unfavorable effects on the liver. Inflammatory stress is a... 
OXIDATIVE STRESS | LIPID-PEROXIDATION | HIGH-FAT DIET | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MITOCHONDRIAL DYSFUNCTION | NONALCOHOLIC STEATOHEPATITIS | NRF2-NULL MICE | HEPATOTOXICITY | METABOLIC-DISORDERS | KNOCKOUT MICE | Liver - pathology | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Apolipoproteins E - deficiency | Male | RNA, Messenger - metabolism | Liver - drug effects | Caseins | NF-E2-Related Factor 2 - genetics | Chemical and Drug Induced Liver Injury - pathology | Atorvastatin Calcium - adverse effects | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Catalase - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Inflammation | Chemical and Drug Induced Liver Injury - genetics | Mice, Knockout | Catalase - metabolism | Animals | Chemical and Drug Induced Liver Injury - metabolism | Apolipoproteins E - genetics | NF-E2-Related Factor 2 - metabolism | Mice | Liver | Analysis | Nephrology | Lipid peroxidation | Risk factors | Antioxidants | Hepatitis | Toxicology | Casein | Education | Stresses | Enzymes | Cytokines | Injection | Metabolism | College campuses | Malondialdehyde | Hospitals | Infectious diseases | Diet | Fibrosis | Atorvastatin | Drugs | Oxidative stress | Reactive oxygen species | Laboratories | Toxicity | Lipids | Superoxide dismutase | mRNA | Research | Interleukin 6 | Fatty liver | Catalase | Apolipoprotein E | Rodents | Gastroenterology | Statins | Injuries | Adaptation | Alanine | Oral administration | Superoxide | Cholesterol | Steatosis | Alanine transaminase | Aspartate aminotransferase | Molecular biology | Index Medicus | Stress
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 08/2017, Volume 27, Issue 4, pp. 21 - 214
Aims: Cluster of differentiation 36 (CD36) is involved in the development of nonalcoholic steatohepatitis (NASH). Excess CD36 facilitates liver cells taking... 
Original Research Communications | MCP-1 | CD36 | NASH | ROS | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDIZED LDL | PALMITATE | INHIBITION | SCAVENGER RECEPTOR CD36 | INSULIN-RESISTANCE | LIVER | ENDOCRINOLOGY & METABOLISM | KUPFFER CELLS | MICE | STEATOHEPATITIS | Up-Regulation | CD36 Antigens - deficiency | CD36 Antigens - genetics | Reactive Oxygen Species - metabolism | Coculture Techniques | Humans | Hepatocytes - metabolism | Hepatocytes - cytology | Cell Nucleus - metabolism | Disease Models, Animal | Promoter Regions, Genetic | Non-alcoholic Fatty Liver Disease - genetics | Signal Transduction | Cells, Cultured | THP-1 Cells | Chemokine CCL2 - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Macrophages - cytology | Gene Knockout Techniques | Hep G2 Cells | Macrophages - metabolism | Animals | Mice | Histone Deacetylase 2 - metabolism | Histones - metabolism | Cell Movement | Histones | Monocytes | Inflammation | Research | Gene expression | Macrophages | Histone deacetylase | Reactive oxygen species | Hydrogen peroxide | Leukocyte migration | Liver | Innovations | Inflammatory response | Reduction | Fatty liver | Clonal deletion | Rodents | Transcription activation | Clusters | Deletion | HDAC2 protein | Liver diseases | CD36 antigen | Fatty acids | Promoters | Steatosis | Hepatocytes | Fibrosis | Infiltration | Differentiation | Monocyte chemoattractant protein 1 | Cell migration | Index Medicus
Journal Article
Nature Reviews Nephrology, ISSN 1759-5061, 12/2009, Volume 5, Issue 12, p. 713
When the 'lipid nephrotoxicity hypothesis' was proposed in 1982, it brought together several disparate experimental findings in hyperlipidemia and renal... 
Care and treatment | Usage | Physiological aspects | Kidney diseases | Diagnosis | Research | Lipid metabolism | Health aspects | Risk factors | Statins
Journal Article
Journal Article
Journal of Gastroenterology and Hepatology, ISSN 0815-9319, 05/2011, Volume 26, Issue 5, pp. 875 - 883
Journal Article
Scientific Reports, ISSN 2045-2322, 10/2015, Volume 5, Issue 1, pp. 14959 - 14959
Insulin resistance is closely related to inflammatory stress and the mammalian target of rapamycin/S6 kinase (mTOR/S6K) pathway. The present study investigated... 
C-REACTIVE PROTEIN | DIABETES-MELLITUS | MAMMALIAN TARGET | HEPATIC GLUCONEOGENESIS | AMINO-ACID | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | GLUCOSE-UPTAKE | BETA-CELL FUNCTION | ADIPOSE-TISSUE | RECEPTOR SUBSTRATE-1 | Cell Line | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Mice, Inbred C57BL | Male | Insulin Receptor Substrate Proteins - metabolism | 3T3-L1 Cells | Sirolimus - pharmacology | Blotting, Western | Hep G2 Cells | Tumor Necrosis Factor-alpha - pharmacology | Inflammation - metabolism | Insulin-Secreting Cells - metabolism | Animals | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Insulin Resistance - physiology | Mice | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Immunosuppressive Agents - pharmacology | Inflammation - physiopathology | TOR protein | Phosphorylation | Serine | Liver | AKT protein | Adipocytes | Glucose | Interleukin 6 | Glucose metabolism | Signal transduction | Hyperglycemia | Casein | Rodents | Tumor necrosis factor-TNF | Pancreas | Gluconeogenesis | Rapamycin | Inflammation | Tumor necrosis factor-α | Insulin | Myoblasts | Glucose tolerance | Intolerance | Insulin receptor substrate 1 | Hepatocytes | Insulin resistance | Apoptosis | Index Medicus
Journal Article