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schizophrenia (11) 11
humans (10) 10
female (9) 9
psychiatry (9) 9
male (8) 8
folate (7) 7
schizophrenia - genetics (7) 7
adult (6) 6
association (6) 6
homocysteine (6) 6
methylenetetrahydrofolate reductase - genetics (6) 6
genetics (5) 5
metaanalysis (5) 5
middle aged (5) 5
neurosciences (5) 5
risk factors (5) 5
case-control studies (4) 4
disorders (4) 4
index medicus (4) 4
candidate gene (3) 3
clinical neurology (3) 3
common mutation (3) 3
copy number variation (3) 3
cytogenetic abnormality (3) 3
deletion (3) 3
duplication (3) 3
enzyme-activity (3) 3
folic acid (3) 3
gene frequency (3) 3
genetics & heredity (3) 3
genotype (3) 3
homocysteine - blood (3) 3
methylenetetrahydrofolate reductase (3) 3
netherlands (3) 3
neural-tube defects (3) 3
neurodevelopment (3) 3
pharmacology & pharmacy (3) 3
polymorphism, genetic (3) 3
psychiatric disorder (3) 3
risk-factor (3) 3
schizophrenia - epidemiology (3) 3
alleles (2) 2
analysis (2) 2
bipolar disorder (2) 2
catechol o-methyltransferase - genetics (2) 2
catechol-o-methyltransferase (2) 2
comt (2) 2
deficiency (2) 2
development and progression (2) 2
disease (2) 2
enzymes (2) 2
gene (2) 2
genes (2) 2
genetic aspects (2) 2
genetic polymorphisms (2) 2
genetic predisposition to disease (2) 2
hidden-markov model (2) 2
homocysteine metabolism (2) 2
human brain (2) 2
internal medicine (2) 2
medical genetics (2) 2
mental disorders (2) 2
metabolism (2) 2
methylenetetrahydrofolate reductase gene (2) 2
mthfr (2) 2
neurodevelopmental (2) 2
odds ratio (2) 2
plasma homocysteine (2) 2
polymorphism, single nucleotide (2) 2
recurrent rearrangements (2) 2
risk assessment (2) 2
schizophrenia - etiology (2) 2
seasonality (2) 2
symptoms (2) 2
variant (2) 2
variants (2) 2
vascular-disease (2) 2
5,10-methylenetetrahydrofolate reductase (1) 1
abnormalities (1) 1
adolescence (1) 1
adults (1) 1
age (1) 1
age differences (1) 1
age factors (1) 1
age groups (1) 1
age of onset (1) 1
aged (1) 1
animals (1) 1
article (1) 1
autism (1) 1
autism spectrum disorder - diagnosis (1) 1
autism spectrum disorder - epidemiology (1) 1
autism spectrum quotient (1) 1
base pairing - genetics (1) 1
base sequence - genetics (1) 1
bipolar-disorder (1) 1
blood coagulation, fibrinolysis and cellular haemostasis (1) 1
candidate genes (1) 1
carbon cycle (1) 1
catechol- o-methyltransferase (1) 1
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1. Full Text Differences of Symptom Distribution Across Adult Age in High Functioning Individuals on the Autism Spectrum Using Subscales of the Autism Spectrum Quotient
by Siebes, R.A and Muntjewerff, J.W and Staal, W.G
Journal of Autism and Developmental Disorders, ISSN 0162-3257, 2018, Volume 48, Issue 11, pp. 3939 - 3944
Little is known about the distribution of symptoms of Autism Spectrum Disorder (ASD) across the lifespan. In this cross-sectional study, we examined... 
Pediatrics | Child and School Psychology | Neurosciences | Public Health | Autism Spectrum Quotient (AQ) | Subscales | Psychology | Adults | Age groups | LANGUAGE | PSYCHOLOGY, DEVELOPMENTAL | EARLY-CHILDHOOD | VALIDATION | FOLLOW-UP | DISORDERS | ADOLESCENCE | VERSION | VALIDITY | Autism | Pervasive Developmental Disorders | Age Differences | Questionnaires | Scores | Spouses | Symptoms (Individual Disorders) | Age Factors | Autism Spectrum Disorder - epidemiology | Humans | Adult | Female | Male | Autism Spectrum Disorder - diagnosis | Medical research | Life cycle, Human | Pervasive developmental disorders | Medicine, Experimental | Development and progression | Research | Health aspects | Surveys | Diagnosis | Patient outcomes | Analysis | Domestic relations | Original Paper
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2. Full Text Genome-Wide Analysis Shows Increased Frequency of Copy Number Variation Deletions in Dutch Schizophrenia Patients
by Buizer-Voskamp, Jacobine E and Muntjewerff, Jan-Willem and Strengman, Eric and Sabatti, Chiara and Stefansson, Hreinn and Vorstman, Jacob A.S and Ophoff, Roel A and Genetic Risk Outcome Psychosis Grp and Genetic Risk and Outcome in Psychosis (GROUP) Consortium Members
Biological Psychiatry, ISSN 0006-3223, 2011, Volume 70, Issue 7, pp. 655 - 662
Background Since 2008, multiple studies have reported on copy number variations (CNVs) in schizophrenia. However, many regions are unique events with minimal... 
Psychiatry | cytogenetic abnormality | Candidate gene | schizophrenia | copy number variation | deletion | duplication | METAANALYSIS | VARIANTS | ABNORMALITIES | HIDDEN-MARKOV MODEL | RECURRENT REARRANGEMENTS | BIPOLAR DISORDER | IDENTIFICATION | NEUROSCIENCES | GENETICS | GENES | ASSOCIATION | Base Sequence - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Netherlands | Schizophrenia - genetics | Humans | DNA Copy Number Variations - genetics | Case-Control Studies | Sequence Deletion - genetics | Neurosciences | Analysis | Genomics | Medical genetics | Genetic research | Schizophrenia | Development and progression
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3. Full Text Genome-wide analysis shows increased frequency of CNV deletions in Dutch schizophrenia patients
by Buizer-Voskamp, Jacobine E and Muntjewerff, Jan-Willem and and Strengman, Eric and Sabatti, Chiara and Stefansson, Hreinn and Vorstman, Jacob AS and Ophoff, Roel A
Biological psychiatry, ISSN 0006-3223, 10/2011, Volume 70, Issue 7, pp. 655 - 662
cytogenetic abnormality | candidate gene | schizophrenia | copy number variation | deletion | duplication
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4. Full Text Effects of season of birth and a common MTHFR gene variant on the risk of schizophrenia
by Muntjewerff, Jan-Willem and Ophoff, Roel A and Buizer-Voskamp, Jacobine E and Strengman, Eric and van Os, Jim and den Heijer, Martin
European Neuropsychopharmacology, ISSN 0924-977X, 04/2011, Volume 21, Issue 4, pp. 300 - 305
disorders | Neurodevelopmental | Seasonality | Schizophrenia | MTHFR | Folate
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5. Full Text Effects of season of birth and a common MTHFR gene variant on the risk of schizophrenia
by Muntjewerff, Jan-Willem and Ophoff, Roel A and Buizer-Voskamp, Jacobine E and Strengman, Eric and den Heijer, Martin and GRP Consortium and GROUP Consortium
European Neuropsychopharmacology, ISSN 0924-977X, 2011, Volume 21, Issue 4, pp. 300 - 305
Abstract Season of birth – in particular winter birth – has been persistently related to increased schizophrenia risk. Variation in folate intake is among the... 
Internal Medicine | Psychiatry | Schizophrenia | MTHFR | Neurodevelopmental disorders | Folate | Seasonality | Neurodevelopmental | METAANALYSIS | PSYCHIATRY | NEURAL-TUBE DEFECTS | SUMMER BIRTH | NEUROSCIENCES | CLINICAL NEUROLOGY | METHYLENETETRAHYDROFOLATE REDUCTASE | disorders | HUMAN-LEUKOCYTE ANTIGEN | METABOLISM | PHARMACOLOGY & PHARMACY | WIDE ASSOCIATION | JAPANESE PATIENTS | PLASMA HOMOCYSTEINE | Genetic Predisposition to Disease | Maternal Nutritional Physiological Phenomena | Genetic Association Studies | Humans | Middle Aged | Risk Factors | Male | Schizophrenia - epidemiology | Case-Control Studies | Folic Acid Deficiency - physiopathology | Schizophrenia - etiology | Netherlands | Schizophrenia - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Adult | Female | Polymorphism, Single Nucleotide | Seasons | Enzymes | Methylenetetrahydrofolate reductase | Mental disorders | Folic acid
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6. Full Text Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: a combined analysis of independent samples
by Saetre, P and Vares, M and Werge, T and Aneassen, O.A and Arinami, T and Ishiguro, H and Nanko, S and Tan, E and Han, D.H and Roffman, J.L and Muntjewerff, J.W and Jagodzinski, P.P and Kempisty, B and Hauser, J and Vilella, E and Betcheva, E and Nakamura, Y and Regland, B and Agartz, I and Hall, H and Terenius, L and Jonsson, E.G and Medicinska fakulteten and Geriatrik and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för folkhälso- och vårdvetenskap
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, ISSN 1552-4841, 2011, Volume 156, Issue 2, pp. 215 - 224
Methylenetetrahydrofolate reductase (MTHFR) is involved in the one-carbon cycle, which is of importance for nucleotide synthesis and methylation of DNA,... 
methylenetetrahydrofolate reductase gene (MTHFR) | schizophrenia | age of onset | Age of onset | Schizophrenia | Methylenetetrahydrofolate reductase gene (MTHFR) | COMMON VARIANTS | GENETIC POLYMORPHISMS | ENZYME-ACTIVITY | PSYCHIATRY | CANDIDATE GENES | BIPOLAR-DISORDER | VASCULAR-DISEASE | EXECUTIVE FUNCTION | NO ASSOCIATION | RISK-FACTOR | GENETICS & HEREDITY | PLASMA HOMOCYSTEINE | Young Adult | European Continental Ancestry Group - genetics | Meta-Analysis as Topic | Carbon Cycle | Schizophrenia - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Humans | Age of Onset | Alleles | Female | Male | Polymorphism, Genetic | Enzymes | Reviews | Mental disorders | DNA methylation | Lipids | Methylenetetrahydrofolate reductase | Nucleotides | Gene polymorphism | Age | Membrane proteins | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | MEDICINE
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7. Full Text Aberrant folate status in schizophrenic patients: What is the evidence?
by Muntjewerff, Jan-Willem and Blom, Henk J
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 2005, Volume 29, Issue 7, pp. 1133 - 1139
A vast amount of case reports, open studies and, to a lesser extent, case–control studies have been published on the topic of psychopathology and folate... 
Vitamin | Neurodevelopment | Schizophrenia | Genetics | Homocysteine | Folate | Psychiatric disorder | homocysteine | psychiatric disorder | PSYCHIATRY | DISORDERS | schizophrenia | FOLIC-ACID | NEUROSCIENCES | vitamin | DEFICIENCY | CLINICAL NEUROLOGY | HOMOCYSTEINE LEVELS | folate | genetics | neurodevelopment | PSYCHIATRIC PATIENTS | RISK-FACTOR | METABOLISM | DISEASE | PHARMACOLOGY & PHARMACY | SERUM FOLATE | ASSOCIATION | MEDLINE | Folic Acid Deficiency - metabolism | Schizophrenia - metabolism | Folic Acid Deficiency - complications | Humans | Folic Acid - metabolism | Schizophrenia - complications | Folic Acid Deficiency - genetics | Physiological aspects | Folic acid
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8. Full Text Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study
by Muntjewerff, J.W and Hoogendoorn, M.L and Kahn, R.S and Sinke, R.J and Heijer, M. den and Kluijtmans, L.A.J and Blom, H.J
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, ISSN 1552-4841, 2005, Volume 135, Issue 1, pp. 69 - 72
Evidence for an involvement of aberrant homocysteine metabolism in the aetiology of schizophrenia is limited and controversial. A case-control study was... 
homocysteine | psychiatric disorder | folate | neurodegenerative disorder | genetics | neurodevelopment | Neurodegenerative disorder | Neurodevelopment | Genetics | Homocysteine | Folate | Psychiatric disorder | HOMOCYSTEINE METABOLISM | PSYCHIATRY | SYMPTOMS | COMMON MUTATION | VARIANT | GENE | DISEASE | GENETICS & HEREDITY | ASSOCIATION | Gene Frequency | Humans | Middle Aged | Risk Factors | Homocysteine - blood | Male | Case-Control Studies | Polymorphism, Genetic | Schizophrenia - etiology | Netherlands | Schizophrenia - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Adult | Female | Hyperhomocysteinemia - complications
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9. Full Text Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia
by Muntjewerff, Jan-Willem and van der Put, Nathalie and Eskes, Tom and Ellenbroek, Bart and Steegers, Eric and Blom, Henk and Zitman, Frans
Psychiatry Research, ISSN 0165-1781, 2003, Volume 121, Issue 1, pp. 1 - 9
Two apparently unrelated disorders, neural tube defects (NTD) and schizophrenia showed increased risks in birth cohorts exposed to famine during early... 
Schizophrenia | Methylenetetrahydrofolate reductase gene | Homocysteine | Vitamins | Polymorphism | homocysteine | METHYLATION | PSYCHIATRY | NEURAL-TUBE DEFECTS | PREVENTION | methylenetetrahydrofolate reductase gene | polymorphism | schizophrenia | VARIANT | DEFICIENCY | PATHOGENESIS | vitamins | MUTATION | ASSOCIATION | Risk Assessment | Humans | Middle Aged | Homocysteine - blood | Male | Gene Expression Regulation, Enzymologic - physiology | Vitamin B 12 - blood | Vitamin B 6 - blood | Schizophrenic Psychology | Schizophrenia - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Schizophrenia - diagnosis | DNA Mutational Analysis | Base Pairing - genetics | Folic Acid - blood | Adult | Female | Polymorphism, Genetic - genetics | Schizophrenia - enzymology | Erythrocytes - enzymology
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10. Full Text Polymorphisms in catechol- O -methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia
by Muntjewerff, Jan-Willem and Gellekink, Henkjan and den Heijer, Martin and Hoogendoorn, Mechteld L.C and Kahn, René S and Sinke, Richard J and Blom, Henk J
European Neuropsychopharmacology, ISSN 0924-977X, 2008, Volume 18, Issue 2, pp. 99 - 106
Abstract Background Evidence is emerging for the association of aberrant homocysteine-methylation cycle and increased risk of schizophrenia. Methods We... 
Internal Medicine | Psychiatry | Schizophrenia | Genetics | Methylenetetrahydrofolate reductase | Catechol- O-methyltransferase | Homocysteine | Folate | Catechol-O-methyltransferase | catechol-O-methyltransferase | homocysteine | FUNCTIONAL POLYMORPHISM | HUMAN BRAIN | ENZYME-ACTIVITY | PSYCHIATRY | schizophrenia | COMMON MUTATION | INDIVIDUAL VARIATION | COMT | NEUROSCIENCES | CLINICAL NEUROLOGY | GENETIC-VARIATION | folate | methylenetetrahydrofolate reductase | genetics | PHARMACOLOGY & PHARMACY | ASSOCIATION | WORKING-MEMORY | Genetic Predisposition to Disease | Gene Frequency | Humans | Middle Aged | Risk Factors | Genotype | Male | Catechol O-Methyltransferase - genetics | Schizophrenia - epidemiology | Polymorphism, Genetic | Schizophrenia - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Adult | Female | Odds Ratio | Genetic aspects | Folic acid | Medical genetics
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11. Full Text THE METHYLENETETRAHYDROFOLATE REDUCTASE GENE ( MTHFR ) AND RISK FOR SCHIZOPHRENIA. ARE FUNCTIONAL MTHFR GENE POLYMORPHISMS ASSOCIATED WITH AGE OF ONSET?
by Jönsson, Erik G and Saetre, Peter and Vares, Maria and Werge, Thomas and Andreassen, Ole A and Arinami, Tadao and Nanko, Shinichiro and Tan, Ene Choo and Han, Doug Hyun and Roffman, Joshua and Muntjewerff, Jan-Willem and Jagodzinski, Pawel and Vilella, Elisabet and Betcheva, Elitza and Nakamura, Yusuke and Regland, Björn
Schizophrenia Research, ISSN 0920-9964, 2010, Volume 117, Issue 2, pp. 336 - 336
Psychiatry | Schizophrenia | Medical colleges | Genetic aspects | Genetic polymorphisms
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12. Full Text Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk
by Gellekink, H and Muntjewerff, J.W and Vermeulen, S and Hermus, A.R.M.M and Blom, H.J and Heijer, M. den
Thrombosis and Haemostasis, ISSN 0340-6245, 2007, Volume 98, Issue 6, pp. 1226 - 1231
A disturbed methylation has been proposed as a mechanism via which homocysteine is associated with diseases like vascular disease, neural tube defects and... 
homocysteine | catechol-O-methyltransferase | Venous thrombosis | haplotype | Blood Coagulation, Fibrinolysis and Cellular Haemostasis | Catechol-O-methyltransferase | Homocysteine | Haplotype | HYPERHOMOCYSTEINEMIA | HUMAN BRAIN | METAANALYSIS | ENZYME-ACTIVITY | DNA HYPOMETHYLATION | SCHIZOPHRENIA | COMT | PARKINSONS-DISEASE PATIENTS | S-ADENOSYLHOMOCYSTEINE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | venous thrombosis | FOLATE | Haplotypes | Recurrence | Venous Thrombosis - enzymology | Risk Assessment | Gene Frequency | Humans | Middle Aged | Risk Factors | Venous Thrombosis - blood | Homocysteine - blood | Genotype | Male | Catechol O-Methyltransferase - genetics | Case-Control Studies | Linkage Disequilibrium | Phenotype | Adult | Female | Aged | Polymorphism, Single Nucleotide | Venous Thrombosis - genetics | Odds Ratio
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13. Full Text No evidence for a preferential transmission of the methylenetetrahydrofolate reductase 677T allele in families with schizophrenia offspring
by Muntjewerff, J.W and Hoogendoorn, M.L and Aukes, M.F and Kahn, R.S and Sinke, R.J and Blom, H.J and Heijer, M. den
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, ISSN 1552-4841, 2007, Volume 144, Issue 7, pp. 891 - 894
The methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism has been associated with an increased risk of schizophrenia in various case-control... 
homocysteine | psychiatric disorder | folate | neurodevelopment | family‐based study | Neurodevelopment | Homocysteine | Family-based study | Folate | Psychiatric disorder | HOMOCYSTEINE METABOLISM | METAANALYSIS | PSYCHIATRY | NEURAL-TUBE DEFECTS | family-based study | 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE | COMMON MUTATION | VASCULAR-DISEASE | RISK-FACTOR | GENE | DOWN-SYNDROME | GENETICS & HEREDITY | Prevalence | Schizophrenia - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Humans | Risk Factors | Alleles | Family Health | Female | Genotype | Male | Schizophrenia - epidemiology
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14. Full Text Genome-Wide Analysis Shows Increased Frequency of Copy Number Variation Deletions in Dutch Schizophrenia Patients
by Buizer-Voskamp, Jacobine E and Muntjewerff, Jan-Willem and Strengman, Eric and Sabatti, Chiara and Stefansson, Hreinn and Vorstman, Jacob A. S and Ophoff, Roel A and GROUP investigators, [No Value]
Biological Psychiatry, ISSN 1873-2402, 10/2011, Volume 70, Issue 7, pp. 655 - 662
Background: Since 2008, multiple studies have reported on copy number variations (CNVs) in schizophrenia. However, many regions are unique events with minimal... 
DUPLICATIONS | METAANALYSIS | VARIANTS | HIDDEN-MARKOV MODEL | cytogenetic abnormality | RECURRENT REARRANGEMENTS | schizophrenia | BIPOLAR DISORDER | UMCG Approved | duplication | copy number variation | SNP GENOTYPING DATA | deletion | GENETICS | GENES | Candidate gene | ASSOCIATION
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15. Full Text Sexual behavior and sexual orientation of the female rat after hormonal treatment during various stages of development
by de Jonge, Francien H and Muntjewerff, Jan-Willem and Louwerse, Annet L and van de Poll, Nanne E
Hormones and Behavior, ISSN 0018-506X, 1988, Volume 22, Issue 1, pp. 100 - 115
The amount of circulating sex steroids during Postnatal Days 30-90 was varied in normally developed and in androgenized female rats. The influence of these... 
Pregnancy | Animals | Ovariectomy | Rats | Female | Genitalia, Female - drug effects | Rats, Inbred Strains | Testosterone - pharmacology | Sexual Behavior, Animal - drug effects | Estradiol - pharmacology | Posture
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