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1. Full Text The therapeutic potential of carbon monoxide
by Otterbein, Leo E and Motterlini, Roberto
Nature Reviews Drug Discovery, ISSN 1474-1776, 09/2010, Volume 9, Issue 9, pp. 728 - 743
Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic molecule with important signalling capabilities in physiological and... 
ISCHEMIA-REPERFUSION INJURY | PROTEIN-KINASE PATHWAY | CO-RELEASING MOLECULE | CARDIAC MITOCHONDRIAL BIOGENESIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | OXYGENASE-1 GENE PROMOTER | INDUCED LUNG INJURY | PHARMACOLOGY & PHARMACY | EX-VIVO APPLICATION | ENDOTHELIAL-CELL APOPTOSIS | HEPATIC ISCHEMIA/REPERFUSION INJURY | CHRONIC ALLOGRAFT NEPHROPATHY | Cardiovascular Diseases - physiopathology | Animals | Carbon Monoxide - pharmacology | Carbon Monoxide - therapeutic use | Signal Transduction | Inflammation - drug therapy | Cardiovascular Diseases - drug therapy | Humans | Homeostasis | Organ Transplantation - methods | Carbon Monoxide - metabolism | Inflammation - physiopathology | Drugs | Drug delivery systems | Lung diseases | Patient outcomes | Carbon monoxide | Health aspects | Risk factors | Vehicles
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2. Full Text Glomerular hyperfiltration and renal disease progression in type 2 diabetes
by Ruggenenti, Piero and Porrini, Esteban L and Gaspari, Flavio and Motterlini, Nicola and Cannata, Antonio and Carrara, Fabiola and Cella, Claudia and Ferrari, Silvia and Stucchi, Nadia and Parvanova, Aneliya and Iliev, Ilian and Dodesini, Alessandro Roberto and Trevisan, Roberto and Bossi, Antonio and Zaletel, Jelka and Remuzzi, Giuseppe and GFR Study Investigators and for the GFR Study Investigators
Diabetes Care, ISSN 0149-5992, 10/2012, Volume 35, Issue 10, pp. 2061 - 2068
OBJECTIVE-To describe the prevalence and determinants of hyperfiltration (glomerular Nitration rate [GFR] >= 120 mL/min/1.73 m(2)), GFR decline, and... 
KIDNEY-DISEASE | FUNCTION DECLINE | GLYCEMIC CONTROL | ALBUMIN EXCRETION | ENDOCRINOLOGY & METABOLISM | FILTRATION-RATE | LONGITUDINAL DATA | PREDICTION EQUATIONS | PLASMA-CLEARANCE | AFRICAN-AMERICAN | ANTIHYPERTENSIVE TREATMENT | Albuminuria - complications | Diabetic Nephropathies - etiology | Humans | Middle Aged | Kidney Glomerulus - physiopathology | Blood Glucose | Male | Glomerular Filtration Rate - physiology | Diabetes Mellitus, Type 2 - physiopathology | Female | Aged | Diabetes Mellitus, Type 2 - complications | Cohort Studies | Type 2 diabetes | Hypertension | Medical research | Medicine, Experimental | Development and progression | Research | Kidney diseases | Studies | Kidneys | Diabetes | Disease | Original Research
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3. Full Text Heme Oxygenase-1 As a Target for Drug Discovery
by Motterlini, Roberto and Foresti, Roberta
Antioxidants & Redox Signaling, ISSN 1523-0864, 04/2014, Volume 20, Issue 11, pp. 181 - 1826
Significance: Heme oxygenase enzymes, which exist as constitutive (HO-2) and inducible (HO-1) isoforms, degrade heme to carbon monoxide (CO) and the bile... 
Forum Review Articles | ISCHEMIA-REPERFUSION INJURY | SMOKE-INDUCED EMPHYSEMA | THERAPEUTIC APPLICATIONS | OXIDATIVE STRESS | TRANSCRIPTION FACTOR NRF2 | CARBON-MONOXIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | ENDOCRINOLOGY & METABOLISM | HYPEROXIC LUNG INJURY | NITRIC-OXIDE | MONOXIDE-RELEASING MOLECULES | Up-Regulation - drug effects | Animals | Carbon Monoxide - pharmacology | Carbon Monoxide - therapeutic use | Oxidative Stress | Anti-Inflammatory Agents - pharmacology | Humans | Heme Oxygenase-1 - physiology | Anti-Inflammatory Agents - therapeutic use | Enzyme Induction - drug effects | Drug Discovery | Inflammation - enzymology | Oxidases | Influence | Drug discovery | Carbon monoxide | Research | Analysis
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4. Full Text Biological signaling by carbon monoxide and carbon monoxide-releasing molecules
by Motterlini, Roberto and Foresti, Roberta
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 03/2017, Volume 312, Issue 3, pp. C302 - C313
Carbon monoxide (CO) is continuously produced in mammalian cells during the degradation of heme. It is a stable gaseous molecule that reacts selectively with... 
Hemoglobin | Mitochondria | Carbon monoxide | Carbon monoxide-releasing molecules (CO-RMs) | Cytochrome-c oxidase | Hemoproteins | PROTEIN-KINASE PATHWAY | cytochrome-c oxidase | OXIDATIVE STRESS | PHYSIOLOGY | mitochondria | carbon monoxide | CYSTATHIONINE BETA-SYNTHASE | hemoglobin | CELL BIOLOGY | hemoproteins | UNCOUPLES MITOCHONDRIAL RESPIRATION | IN-VIVO | carbon monoxide-releasing molecules (CO-RMs) | AIRWAY SMOOTH-MUSCLE | HEME OXYGENASE-1 | CA2+-ACTIVATED K+-CHANNELS | FLUORESCENT-PROBE | LIVING CELLS | Animals | Heme - metabolism | Models, Biological | Humans | Signal Transduction - physiology | Blood Vessels - physiology | Carbon Monoxide - metabolism | Blood Flow Velocity - physiology | Physiological aspects | Ligands (Biochemistry) | Heme
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5. Full Text Use of carbon monoxide as a therapeutic agent: promises and challenges
by Foresti, Roberta and Bani-Hani, Mohamed G and Motterlini, Roberto
Intensive Care Medicine, ISSN 0342-4642, 4/2008, Volume 34, Issue 4, pp. 649 - 658
As a by-product of heme catabolism by the heme oxygenase system, carbon monoxide (CO) has been neglected for many years, and only recently has its role as an... 
Pediatrics | Pain Medicine | Pneumology/Respiratory System | Emergency Medicine | Medicine & Public Health | Intensive / Critical Care Medicine | Anesthesiology | PROTEIN-KINASE PATHWAY | PROTECTION | ARTERIAL CARBOXYHEMOGLOBIN | INHALATION | LUNG INJURY | REPERFUSION | HEME OXYGENASE-1 | MOLECULES CO-RMS | EXPRESSION | ENDOTOXIC-SHOCK | CRITICAL CARE MEDICINE | Biomarkers - metabolism | Vasodilator Agents - pharmacology | Humans | Administration, Inhalation | Carbon Monoxide - metabolism | Drug Carriers | Antimetabolites - administration & dosage | Organometallic Compounds | Carbon Monoxide - pharmacology | Signal Transduction - drug effects | Boranes | Carbonates | Carbon Monoxide - administration & dosage | Vasodilator Agents - administration & dosage | Antimetabolites - pharmacology | Oxidases | Care and treatment | Patient outcomes | Dosage and administration | Carbon monoxide | Cardiovascular diseases | Health aspects | Index Medicus
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6. Full Text Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo
by Yiru Guo and Adam B. Stein and Wen-Jian Wu and Wei Tan and Xiaoping Zhu and Qian-Hong Li and Buddhadeb Dawn and Roberto Motterlini and Roberto Bolli
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2004, Volume 286, Issue 5, pp. 1649 - 1653
Although carbon monoxide (CO) has traditionally been viewed as a toxic gas, increasing evidence suggests that it plays an important homeostatic and... 
Myocardial ischemia | Carbon monoxide-releasing molecules | Reperfusion injury | Transition metal carbonyls | PROTEIN-KINASE PATHWAY | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | carbon monoxide-releasing molecules | LATE-PHASE | INJURY | reperfusion injury | transition metal carbonyls | P38 MAP KINASE | INHIBITION | CARBON MONOXIDE PRODUCTION | PERIPHERAL VASCULAR DISEASE | myocardial ischemia | MICE | HEME OXYGENASE-1 | EXPRESSION | Heart Rate | Myocardial Infarction - blood | Drug Administration Schedule | Male | Body Temperature | Carbon Monoxide - metabolism | Mice, Inbred ICR | Myocardial Reperfusion Injury - physiopathology | Myocardial Ischemia - pathology | Carboxyhemoglobin - metabolism | Myocardial Reperfusion Injury - pathology | Pilot Projects | Animals | Cardiotonic Agents - administration & dosage | Myocardial Infarction - pathology | Myocardial Ischemia - physiopathology | Myocardial Infarction - physiopathology | Mice | Myocardial Reperfusion Injury - blood | Organometallic Compounds - administration & dosage
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7. Full Text Heme Oxygenase-1 and Carbon Monoxide in the Heart: The Balancing Act Between Danger Signaling and Pro-Survival
by Otterbein, Leo E and Foresti, Roberta and Motterlini, Roberto
Circulation Research, ISSN 0009-7330, 06/2016, Volume 118, Issue 12, pp. 1940 - 1959
Understanding the processes governing the ability of the heart to repair and regenerate after injury is crucial for developing translational medical solutions.... 
carbon monoxide | myocardial ischemia | heme oxygenase-1 | inflammation | mitochondria | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | HUMAN-SKIN FIBROBLASTS | ISCHEMIC-HEART | MESENCHYMAL STEM-CELLS | CO-RELEASING MOLECULE | CARDIAC MITOCHONDRIAL BIOGENESIS | IN-VIVO | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | ALBUMIN-BOUND BILIRUBIN | ESTABLISHED PULMONARY-HYPERTENSION | Heme Oxygenase-1 - genetics | Myocardial Ischemia - metabolism | Heme Oxygenase-1 - metabolism | Animals | Mitochondria, Heart - metabolism | Humans | Myocardium - metabolism | Carbon Monoxide - metabolism | cardiac ischemia
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8. Full Text Chemistry and biological activities of CO-releasing molecules (CORMs) and transition metal complexes
by Alberto, Roger and Motterlini, Roberto
Dalton Transactions, ISSN 1477-9226, 2007, Issue 17, pp. 1651 - 1660
The advent of CO as a small molecule that, in addition to NO, elicits essential biological functions has initiated the search for compounds and complexes... 
EXHALED CARBON-MONOXIDE | THERAPEUTIC APPLICATIONS | ISCHEMIA/REPERFUSION INJURY | OXIDATIVE STRESS | NITRIC-OXIDE SYNTHASE | BORINE CARBONYL | MURINE MACROPHAGES | AMINE-DICARBOXYBORANES | HEME OXYGENASE-1 DEFICIENCY | BORON ANALOGS | CHEMISTRY, INORGANIC & NUCLEAR | Models, Molecular | Carbon Monoxide - chemistry | Metals - chemistry | X-Ray Diffraction
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9. Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis
by Lancel, Steve and Hassoun, Sidi Mohamed and Favory, Raphael and Decoster, Brigitte and Motterlini, Roberto and Neviere, Remi
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2009, Volume 329, Issue 2, pp. 641 - 648
Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis... 
REPERFUSION | PHARMACOLOGY & PHARMACY | MECHANISMS | PROTECTION | MOLECULES CO-RMS | ENDOTOXIC-SHOCK | Sepsis - etiology | Sepsis - prevention & control | Mitochondria, Heart - metabolism | Peritonitis - complications | Male | Mitochondria, Heart - drug effects | Carbon Monoxide - metabolism | Membrane Potential, Mitochondrial - drug effects | Mice, Inbred ICR | Animals | Carbon Monoxide - pharmacology | Oxygen Consumption - drug effects | Sepsis - metabolism | Mice | Oxidative Stress - drug effects | Energy Metabolism - drug effects | NAD - metabolism | DNA, Mitochondrial - biosynthesis | Disease Models, Animal | Organometallic Compounds - administration & dosage
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10. Interaction of carbon monoxide with transition metals: Evolutionary insights into drug target discovery
by Foresti, Roberta and Motterlini, Roberto
Current Drug Targets, ISSN 1389-4501, 2012, Volume 11, Issue 12, pp. 1595 - 1604
The perception that carbon monoxide (CO) is poisonous and life-threatening for mammalian organisms stems from its intrinsic propensity to bind iron in... 
Hemoglobin | Mitochondria | Transition metals | Carbon monoxide | Carbon monoxide-releasing molecules | OXIDATIVE STRESS | carbon monoxide-releasing molecules | PROTEIN | MITOCHONDRIAL BIOGENESIS | mitochondria | transition metals | hemoglobin | HEMORRHAGIC-SHOCK | CYTOCHROME-C | INFARCT SIZE | HEME OXYGENASE-1 INDUCTION | RHODOSPIRILLUM-RUBRUM | CARBOXYHEMOGLOBIN LEVELS | PHARMACOLOGY & PHARMACY | MOLECULES CO-RMS
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11. Full Text The GFR and GFR decline cannot be accurately estimated in type 2 diabetics
by Gaspari, Flavio and Ruggenenti, Piero and Porrini, Esteban and Motterlini, Nicola and Cannata, Antonio and Carrara, Fabiola and Jiménez Sosa, Alejandro and Cella, Claudia and Ferrari, Silvia and Stucchi, Nadia and Parvanova, Aneliya and Iliev, Ilian and Trevisan, Roberto and Bossi, Antonio and Zaletel, Jelka and Remuzzi, Giuseppe and GFR Study Investigators
Kidney International, ISSN 0085-2538, 07/2013, Volume 84, Issue 1, pp. 164 - 173
There are no adequate studies that have formally tested the performance of different estimating formulas in patients with type 2 diabetes both with and without... 
glomerular filtration rate | diabetes mellitus | hyperfiltration | STATISTICAL-METHODS | PREDICTION EQUATIONS | CKD-EPI EQUATION | SERUM CREATININE | GLOMERULAR-FILTRATION-RATE | ASSESSING AGREEMENT | KIDNEY-FUNCTION | DISEASE | UROLOGY & NEPHROLOGY | RENAL-FUNCTION DECLINE | PLASMA-CLEARANCE | Predictive Value of Tests | Glomerular Filtration Rate | Diabetic Nephropathies - etiology | Humans | Middle Aged | Iohexol | Biomarkers - blood | Diabetic Nephropathies - blood | Diabetic Nephropathies - diagnosis | Disease Progression | Randomized Controlled Trials as Topic | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - physiopathology | Diabetic Nephropathies - physiopathology | Time Factors | Models, Biological | Aged, 80 and over | Creatinine - blood | Italy | Aged | Slovenia | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology
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