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Angewandte Chemie International Edition, ISSN 1433-7851, 05/2006, Volume 45, Issue 22, pp. 3635 - 3638
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 12/2016, Volume 12, Issue 12, pp. 1065 - 1074
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2014, Volume 57, Issue 6, pp. 2746 - 2754
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2015, Volume 58, Issue 14, pp. 5561 - 5578
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0120295
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 08/2012, Volume 53, Issue 32, pp. 4114 - 4116
Matrix metalloproteinases (MMPs), a class of zinc-enzymes over-activated in many pathologies, such as arthritis and cancer, can be efficiently inhibited by a... 
Ring closing metathesis | Metalloproteinase inhibitors | Zinc-enzymes | N-Hydroxylactams | MATRIX METALLOPROTEINASES | DESIGN | DRUG DISCOVERY | DISEASE | CHEMISTRY, ORGANIC
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2012, Volume 77, Issue 17, pp. 7187 - 7211
Journal Article
Organic Letters, ISSN 1523-7060, 11/2010, Volume 12, Issue 22, pp. 5230 - 5233
A short and modular synthetic pathway using intramolecular 1,3-dipolar cycloaddition reactions and yielding functionalized isoxazoles, isoxazolines, and... 
REARRANGEMENT | ALCOHOLS | NITRONES | ACIDS | NITRILE OXIDES | CHEMISTRY, ORGANIC | OLEFINS | 1,3 TRANSPOSITION | AMINE FUNCTIONS | INTRAMOLECULAR CYCLOADDITION | CYCLIZATION | Molecular Structure | Isoxazoles - chemistry | Cyclization | Stereoisomerism | Letter
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 08/2017, Volume 13, Issue 8, pp. 922 - 922
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2014, Volume 5, Issue 2, pp. 149 - 153
A phenotypic high-throughput screen using ∼100,000 compounds prepared using Diversity-Oriented Synthesis yielded stereoisomeric compounds with nanomolar... 
Molecular Libraries Probe Production Centers Network | infectious disease | diversity-oriented synthesis | high-throughput screening | neglected disease | Chagas disease | phenotypic assay | Trypanosoma cruzi | CHEMISTRY, MEDICINAL | TRYPANOSOMA-CRUZI | LIBRARY
Journal Article
Nature chemical biology, ISSN 1552-4469, 2016, Volume 12, Issue 12, p. 1065
Journal Article
ACS Infectious Diseases, ISSN 2373-8227, 05/2017, Volume 3, Issue 5, pp. 349 - 359
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the... 
CDAD | C. difficile | diversity-oriented synthesis | glutamate racemase | INFECTIOUS DISEASES | CHEMISTRY, MEDICINAL | FECAL MICROBIOTA TRANSPLANTATION | MODEL | DISCOVERY | LIBRARIES | FIDAXOMICIN | VANCOMYCIN | COLITIS | TARGETS | INFECTION | Species Specificity | Gram-Positive Bacteria - drug effects | Amino Acid Isomerases - antagonists & inhibitors | Clostridium difficile - genetics | Enterocolitis, Pseudomembranous - microbiology | Structure-Activity Relationship | Quinolines - pharmacology | Microbial Sensitivity Tests | Enterocolitis, Pseudomembranous - mortality | Clostridium difficile - enzymology | Drug Design | Female | Gram-Positive Bacteria - growth & development | Bacterial Proteins - antagonists & inhibitors | Gene Expression | Mice, Inbred C57BL | Bacterial Proteins - genetics | Enterocolitis, Pseudomembranous - pathology | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Quinolines - chemical synthesis | Gram-Negative Bacteria - drug effects | Enterocolitis, Pseudomembranous - drug therapy | Pyrroles - pharmacology | Animals | Phenylurea Compounds - chemical synthesis | Pyrroles - chemical synthesis | Amino Acid Isomerases - metabolism | Amino Acid Isomerases - genetics | Gram-Negative Bacteria - growth & development | Survival Analysis | Bacterial Proteins - metabolism | Clostridium difficile - growth & development | Anti-Bacterial Agents - pharmacology | Mice | Phenylurea Compounds - pharmacology | Heterocyclic Compounds, 2-Ring - chemical synthesis | Clostridium difficile - drug effects
Journal Article
European Journal of Cancer, ISSN 0959-8049, 1993, Volume 29, pp. S250 - S250
Journal Article
International Journal of Oncology, ISSN 1019-6439, 1993, Volume 2, Issue 2, pp. 335 - 338
MCA serum levels were determined in 196 patients with benign breast disease (BD) and in 371 patients with breast cancer. MCA values were abnormal in 30.6% of... 
MCA | MANAGEMENT | ONCOLOGY | BREAST CANCER | MONOCLONAL-ANTIBODIES | TUMOR MARKER
Journal Article
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