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Journal Article
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2007, Volume 28, Issue 7, pp. 350 - 357
Constitutive activity has been mainly recorded for numerous overexpressed and/or mutated receptors. The histamine H3 receptor (H3 R) is a target of choice to... 
Advanced Basic Science | Brain - metabolism | Histamine Antagonists - pharmacology | Animals | Histamine Agonists - pharmacology | Receptors, Histamine H3 - metabolism | Humans | Life Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2016, Volume 113, Issue 43, pp. 12310 - 12315
Active G protein-coupled receptor (GPCR) conformations not only are promoted by agonists but also occur in their absence, leading to constitutive activity.... 
Life Sciences
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 7, pp. 590 - 597
Journal Article
Current Neuropharmacology, ISSN 1570-159X, 02/2017, Volume 15, Issue 2, pp. 260 - 275
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, p. 12310
  Active G protein-coupled receptor (GPCR) conformations not only are promoted by agonists but also occur in their absence, leading to constitutive activity.... 
Proteins | Phosphorylation | Serotonin | Cellular biology
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, pp. 12310 - 12315
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 11/2009, Volume 94, Issue 11, pp. 4334 - 4341
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2007, Volume 28, Issue 7, pp. 350 - 357
Constitutive activity has been mainly recorded for numerous overexpressed and/or mutated receptors. The histamine H receptor (H R) is a target of choice to... 
INVERSE AGONIST RADIOLIGAND | PRECLINICAL PHARMACOLOGY | LIGANDS | ANTAGONISTS/INVERSE AGONISTS | BRAIN HISTAMINE | PHARMACOLOGICAL CHARACTERIZATION | IN-VIVO | DRUG DISCOVERY | PROTEIN-COUPLED RECEPTORS | PHARMACOLOGY & PHARMACY | RAT-BRAIN
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2003, Volume 100, Issue 19, pp. 11086 - 11091
G protein-coupled receptors (GPCRs) are allosteric proteins that adopt inactive (R) and active (R * ) conformations in equilibrium. R * is promoted by agonists... 
Cricetinae | Animals | Receptors, Histamine H3 - drug effects | Histamine Antagonists - pharmacology | Imidazoles - pharmacology | In Vitro Techniques | CHO Cells | Mitogen-Activated Protein Kinases - metabolism | Life Sciences | Biological Sciences
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2009, Volume 4, Issue 6, p. e6004
Background Histamine is a biogenic amine that has been shown to contribute to several pathological conditions, such as allergic conditions, experimental... 
Brain | Neurosciences | Animal models | Encephalomyelitis | Pathogenesis | Central nervous system | Nervous system | Infections | Parasites | Kinases | Inflammatory diseases | Proteins | Receptors | Biological effects | Cell growth | Blood-brain barrier | Vector-borne diseases | Lymphatic system | Malaria | Cytokines | Risk reduction | Permeability | Histamine | Signaling | Mosquitoes | Mice | Plasma levels
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 04/2007, Volume 73, Issue 8, pp. 1172 - 1181
The interactions in the rat striatum between H receptors (H Rs) and D receptors (D Rs) were investigated with the [ S]GTPγ[S] binding assay. The H R agonist... 
S]GTPγS | Histamine | receptor | Constitutive activity | protein | Life Sciences
Journal Article
Nature, ISSN 0028-0836, 12/2000, Volume 408, Issue 6814, pp. 860 - 864
Journal Article
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