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PLoS ONE, ISSN 1932-6203, 10/2018, Volume 13, Issue 10, p. e0206613
The positron emission tomography (PET) tracer [F-18]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for... 
PDE10A | TRACER | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TRANSCRIPTION | RECEPTOR | MICE | PHOSPHODIESTERASE 10A | STRIATUM | CT imaging | Usage | Tracers (Biology) | PET imaging | Huntington's chorea | Development and progression | Research | Diagnosis
Journal Article
Current topics in behavioral neurosciences, ISSN 1866-3370, 2015, Volume 22, pp. 161 - 201
Journal Article
Neuron, ISSN 0896-6273, 12/2016, Volume 92, Issue 6, pp. 1220 - 1237
Journal Article
Current topics in behavioral neurosciences, ISSN 1866-3370, 2015, Volume 22, p. 161
Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease, caused by expansion of the CAG repeat in the huntingtin (HTT) gene and... 
Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Humans | Huntington Disease - drug therapy
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 11/2018, Volume 59, Issue 11, pp. 1722 - 1727
Journal Article
Experimental Neurology, ISSN 0014-4886, 08/2016, Volume 282, pp. 99 - 118
Dysregulation of the kynurenine (Kyn) pathway has been associated with the progression of Huntington's disease (HD). In particular, elevated levels of the... 
R6/2 | Neurodegeneration | Kynurenine | Pharmacodynamic | Inhibitor | Kynurenic acid | Quinolinic acid | Q175 | Huntington's disease | QUINOLINIC ACID LEVELS | GLYCINE SITE | NICOTINIC ACETYLCHOLINE-RECEPTORS | CEREBROSPINAL-FLUID | D-ASPARTATE RECEPTOR | NEUROSCIENCES | PATHWAY-METABOLISM | HIV-INFECTION | KYNURENINE 3-MONOOXYGENASE INHIBITION | GLUTAMATE LEVELS | TRANSGENIC MICE | Electric Stimulation | Kynurenine 3-Monooxygenase - antagonists & inhibitors | Electrophysiological Phenomena - genetics | Humans | Male | Green Fluorescent Proteins - genetics | Hippocampus - drug effects | Kynurenic Acid - metabolism | Trinucleotide Repeats - genetics | Excitatory Postsynaptic Potentials - drug effects | Pyrimidines - chemistry | Pyrimidines - metabolism | Receptors, N-Methyl-D-Aspartate - genetics | Brain - metabolism | Dose-Response Relationship, Drug | Transfection | Enzyme Inhibitors - chemistry | HEK293 Cells | Huntington Disease - drug therapy | Excitatory Postsynaptic Potentials - genetics | Huntington Disease - physiopathology | Disease Models, Animal | Green Fluorescent Proteins - metabolism | Enzyme Inhibitors - pharmacology | alpha7 Nicotinic Acetylcholine Receptor - genetics | Kynurenine 3-Monooxygenase - metabolism | Mice, Transgenic | Signal Transduction - genetics | Pyrimidines - pharmacology | Enzyme Inhibitors - therapeutic use | Brain - drug effects | Animals | Microdialysis | Analysis of Variance | Signal Transduction - drug effects | Pyrimidines - therapeutic use | Quinolinic Acid - metabolism | Brain - pathology | Huntington Disease - genetics | Mice | alpha7 Nicotinic Acetylcholine Receptor - metabolism | Huntingtin Protein - genetics | In Vitro Techniques | Electrophysiological Phenomena - drug effects | Genetic engineering | Models | Metabolites | Analysis
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2019, Volume 25, Issue 7, pp. 1131 - 1142
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which... 
Huntingtons disease | Brain | Transcription factors | Animal models | Polyglutamine | Huntingtin | Neurodegenerative diseases | Neurons | Medical treatment | Trinucleotide repeats | Gene expression | Huntington's disease | Zinc | Proteins | Gene silencing | Molecular modelling | Alleles | Fibroblasts | Zinc finger proteins | Trinucleotide repeat diseases
Journal Article
FRONTIERS IN NEUROLOGY, ISSN 1664-2295, 06/2018, Volume 9, p. 516
Impairment of the metabotropic glutamate receptor 5 (mGluR5) has been implicated with various neurologic disorders. Although mGluR5 density can be quantified... 
HUMAN BRAIN | PET imaging | IMMUNOREACTIVITY | RADIOLIGAND | test-retest | input function | METABOTROPIC GLUTAMATE RECEPTORS | [C-11]ABP688 | NEUROSCIENCES | CLINICAL NEUROLOGY | POSITRON-EMISSION-TOMOGRAPHY | IN-VIVO | RAT-BRAIN | 5 AVAILABILITY | mGluR5 | HUNTINGTONS-DISEASE | [11C]ABP688
Journal Article
Movement disorders : official journal of the Movement Disorder Society, ISSN 0885-3185, 01/2020
Changes in phosphodiesterase 10A enzyme levels may be a suitable biomarker of disease progression in Huntington's disease. To evaluate phosphodiesterase 10A... 
Journal Article
PloS one, 2018, Volume 13, Issue 10, p. e0206613
The positron emission tomography (PET) tracer [18F]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for... 
Journal Article
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, ISSN 0271-678X, 07/2019, p. 271678X19864081
Synaptic pathology is associated with several brain disorders, thus positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) using... 
Journal Article
Science, ISSN 0036-8075, 3/2000, Volume 287, Issue 5458, pp. 1660 - 1664
Journal Article
Neuroimage, ISSN 1053-8119, 05/2017, Volume 152, p. 330
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.neuroimage.2017.02.047 
Enzymes | Image processing | Physiological aspects | Phenols
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2015, Volume 78, Issue 7, pp. 452 - 462
Journal Article