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Seikagaku, ISSN 0037-1017, 2016, Volume 88, Issue 4, pp. 511 - 515
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76280 - e76280
Selective free fatty acid receptor 1 (FFAR1)/GPR40 agonist fasiglifam (TAK-875), an antidiabetic drug under phase 3 development, potentiates insulin secretion... 
STIMULATED INSULIN-SECRETION | GPR40 AGONIST | GLUCOSE | MULTIDISCIPLINARY SCIENCES | DOUBLE-BLIND | PANCREATIC BETA-CELLS | TAK-875 | IDENTIFICATION | FREE FATTY-ACID | RECEPTOR 1 AGONIST | DISCOVERY | Sulfones - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Benzofurans - pharmacology | Male | Diabetes Mellitus, Type 2 - metabolism | Receptors, G-Protein-Coupled - agonists | Sulfones - pharmacology | Fatty Acids, Nonesterified - metabolism | Insulin Secretion | gamma-Linolenic Acid - metabolism | Allosteric Regulation - drug effects | Hypoglycemic Agents - therapeutic use | Cell Line | Cricetinae | Benzofurans - therapeutic use | Drug Partial Agonism | Rats | Hypoglycemic Agents - pharmacology | Insulin - metabolism | Animals | Mice | Receptors, G-Protein-Coupled - genetics | Mutation | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Pancreatic beta cells | Gene mutations | Linolenic acids | Glucose | Insulin | Dextrose | Diabetes therapy | Nervous system | Calcium influx | Proteins | Allosteric properties | Rodents | Pharmaceutical industry | Pancreas | Diabetes mellitus (non-insulin dependent) | Research & development--R&D | Secretion | Diabetes mellitus | Cloning | Health risks | Pharmacology | Hypoglycemia | Metabolism | Patients | Fatty acids | Lipolysis | Linolenic acid | Plasmids | Cell lines | Ligands | Diabetes | Binding sites | Calcium ions | Index Medicus | Research & development | R&D
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, pp. e0118510 - e0118510
Various types of antipsychotics have been developed for the treatment of schizophrenia since the accidental discovery of the antipsychotic activity of... 
DOPAMINE-RECEPTOR | NMDA CURRENTS | IMMEDIATE-EARLY GENE | ACTIVATION | MESSENGER-RNA | FOS EXPRESSION | MULTIDISCIPLINARY SCIENCES | SCHIZOPHRENIA | GROWTH-FACTOR | STRIATAL NEURONS | AMPHETAMINE | Methamphetamine - pharmacology | Phencyclidine - pharmacology | Benzodiazepines - pharmacology | Hallucinogens - administration & dosage | Hallucinogens - pharmacology | Receptors, Dopamine D2 - agonists | Haloperidol - administration & dosage | Gene Expression Profiling - methods | Receptors, Dopamine D2 - genetics | Antipsychotic Agents - administration & dosage | Brain - drug effects | Gene Expression Regulation - drug effects | Animals | Aripiprazole - pharmacology | Methamphetamine - administration & dosage | Aripiprazole - administration & dosage | Dizocilpine Maleate - administration & dosage | Benzodiazepines - administration & dosage | Phencyclidine - administration & dosage | Mice | Antipsychotic Agents - pharmacology | Dizocilpine Maleate - pharmacology | Haloperidol - pharmacology | Drugs | Schizophrenia | Antipsychotic drugs | Genetic transcription | Brain | Drug abuse | Neurosciences | Neuroleptics | Olanzapine | Transcription | Fingerprints | Mental disorders | Glutamic acid receptors (ionotropic) | Homology | Antagonists | Haloperidol | Aripiprazole | Drug development | Kinases | Experiments | Chlorpromazine | Sulpiride | Psychotropic drugs | MK-801 | Phencyclidine | Methamphetamines | Rodents | Neostriatum | Pharmaceutical industry | Dopamine D2 receptors | Drug dosages | Neurochemistry | Dopamine | Serotonin | Research & development--R&D | Methamphetamine | N-Methyl-D-aspartic acid receptors | Pharmacology | Clozapine | Metabolism | Gene expression | Nucleus accumbens | Quinpirole | Immediate-early proteins | Hypotheses | Brain research | Laboratory animals | Animal cognition | Index Medicus | Research & development | R&D
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 7132 - 14
Journal Article
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN 0721-832X, 4/2018, Volume 256, Issue 4, pp. 751 - 757
This study investigates the possible role of the filtration bleb in the continuous decrease in corneal endothelial cell (CEC) density observed following... 
Trabeculectomy | Ophthalmology | Medicine & Public Health | Specular microscopy | Corneal endothelial cell | CELL-DENSITY | MITOMYCIN-C | OPHTHALMOLOGY | GLAUCOMA | Glaucoma | Microscope and microscopy | Analysis | Endothelium | Eye | Cornea | Filtration | Microscopy | Endothelial cells | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2017, Volume 127, Issue 11, pp. 4136 - 4147
Journal Article
Journal Article
Sensors (Basel, Switzerland), ISSN 1424-8220, 10/2018, Volume 18, Issue 11, p. 3642
We have developed a direct time-of-flight (TOF) 250 m ranging Complementary Metal Oxide Semiconductor (CMOS) image sensor (CIS) based on a 688 x 384 pixels... 
ranging | vertical avalanche photodiode | avalanche photodiode | CMOS image sensor | photon counting | time-of-flight | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | INSTRUMENTS & INSTRUMENTATION
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2019, Volume 294, Issue 30, pp. 11513 - 11524
Dysfunction of tight junctions is a critical step during the initial stage of tumor progression. Trophoblast cell surface antigen 2 (Trop-2) belongs to the... 
METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | transmembrane glycoprotein | DOWN-REGULATION | protein phosphorylation | trophoblast cell surface antigen 2 (Trop-2) | IDENTIFICATION | cell motility | INVASIVENESS | INVASION | CARCINOGENESIS | protein kinase C (PKC) | cell adhesion | cell signaling | cancer | claudin-7 | EXPRESSION | CARCINOMA | tight junction | Index Medicus
Journal Article
BBA - General Subjects, ISSN 0304-4165, 06/2014, Volume 1840, Issue 6, p. 1790
Galectin-3 is expressed in a variety of tumors and its expression level is related with tumor progression. Aberrant expression of MUC1 in various tumors is... 
Mucins
Journal Article
Chemistry Letters, ISSN 0366-7022, 4/2017, Volume 46, Issue 4, pp. 453 - 455
A simple and ubiquitous nickel(II) complex NiCl2(PPh3)2 catalyzes polymerization of oligothiophenes. Treatment of chlorobithiophene with chloromagnesium... 
Chlorinated oligothiophene | NiCl | PPh | Poly(3-hexylthiophene) (P3HT)
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e90134 - e90134
Many drugs of abuse and most neuropharmacological agents regulate G protein-coupled receptors (GPCRs) in the central nervous system (CNS)_ENREF_1. The... 
ATYPICAL ANTIPSYCHOTIC-DRUGS | MULTIDISCIPLINARY SCIENCES | DOPAMINE D1 RECEPTORS | LATERAL HABENULA | SCHIZOPHRENIA | SYNAPTIC TRANSMISSION | NUCLEOTIDE-GATED CHANNELS | EXPRESSION | NEURON | OLFACTORY GLOMERULI | TRANSGENIC MICE | Receptors, G-Protein-Coupled - metabolism | Dopaminergic Neurons - pathology | Humans | Transcriptome | Molecular Sequence Data | Gene Expression Profiling | Receptors, Dopamine D2 - metabolism | Corpus Striatum - metabolism | Emotions - drug effects | Receptors, Dopamine D1 - metabolism | Psychotic Disorders - physiopathology | Dopaminergic Neurons - metabolism | Conserved Sequence | Dopaminergic Neurons - drug effects | Reserpine - pharmacology | Behavior, Animal - drug effects | Amino Acid Sequence | Ventral Tegmental Area - drug effects | Corpus Striatum - physiopathology | Signal Transduction | Ventral Tegmental Area - physiopathology | Gene Expression Regulation | Mice, Transgenic | Cognition - drug effects | Receptors, Dopamine D2 - genetics | Psychotic Disorders - metabolism | Psychotic Disorders - genetics | Animals | Ventral Tegmental Area - metabolism | Corpus Striatum - drug effects | Mice | Psychotic Disorders - drug therapy | Receptors, G-Protein-Coupled - genetics | Antipsychotic Agents - pharmacology | Receptors, Dopamine D1 - genetics | Genetic engineering | Antipsychotic drugs | G proteins | Mental illness | Health aspects | Drugs | Drug abuse | Basal ganglia | Neuroleptics | G protein-coupled receptors | Target recognition | Transcription | Mental disorders | Coupling agents | Laboratories | Central nervous system | Disorders | Cognitive ability | Schizophrenia | Drug development | Proteins | Psychosis | Psychotropic drugs | Receptors | Methamphetamines | Transgenic animals | Rodents | Neostriatum | Physiology | Trends | Pharmaceutical industry | Dopamine D2 receptors | Reserpine | Dopamine receptors | Ventral tegmentum | Dopamine | Research & development--R&D | Transgenic mice | Behavior disorders | Metabolism | Gene expression | Ganglia | Vertebrates | Dopamine D1 receptors | Liquid oxygen | Ligands | Glutamatergic transmission | Index Medicus | Research & development | R&D
Journal Article