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Nature Medicine, ISSN 1078-8956, 07/2009, Volume 15, Issue 7, pp. 781 - 787
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 02/2014, Volume 6, Issue 2, pp. 226 - 238
Multiple sclerosis ( MS ) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of... 
proteasome | immunoproteasome | experimental autoimmune encephalomyelitis | multiple sclerosis | Experimental autoimmune encephalomyelitis | Multiple sclerosis | Immunoproteasome | Proteasome | MEDICINE, RESEARCH & EXPERIMENTAL | ALLERGIC ENCEPHALOMYELITIS | MOUSE MODELS | SELECTIVE INHIBITOR | CYTOKINE PRODUCTION | DUAL INHIBITION | MULTIPLE-SCLEROSIS | PHASE-I TRIAL | GM-CSF | T-CELL REPERTOIRE | PROTEASOME INHIBITORS | Inflammation - pathology | Peptide Fragments | Spinal Cord - drug effects | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Oligopeptides - therapeutic use | Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis | T-Lymphocytes - metabolism | Spinal Cord - pathology | T-Lymphocytes - drug effects | Female | Proteasome Endopeptidase Complex - immunology | Disease Models, Animal | Proteasome Inhibitors - pharmacology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Myelin-Oligodendrocyte Glycoprotein | Disease Progression | Proteasome Inhibitors - therapeutic use | Brain - drug effects | Cell Differentiation - immunology | Proteasome Endopeptidase Complex - deficiency | Animals | Brain - pathology | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Mice | Proteasome Endopeptidase Complex - metabolism | Oligopeptides - pharmacology | Development and progression | Encephalomyelitis | T cells | Analysis | Disease | Autoimmune diseases | Rodents | Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. 4796 - 4796
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 24, pp. 11127 - 11143
Selective immunoproteasome inhibition is a promising approach for treating autoimmune disorders, but optimal proteolytic active site subunit inhibition... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2009, Volume 52, Issue 9, pp. 3028 - 3038
Journal Article
Immunity, ISSN 1074-7613, 2001, Volume 15, Issue 6, pp. 985 - 995
We have characterized a cytokine produced by Th2 cells, designated as IL-25. Infusion of mice with IL-25 induced IL-4, IL-5, and IL-13 gene expression. The... 
CELLS | RESPONSES | CYTOKINES | BINDING SUBUNIT | INTERLEUKIN-13 RECEPTOR | GRANULOPOIESIS | COMPONENT | DEFICIENT MICE | IMMUNOLOGY | EXPRESSION | REQUIREMENT | Humans | Hyperplasia | Interleukin-5 - genetics | Eosinophilia - pathology | Integrin alphaXbeta2 - analysis | RNA, Messenger - biosynthesis | Interleukin-13 - genetics | Interleukin-4 - biosynthesis | Interleukins | T-Lymphocyte Subsets - drug effects | Gastrointestinal Diseases - pathology | Amino Acid Sequence | Hypergammaglobulinemia - chemically induced | Histocompatibility Antigens Class II - analysis | Mice, Knockout | Nuclear Proteins | Receptors, Interleukin-4 - deficiency | Cell Lineage | Growth Substances - pharmacology | Mice | Mice, Inbred BALB C | Hypertrophy | Intestinal Mucosa - pathology | Th2 Cells - secretion | Growth Substances - secretion | Eosinophilia - chemically induced | Pulmonary Eosinophilia - chemically induced | Molecular Sequence Data | Gastric Mucosa - pathology | Interleukin-5 - biosynthesis | Th2 Cells - chemistry | DNA-Binding Proteins - deficiency | Interleukin-13 - biosynthesis | Cloning, Molecular | Interleukin-17 | Interleukin-4 - genetics | Growth Substances - toxicity | Gastrointestinal Diseases - immunology | Pulmonary Eosinophilia - immunology | Lung - pathology | Mice, Inbred C57BL | Cells, Cultured | DNA-Binding Proteins - genetics | Pulmonary Eosinophilia - pathology | Gene Expression Regulation - drug effects | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Eosinophilia - immunology | Growth Substances - isolation & purification | Receptors, Interleukin-4 - genetics | T-Lymphocyte Subsets - secretion | Gastrointestinal Diseases - chemically induced | interleukin 25 | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/2002, Volume 169, Issue 1, pp. 443 - 453
We have biologically characterized two new members of the IL-17 cytokine family: IL-17F and IL-25. In contrast to conventional in vitro screening approaches,... 
RECEPTOR-GAMMA CHAIN | LYMPHOID DEVELOPMENT | ANTIBODY | ASTHMA | GENE-THERAPY | AIRWAY HYPERRESPONSIVENESS | DEFICIENT MICE | IMMUNOLOGY | IDENTIFICATION | CELL | EXPRESSION | Interleukin-13 - physiology | Bronchial Hyperreactivity - immunology | Humans | Pulmonary Eosinophilia - genetics | Pulmonary Eosinophilia - virology | Interleukin-17 - physiology | Male | Th2 Cells - immunology | Lymphocyte Subsets - immunology | Leukocytosis - virology | Cell Movement - immunology | Th1 Cells - metabolism | RNA, Messenger - biosynthesis | Growth Substances - genetics | Interleukins | Adenoviridae - immunology | Growth Substances - administration & dosage | Amino Acid Sequence | Leukocytosis - immunology | Interleukin-17 - genetics | Neutrophils - virology | Intestinal Diseases, Parasitic - immunology | Mice, Knockout | Mice | Mice, Inbred BALB C | Amino Acid Motifs - genetics | Strongylida Infections - genetics | Molecular Sequence Data | Interleukin-5 - biosynthesis | Th1 Cells - immunology | Hematopoietic Stem Cells - immunology | Interleukin-17 - chemistry | Intestinal Diseases, Parasitic - genetics | Growth Substances - chemistry | Strongylida Infections - immunology | Basophils - immunology | Adenoviridae - genetics | Killer Cells, Natural - immunology | Female | Mucus - metabolism | Interleukin-5 - physiology | Lung - metabolism | Pulmonary Eosinophilia - immunology | Mast Cells - immunology | Lung - pathology | Mice, Inbred C57BL | Aspergillosis - genetics | Neutrophils - immunology | Hematopoietic Stem Cells - metabolism | Inflammation - immunology | Interleukin-17 - biosynthesis | Administration, Intranasal | Th2 Cells - metabolism | Sequence Homology, Amino Acid | Animals | Amino Acid Motifs - immunology | Growth Substances - physiology | Inflammation - genetics | Genetic Vectors | Leukocytosis - genetics | Granulocytes - immunology | Lung - immunology | Aspergillosis - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 8 Supplement, pp. 2607 - 2607
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2861 - 2861
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 04/2017, Volume 8, Issue 4, pp. 413 - 417
Building upon the success of bortezomib (VELCADE) and carfilzomib (KYPROLIS), the design of a next generation of inhibitors targeting specific subunits within... 
LMP2 | β1c | immunoproteasome | constitutive proteasome | β1i | 20S PROTEASOME | CARFILZOMIB | DESIGN | CHEMISTRY, MEDICINAL | beta 1i | PHARMACOKINETICS | METABOLISM | beta lc
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 1993, Volume 177, Issue 4, pp. 1205 - 1208
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/1994, Volume 179, Issue 1, pp. 305 - 310
We have previously shown that continuous administration of anti-interleukin 10 (anti-IL-10) antibodies (Abs) to BALB/c mice modifies endogenous levels of... 
GEL-ELECTROPHORESIS | B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | INTERFERON | HLA-DR | SYSTEMIC LUPUS-ERYTHEMATOSUS | MONOCLONAL-ANTIBODY | MAJOR HISTOCOMPATIBILITY COMPLEX | IMMUNOLOGY | GENETIC PREDISPOSITION | FACTOR-ALPHA | Index Medicus
Journal Article
02/2019
Provided herein are methods of treating autoimmune diseases comprising administering to a subject suffering therefrom an immunoproteasome inhibitor and an... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
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