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STEM CELLS Translational Medicine, ISSN 2157-6564, 02/2017, Volume 6, Issue 2, pp. 382 - 393
Iatrogenic tumorigenesis is a major limitation for the use of human induced pluripotent stem cells (hiPSCs) in hematology. The teratoma risk comes from the... 
Thymidine kinase | Teratoma | Survivin inhibitor | Hematology | Induced pluripotent stem cells | Hematopoietic stem cell | Regenerative medicine | Safety | Suicide gene | iCaspase‐9 | Teratoma x Hematology | iCaspase-9 | TUMORIGENICITY | CELL & TISSUE ENGINEERING | INHIBITION | EMBRYONIC STEM-CELLS | TARGETS | Caspase 9 - genetics | Caspase 9 - metabolism | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Hematologic Diseases - surgery | Hematopoietic Stem Cells - pathology | Tacrolimus - analogs & derivatives | Regenerative Medicine - methods | Teratoma - metabolism | Dose-Response Relationship, Drug | Time Factors | Cell Transformation, Neoplastic - genetics | Hematopoietic Stem Cell Transplantation - adverse effects | Tacrolimus - pharmacology | Induced Pluripotent Stem Cells - metabolism | Hematopoietic Stem Cells - drug effects | Induced Pluripotent Stem Cells - pathology | Survivin - metabolism | Cell Line | Genes, Transgenic, Suicide | Induced Pluripotent Stem Cells - drug effects | Risk Assessment | Teratoma - prevention & control | Induced Pluripotent Stem Cells - transplantation | Naphthoquinones - pharmacology | Survivin - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Imidazoles - pharmacology | Tumor Burden | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Xenograft Model Antitumor Assays | Phenotype | Teratoma - pathology | Animals | Teratoma - genetics | Mice, Inbred NOD | Cell Transformation, Neoplastic - drug effects | Hematopoietic Stem Cell Transplantation - methods | Cell Transformation, Neoplastic - pathology | Flow cytometry | Transplants & implants | Toxicity | Stem cell transplantation | Thymidine | Kinases | Suicide | Ganciclovir | Reporter gene | Efficiency | Population | Tumorigenesis | Suicide genes | CD34 antigen | Repopulation | Caspase | Injection | Survivin | Cell differentiation | Gene expression | Embryos | Hemopoiesis | Medicine | Regeneration | Stem cells | Pluripotency | Cancer | Apoptosis | Pluripotent Stem Cells | Translational s and Reviews
Journal Article
Translational Oncology, ISSN 1936-5233, 11/2019, Volume 12, Issue 11, pp. 1395 - 1403
Tumor-released extracellular vesicles (EVs) contain tumor-specific cargo distinguishing them from healthy EVs, and making them eligible as circulating... 
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 04/2017, Volume 31, Issue 4, pp. 1531 - 1546
Journal Article
Molecular Cancer, ISSN 1476-4598, 10/2012, Volume 11, Issue 1, pp. 81 - 81
Background: Pancreatic ductal adenocarcinoma is a deadly malignancy resistant to current therapies. It is critical to test new strategies, including... 
Pancreatic adenocarcinoma | Targeted therapy | Surface marker | SYSTEM | THERAPY | CANCER CELLS | ONCOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSDUCTION | LENTIVIRAL VECTORS | DELIVERY | Gene Targeting - methods | Luciferases - metabolism | Humans | Green Fluorescent Proteins - genetics | Viral Proteins - metabolism | Carcinoma, Pancreatic Ductal - genetics | Drug Delivery Systems | Luciferases - genetics | Claudins - metabolism | Antigens, Surface - metabolism | Ganciclovir - pharmacology | Lentivirus - genetics | Claudins - genetics | Gene Transfer Techniques | Green Fluorescent Proteins - metabolism | Thymidine Kinase - genetics | Mucin-4 - metabolism | Viral Proteins - genetics | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - therapy | Mice, SCID | Mucin-4 - genetics | Xenograft Model Antitumor Assays | Animals | Thymidine Kinase - metabolism | Cell Line, Tumor | Mice | Genetic Therapy - methods | Pancreatic Neoplasms - therapy | Adenocarcinoma | Antigens | Medical equipment and supplies industry | Medical test kit industry | Genes | Fluorescence | Proteins | Analysis | Pancreatic cancer | Genetic research | Genetic aspects | Gene therapy | Health aspects | Biotechnology industry | Cancer | Studies | Stem cells | Kinases | Cancer therapies | Prostate cancer | Tumors | Apoptosis | Life Sciences | Biochemistry, Molecular Biology | Genomics
Journal Article
Cancers, ISSN 2072-6694, 10/2019, Volume 11, Issue 11, p. 1656
Purpose: Expediting the diagnosis of pancreatic ductal adenocarcinoma (PDAC) would benefit care management, especially for the start of treatments requiring... 
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2019, Volume 517, Issue 4, pp. 677 - 683
Primary hyperoxaluria type 1 (PH1) is an inherited metabolic disorder caused by a deficiency of the peroxisomal enzyme alanine-glyoxylate aminotransferase... 
Hyperoxaluria | Genome editing | AAVS1 locus | CRISPR/Cas9 | Induced pluripotent stem cells | Hepatic differentiation | Enzymes | Liver | Genes | Genomics | Transplantation | Cell differentiation | Immunosuppressive agents | Anopheles | Codon | Oxalic acid | Stem cells | Genetic research | Oxalates | Gene therapy | Health aspects
Journal Article
Journal Article
Stem cells translational medicine, ISSN 2157-6564, 09/2016
: Iatrogenic tumorigenesis is a major limitation for the use of human induced pluripotent stem cells (hiPSCs) in hematology. The teratoma risk comes from the... 
Journal Article
Molecular Cancer, ISSN 1476-4598, 07/2013, Volume 12, Issue 1, pp. 83 - 83
Journal Article
FEBS Letters, ISSN 0014-5793, 2006, Volume 580, Issue 16, pp. 3845 - 3852
Oxidative stress is known to produce tissue injury and to activate various signaling pathways. To investigate the molecular events linked to acute oxidative... 
Cell proliferation | Oxidative stress | Paraquat | Gene expression | Extracellular signal-regulated kinases | Necrosis | guanine nucleotide binding protein alpha sub-unit | serine protease inhibitor | TBS | 5-bromo-2′-deoxyuridine | MAPK | PI 2 | Tris buffered saline | mitogen-activated protein kinase | ERKs | Wt1 | ROS | reactive oxygen species | Wilm's tumor homolog | BrdU | extracellular signal-related kinases | PROGENITOR CELLS | PARTIAL-HEPATECTOMY | APOPTOSIS | extracellular signal-regulated kinases | ACTIVATION | paraquat | cell proliferation | RAT HEPATOCYTES | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | P38 KINASE | CELL BIOLOGY | BIOPHYSICS | necrosis | GENE-EXPRESSION | MICE | oxidative stress | gene expression | PARAQUAT TOXICITY | Phosphorylation | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Oxidative Stress | Liver - metabolism | Mice, Inbred C57BL | Genes - genetics | Bromodeoxyuridine | Up-Regulation - genetics | Alanine Transaminase - blood | Extracellular Signal-Regulated MAP Kinases - metabolism | Animals | Liver - drug effects | Time Factors | Cyclic AMP Response Element-Binding Protein - metabolism | DNA - biosynthesis | Liver - cytology | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Paraquat - pharmacology | bcl-X Protein - metabolism | Liver Regeneration - drug effects | Herbicides | Purines | Protease inhibitors | Liver | Thrombin | G proteins | Protein kinases | Protein binding
Journal Article
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