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Autophagy, ISSN 1554-8627, 11/2019, Volume 15, Issue 11, pp. 1970 - 1989
We previously reported autophagic structures in rod photoreceptors expressing a misfolding RHO (rhodopsin) mutant (RHO P23H ), suggesting that autophagy may... 
knockout | retinitis pigmentosa; rhodopsin | CRISPR/cas9 | retinal degeneration | transducin | GNAT1 | rpe65 | Chromophore
Journal Article
Autophagy, 04/2019, p. 1
We previously reported autophagic structures in rod photoreceptors expressing a misfolding RHO (rhodopsin) mutant (RHO ), suggesting that autophagy may play a... 
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2019, Volume 1834, pp. 193 - 207
Xenopus laevis have proven to be a useful system for rapid generation and analysis of transgenic models of human retinal disease. However, experimental... 
Retinal degeneration | CRISPR | Genome editing | Cas9 | Xenopus laevis | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2009, Volume 28, Issue 3, pp. 183 - 192
Dysfunctions of primary cilia and cilia‐derived sensory organelles underlie a multitude of human disorders, including retinal degeneration, yet membrane... 
rhodopsin | Arfs | cilium | trafficking | Rabs | Rhodopsin | Cilium | Trafficking | MOLECULAR CHARACTERIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GTPASE-ACTIVATING PROTEIN | MEMBRANE TRAFFICKING | PRIMARY CILIUM | CELL BIOLOGY | ADP-RIBOSYLATION FACTORS | RECYCLING ENDOSOMES | POST-GOLGI TRAFFICKING | RETINITIS-PIGMENTOSA | RAB11-INTERACTING PROTEINS | RETINAL PHOTORECEPTORS | Xenopus - genetics | Molecular Sequence Data | Guanosine Triphosphate - metabolism | GTPase-Activating Proteins - metabolism | Rhodopsin - metabolism | Retinal Degeneration - metabolism | Intracellular Membranes - ultrastructure | I-kappa B Kinase - metabolism | Cilia - ultrastructure | ADP-Ribosylation Factors - metabolism | Rhodopsin - chemistry | Protein Structure, Tertiary | rab GTP-Binding Proteins - metabolism | Amino Acid Sequence | Actin Cytoskeleton - metabolism | Animals, Genetically Modified | Mutant Proteins - metabolism | Organ Specificity | Cilia - metabolism | Protein Sorting Signals | Amino Acid Motifs | Protein Transport | Hydrolysis | trans-Golgi Network - ultrastructure | Animals | Protein Binding | Xenopus Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | I-kappa B Kinase - chemistry | Intracellular Membranes - metabolism | Proteins | Signal transduction | Membranes | Cellular biology | Molecular biology | Index Medicus
Journal Article
Journal of cell science, ISSN 0021-9533, 2018, Volume 131, Issue 24, p. jcs222034
The Arf4-rhodopsin complex (mediated by the VxPx motif in rhodopsin) initiates expansion of vertebrate rod photoreceptor ciliaderived light-sensing organelles... 
Rab GTPase | Rhodopsin | VAMP7 | Sensory receptor | Cilium | SNARE | POST-GOLGI MEMBRANES | EXCHANGE FACTOR | COATED VESICLES | ACTIVATING PROTEIN | PLASMA-MEMBRANE | PRIMARY CILIUM | CELL BIOLOGY | RHODOPSIN TRANSPORT | EFFECTOR FIP3 | NEURITE OUTGROWTH | TI-VAMP
Journal Article
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 03/2019, Volume 60, Issue 4, pp. 933 - 943
PURPOSE. The rhodopsin mutation P23H is responsible for a significant portion of autosomal-dominant retinitis pigmentosa, a disorder characterized by rod... 
Photoresponse | Phototransduction | Rhodopsin | Retinitis pigmentosa | Photorecep-tor | RETINAL DEGENERATION | photoresponse | RHODOPSIN MODEL | ROD OUTER SEGMENT | photoreceptor | LIGHT | phototransduction | rhodopsin | CYCLIC-GMP | retinitis pigmentosa | OPHTHALMOLOGY | DARK-ADAPTATION | MUTATIONS | XENOPUS-LAEVIS MODEL | PHOTORECEPTORS
Journal Article
Journal Article
Journal Article
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 01/2017, Volume 37, Issue 4, pp. 1039 - 1054
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 12/2000, Volume 151, Issue 7, pp. 1369 - 1380
Mislocalization of the photopigment rhodopsin may be involved in the pathology of certain inherited retinal degenerative diseases. Here, we have elucidated... 
Epithelial cells | Transgenic animals | Neurons | Photoreceptors | Amino acids | Cell membranes | Transgenes | Synapses | Cells | P branes | Rhodopsin | Cell polarity | Membrane proteins | CYTOPLASMIC DOMAIN | MDCK CELLS | CANINE KIDNEY-CELLS | PROTEIN-KINASE | PLASMA-MEMBRANE | DOMINANT RETINITIS-PIGMENTOSA | CELL BIOLOGY | rhodopsin | photoreceptors | transgenic animals | membrane proteins | BOVINE RHODOPSIN | cell polarity | GAMMA-AMINOBUTYRIC-ACID | POLARIZED EPITHELIAL-CELLS | SORTING SIGNALS | Cell Polarity | Green Fluorescent Proteins | Palmitic Acid - metabolism | Protein Sorting Signals - physiology | Rod Cell Outer Segment - metabolism | Molecular Sequence Data | Rhodopsin - metabolism | Promoter Regions, Genetic - genetics | Recombinant Fusion Proteins - metabolism | Rod Opsins - genetics | Cell Membrane - metabolism | Xenopus laevis - genetics | Xenopus laevis - growth & development | Receptors, Adrenergic, alpha - genetics | Rhodopsin - chemistry | Receptors, Adrenergic, alpha - metabolism | Amino Acid Sequence | Animals, Genetically Modified | Larva - metabolism | Transgenes - genetics | Receptors, Adrenergic, alpha - chemistry | Mutation - genetics | Larva - cytology | Protein Transport | Myristic Acid - metabolism | Animals | Rhodopsin - genetics | Protein Sorting Signals - genetics | Xenopus laevis - metabolism | Protein Binding | Luminescent Proteins - metabolism | Xenopus | Genetically modified animals | Gene mutations | Research | Retinal diseases | Cellular biology | Pigments | Identification | Index Medicus | Original
Journal Article