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Journal Article
by van Rheenen, Wouter and Shatunov, Aleksey and Dekker, Annelot M and McLaughlin, Russell L and Diekstra, Frank P and Pulit, Sara L and van der Spek, Rick A. A and Võsa, Urmo and de Jong, Simone and Robinson, Matthew R and Yang, Jian and Fogh, Isabella and van Doormaal, Perry Tc and Tazelaar, Gijs H. P and Koppers, Max and Blokhuis, Anna M and Sproviero, William and Jones, Ashley R and Kenna, Kevin P and van Eijk, Kristel R and Harschnitz, Oliver and Schellevis, Raymond D and Brands, William J and Medic, Jelena and Menelaou, Anoniki and Vajda, Alice and Ticozzi, Nicola and Lin, Kuang and Rogelj, Boris and Vrabec, Katarina and Ravnik-Glavač, Metka and Koritnik, Blaž and Zidar, Janez and Leonardis, Lea and Grošelj, Leja Dolenc and Millecamps, Stéphanie and Salachas, François and Meininger, Vincent and de Carvalho, Mamede and Pinto, Susana and Mora, Jesus S and Rojas-García, Ricardo and Polak, Meraida and Chanan, Siddharthan and Colville, Shuna and Swingler, Robert and Morrison, Karen E and Shaw, Pamela J and Hardy, John and Orrell, Richard W and Pittman, Alan and Sidle, Katie and Fratta, Pietro and Malaspina, Anea and Topp, Simon and Petri, Susanne and Abdulla, Susanne and pper, Carsten and Sendtner, Michael and Meyer, Thomas and Ophoff, Roel A and Staats, Kim A and Wiedau-Pazos, Martina and Lomen-Hoerth, Catherine and van Deerlin, Vivianna M and Trojanowski, John Q and Elman, Lauren and McCluskey, Leo and Basak, A. Nazli and Tunca, Ceren and Hamzeiy, Hamid and Parman, Yesim and Meitinger, Thomas and Lichtner, Peter and Radivojkov-Blagojevic, Milena and Anes, Christian R and Maurel, Cindy and Bensimon, Gilbert and Landwehrmeyer, Bernhard and Brice, Alexis and Payan, Christine A. M and Saker-Delye, Safaa and Dürr, Alexana and Wood, Nicholas W and Tittmann, Lukas and Lieb, Wolfgang and Franke, Ane and Rietschel, Marcella and Cichon, Sven and Nöthen, Markus M and Amouyel, Philippe and Tzourio, Christophe and Dartigues, Jean-François and Uitterlinden, Ane G and Rivadeneira, Fernando and Estrada, Karol and Hofman, Albert and Curtis, Charles and Blauw, Hylke M and van der Kooi, Anneke J and ... and PARALS Registry and FALS Sequencing Consortium and SLALOM Grp and SLAGEN Consortium and NNIPPS Study Grp and SLAP Registry and SLALOM Group and NNIPPS Study Group and Medicinska fakulteten and Institutionen för farmakologi och klinisk neurovetenskap and Klinisk neurovetenskap and Umeå universitet
Nature genetics, ISSN 1061-4036, 2016, Volume 48, Issue 9, pp. 1043 - 1048
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 5931 - 8
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects 1 in similar to 350 individuals. Genetic association studies have... 
GENETIC-VARIATION | PLINK | MULTIDISCIPLINARY SCIENCES | INJURY | POWER | ANALYSES IDENTIFY | LINKAGE | HEXANUCLEOTIDE REPEAT | ASSOCIATION | C9ORF72 | STRATEGIES | Nek1 protein | Statistical analysis | Genotyping | Neurodegenerative diseases | Amyotrophic lateral sclerosis | Heritability | Genomes | Genetic diversity | Variation | Sclerosis
Journal Article
European Journal of Human Genetics, ISSN 1018-4813, 10/2018, Volume 26, Issue 10, pp. 1537 - 1546
The most recent genome-wide association study in amyotrophic lateral sclerosis (ALS) demonstrates a disproportionate contribution from low-frequency variants... 
POPULATION | DIAGNOSIS | METAANALYSIS | PROTEIN | RARE VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | ALS | WIDE ASSOCIATION | MUTATIONS | HEXANUCLEOTIDE REPEAT | C9ORF72 | Nucleotide sequence | Gene frequency | Alleles | Data processing | Amyotrophic lateral sclerosis | Genomes | Genetic diversity | Sclerosis | Index Medicus
Journal Article
Journal Article
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, ISSN 2167-8421, 07/2018, Volume 19, Issue 5-6, pp. 321 - 330
Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease that causes skeletal muscle weakness, including muscles involved with... 
pulmonary function tests | slow vital capacity | Non-invasive ventilation | amyotrophic lateral sclerosis | NASAL INSPIRATORY PRESSURE | CLINICAL-TRIAL | PHRENIC-NERVE | CLINICAL NEUROLOGY | OBSTRUCTIVE PULMONARY-DISEASE | MUSCLE STRENGTH | NEUROMUSCULAR DISEASE | QUALITY-OF-LIFE | NONINVASIVE VENTILATION | PREDICT SURVIVAL
Journal Article
Amyotrophic lateral sclerosis & frontotemporal degeneration, ISSN 2167-8421, 07/2019, pp. 1 - 10
To assess masitinib in the treatment of ALS. Double-blind study, randomly assigning 394 patients (1:1:1) to receive riluzole (100 mg/d) plus placebo or... 
Index Medicus
Journal Article
by Lenglet, T and Lacomblez, L and Abitbol, J. L and Ludolph, A and Mora, J. S and Robberecht, W and Shaw, P. J and Pruss, R. M and Cuvier, V and Meininger, V and Meininger, Vincent and Lacomblez, Pr Lucette and Salachas, François and Bruneteau, Gaëlle and Pradat, Pierre‐François and Lenglet, Timothée and Lebouteux, Marie and Pibiri, Vanessa and Pouget, Jean and Verschueren, Annie and Campana‐Salort, Emmanuelle and Attarian, Sharam and Couratier, Philippe and Nicolaud, Blerta and Lautrette, Géraldine and Camu, William and Morales, Raoul and Pageot, Nicolas and Desnuelle, Claude and Soriani, Marie‐Hélène and Delmont, Emilien and Destee, Alain and Danel‐Brunaud, Véronique and Devos, David and Vandenberghe, Nadia and Broussolle, Emmanuel and Vial, Christophe and Díaz, Rubén Martires Blanco and Bouhour, Françoise and Mora Pardina, Jesús S and Chaverri, Delia and Mascías, Javier and Hernández, María and Marín, Saul and Salas, Teresa and Moran, Yolanda and Robberecht, Wim and Damme, Philip and Demeestere, Jelle and Al‐Chalabi, Ammar and Leigh, Nigel and Guevara, Carlos and Dimitrov, Nikolay and Wijesekera, Lokesh and Shaw, Pamela and McDermott, Christopher J and Rafiq, Muhammad and Ludolph, Albert and Dorst, Johannes and Waibel, Stefan and Weiland, Ulriche and Hendrich, Corinna and Dengler, Reinhardt and Petri, Suzanne and Kollewe, Katja Maureen and Schmalbach, Sonja and Cordes, Anna‐Lena and Rath, Klaus and Bonzel, Linda and Bolat, Seza and Meyer, Thomas and Maier, André and Dullinger, Jörn and Linke, Peter and Holm, Teresa and Borisow, Nadja and Zierz, Stephan and Hanisch, Frank and Mitotarget Study Grp and Mitotarget study group and the Mitotarget study group
European Journal of Neurology, ISSN 1351-5101, 03/2014, Volume 21, Issue 3, pp. 529 - 536
Journal Article
by McLaughlin, Russell L and Schijven, Dick and van Rheenen, Wouter and van Eijk, Kristel R and O'Brien, Margaret and Kahn, René S and Ophoff, Roel A and Goris, An and Bradley, Daniel G and Al-Chalabi, Ammar and van den Berg, Leonard H and Luykx, Jurjen J and Hardiman, Orla and Veldink, Jan H and Shatunov, Aleksey and Dekker, Annelot M and Diekstra, Frank P and Pulit, Sara L and van der Spek, Rick A. A and van Doormaal, Perry T. C and Sproviero, William and Jones, Ashley R and Nicholson, Garth A and Rowe, Dominic B and Pamphlett, Roger and Kiernan, Matthew C and Bauer, Denis and Kahlke, Tim and Williams, Kelly and Eftimov, Filip and Fogh, Isabella and Ticozzi, Nicola and Lin, Kuang and Millecamps, Stéphanie and Salachas, François and Meininger, Vincent and de Carvalho, Mamede and Pinto, Susana and Mora, Jesus S and Rojas-García, Ricardo and Polak, Meraida and Chanan, Siddharthan and Colville, Shuna and Swingler, Robert and Morrison, Karen E and Shaw, Pamela J and Hardy, John and Orrell, Richard W and Pittman, Alan and Sidle, Katie and Fratta, Pietro and Malaspina, Anea and Petri, Susanne and Abdulla, Susanna and pper, Carsten and Sendtner, Michael and Meyer, Thomas and Wiedau-Pazos, Martina and Lomen-Hoerth, Catherine and van Deerlin, Vivianna M and Trojanowski, John Q and Elman, Lauren and McCluskey, Leo and Basak, Nazli and Meitinger, Thomas and Lichtner, Peter and Blagojevic-Radivojkov, Milena and Anes, Christian R and Maurel, Cindy and Bensimon, Gilbert and Landwehrmeyer, Bernhard and Brice, Alexis and Payan, Christine A. M and Saker-Delye, Safa and Dürr, Alexana and Wood, Nicholas and Tittmann, Lukas and Lieb, Wolfgang and Franke, Ane and Rietschel, Marcella and Cichon, Sven and Nöuthen, Markus M and Amouyel, Philippe and Tzourio, Christophe and Dartigues, Jean-François and Uitterlinden, Ane G and Rivadeneira, Fernando and Estrada, Karol and Hofman, Albert and Curtis, Charles and van der Kooi, Anneke J and de Visser, Marianne and Weber, Markus and Shaw, Christopher E and Smith, Bradley N and Pansarasa, Orietta and Cereda, Cristina and del Bo, Roberto and Comi, Giacomo P and D'alfonso, Sana and ... and Project MinE GWAS Consortium and Schizophrenia Working Grp Psychiat and Schizophrenia Working Group of the Psychiatric Genomics Consortium
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 14774 - 14774
Journal Article