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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1518 - 13
Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells. It is overexpressed in various... 
APOPTOSIS | HYPERMETHYLATION | IRON HOMEOSTASIS | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | GROWTH | C-MYC | GENE-EXPRESSION | CELL-CYCLE | PROLIFERATION | MICRORNA | Cell proliferation | Post-transcription | Liver cancer | Cell growth | Transferrin | 3' Untranslated regions | Gene regulation | MiRNA | Hepatocellular carcinoma | Iron | Regulatory sequences | Mammalian cells
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. SCI-43 - SCI-43
Imbalances of iron homeostasis account for some of the most common human diseases. Pathologies result from both, iron deficiency or overload and frequently... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Suppl_1, pp. 3625 - 3625
Abstract Iron overload is common in MDS, as a consequence of chronic red blood cell (RBC) transfusions and to a lesser extent, increased intestinal iron... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3626 - 3626
Abstract Liver is a heterogeneous organ central for the control of systemic iron homeostasis. Among the different cell types, only hepatocytes (parenchymal... 
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 12/2015, Volume 119, Issue 12, p. 1432
  Adequate acclimatization time to enable adjustment to hypoxic conditions is one of the most important aspects for mountaineers ascending to high altitude.... 
Oxygen | Homeostasis | Hypoxia | Iron | Hormones | Gene expression | Cells
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3624 - 3624
Abstract Transferrin receptor 2 (TFR2), the type 3 hemochromatosis gene, is an activator of the iron hormone hepcidin in the liver and a partner of... 
Journal Article
European heart journal, ISSN 0195-668X, 03/2019
Whether and how iron affects the progression of atherosclerosis remains highly debated. Here, we investigate susceptibility to atherosclerosis in a mouse model... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2340 - 2340
Abstract Accumulation of excess iron in tissues causes organ damage and dysfunction and may lead to serious clinical consequences including liver cirrhosis,... 
Journal Article
Pharmaceuticals, ISSN 1424-8247, 03/2019, Volume 12, Issue 1, p. 5
A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled... 
Iron homeostasis | Hypoxia | Oxygen sensing | Lung diseases | lung diseases | hypoxia | oxygen sensing | iron homeostasis
Journal Article
Nature communications, 08/2018, Volume 9, Issue 1, p. 3129
Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are... 
Mitochondrial Dynamics | Humans | Middle Aged | Carnitine - blood | Diabetes Mellitus - metabolism | Male | Mitochondria - metabolism | Case-Control Studies | Stearic Acids - metabolism | Cross-Over Studies | Musa | Diet | Oxygen - chemistry | Adult | Female | Carnitine - analogs & derivatives | Beverages | Fatty Acids - metabolism
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 199 - 199
Abstract In 1981 Sullivan proposed the "iron hypothesis", which states that iron is detrimental for the cardiovascular system, promoting atherosclerosis... 
Journal Article
Journal Article
Blood, ISSN 0006-4971, 08/2014, Volume 124, Issue 8, pp. 1212 - 1213
In this issue of Blood , Wu et al describe the molecular function of HFE , the gene most commonly mutated in hereditary hemochromatosis (HH). 1 HH is the most... 
REGULATOR | PROTEIN | HEPCIDIN EXPRESSION | HEMATOLOGY | IRON OVERLOAD | BMP6 | Histocompatibility Antigens Class I - metabolism | Animals | Hemochromatosis Protein | Hepcidins - biosynthesis | Humans | Gene Expression Regulation - physiology | Membrane Proteins - metabolism | Bone Morphogenetic Protein Receptors, Type I - metabolism | Inside
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 01/2014, Volume 10, Issue 1
  Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron... 
Proteins | Phosphorylation | Transcription factors | Disease | Cytokines | Feedback | Homeostasis | Iron | RNA polymerase | Gene expression | Experiments | Control | Circuits | Control equipment | Mathematical models | Combinatorial analysis | Diseases
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 1040 - 1040
Abstract Pathologies associated with increased circulating iron levels include primary iron overload disorders, such as hereditary hemochromatosis, as well as... 
Journal Article
Cell Metabolism, ISSN 1550-4131, 2008, Volume 8, Issue 1, pp. 1 - 3
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 214 - 214
Abstract Hypoferremia represents an innate immune response to infection and inflammation sequestering iron from pathogens. The iron-hormone hepcidin is induced... 
Journal Article
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