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Journal Article
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 216 - U107
Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model... 
AMYLOID BETA-PROTEIN | APP | MICROTUBULE-BINDING | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DOWN-SYNDROME | MOUSE MODEL | TAU | DYSFUNCTION | FIBROBLASTS | SENILE PLAQUES | Neurons - pathology | Coculture Techniques | Humans | Middle Aged | Amyloid beta-Peptides - secretion | tau Proteins - metabolism | Male | Phosphoproteins - metabolism | Endosomes - metabolism | Synapsins - metabolism | Alzheimer Disease - pathology | Cellular Reprogramming | Protease Inhibitors - pharmacology | Amyloid beta-Protein Precursor - secretion | Proteolysis | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Aged, 80 and over | Female | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Astrocytes - cytology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Peptide Fragments - metabolism | Cells, Cultured | Peptide Fragments - secretion | Glycogen Synthase Kinase 3 - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Models, Biological | Alzheimer Disease - metabolism | Fibroblasts - cytology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Enzyme Activation | Messenger RNA | Synthesis | Glycogen | Stem cells | Physiological aspects | Research | Alzheimer's disease | Proteins | Phosphorylation | Neurons | Efficiency | Genomes | Mutation | Alzheimers disease | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 50, Issue 1, pp. 115 - 125
Sensory experience plays an instructive role in the development of the nervous system. Here we showed that visual experience can induce persistent modification... 
SYSNEURO | MOLNEURO | SUPERIOR COLLICULUS | NMDA RECEPTOR | NEUROTROPHIC FACTOR | IN-VIVO | NITRIC-OXIDE | OCULAR DOMINANCE | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | DIRECTION SELECTIVITY | 2-Amino-5-phosphonovalerate - pharmacology | Neuronal Plasticity - drug effects | Superior Colliculi - physiology | Long-Term Synaptic Depression - drug effects | Patch-Clamp Techniques - methods | Indole Alkaloids | Visual Pathways - physiology | Neuronal Plasticity - physiology | Long-Term Potentiation - drug effects | Time Factors | Neurons - physiology | Long-Term Potentiation - physiology | Action Potentials - radiation effects | Neurons - drug effects | Motion Perception - physiology | Action Potentials - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Long-Term Synaptic Depression - physiology | Xenopus laevis | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Reaction Time - physiology | Long-Term Potentiation - radiation effects | Action Potentials - physiology | Retina - physiology | Animals | Photic Stimulation - methods | Superior Colliculi - cytology | Carbazoles - pharmacology | In Vitro Techniques | Long-Term Synaptic Depression - radiation effects | Peptide hormones | Nitric oxide | Retina | Experiments | Light | Rodents | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, pp. e17540 - e17540
Background: Neural induction of human pluripotent stem cells often yields heterogeneous cell populations that can hamper quantitative and comparative analyses.... 
PROGENITOR CELLS | NERVOUS-SYSTEM | HUMAN ES | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | SELF-RENEWAL | FLOW-CYTOMETRIC ANALYSIS | DOPAMINERGIC-NEURONS | DIFFERENTIATION | FETAL | HUMAN BLASTOCYSTS | Cell Proliferation | Antibodies - metabolism | Humans | Neurons - cytology | Neural Stem Cells - cytology | Antigens, CD - metabolism | Neuroglia - cytology | Spinal Cord - pathology | Neural Stem Cells - transplantation | Cell Differentiation | Cell Membrane - metabolism | Neurons - metabolism | Biomarkers - metabolism | Pluripotent Stem Cells - cytology | Cell Survival | Cells, Cultured | Rats | Cell Separation - methods | Rats, Sprague-Dawley | Pluripotent Stem Cells - metabolism | Phenotype | Animals | Models, Biological | Neuroglia - metabolism | Mice | Neural Stem Cells - metabolism | Viral antibodies | Antibodies | Comparative analysis | Cell differentiation | Embryonic stem cells | Neurons | Flow cytometry | Neurosciences | Populations | Transplants & implants | Image processing | Laboratories | Embryo cells | Fluorescence | Cell surface | Neuronal-glial interactions | CD44 antigen | Rodents | Paralysis | Signatures | Drug dosages | Astrocytes | Glial fibrillary acidic protein | Markers | Cultures | Embryos | Screens | Medicine | Studies | Brain research | Stem cells | Neural stem cells | CD18 antigen | Spinal cord injuries | Anesthesiology | Differentiation | Surface markers | Pluripotency | Cell culture | Mixed culture | Action potential | Glia | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2013, Volume 19, Issue 4, pp. 473 - 480
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 12/2008, Volume 3, Issue 6, pp. 649 - 657
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. ALS can be induced by mutations in the superoxide... 
STEMCELL
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2011, Volume 108, Issue 51, pp. 20382 - 20387
Long interspersed element-1 (L1) retrotransposons compose ∼20% of the mammalian genome, and ongoing L1 retrotransposition events can impact genetic diversity... 
Genetic transposition | Retrotransposons | TELOMERASE AND RETROTRANSPOSONS: REVERSE TRANSCRIPTASES THAT SHAPED GENOMES SPECIAL FEATURE SACKLER COLLOQUIUM | HCT116 cells | Neurons | Somatic cells | DNA | Genomics | Cell lines | Cell cycle | CHO cells | APOPTOSIS | INDEPENDENT LINE-1 RETROTRANSPOSITION | RNA | ORF1 PROTEIN | MULTIDISCIPLINARY SCIENCES | REVERSE-TRANSCRIPTASE | DISEASE | MAMMALIAN-CELLS | P53 | Cell Line | Green Fluorescent Proteins - metabolism | Signal Transduction | Humans | Long Interspersed Nucleotide Elements - genetics | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Ataxia Telangiectasia Mutated Proteins | Endonucleases - metabolism | DNA-Binding Proteins - genetics | Neural Stem Cells - cytology | Retroelements - genetics | Animals | DNA Repair | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Fibroblasts - cytology | Mice | Physiological aspects | Ataxia telangiectasia | Genetic aspects | Health aspects | Stem cells | Proteins | Genomes | Mutation | DNA damage | Cells | Brain | Neurodegenerative diseases | Reverse transcription | Data processing | Genetic diversity | Retrotransposition | Embryogenesis | Rett syndrome | Development | Ataxia telangiectasia mutated protein | Neural stem cells | Protein-serine/threonine kinase | copy number | Index Medicus | Biological Sciences | Telomerase and Retrotransposons
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5627 - 5627
Journal Article