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by George, J and Lim, J.S and Jang, S.J and Cun, Y.P and Ozretic, L and Kong, G and Leenders, F and Lu, X and Fernandez-Cuesta, L and Bosco, G and Muller, C and Dahmen, I and Jahchan, N.S and Park, K.S and Yang, D and Karnezis, A.N and Vaka, D and Torres, A and Wang, M.S and Korbel, J.O and Menon, R and Chun, S.M and Kim, D and Wilkerson, M and Hayes, N and Engelmann, D and Putzer, B and Bos, M and Michels, S and Vlasic, I and Seidel, D and Pinther, B and Schaub, P and Becker, C and Altmuller, J and Yokota, J and Kohno, T and Iwakawa, R and Tsuta, K and Noguchi, M and Muley, T and Hoffmann, H and Schnabel, P.A and Petersen, I and Chen, Y and Soltermann, A and Tischler, V and Choi, C.M and Kim, Y.H and Massion, P.P and Zou, Y and Jovanovic, D and Kontic, M and Wright, G.M and Russell, P.A and Solomon, B and Koch, I and Lindner, M and Muscarella, L.A and la Torre, A and Field, J.K and Jakopovic, M and Knezevic, J and Castanos-Velez, E and Roz, L and Pastorino, U and Brustugun, O.T and Lund-Iversen, M and Thunnissen, E and Kohler, J and Schuler, M and Botling, J and Sandelin, M and Sanchez-Cespedes, M and Salvesen, H.B and Achter, V and Lang, U and Bogus, M and Schneider, P.M and Zander, T and Ansen, S and Hallek, M and Wolf, J and Vingron, M and Yatabe, Y and Travis, W.D and Nurnberg, P and Reinhardt, C and Perner, S and Heukamp, L and Buttner, R and Haas, S.A and Brambilla, E and Peifer, M and Sage, J and Thomas, R.K and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Lungmedicin och allergologi and Uppsala universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 2015, Volume 524, Issue 7563, pp. 47 - 53
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic... 
NEUROENDOCRINE TUMORS | PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | IN-VIVO | GENES | CYCLE ARREST | NOTCH | C-KIT | MUTATIONS | CARCINOMA | Neurosecretory Systems - pathology | Receptors, Notch - metabolism | Chromosome Breakpoints | Genomics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Receptors, Notch - genetics | Gene Expression Profiling | Tumor Suppressor Protein p53 - genetics | Small Cell Lung Carcinoma - metabolism | Tumor Suppressor Proteins - genetics | Neurosecretory Systems - metabolism | Female | Nuclear Proteins - genetics | Disease Models, Animal | Lung Neoplasms - genetics | Signal Transduction - genetics | Small Cell Lung Carcinoma - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Genome, Human - genetics | Small Cell Lung Carcinoma - pathology | Tumor Protein p73 | Animals | Cyclin D1 - genetics | Retinoblastoma Protein - genetics | Alleles | Cell Line, Tumor | Mice | Gene mutations | Analysis | Exome sequencing | Lung cancer, Small cell | Genetic aspects | Drug therapy | Cancer | Pathogenesis | Lung cancer | Genomes | Mutation | Kinases | Gene expression | Cancer therapies | Tumors | Clinical Medicine | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
Nature Genetics, ISSN 1061-4036, 2012, Volume 44, Issue 10, pp. 1104 - 1110
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Journal Article
Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 209, pp. 209ra153 - 209ra153
We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically... 
GEFITINIB | FUSION | GENE | ADENOCARCINOMA | OPEN-LABEL | SQUAMOUS-CELL CARCINOMAS | HUMAN CANCER | ACTIVATING MUTATIONS | DRIVER MUTATIONS | EGFR | MEDICINE, RESEARCH & EXPERIMENTAL | NRF2 | CANCER | CELL BIOLOGY | Lung Neoplasms - genetics | Lung Neoplasms - classification | Automation | Genomics | Humans | Lung Neoplasms - pathology | Lung Neoplasms - diagnosis | Genome, Human - genetics
Journal Article
Journal Article
Human Pathology, ISSN 0046-8177, 2014, Volume 45, Issue 6, pp. 1162 - 1168
Journal Article
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, p. 33505
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Journal Article
Journal Article
by Hammerman, Peter S and Voet, Doug and Lawrence, Michael S and Voet, Doug and Jing, Rui and Cibulskis, Kristian and Sivachenko, Andrey and Stojanov, Petar and McKenna, Aaron and Lander, Eric S and Gabriel, Stacey and Getz, Gad and Imielinski, Marcin and Helman, Elena and Hernandez, Bryan and Pho, Nam H and Meyerson, Matthew and Chu, Andy and Hye-Chun, Jung E and Mungall, Andrew J and Pleasance, Erin and Robertson, A. Gordon and Sipahimalani, Payal and Stoll, Dominik and Balasundaram, Miruna and Birol, Inanc and Butterfield, Yaron S.N and Chuah, Eric and Coope, Robin J.N and Corbett, Richard and Dhalla, Noreen and Guin, Ranabir and He, An and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Mungall, Karen and Nip, Ka Ming and Olshen, Adam and Schein, Jacqueline E and Slobodan, Jared R and Tam, Angela and Thiessen, Nina and Varhol, Richard and Zeng, Thomas and Zhao, Yongjun and Jones, Steven J.M and Marra, Marco A and Saksena, Gordon and Cherniack, Andrew D and Schumacher, Stephen E and Tabak, Barbara and Carter, Scott L and Nguyen, Huy and Onofrio, Robert C and Crenshaw, Andrew and Ardlie, Kristin and Beroukhim, Rameen and Winckler, Wendy and Protopopov, Alexei and Zhang, Jianhua and Hadjipanayis, Angela and Lee, Semin and Xi, Ruibin and Yang, Lixing and Ren, Xiaojia and Zhang, Hailei and Shukla, Sachet and Chen, Peng-Chieh and Haseley, Psalm and Lee, Eunjung and Chin, Lynda and Park, Peter J and Kucherlapati, Raju and Socci, Nicholas D and Liang, Yupu and Schultz, Nikolaus and Borsu, Laetitia and Lash, Alex E and Viale, Agnes and Sander, Chris and Ladanyi, Marc and Auman, J. Todd and Hoadley, Katherine A and Wilkerson, Matthew D and Shi, Yan and Liquori, Christina and Meng, Shaowu and Li, Ling and Turman, Yidi J and Topal, Michael D and Tan, Donghui and Waring, Scot and Buda, Elizabeth and Walsh, Jesse and Jones, Corbin D and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7417, pp. 519 - 525
Journal Article