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urea (33) 33
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lipids (32) 32
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preservation of bodies of humans or animals or plants or partsthereof (22) 22
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8,11,14-eicosatrienoic acid - analogs & derivatives (20) 20
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inhibitory concentration 50 (18) 18
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1. Full Text Role of epoxide hydrolases in lipid metabolism
by Morisseau, Christophe
Biochimie, ISSN 0300-9084, 01/2013, Volume 95, Issue 1, pp. 91 - 95
Cholesterol epoxide | Epoxide hydrolase | Epoxy-fatty acids | Juvenile hormone | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Epoxy Compounds - metabolism | Cholesterol - analogs & derivatives | Microsomes - metabolism | Juvenile Hormones - metabolism | Solubility | Microsomes - enzymology | Juvenile Hormones - genetics | Cholesterol - metabolism | Mammals | Cholesterol - genetics | Epoxide Hydrolases - genetics | Cholesterol - chemistry | Animals | Epoxy Compounds - chemistry | Juvenile Hormones - biosynthesis | Lipid Metabolism - genetics | Epoxide Hydrolases - metabolism | Epoxide Hydrolases - chemistry | Lipid Metabolism - physiology | Physiological aspects | Enzymes | Lipids | Hydrolases | Heterocyclic compounds | Index Medicus | cholesterol epoxide | epoxy-fatty acids | juvenile hormone | epoxide hydrolase
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2. Full Text Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation
by Kodani, Sean D and Morisseau, Christophe
Biochimie, ISSN 0300-9084, 04/2019, Volume 159, pp. 59 - 65
Epoxyeicosatrienoic acids | Parkinson's disease | Alzheimer disease | Epoxide hydrolase | Dementia | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Epoxy Compounds - metabolism | Parkinson Disease - pathology | Signal Transduction | Humans | Alzheimer Disease - metabolism | Parkinson Disease - metabolism | Epoxide Hydrolases - metabolism | Alzheimer Disease - pathology | Prostaglandins - metabolism | Medical research | Enzymes | COX-2 inhibitors | Nervous system diseases | Tissue plasminogen activator | Cytochrome P-450 | Fatty acids | Prostaglandins | Epoxy resins | Medicine, Experimental | Hydrolases | Single nucleotide polymorphisms | Chromosomes | Alzheimer's disease | Index Medicus | dementia | epoxide hydrolase | epoxyeicosatrienoic acids | Parkinson’s disease
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3. Full Text Epoxide hydrolases: Mechanisms, inhibitor designs, and biological roles
by Morisseau, Christophe and Hammock, Bruce D
Annual review of pharmacology and toxicology, ISSN 0362-1642, 2005, Volume 45, Issue 1, pp. 311 - 333
Hypertension | Epoxy-eicosatrienoic acids | α/β-hydrolase fold family | N,N′-dialkyl-ureas | Hydroxyl-alkyl-enzyme intermediate | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Hydrolases | Analytical, structural and metabolic biochemistry | Enzymes and enzyme inhibitors | Protease Inhibitors - pharmacology | Animals | Humans | Drug Design | Protease Inhibitors - chemistry | Protease Inhibitors - metabolism | Epoxide Hydrolases - metabolism | Epoxide Hydrolases - antagonists & inhibitors | Epoxide Hydrolases - chemistry | Index Medicus
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4. Full Text Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors
by Imig, John D and Morisseau, Christophe
Frontiers in pharmacology, ISSN 1663-9812, 09/2020, Volume 11, pp. 598858 - 598858
eicosanoids, oxylipins | neurological diseases | kidney disease | pain | inflammation | heart disease | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology
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5. Full Text Nanobody Based Immunoassay for Human Soluble Epoxide Hydrolase Detection Using Polymeric Horseradish Peroxidase (PolyHRP) for Signal Enhancement: The Rediscovery of PolyHRP?
by Li, Dongyang and Cui, Yongliang and Morisseau, Christophe and Gee, Shirley J and Bever, Candace S and Liu, Xiangjiang and Wu, Jian and Hammock, Bruce D and Ying, Yibin
Analytical chemistry (Washington), ISSN 0003-2700, 06/2017, Volume 89, Issue 11, pp. 6248 - 6256
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Enzyme-Linked Immunosorbent Assay | Epoxide Hydrolases - immunology | Single-Domain Antibodies - chemistry | Epoxide Hydrolases - analysis | Humans | Antibodies - immunology | Horseradish Peroxidase - metabolism | Polymers - chemistry | Epoxide Hydrolases - metabolism | Polymers - metabolism | Immunoassay | Research | Chemical properties | Nanotechnology | Epoxy compounds | Hypertension | Enzyme activity | Medical treatment | Horseradish peroxidase | Pharmacology | Selectivity | Nanostructure | Chains (polymeric) | Tissues | Epoxide hydrolase | Optical density | Sensitivity | Pain | Enzymatic activity | Peroxidase | Staphylococcal enterotoxin H | Enzyme-linked immunosorbent assay | Immunoassays | Target detection | Cancer | Tracers | Index Medicus
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6. Full Text Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health
by Morisseau, Christophe and Hammock, Bruce D
Annual review of pharmacology and toxicology, ISSN 0362-1642, 01/2013, Volume 53, Issue 1, pp. 37 - 58
pain | cancer | epoxy-fatty acid | inflammation | hypertension | Cardiology. Vascular system | Arterial hypertension. Arterial hypotension | General and cellular metabolism. Vitamins | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Blood and lymphatic vessels | Epoxy Compounds - metabolism | Animals | Epoxide Hydrolases - metabolism | Health Status | Humans | Enzymes | Physiological aspects | Hydrolases | Research | Metabolism | Health aspects | Fatty acids | Pharmaceutical chemistry | Index Medicus
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7. Full Text Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
by Grzegorzewicz, Anna E and Pham, Ha and Gundi, Vijay A.K.B and Scherman, Michael S and North, Elton J and Hess, Tamara and Jones, Victoria and Gruppo, Veronica and Born, Sarah E.M and Korduláková, Jana and Chavadi, Sivagami Sundaram and Morisseau, Christophe and Lenaerts, Anne J and Lee, Richard E and McNeil, Michael R and Jackson, Mary
Nature chemical biology, ISSN 1552-4450, 2012, Volume 8, Issue 4, pp. 334 - 341
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Drug Resistance, Bacterial | Mycobacterium tuberculosis - drug effects | Microbial Sensitivity Tests | Membrane Transport Proteins - genetics | Phenylurea Compounds - chemistry | Anti-Bacterial Agents - chemistry | Membrane Transport Proteins - metabolism | Biological Transport - drug effects | Cell Membrane - metabolism | Mycobacterium tuberculosis - metabolism | Cell Membrane - drug effects | Adamantane - analogs & derivatives | Drug Evaluation, Preclinical - methods | Adamantane - pharmacology | Cord Factors | Trehalose - metabolism | Small Molecule Libraries | Anti-Bacterial Agents - pharmacokinetics | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Mycolic Acids - metabolism | Phenylurea Compounds - pharmacology | Adamantane - chemistry | Mutation | Mycobacterium tuberculosis - genetics | Plasma | Bacteria | Membranes | Tuberculosis | Acids | Index Medicus
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8. Full Text Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients
by Duflot, Thomas and Laurent, Charlotte and Soudey, Anne and Fonrose, Xavier and Hamzaoui, Mouad and Iacob, Michèle and Bertrand, Dominique and Favre, Julie and Etienne, Isabelle and Roche, Clothilde and Coquerel, David and Le Besnerais, Maëlle and Louhichi, Safa and Tarlet, Tracy and Li, Dongyang and Brunel, Valéry and Morisseau, Christophe and Richard, Vincent and Joannidès, Robinson and Stanke-Labesque, Françoise and Lamoureux, Fabien and Guerrot, Dominique and Bellien, Jérémy
Scientific reports, ISSN 2045-2322, 02/2021, Volume 11, Issue 1, pp. 3739 - 3739
Drinking water | Renal function | Kidneys | Preservation | Syngeneic grafts | Single-nucleotide polymorphism | Bioavailability | Epoxide hydrolase | Mimicry | Kidney transplants | Reperfusion | Acids | Ischemia | Surgery | Peripheral blood | Fibrosis | Plasma levels | Staphylococcal enterotoxin H | Cardiovascular diseases | Kidney transplantation | Index Medicus
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9. Full Text Development of a Highly Sensitive Enzyme-Linked Immunosorbent Assay for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Capture Antibody with a Nanobody Tracer
by Li, Dongyang and Cui, Yongliang and Morisseau, Christophe and Wagner, Karen M and Cho, Young Sik and Hammock, Bruce D
Analytical chemistry (Washington), ISSN 0003-2700, 09/2020, Volume 92, Issue 17, pp. 11654 - 11663
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Immunoassay | Animal models | Pathogenesis | Phages | Antibodies | Horseradish peroxidase | Selectivity | Epoxide hydrolase | Filters | Phage display | Format | Streptavidin | Fluid filters | Peroxidase | Enzyme-linked immunosorbent assay | Enzymes | Cross-reactivity | Biotin | Metabolism | Fatty acids | Biological activity | Sensitivity | Diagnostic software | Biomarkers | Diagnostic systems | Staphylococcal enterotoxin H | Immunoassays | Index Medicus
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10. Full Text Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation
by McReynolds, Cindy and Morisseau, Christophe and Wagner, Karen and Hammock, Bruce
09/2020, Advances in Experimental Medicine and Biology, ISBN 9783030506209, Volume 1274
Lipid metabolism | PUFA | Oxylipin | sEH | Epoxide | Inflammation - pathology | Cardiovascular Diseases - metabolism | Endoplasmic Reticulum Stress - drug effects | Cardiovascular Diseases - drug therapy | Humans | Pain Management | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Molecular Targeted Therapy | Pain | Inflammation - drug therapy | Fatty Acids - metabolism
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11. Full Text Investigation of Human Exposure to Triclocarban after Showering and Preliminary Evaluation of Its Biological Effects
by Schebb, Nils Helge and Inceoglu, Bora and Ahn, Ki Chang and Morisseau, Christophe and Gee, Shirley J and Hammock, Bruce D
Environmental science & technology, ISSN 0013-936X, 04/2011, Volume 45, Issue 7, pp. 3109 - 3115
Ecotoxicology and Human Environmental Health | Engineering | Engineering, Environmental | Life Sciences & Biomedicine | Technology | Environmental Sciences & Ecology | Science & Technology | Environmental Sciences | Pollution | Toxicology | Domestic and cosmetic products toxicology | Exact sciences and technology | Applied sciences | Biological and medical sciences | Medical sciences | Anti-Infective Agents, Local - metabolism | Baths - statistics & numerical data | Carbanilides - analysis | Anti-Infective Agents, Local - analysis | Humans | Rats | Male | Environmental Exposure - analysis | Water Pollutants, Chemical - analysis | Tandem Mass Spectrometry | Water Pollutants, Chemical - metabolism | Carbanilides - toxicity | Animals | Water Pollutants, Chemical - toxicity | Solid Phase Extraction | Carbanilides - metabolism | Chromatography, Liquid | Environmental Exposure - statistics & numerical data | Anti-Infective Agents, Local - toxicity | Studies | Enzymes | Extraction processes | Human exposure | Antimicrobial agents | Soap | Chemical compounds | Index Medicus | oxylipin metabolomics | online-solid phase extraction | Triclorcarban | metabolite | human exposure | soluble epoxide hydrolase inhibition
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12. Full Text Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function
by Yamanashi, Haruto and Boeglin, William E and Morisseau, Christophe and Davis, Robert W and Sulikowski, Gary A and Hammock, Bruce D and Brash, Alan R
Journal of lipid research, ISSN 0022-2275, 2018, Volume 59, Issue 4, pp. 684 - 695
14,15-epoxyeicosatrienoic acid | Epidermis | Trihydroxy-linoleate | Lipoxygenase | Ichthyosis | Linoleic acid | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Epoxy Compounds - metabolism | Cell Line | Biocatalysis | Fatty Acids - chemistry | Skin - metabolism | Stereoisomerism | Humans | Animals | Epoxy Compounds - chemistry | Mice | Epoxide Hydrolases - metabolism | Fatty Acids - metabolism | Skin - pathology | Hydrogen-Ion Concentration | Lipids | Permeability | pH effects | Fatty acids | Isomers | Epoxide hydrolase | Hydrolysis | Skin | Oxidation | Staphylococcal enterotoxin H | Epoxides | Index Medicus | linoleic acid | lipoxygenase | trihydroxy-linoleate | ichthyosis | epidermis
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13. Full Text Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence
by Wang, Yuxin and Wagner, Karen M and Morisseau, Christophe and Hammock, Bruce D
Journal of pain research, ISSN 1178-7090, 2021, Volume 14, pp. 61 - 72
Enzymes | Care and treatment | Pain | Epoxy resins | Amino acids | Hydrolases | Health aspects | Mediation | Fatty acids | Chronic pain | Adenosine | Disease | Oral administration | Lipids | Diabetic neuropathy | Inflammation | Metabolites | Analgesics | Pain management | Diabetes | Nonsteroidal anti-inflammatory drugs
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