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2010, Drugs and the pharmaceutical sciences, ISBN 1420086685, Volume 194, xvi, 471
Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development presents the work of an international group of leading experts in drug... 
Biotechnologie pharmaceutique | Biopharmaceutics | Drug Design & Development | Pharmaceutical biotechnology
Book
2010, Drugs and the pharmaceutical sciences, ISBN 1420086685, Volume 194.
Web Resource
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 11/2013, Volume 102, Issue 11, pp. 3998 - 4008
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 2, pp. 239 - 246
This present study aimed to determine the optimal oral insulin delivery conditions that would maximize the utility of cell-penetrating peptides (CPPs) by using... 
insulin | penetratin | cell-penetrating peptide | oral delivery | intermolecular interaction | Intermolecular interaction | Penetratin | Insulin | Oral delivery | Cell-penetrating peptide | DRUG-DELIVERY | ANALOGS | BASAL INSULINS | INTESTINAL EPITHELIUM | SYSTEMS | PHARMACOLOGY & PHARMACY | ABSORPTION | PERMEATION | Surface Plasmon Resonance | Gastric Acid - chemistry | Histamine H2 Antagonists - pharmacology | Insulin, Regular, Human - genetics | Stereoisomerism | Intestinal Absorption - drug effects | Cell-Penetrating Peptides - pharmacokinetics | Insulin, Regular, Human - pharmacology | Biological Availability | Male | Recombinant Proteins - pharmacokinetics | Drug Delivery Systems | Dose-Response Relationship, Drug | Gastric Acid - secretion | Cell-Penetrating Peptides - pharmacology | Hypoglycemic Agents - administration & dosage | Carrier Proteins - pharmacology | Carrier Proteins - administration & dosage | Gastric Mucosa - drug effects | Carrier Proteins - chemistry | Animals, Outbred Strains | Cell-Penetrating Peptides - chemistry | Hypoglycemic Agents - pharmacokinetics | Administration, Oral | Recombinant Proteins - pharmacology | Insulin, Regular, Human - pharmacokinetics | Recombinant Proteins - administration & dosage | Hypoglycemic Agents - pharmacology | Drug Synergism | Insulin, Regular, Human - administration & dosage | Animals | Gastric Mucosa - secretion | Ligands | Mice | Cell-Penetrating Peptides - administration & dosage | Famotidine - pharmacology | Carrier Proteins - pharmacokinetics | Absorption | Peptides | Oral administration | Exploration | Strategy | Surface plasmon resonance | In vivo methods and tests | pH effects | Optimization
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 4, pp. 546 - 554
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 06/2013, Volume 53, Issue 6, pp. 654 - 661
We investigated the mechanisms of ritonavir‐mediated enhancement effect on the pharmacokinetics of saquinavir using in vivo probes for CYP3A4 (midazolam),... 
boosting | midazolam | fexofenadine | ritonavir | saquinavir | Saquinavir | Boosting | Fexofenadine | Midazolam | Ritonavir | HIV PROTEASE INHIBITORS | PHARMACODYNAMICS | PREDICTION | MICRODOSE | POLYMORPHISMS | METABOLISM | DIGOXIN | CACO-2 CELL MONOLAYERS | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | PROTEIN-2 | Intestines - drug effects | Liver - enzymology | Area Under Curve | Humans | Male | Organic Anion Transporters - metabolism | Dose-Response Relationship, Drug | HIV Protease Inhibitors - pharmacology | Young Adult | Tandem Mass Spectrometry | Drug Interactions | Liver - drug effects | HIV Protease Inhibitors - pharmacokinetics | Chromatography, Liquid | Adult | Ritonavir - pharmacology | Terfenadine - pharmacokinetics | Ritonavir - administration & dosage | Terfenadine - analogs & derivatives | HIV Protease Inhibitors - administration & dosage | Midazolam - pharmacokinetics | Cross-Over Studies | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Saquinavir - pharmacokinetics | Liver-Specific Organic Anion Transporter 1 | Organic Anion Transporters - drug effects | Pravastatin - pharmacokinetics | Intestines - enzymology | Physiological aspects | Research | Analysis | Drug interactions
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 5, pp. 811 - 814
In previous studies we showed that the complexation hydrogels based in poly(methacrylic acid-g-ethylene glycol) [P(MAA-g-EG)] rapidly release insulin in the... 
intestinal absorption | insulin | cell-penetrating peptide | complexation hydrogel | oral delivery | Complexation hydrogel | Intestinal absorption | Insulin | Oral delivery | Cell-penetrating peptide | RATS | SYSTEMS | PHARMACOLOGY & PHARMACY | POLYMER HYDROGELS | ABSORPTION | Rats, Wistar | Cell-Penetrating Peptides - pharmacokinetics | Drug Carriers - administration & dosage | Ileum - metabolism | Hydrogels - pharmacokinetics | Male | Insulin - blood | Drug Carriers - chemistry | Intestinal Absorption | Hypoglycemic Agents - blood | Hypoglycemic Agents - administration & dosage | Hydrogels - administration & dosage | Oligopeptides - chemistry | Cell-Penetrating Peptides - chemistry | Hypoglycemic Agents - pharmacokinetics | Blood Glucose - analysis | Administration, Oral | Oligopeptides - pharmacokinetics | Ethylene Glycol - pharmacokinetics | Insulin - administration & dosage | Hypoglycemic Agents - chemistry | Polymethacrylic Acids - chemistry | Animals | Insulin - chemistry | Polymethacrylic Acids - pharmacokinetics | Drug Liberation | Ethylene Glycol - chemistry | Drug Carriers - pharmacokinetics | Oligopeptides - administration & dosage | Cell-Penetrating Peptides - administration & dosage | Insulin - pharmacokinetics | Hydrogels - chemistry | Complexation | Ethylene glycol | Hydrogels | Peptides | Macromolecules | Crosslinking | Methacrylic acid | Glucose | pH effects | Absorption | Arginine | Intestine | Polyethylene glycol | Strategy
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2016, Volume 113, Issue 27, pp. 7632 - 7637
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 02/2013, Volume 102, Issue 2, pp. 469 - 479
Our recent work has shown that the intestinal absorption of insulin can be improved significantly by coadministration of cell-penetrating peptides (CPPs),... 
molecular orbital analysis | insulin | bioavailability | self-organizing map | intestinal absorption | penetratin | cell-penetrating peptide | multivariate analysis | absorption enhancer | simulations | self‐organizing map | cell‐penetrating peptide | Simulations | Penetratin | Self-organizing map | Absorption enhancer | Bioavailability | Intestinal absorption | Multivariate analysis | Insulin | Molecular orbital analysis | Cell-penetrating peptide | CHEMISTRY, MEDICINAL | ANTENNAPEDIA HOMEODOMAIN | CLASSIFICATION | MECHANISMS | ENDOCYTOSIS | CHEMISTRY, MULTIDISCIPLINARY | PROTEIN TRANSDUCTION | P-GLYCOPROTEIN | INTERNALIZATION | INTRACELLULAR DELIVERY | PHARMACOLOGY & PHARMACY | ABSORPTION | 3RD HELIX | Recombinant Proteins - metabolism | Amino Acid Sequence | Sequence Analysis, Protein - methods | Humans | Intestinal Absorption - drug effects | Molecular Sequence Data | Rats | Insulin - administration & dosage | Male | Recombinant Proteins - genetics | Rats, Sprague-Dawley | Recombinant Proteins - administration & dosage | Insulin - metabolism | Animals | Cell Membrane - metabolism | Insulin - genetics | Drug Delivery Systems - methods | Cell Membrane - drug effects | Intestinal Absorption - physiology | Protein Binding - physiology | Drugs | Drug delivery systems | Peptides | Heterocyclic compounds | Universities and colleges | Vehicles | Diabetes therapy
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 5, pp. 811 - 814
In previous studies we showed that the complexation hydrogels based in poly(methacrylic acid-g-ethylene glycol) [P(MAA-g-EG)] rapidly release insulin in the... 
Journal Article
Drug Discovery Today, ISSN 1359-6446, 2006, Volume 11, Issue 19, pp. 905 - 910
Journal Article