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by Webb, Thomas R and Erdmann, Jeanette and Stirrups, Kathleen E and Stitziel, Nathan O and Masca, Nicholas G.D and Jansen, Henning and Kanoni, Stavroula and Nelson, Christopher P and Ferrario, Paola G and König, Inke R and Eicher, John D and Johnson, Andrew D and Hamby, Stephen E and Betsholtz, Christer and Ruusalepp, Arno and Franzén, Oscar and Schadt, Eric E and Björkegren, Johan L.M and Weeke, Peter E and Auer, Paul L and Schick, Ursula M and Lu, Yingchang and Zhang, He and Dube, Marie-Pierre and Goel, Anuj and Farrall, Martin and Peloso, Gina M and Won, Hong-Hee and Do, Ron and van Iperen, Erik and Kruppa, Jochen and Mahajan, Anubha and Scott, Robert A and Willenborg, Christina and Braund, Peter S and van Capelleveen, Julian C and Doney, Alex S.F and Donnelly, Louise A and Asselta, Rosanna and Merlini, Pier A and Duga, Stefano and Marziliano, Nicola and Denny, Josh C and Shaffer, Christian and El-Mokhtari, Nour Eddine and Franke, Andre and Heilmann, Stefanie and Hengstenberg, Christian and Hoffmann, Per and Holmen, Oddgeir L and Hveem, Kristian and Jansson, Jan-Håkan and Jöckel, Karl-Heinz and Kessler, Thorsten and Kriebel, Jennifer and Laugwitz, Karl L and Marouli, Eirini and Martinelli, Nicola and McCarthy, Mark I and Van Zuydam, Natalie R and Meisinger, Christa and Esko, Tõnu and Mihailov, Evelin and Escher, Stefan A and Alver, Maris and Moebus, Susanne and Morris, Andrew D and Virtamo, Jarma and Nikpay, Majid and Olivieri, Oliviero and Provost, Sylvie and AlQarawi, Alaa and Robertson, Neil R and Akinsansya, Karen O and Reilly, Dermot F and Vogt, Thomas F and Yin, Wu and Asselbergs, Folkert W and Kooperberg, Charles and Jackson, Rebecca D and Stahl, Eli and Müller-Nurasyid, Martina and Strauch, Konstantin and Varga, Tibor V and Waldenberger, Melanie and Zeng, Lingyao and Chowdhury, Rajiv and Salomaa, Veikko and Ford, Ian and Jukema, J. Wouter and Amouyel, Philippe and Kontto, Jukka and Nordestgaard, Børge G and Ferrières, Jean and Saleheen, Danish and Sattar, Naveed and Surendran, Praveen and Wagner, Aline and Young, Robin and Howson, Joanna M.M and ... and Wellcome Trust Case Control Consortium and Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators and MORGAM Investigators and Wellcome Trust Case Control and Myocardial Infarction Genetics
Journal of the American College of Cardiology, ISSN 0735-1097, 2017, Volume 69, Issue 7, pp. 823 - 836
Abstract Background Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show... 
Cardiovascular | Internal Medicine | expression quantitative trait loci | genetics | genome-wide association | single nucleotide polymorphism | cholesteryl ester transfer protein | SR-BI | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CETP MASS | SUSCEPTIBILITY | RISK | PHOSPHOLIPASE A | VARIANT | SCAVENGER RECEPTOR | ABDOMINAL AORTIC-ANEURYSM | Genome-Wide Association Study | Gene Frequency | Humans | Coronary Artery Disease - genetics | Female | Male | Coronary Artery Disease - epidemiology | Genetic Pleiotropy | Polymorphism, Single Nucleotide | Genetic Loci | Odds Ratio | Case-Control Studies | Coronary heart disease | Analysis | Genealogy | Cardiovascular disease | Genomes | Metabolism | Gene expression | Blood | Risk factors | Studies | Celiac disease | Lipoproteins | Coronary vessels | Rheumatoid arthritis | Quality control | Calcification | Diabetes | Bioinformatics | LD, linkage disequilibrium | CETP, cholesteryl ester transfer protein | eQTL, expression quantitative trait locus | CAD, coronary artery disease | GWAS, genome-wide association study | BMI, body mass index | SNP, single nucleotide polymorphism | HDL, high-density lipoprotein | LDL, low-density lipoprotein | Original Investigation | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article
by Gusarova, Viktoria and O’Dushlaine, Colm and Teslovich, Tanya M and Benotti, Peter N and Mirshahi, Tooraj and Gottesman, Omri and Van Hout, Cristopher V and Murray, Michael F and Mahajan, Anubha and Nielsen, Jonas B and Fritsche, Lars and Wulff, Anders Berg and Gudbjartsson, Daniel F and Sjögren, Marketa and Emdin, Connor A and Scott, Robert A and Lee, Wen-Jane and Small, Aeron and Kwee, Lydia C and Dwivedi, Om Prakash and Prasad, Rashmi B and Bruse, Shannon and Lopez, Alexander E and Penn, John and Marcketta, Anthony and Leader, Joseph B and Still, Christopher D and Kirchner, H. Lester and Mirshahi, Uyenlinh L and Wardeh, Amr H and Hartle, Cassandra M and Habegger, Lukas and Fetterolf, Samantha N and Tusie-Luna, Teresa and Morris, Andrew P and Holm, Hilma and Steinthorsdottir, Valgerdur and Sulem, Patrick and Thorsteinsdottir, Unnur and Rotter, Jerome I and Chuang, Lee-Ming and Damrauer, Scott and Birtwell, David and Brummett, Chad M and Khera, Amit V and Natarajan, Pradeep and Orho-Melander, Marju and Flannick, Jason and Lotta, Luca A and Willer, Cristen J and Holmen, Oddgeir L and Ritchie, Marylyn D and Ledbetter, David H and Murphy, Andrew J and Borecki, Ingrid B and Reid, Jeffrey G and Overton, John D and Hansson, Ola and Groop, Leif and Shah, Svati H and Kraus, William E and Rader, Daniel J and Chen, Yii-Der I and Hveem, Kristian and Wareham, Nicholas J and Kathiresan, Sekar and Melander, Olle and Stefansson, Kari and Nordestgaard, Børge G and Tybjærg-Hansen, Anne and Abecasis, Goncalo R and Altshuler, David and Florez, Jose C and Boehnke, Michael and McCarthy, Mark I and Yancopoulos, George D and Carey, David J and Shuldiner, Alan R and Baras, Aris and Dewey, Frederick E and Gromada, Jesper
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 2252 - 11
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient... 
HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | MULTIDISCIPLINARY SCIENCES | MICE | ANGIOPOIETIN-LIKE PROTEIN-4 | LIPOPROTEIN-LIPASE | HAN CHINESE | CHINESE POPULATION | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Diabetes Mellitus, Type 2 - genetics | Humans | Homeostasis | Male | Diabetes Mellitus, Type 2 - metabolism | Case-Control Studies | Genetic Variation | Diabetes Mellitus, Type 2 - etiology | Female | Lipoprotein Lipase - metabolism | Genetic Association Studies | Mice, Inbred C57BL | Risk Factors | Gene Silencing | Angiopoietin-like 4 Protein - deficiency | Mice, Knockout | Whole Exome Sequencing | Animals | Insulin Resistance - genetics | Angiopoietin-like 4 Protein - metabolism | Heterozygote | Mice | Blood Glucose - metabolism | Amino Acid Substitution | Angiopoietin-like 4 Protein - genetics | Deactivation | Angiopoietin | Diabetes mellitus | Health risks | Risk reduction | Risk | Lipoprotein lipase | Glucose | Lipase | Inactivation | Insulin | Proteins | Confidence intervals | Sensitivity | Nutrient loss | Rodents | Arteriosclerosis | Atherosclerosis | Genetics | Diabetes | Diabetes mellitus (non-insulin dependent) | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Endocrinology and Diabetes
Journal Article
by Vimaleswaran, Karani S and Berry, Diane J and Lu, Chen and Tikkanen, Emmi and Pilz, Stefan and Hiraki, Linda T and Cooper, Jason D and Dastani, Zari and Li, Rui and Houston, Denise K and Wood, Andrew R and Michaëlsson, Karl and Vandenput, Liesbeth and Zgaga, Lina and Yerges-Armstrong, Laura M and McCarthy, Mark I and Dupuis, Josée and Kaakinen, Marika and Kleber, Marcus E and Jameson, Karen and Arden, Nigel and Raitakari, Olli and Viikari, Jorma and Lohman, Kurt K and Ferrucci, Luigi and Melhus, Håkan and Ingelsson, Erik and Byberg, Liisa and Lind, Lars and Lorentzon, Mattias and Salomaa, Veikko and Campbell, Harry and Dunlop, Malcolm and Mitchell, Braxton D and Herzig, Karl-Heinz and Pouta, Anneli and Hartikainen, Anna-Liisa and Streeten, Elizabeth A and Theodoratou, Evropi and Jula, Antti and Wareham, Nicholas J and Ohlsson, Claes and Frayling, Timothy M and Kritchevsky, Stephen B and Spector, Timothy D and Richards, J. Brent and Lehtimäki, Terho and Ouwehand, Willem H and Kraft, Peter and Cooper, Cyrus and März, Winfried and Power, Chris and Loos, Ruth J. F and Wang, Thomas J and Järvelin, Marjo-Riitta and Whittaker, John C and Hingorani, Aroon D and Hyppönen, Elina and Genetic Invest Anthropometric Trai and Genetic Investigation of Anthropometric Traits-GIANT Consortium and the Genetic Investigation of Anthropometric Traits (GIANT) consortium and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
PLoS medicine, ISSN 1549-1676, 2013, Volume 10, Issue 2, p. e1001383
Journal Article
by Lawrence, Michael S and Sougnez, Carrie and Lichtenstein, Lee and Cibulskis, Kristian and Lander, Eric and Gabriel, Stacey B and Getz, Gad and Ally, Adrian and Balasundaram, Miruna and Birol, Inanc and Bowlby, Reanne and Brooks, Denise and Butterfield, Yaron S. N and Carlsen, Rebecca and Cheng, Dean and Chu, Andy and Dhalla, Noreen and Guin, Ranabir and Holt, Robert A and Jones, Steven J.M and Lee, Darlene and Li, Haiyan I and Marra, Marco A and Mayo, Michael and Moore, Richard A and Mungall, Andrew J and Robertson, A. Gordon and Schein, Jacqueline E and Sipahimalani, Payal and Tam, Angela and Thiessen, Nina and Wong, Tina and Protopopov, Alexei and Santoso, Netty and Lee, Semin and Parfenov, Michael and Zhang, Jianhua and Mahadeshwar, Harshad S and Tang, Jiabin and Ren, Xiaojia and Seth, Sahil and Haseley, Psalm and Zeng, Dong and Yang, Lixing and Xu, Andrew W and Song, Xingzhi and Pantazi, Angeliki and Bristow, Christopher A and Hadjipanayis, Angela and Seidman, Jonathan and Chin, Lynda and Park, Peter J and Kucherlapati, Raju and Akbani, Rehan and Casasent, Tod and Liu, Wenbin and Lu, Yiling and Mills, Gordon and Motter, Thomas and Weinstein, John and Diao, Lixia and Wang, Jing and Hong Fan, You and Liu, Jinze and Wang, Kai and Auman, J. Todd and Balu, Saianand and Bodenheimer, Thomas and Buda, Elizabeth and Hayes, D. Neil and Hoadley, Katherine A and Hoyle, Alan P and Jefferys, Stuart R and Jones, Corbin D and Kimes, Patrick K and Liu, Yufeng and Marron, J.S and Meng, Shaowu and Mieczkowski, Piotr A and Mose, Lisle E and Parker, Joel S and Perou, Charles M and Prins, Jan F and Roach, Jeffrey and Shi, Yan and Simons, Janae V and Singh, Darshan and Soloway, Matthew G and Tan, Donghui and Veluvolu, Umadevi and Walter, Vonn and Waring, Scot and Wilkerson, Matthew D and Wu, Junyuan and Zhao, Ni and Cherniack, Andrew D and Hammerman, Peter S and Tward, Aaron D and Pedamallu, Chandra Sekhar and Saksena, Gordon and ... and The Cancer Genome Atlas Network and Canc Genome Atlas Network and Cancer Genome Atlas Network
Nature (London), ISSN 1476-4687, 2015, Volume 517, Issue 7536, pp. 576 - 582
Journal Article
by Jankowski, Janusz A Z and de Caestecker, John and Love, Sharon B and Reilly, Gavin and Watson, Peter and Sanders, Scott and Ang, Yeng and Morris, Danielle and Bhandari, Pradeep and Brooks, Claire and Attwood, Stephen and Harrison, Rebecca and Barr, Hugh and Moayyedi, Paul and Ragunath, Krish and Rameh, Bashir and Fullarton, Grant and Tucker, Art and Penman, Ian and Rodgers, Colin and Neale, James and Edwards, Cathryn and Wise, Adelyn and Jones, Stephen and Church, Nicholas and Vaidya, Kishor and Balata, Sherzad and Todd, John and Gibbons, Michael and Johnston, David and Anderson, Mark and Davies, Gareth and Dickey, William and Murdock, Andrew and Turner, Graham and Goddard, Andrew and Gore, Stephen and Haigh, Chris and Harding, Timothy and Jackson, Lucina and Murray, Iain and Worthingon, Joy and Lee, Thomas and Lim, Peik Loon and McLoughlin, James and Macdonald, Christopher and Mairs, Philip and Monk, David and Preston, Sean and Pugh, Stirling and Smart, Howard and Soliman, Ashraf and Isaacs, Peter and Aldulaimi, David and Trudgill, Nigel and Teare, Julian and Benhamida, Abduljalil and Bell, Andrew and Boulton-Jones, Robert and Daneshmend, Tawfique and Suzuki, Hisaharu and Cullen, Sue and Fitzgerald, Rebecca and Ransford, Rupert and Rahman, Mohammad Mesbahur and Tebala, Giovanni Domenico and Hallissey, Michael and Kelly, Carrie and Hickish, Tamas and Taha, Ali and Rademaker, Johan and Whitehead, Mark and Kelly, Sean and Phull, Perminder and Sharma, Naveen and Perry, Ian and Sankara-Raman, Vankatraman and Ali, Haythem and Khan, Iqbal and Curtis, Howard and Wadley, Martin and Stone, Adam and Sukumaran, Sumesh and Higham, Andrew and Lewis, Stephen and Haycock, Adam and Usselmann, Bernhard and Johnston, Simon Douglas and Tham, Tony and Campbell, Stewart and Douds, Andrew and Dunn, Jason and Sargeant, Ian and Narain, Mark and Maynard, Nick and Chilton, Andrew and Green, Susi and Loft, Duncan and Decadt, Bart and Mendall, Michael and ... and AspECT Trial Team
The Lancet (British edition), ISSN 0140-6736, 2018, Volume 392, Issue 10145, pp. 400 - 408
Journal Article